論文・総説 - 細谷　孝充

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  1. Okamoto M, Hidaka A, Toyama M, Hosoya T, Yamamoto M, Hagiwara M, Baba M. Selective inhibition of HIV-1 replication by the CDK9 inhibitor FIT-039. Antiviral Res. 2015.11; 123 1-4. ( PubMed, DOI )

  2. Yoshida S, Shimomori K, Nonaka T, Hosoya T. Facile Synthesis of Diverse Multisubstituted ortho-Silylaryl Triflates via C–H Borylation. Chem Lett. 2015.10; 44 (10): 1324-1326. ( DOI )

  3. Hosoya T, Iimori R, Yoshida S, Sumida Y, Sahara-Miura Y, Sato J, Inouye S. Concise Synthesis of v-Coelenterazines. Org Lett. 2015.08; 17 (15): 3888-3891. ( PubMed, DOI )

  4. Masaki S, Kii I, Sumida Y, Kato-Sumida T, Ogawa Y, Ito N, Nakamura M, Sonamoto R, Kataoka N, Hosoya T, Hagiwara M. Design and synthesis of a potent inhibitor of class 1 DYRK kinases as a suppressor of adipogenesis. Bioorg Med Chem. 2015.08; 23 (15): 4434-4441. ( PubMed, DOI )

  5. Morooka S, Hoshina M, Kii I, Okabe T, Kojima H, Inoue N, Okuno Y, Denawa M, Yoshida S, Fukuhara J, Ninomiya K, Ikura T, Furuya T, Nagano T, Noda K, Ishida S, Hosoya T, Ito N, Yoshimura N, Hagiwara M. Identification of a Dual Inhibitor of SRPK1 and CK2 That Attenuates Pathological Angiogenesis of Macular Degeneration in Mice. Mol Pharmacol. 2015.08; 88 (2): 316-325. ( PubMed, DOI )

  6. Sonamoto R, Kii I, Koike Y, Sumida Y, Kato-Sumida T, Okuno Y, Hosoya T, Hagiwara M. Identification of a DYRK1A Inhibitor that Induces Degradation of the Target Kinase using Co-chaperone CDC37 fused with Luciferase nanoKAZ. Sci Rep. 2015.08; 5 12728. ( PubMed, DOI )

  7. Yoshida S, Hazama Y, Sumida Y, Yano T, Hosoya T. An Alternative Method for Generating Arynes from ortho-Silylaryl Triflates: Activation by Cesium Carbonate in the Presence of a Crown Ether. Molecules. 2015.06; 20 (6): 10131-10140. ( PubMed, DOI )

  8. Yoshida S, Uchida K, Hosoya T. Generation of Arynes Using Trimethylsilylmethyl Grignard Reagent for Activation of ortho-Iodoaryl or ortho-Sulfinylaryl Triflates. Chem Lett. 2015.05; 44 (5): 691-693. ( DOI )

  9. Yoshida S, Karaki F, Uchida F, Hosoya T. Generation of cycloheptynes and cyclooctynes via a sulfoxide-magnesium exchange reaction of readily synthesized 2-sulfinylcycloalkenyl triflates. Chem Commun. 2015.05; 51 (42): 8745-8748. ( PubMed, DOI )

  10. Yoshida M, Kataoka N, Miyauchi K, Ohe K, Iida K, Yoshida S, Nojima T, Okuno Y, Onogi H, Usui T, Takeuchi A, Hosoya T, Suzuki T, Hagiwara M. Rectifier of aberrant mRNA splicing recovers tRNA modification in familial dysautonomia. Proc Natl Acad Sci USA. 2015.03; 112 (9): 2764-2769. ( PubMed, DOI )

  11. Yoshida S, Uchida K, Igawa K, Tomooka K, Hosoya T. An efficient generation method and remarkable reactivities of 3-triflyloxybenzyne. Chem Commun (Camb.). 2014.11; 50 (95): 15059-15062. ( PubMed, DOI )

  12. Sumida Y, Harada R, Kato-Sumida T, Johmoto K, Uekusa H, Hosoya T. Boron-Selective Biaryl Coupling Approach to Versatile Dibenzoxaborins and Application to Concise Synthesis of Defucogilvocarcin M. Org Lett. 2014.11; 16 (23): 6240-6243. ( PubMed, DOI )

  13. Xu F, Peng L, Shinohara K, Morita T, Yoshida S, Hosoya T, Orita A, Otera J. Substituted 5,6,11,12-Tetradehydrodibenzo[a,e]cyclooctenes: Syntheses, Properties, and DFT Studies of Substituted Sondheimer-Wong Diynes. J Org Chem. 2014.11; 79 (23): 11592-11608. ( PubMed, DOI )

  14. Yoshida S, Nonaka T, Morita T, Hosoya T. Modular synthesis of bis- and tris-1,2,3-triazoles by permutable sequential azide-aryne and azide-alkyne cycloadditions. Org Biomol Chem. 2014.10; 12 (38): 7489-7493. ( PubMed, DOI )

  15. Yoshida S, Hatakeyama Y, Johmoto K, Uekusa H, Hosoya T. Transient protection of strained alkynes from click reaction via complexation with copper. J Am Chem Soc. 2014.10; 136 (39): 13590-13593. ( PubMed, DOI )

  16. Inouye S, Sato J-i, Sahara-Miura Y, Hosoya T, Suzuki T. Unconventional secretion of the mutated 19 kDa protein of Oplophorus luciferase (nanoKAZ) in mammalian cells. Biochem Biophys Res Commun. 2014.08; 450 (4): 1313-1319. ( PubMed, DOI )

  17. Yamamoto M, Onogi H, Kii I, Yoshida S, Iida K, Sakai H, Abe M, Tsubota T, Ito N, Hosoya T, Hagiwara M. CDK9 inhibitor FIT-039 prevents replication of multiple DNA viruses. J Clin Invest. 2014.08; 124 (8): 3479-3488. ( PubMed, DOI )

  18. Suzuki M, Doi H, Koyama H, Zhang Z, Hosoya T, Onoe H, Watanabe Y. Pd0-mediated rapid cross-coupling reactions, the rapid C-[11C]methylations, revolutionarily advancing the syntheses of short-lived PET molecular probes. Chem Rec. 2014.06; 14 (3): 516-541. ( PubMed, DOI )

  19. Yoshida S, Misawa Y, Hosoya T. Formal C–H-Azidation Based Shortcut to Diazido Building Blocks for the Versatile Preparation of Photoaffinity Labeling Probes. Eur J Org Chem. 2014.05; (19): 3991-3995. ( DOI )

  20. Takahashi K, Hosoya T, Onoe K, Doi H, Nagata H, Hiramatsu T, Li XL, Watanabe Y, Wada Y, Takashima T, Suzuki M, Onoe H, Watanabe Y. 11C-Cetrozole: An Improved C-11C-Methylated PET Probe for Aromatase Imaging in the Brain. J Nucl Med. 2014.03; 55 (5): 852-857. ( PubMed, DOI )

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