論文・総説 - 秋山　好光

41. 秋山好光. miRNAを利用した癌診断 医学のあゆみ. 2011.07; 238 (5): 560-565.

42. 秋山好光、橋本裕、湯浅保仁. microRNA発現プロファイルの胃癌診断への応用 胃がんperspective. 2011.03; 4 (1): 12-19.

43. Takeshi Otsubo, Yoshimitsu Akiyama, Yutaka Hashimoto, Shu Shimada, Kentaro Goto, Yasuhito Yuasa. MicroRNA-126 inhibits SOX2 expression and contributes to gastric carcinogenesis. PLoS ONE. 2011.01; 6 (1): e16617. ( PubMed, DOI )

44. Rie Wada, Yoshimitsu Akiyama, Yutaka Hashimoto, Hiroshi Fukamachi, Yasuhito Yuasa. miR-212 is downregulated and suppresses methyl-CpG-binding protein MeCP2 in human gastric cancer. Int. J. Cancer. 2010.09; 127 (5): 1106-1114. ( PubMed, DOI )

45. Yutaka Hashimoto, Yoshimitsu Akiyama, Takeshi Otsubo, Shu Shimada, Yasuhito Yuasa. Involvement of epigenetically silenced microRNA-181c in gastric carcinogenesis. Carcinogenesis. 2010.05; 31 (5): 777-784. ( PubMed, DOI )

46. Xian-Zi Wen, Yoshimitsu Akiyama, Kai-Feng Pan, Zhao-Jun Liu, Zhe-Ming Lu, Jing Zhou, Lian-Kun Gu, Cai-Xuan Dong, Bu-Dong Zhu, Jia-Fu Ji, Wei-Cheng You, Da-Jun Deng. Methylation of GATA-4 and GATA-5 and development of sporadic gastric carcinomas. World J. Gastroenterol.. 2010.03; 16 (10): 1201-1208. ( PubMed )

47. Debby M E I Hellebrekers, Marjolein H F M Lentjes, Sandra M van den Bosch, Veerle Melotte, Kim A D Wouters, Kathleen L J Daenen, Kim M Smits, Yoshimitsu Akiyama, Yasuhito Yuasa, Silvia Sanduleanu, Carolina A J Khalid-de Bakker, Daisy Jonkers, Matty P Weijenberg, Joost Louwagie, Wim van Criekinge, Beatriz Carvalho, Gerrit A Meijer, Stephen B Baylin, James G Herman, Adriaan P de Bruïne, Manon van Engeland. GATA4 and GATA5 are potential tumor suppressors and biomarkers in colorectal cancer. Clin. Cancer Res.. 2009.06; 15 (12): 3990-3997. ( PubMed, DOI )

48. Yasuhito Yuasa, Hiromi Nagasaki, Yoshimitsu Akiyama, Yutaka Hashimoto, Touichirou Takizawa, Kazuyuki Kojima, Tatsuyuki Kawano, Kenichi Sugihara, Kazue Imai, Kei Nakachi. DNA methylation status is inversely correlated with green tea intake and physical activity in gastric cancer patients. Int. J. Cancer. 2009.06; 124 (11): 2677-2682. ( PubMed, DOI )

49. Aira Wanajo, Akane Sasaki, Hiromi Nagasaki, Shu Shimada, Takeshi Otsubo, Syuichi Owaki, Yasufumi Shimizu, Yoshinobu Eishi, Kazuyuki Kojima, Yasuaki Nakajima, Tatsuyuki Kawano, Yasuhito Yuasa, Yoshimitsu Akiyama. Methylation of the calcium channel-related gene, CACNA2D3, is frequent and a poor prognostic factor in gastric cancer. Gastroenterology. 2008.08; 135 (2): 580-590. ( PubMed, DOI )

50. Jin SH, Akiyama Y, Fukamachi H, Yanagihara K, Akashi T, Yuasa Y. IQGAP2 inactivation through aberrant promoter methylation and promotion of invasion in gastric cancer cells. Int J Cancer. 2008.03; 122 (5): 1040-1046. ( PubMed, DOI )

51. Otsubo T, Akiyama Y, Yanagihara K, Yuasa Y. SOX2 is frequently downregulated in gastric cancers and inhibits cell growth through cell-cycle arrest and apoptosis. Br J Cancer. 2008.02; 98 (4): 824-831. ( PubMed, DOI )

52. Tani Y, Akiyama Y, Fukamachi H, Yanagihara K, Yuasa Y. Transcription factor SOX2 up-regulates stomach-specific pepsinogen A gene expression. J Cancer Res Clin Oncol. 2007.04; 133 (4): 263-269. ( PubMed, DOI )

53. Jinawath A, Akiyama Y, Sripa B, Yuasa Y. Dual blockade of the Hedgehog and ERK1/2 pathways coordinately decreases proliferation and survival of cholangiocarcinoma cells. J Cancer Res Clin Oncol. 2007.04; 133 (4): 271-278. ( PubMed, DOI )

54. Jinawath A, Akiyama Y, Yuasa Y, Pairojkul C. Expression of phosphorylated ERK1/2 and homeodomain protein CDX2 in cholangiocarcinoma. J Cancer Res Clin Oncol. 2006.12; 132 (12): 805-810. ( PubMed, DOI )

55. Guo M, House MG, Akiyama Y, Qi Y, Capagna D, Harmon J, Baylin SB, Brock MV, Herman JG. Hypermethylation of the GATA gene family in esophageal cancer. Int J Cancer. 2006.11; 119 (9): 2078-2083. ( PubMed, DOI )

56. Wakana K, Akiyama Y, Aso T, Yuasa Y. Involvement of GATA-4/-5 transcription factors in ovarian carcinogenesis. Cancer Lett. 2006.09; 241 (2): 281-288. ( PubMed, DOI )

57. Sekine A, Akiyama Y, Yanagihara K, Yuasa Y. Hath1 up-regulates gastric mucin gene expression in gastric cells. Biochem Biophys Res Commun. 2006.06; 344 (4): 1166-1171. ( PubMed, DOI )

58. Wen XZ, Akiyama Y, Baylin SB, Yuasa Y. Frequent epigenetic silencing of the bone morphogenetic protein 2 gene through methylation in gastric carcinomas. Oncogene. 2006.04; 25 (18): 2666-2673. ( PubMed, DOI )

59. Galm O, Suzuki H, Akiyama Y, Esteller M, Brock MV, Osieka R, Baylin SB, Herman JG. Inactivation of the tissue inhibitor of metalloproteinases-2 gene by promoter hypermethylation in lymphoid malignancies. Oncogene. 2005.07; 24 (30): 4799-4805. ( PubMed, DOI )

60. Wu XS, Akiyama Y, Igari T, Kawamura T, Hiranuma S, Shibata T, Tsuruta K, Koike M, Arii S, Yuasa Y. Expression of homeodomain protein CDX2 in gallbladder carcinomas. J Cancer Res Clin Oncol. 2005.05; 131 (5): 271-278. ( PubMed, DOI )