講演・口頭発表等 - 岡本　隆一

41. Tsuchiya K, Watanabe S, Shirasaki T, Nishimura R, Katsukura N, Hibiya S, Okamoto R, Nakamura T, Watanabe M. TP53 mutation in human colonic organoids acquires resistance to in vitro long-term inflammation.. ECCO2019 2019.03.09 Copenhagen（Denmark）

42. Kawamoto A, Nagata S, Anzai S, Takahashi J, Kawai M, Hama M, Nogawa D, Yamamoto K, Kuno R, Suzuki K, Shimizu H, Hiraguri Y, Yui S, Oshima S, Tsuchiya K, Nakamura T, Ohtsuka K, Kitagawa M, Okamoto R, Watanabe M. Synergy of Notch signalling and TNF-α in the inflamed intestinal epithelia of IBD patients leads to up-regulation of UBD, a ubiquitin-like protein. ECCO2019 2019.03.08 Copenhagen（Denmark）

43. Suzuki K, Shimizu H, Kawai M, Takahashi J, Anzai S, Kawamoto A, Nagata S, Hiraguri Y, Yui S, Tsuchiya K, Nakamura T, Ohtsuka K, Okamoto R, Watanabe M . UC-related and segment-specific properties of patientderived colonic organoids. ECCO2019 2019.03.07 Copenhagen（Denmark）

44. Okamoto R, Watanabe M. 【Session 2: Clinical assessment and therapeutic modulation of intestinal regeneration in IBD】Epithelial transplantation to facilitate mucosal healing. ECCO2019 2019.03.07 Copenhagen（Denmark）

45. Watanabe S, Tsuchiya K, Shirasaki T, Hibiya S, Nishimura S, Katsukura N, Oshima S, Okamoto R, Tetsuya N, Watanabe M. Tp53 mutation enhances cell proliferation and stemness in human colon epithelial organoids and promotes a resistance against long-term inflammation. UEGW 2018 2018.10.22 Vienna（Austria）

46. Kuwabara K, Ishibashi F, Kawamoto A, Anzai S, Takahashi J, Nagata S, Shimizu H, Yui S, Oshima S, Tsuchiya K, Nakamura T, Watanabe M, Okamoto R. Long-lived secretory cells residing in the Mouse proximal colon serve as reserve stem cells Under DNA damage-induced mucosal injury. UEGW 2018 2018.10.22 Vienna（Austria）

47. Ishibashi F, Kuwabara K, Kawamoto A, Anzai S, Takahashi J, Nagata S, Shimizu H, Yui S, Oshima S, Tsuchiya K, Nakamura T, Watanabe M, Okamoto R. Ectopic expression of reg3a in the mice distal Colon is mediated by interactions between notch and Il-22 signaling pathways, and promotes tissue repair By the augmentation of EGFR signaling. UEGW 2018 2018.10.22 Vienna（Austria）

48. Hibiya S, Tsuchiya K, Nishimura R, Shirasaki T, Watanabe S, Katsukura N, Okamoto R, Nakamura T, Watanabe M. Lesion-specific gene expression in the Epithelial cells of Crohn’s disease by comparing Small intestinal organoids from active and inactive Lesion in the same patient. UEGW 2018 2018.10.22 Vienna（Austria）

49. Okamoto R, Watanabe M. Regenerative medicine for the treatment of inflammatory bowel disease. 5th TERMIS World Congress 2018 2018.09.07 Kyoto（JAPAN）

50. Suzuki K, Takahashi J, Hiraguri Y, Yui S, Shimizu H, Tsuchiya K, Nakamura T, Ohtsuka K, Okamoto R, Watanabe M. . Crohn’s disease patient-derived small intestinal organoids reveal diseasestatus related modification of stem cell properties.. 5th TERMIS World Congress 2018 2018.09.07 Kyoto（JAPAN）

51. Suzuki K, Murano T, Hiraguri Y, Takahashi J, Shimizu H,Anzai S, Kuwabara K, Kawamoto A, Ishibashi F, Yui S, Tsuchiya K, Nakamura T, Ohtsuka K, Watanabe M, Okamoto R.. Crohn’s disease patient-derived small intestinal organoids reveal disease-status related modification of stem cell properties.. 5th TERMIS World Congress 2018 2018.09.06 Kyoto（JAPAN）

52. Ishibashi F, Shimizu H, Kawamoto A, Suzuki K, Anzai S, Kuwabara K, Takahashi J, Nagata S, Oshima S, Tsuchiya K, Nakamura T, Watanabe M, Okamoto R. Mouse colonic secretory cells de-differentiate into intestinal stem cells and promote mucosal repair through activation of NF-KB signalin. ISSCR2018 2018.06.20 Melbourne

53. Shirasaki T, Tsuchiya K, Nishimura R, Watanabe S, Hibiya S, Katsukura N, Okamoto R, Nakamura T, Watanabe M.. Identification of lesion-specific epithelial function of ulcerative colitis by comparing colonic organoids from lesion and non-lesion parts of same patients.. DDW2018 2018.06.05 Washington D.C (USA）

54. Hibiya S, Tsuchiya K, Watanabe S, Nishimura R, Shirasaki T, Oshima S, Okamoto R, Nakamura T, Watanabe M.. Human colonic organoid treated with inflammatory factors might mimic the pathophysiology of epithelial cells in ulcerative colitis.. DDW2018 2018.06.05 Washington D.C (USA）

55. Suzuki K, Kuwabara K, Takahashi J, Anzai S, Kuno R, Kawamoto A, Ishibashi F, Nagata S, Hiraguri Y, Yui S, Tsuchiya K, Nakamura T, Ohtsuka K, Okamoto R, Watanabe M.. Single-cell level analysis of organoids derived from CD patients reveals disease-status related modifications of small intestinal stem cells. DDW2018 2018.06.04 Washington D.C (USA）

56. Shiro Yui, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe. Fetalization of colonic epithelium medicated by YAP/TAZ links ECM remodeling to tissue regeneration. GI Research Academy 2018 2018.05.25 Keidanren Kaikan、Tokyo, Japan

57. Nishimura R, Tsuchiya K, Shirasaki T, Watanabe S, Hibiya S, Okamoto R, Nakamura T, Watanabe M.. The identification of lesion-specific gene expression in intestinal epithelial cells of Ulcerative Colitis by comparing colonic organoids from lesion and non-lesion parts of same patients.. The 13th Congress of ECCO 2018.02.16 Vienna

58. Shuji Hibiya, Kiichiro Tsuchiya, Sho Watanabe, Ryu Nishimura, Tomoaki Shirasaki, Shigeru Oshima, Ryuichi Okamoto, Tetsuya Nakamura ,Mamoru Watanabe. Establishment of in vitro human model for Ulcerative Colitis by using human colon organoid culture. 13th Congress of ECCO 2018.02.16 Vienna（Austria）

59. A. Kawamoto G. Ito T. Nakata S. Fujii K. Suzuki F. Ishibashi H. Shimizu S. Nagata S. Anzai R. Kuno K. Kuwabara M. Kawai J. Takahashi M. Hama K. Tsuchiya T. Nakamura R. Okamoto M. Watanabe. The ubiquitin-like protein ubiquitin d is up-regulated by synergy of notch and pro-inflammatory cytokines in the inflamed intestinal epithelia of ibd patients.. UEGW2017 (欧州消化器病学会週間2017） 2017.11.01 Barcelona(Spain)

60. S. Watanabe K. Tsuchiya T. Shirasaki S. Hibiya S. Ooshima T. Nakamura R. Nishimura R. Okamoto M. Watanabe. TP53 mutation acquires higher malignant potential in human colon cancer cells. UEGW2017 (欧州消化器病学会週間2017） 2017.11.01 Barcelona(Spain)