論文・総説 - 秋山　好光

21. Atsushi Oba, Shu Shimada, Yoshimitsu Akiyama, Taketo Nishikawaji, Kaoru Mogushi, Hiromitsu Ito, Satoshi Matsumura, Arihiro Aihara, Yusuke Mitsunori, Daisuke Ban, Takanori Ochiai, Atsushi Kudo, Hiroshi Asahara, Atsushi Kaida, Masahiko Miura, Minoru Tanabe, Shinji Tanaka. ARID2 modulates DNA damage response in human hepatocellular carcinoma cells. J. Hepatol.. 2017.05; 66 (5): 942-951. ( PubMed, DOI )

22. Oze I, Shimada S, Nagasaki H, Akiyama Y, Watanabe M, Yatabe Y, Matsuo K, Yuasa Y.. Plasma miR-103, miR-107, and miR-194 levels are not correlated with human diffuse gastric cancer. Journal of Cancer Research and Clinical Oncology. 2017.03; (143): 551-554.

23. Angel Diaz-Lagares, Ana B Crujeiras, Paula Lopez-Serra, Marta Soler, Fernando Setien, Ashish Goyal, Juan Sandoval, Yutaka Hashimoto, Anna Martinez-Cardús, Antonio Gomez, Holger Heyn, Catia Moutinho, Jesús Espada, August Vidal, Maria Paúles, Maica Galán, Núria Sala, Yoshimitsu Akiyama, María Martínez-Iniesta, Lourdes Farré, Alberto Villanueva, Matthias Gross, Sven Diederichs, Sonia Guil, Manel Esteller. Epigenetic inactivation of the p53-induced long noncoding RNA TP53 target 1 in human cancer. Proc. Natl. Acad. Sci. U.S.A.. 2016.11; 113 (47): E7535-E7544.

24. Nishikawaji T, Akiyama Y, Shimada S, Kojima K, Kawano T, Eishi Y, Yuasa Y, Tanaka S. Oncogenic roles of the SETDB2 histone methyltransferase in gastric cancer. Oncotarget. 2016.10; 7 (41): 67251-67265. ( PubMed, DOI )

25. Akahoshi K, Tanaka S, Mogushi K, Shimada S, Matsumura S, Akiyama Y, Aihara A, Mitsunori Y, Ban D, Ochiai T, Kudo A, Arii S, Tanabe M.. Expression of connective tissue growth factor in the livers of non-viral hepatocellular carcinoma patients with metabolic risk factors. J Gastroenterol. . 2016.09; 51 (9): 910-922.

26. Furuyama T, Tanaka S, Shimada S, Akiyama Y, Matsumura S, Mitsunori Y, Aihara A, Ban D, Ochiai T, Kudo A, Fukamachi H, Arii S, Kawaguchi Y, Tanabe M. Proteasome activity is required for the initiation of precancerous pancreatic lesions. Sci Rep. 2016.05; 6 27044. ( PubMed, DOI )

27. Lentjes MH, Niessen HE, Akiyama Y, de Bruïne AP, Melotte V, van Engeland M. The emerging role of GATA transcription factors in development and disease. Expert Rev Mol Med. 2016.03; 18 e3. ( PubMed, DOI )

28. Katsuta E, Tanaka S, Mogushi K, Shimada S, Akiyama Y, Aihara A, Matsumura S, Mitsunori Y, Ban D, Ochiai T, Kudo A, Fukamachi H, Tanaka H, Nakayama K, Arii S, Tanabe M.. CD73 as a therapeutic target for pancreatic neuroendocrine tumor stem cells. Int J Oncol. . 2016.02; 48 (2): 657-669.

29. Akiyama Y, Koda Y, Byeon SJ, Shimada S, Nishikawaji T, Sakamoto A, Chen Y, Kojima K, Kawano T, Eishi Y, Deng D, Kim WH, Zhu WG, Yuasa Y, Tanaka S. Reduced expression of SET7/9, a histone mono-methyltransferase, is associated with gastric cancer progression. Oncotarget. 2016.01; 7 (4): 3966-3983. ( PubMed, DOI )

30. Ito H, Tanaka S, Akiyama Y, Shimada S, Adikrisna R, Matsumura S, Aihara A, Mitsunori Y, Ban D, Ochiai T, Kudo A, Arii S, Yamaoka S, Tanabe M. Dominant Expression of DCLK1 in Human Pancreatic Cancer Stem Cells Accelerates Tumor Invasion and Metastasis. PLoS ONE. 2016.01; 11 (1): e0146564. ( PubMed, DOI )

31. Hyang Sook Seol, Yoshimitsu Akiyama, Shu Shimada, Hee Jin Lee, Tae Im Kim, Sung Min Chun, Shree Ram Singh, Se Jin Jang. Epigenetic silencing of microRNA-373 to epithelial-mesenchymal transition in non-small cell lung cancer through IRAK2 and LAMP1 axes. Cancer Lett.. 2014.10; 353 (2): 232-241. ( PubMed, DOI )

32. L Chen, L Fu, X Kong, J Xu, Z Wang, X Ma, Y Akiyama, Y Chen, J Fang. Jumonji domain-containing protein 2B silencing induces DNA damage response via STAT3 pathway in colorectal cancer. Br. J. Cancer. 2014.02; 110 (4): 1014-1026. ( PubMed, DOI )

33. 秋山好光. 胃がん、エピジェネティクスと病気 遺伝子医学MOOK25. 2013.08; 25 64-69.

34. Yutaka Hashimoto, Yoshimitsu Akiyama, Yasuhito Yuasa. Multiple-to-multiple relationships between microRNAs and target genes in gastric cancer. PLoS ONE. 2013.05; 8 (5): e62589. ( PubMed, DOI )

35. Donglai Wang, Jingyi Zhou, Xiangyu Liu, Danyu Lu, Changchun Shen, Yipeng Du, Fu-Zheng Wei, Boyan Song, Xiaopeng Lu, Yu Yu, Lina Wang, Ying Zhao, Haiying Wang, Yang Yang, Yoshimitsu Akiyama, Hongquan Zhang, Wei-Guo Zhu. Methylation of SUV39H1 by SET7/9 results in heterochromatin relaxation and genome instability. Proc. Natl. Acad. Sci. U.S.A.. 2013.04; 110 (14): 5516-5521. ( PubMed, DOI )

36. P Rotkrua, S Shimada, K Mogushi, Y Akiyama, H Tanaka, Y Yuasa. Circulating microRNAs as biomarkers for early detection of diffuse-type gastric cancer using a mouse model. Br. J. Cancer. 2013.03; 108 (4): 932-940. ( PubMed, DOI )

37. Yasuhito Yuasa, Hiromi Nagasaki, Isao Oze, Yoshimitsu Akiyama, Shunsuke Yoshida, Kouhei Shitara, Seiji Ito, Satoyo Hosono, Miki Watanabe, Hidemi Ito, Hideo Tanaka, Daehee Kang, Kai-Feng Pan, Wei-Cheng You, Keitaro Matsuo. Insulin-like growth factor 2 hypomethylation of blood leukocyte DNA is associated with gastric cancer risk. Int. J. Cancer. 2012.12; 131 (11): 2596-2603. ( PubMed, DOI )

38. 秋山好光、湯浅保仁. マイクロRNA発現異常とがん Medical Science Digest. 2012.03; 38 (3): 102-105.

39. Shu Shimada, Ayako Mimata, Masaki Sekine, Kaoru Mogushi, Yoshimitsu Akiyama, Hiroshi Fukamachi, Jos Jonkers, Hiroshi Tanaka, Yoshinobu Eishi, Yasuhito Yuasa. Synergistic tumour suppressor activity of E-cadherin and p53 in a conditional mouse model for metastatic diffuse-type gastric cancer. Gut. 2012.03; 61 (3): 344-353. ( PubMed, DOI )

40. Pichayanoot Rotkrua, Yoshimitsu Akiyama, Yutaka Hashimoto, Takeshi Otsubo, Yasuhito Yuasa. MiR-9 downregulates CDX2 expression in gastric cancer cells. Int. J. Cancer. 2011.12; 129 (11): 2611-2620. ( PubMed, DOI )