論文・総説 - 秋山　好光

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  1. Yanagisawa Y, Akiyama Y, Iida S, Ito E, Nomizu T, Sugihara K, Yuasa Y, Maruyama K. Methylation of the hMLH1 promoter in familial gastric cancer with microsatellite instability. Int J Cancer. 2000.01; 85 (1): 50-53. ( PubMed )

  2. Akiyama Y, Arai T, Nagasaki H, Yagi OK, Nakahata A, Nakajima T, Ohkura Y, Iwai T, Saitoh K, Yuasa Y. Frequent allelic imbalance on chromosome 18q21 in early superficial colorectal cancers. Jpn J Cancer Res. 1999.12; 90 (12): 1329-1337. ( PubMed )

  3. Arai T, Akiyama Y, Nagasaki H, Murase N, Okabe S, Ikeuchi T, Saito K, Iwai T, Yuasa Y. EXTL3/EXTR1 alterations in colorectal cancer cell lines. Int J Oncol. 1999.11; 15 (5): 915-919. ( PubMed )

  4. Bai YQ, Akiyama Y, Nagasaki H, Lu SL, Arai T, Morisaki T, Kitamura M, Muto A, Nagashima M, Nomizu T, Iwama T, Itoh H, Baba S, Iwai T, Yuasa Y. Predominant germ-line mutation of the hMSH2 gene in Japanese hereditary non-polyposis colorectal cancer kindreds. Int J Cancer. 1999.08; 82 (4): 512-515. ( PubMed )

  5. Iida S, Akiyama Y, Ichikawa W, Yamashita T, Nomizu T, Nihei Z, Sugihara K, Yuasa Y. Infrequent germ-line mutation of the E-cadherin gene in Japanese familial gastric cancer kindreds. Clin Cancer Res. 1999.06; 5 (6): 1445-1447. ( PubMed )

  6. Ito E, Yanagisawa Y, Iwahashi Y, Suzuki Y, Nagasaki H, Akiyama Y, Sugano S, Yuasa Y, Maruyama K. A core promoter and a frequent single-nucleotide polymorphism of the mismatch repair gene hMLH1. Biochem Biophys Res Commun. 1999.03; 256 (3): 488-494. ( PubMed, DOI )

  7. Yagi OK, Akiyama Y, Yuasa Y. Genomic structure and alterations of homeobox gene CDX2 in colorectal carcinomas. Br J Cancer. 1999.02; 79 (3-4): 440-444. ( PubMed, DOI )

  8. Arai T, Akiyama Y, Okabe S, Saito K, Iwai T, Yuasa Y. Genomic organization and mutation analyses of the DR5/TRAIL receptor 2 gene in colorectal carcinomas. Cancer Lett. 1998.11; 133 (2): 197-204. ( PubMed )

  9. Arai T, Akiyama Y, Yamamura A, Hosoi T, Shibata T, Saitoh K, Okabe S, Yuasa Y. Allelotype analysis of early colorectal cancers with lymph node metastasis. Int J Cancer. 1998.08; 79 (4): 418-423. ( PubMed )

  10. Iwahashi Y, Ito E, Yanagisawa Y, Akiyama Y, Yuasa Y, Onodera T, Maruyama K. Promoter analysis of the human mismatch repair gene hMSH2. Gene. 1998.06; 213 (1-2): 141-147. ( PubMed )

  11. Lu SL, Kawabata M, Imamura T, Akiyama Y, Nomizu T, Miyazono K, Yuasa Y. HNPCC associated with germline mutation in the TGF-beta type II receptor gene. Nat Genet. 1998.05; 19 (1): 17-18. ( PubMed, DOI )

  12. Akiyama Y, Yagi OK, Ishikawa T, Nagasaki H, Saitoh K, Yuasa Y. Genetic alterations are frequent in APC but rare in the TGF-beta type II receptor gene in cancer in adenomas of the colon. Cancer Lett. 1998.03; 125 (1-2): 89-96. ( PubMed )

  13. Yagi OK, Akiyama Y, Nomizu T, Iwama T, Endo M, Yuasa Y. Proapoptotic gene BAX is frequently mutated in hereditary nonpolyposis colorectal cancers but not in adenomas. Gastroenterology. 1998.02; 114 (2): 268-274. ( PubMed )

  14. Yanagisawa Y, Ito E, Iwahashi Y, Akiyama Y, Yuasa Y, Maruyama K. Isolation and characterization of the 5' region of the human mismatch repair gene hPMS1. Biochem Biophys Res Commun. 1998.02; 243 (3): 738-743. ( PubMed, DOI )

  15. Arai T, Akiyama Y, Okabe S, Ando M, Endo M, Yuasa Y. Genomic structure of the human Smad3 gene and its infrequent alterations in colorectal cancers. Cancer Lett. 1998.01; 122 (1-2): 157-163. ( PubMed )

  16. Akiyama Y, Sato H, Yamada T, Nagasaki H, Tsuchiya A, Abe R, Yuasa Y. Germ-line mutation of the hMSH6/GTBP gene in an atypical hereditary nonpolyposis colorectal cancer kindred. Cancer Res. 1997.09; 57 (18): 3920-3923. ( PubMed )

  17. Yagi OK, Akiyama Y, Ohkura Y, Ban S, Endo M, Saitoh K, Yuasa Y. Analyses of the APC and TGF-beta type II receptor genes, and microsatellite instability in mucosal colorectal carcinomas. Jpn J Cancer Res. 1997.08; 88 (8): 718-724. ( PubMed )

  18. Akiyama Y, Tsubouchi N, Yuasa Y. Frequent somatic mutations of hMSH3 with reference to microsatellite instability in hereditary nonpolyposis colorectal cancers. Biochem Biophys Res Commun. 1997.07; 236 (2): 248-252. ( PubMed, DOI )

  19. Akiyama Y, Iwanaga R, Saitoh K, Shiba K, Ushio K, Ikeda E, Iwama T, Nomizu T, Yuasa Y. Transforming growth factor beta type II receptor gene mutations in adenomas from hereditary nonpolyposis colorectal cancer. Gastroenterology. 1997.01; 112 (1): 33-39. ( PubMed )

  20. Akiyama Y, Iwanaga R, Ishikawa T, Sakamoto K, Nishi N, Nihei Z, Iwama T, Saitoh K, Yuasa Y. Mutations of the transforming growth factor-beta type II receptor gene are strongly related to sporadic proximal colon carcinomas with microsatellite instability. Cancer. 1996.12; 78 (12): 2478-2484. ( PubMed )

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