Published Papers & Misc - SASAKI Takehiko
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HK Yum, J Arcaroli, J Kupfner, R Shenkar, JM Penninger, T Sasaki, KY Yang, JS Park, E Abraham. Involvement of phosphoinositide 3-kinases in neutrophil activation and the development of acute lung injury JOURNAL OF IMMUNOLOGY. 2001.12; 167 (11): 6601-6608. ( PubMed, DOI )
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T Sasaki, J Sasaki-Irie, JM Penninger. New insights into the transmembrane protein tyrosine phosphatase CD45 INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY. 2001.11; 33 (11): 1041-1046. ( PubMed, DOI )
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T Sasaki, T Wada, H Kishimoto, J Irie-Sasaki, G Matsumoto, T Goto, Z Yao, A Wakeham, T W Mak, A Suzuki, S K Cho, J C Zuniga-Pflucker, A J Oliveira-dos-Santos, T Katada, H Nishina, J M Penninger. The stress kinase mitogen-activated protein kinase kinase (MKK)7 is a negative regulator of antigen receptor and growth factor receptor-induced proliferation in hematopoietic cells. J. Exp. Med.. 2001.09; 194 (6): 757-768. ( PubMed )
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Teiji Wada, Kentaro Nakagawa, Tomomi Watanabe, Gen Nishitai, Jungwon Seo, Hiroyuki Kishimoto, Daiju Kitagawa, Takehiko Sasaki, Josef M. Penninger, Hiroshi Nishina, Toshiaki Katada. Impaired synergistic activation of stress-activated protein kinase SAPK/ JNK in mouse embryonic stem cells lacking SEK1/MKK4: Different contribution of SEK2/MKK7 isoforms to the synergistic activation Journal of Biological Chemistry. 2001.08; 276 (33): 30892-30897. ( PubMed, DOI )
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A Suzuki, M T Yamaguchi, T Ohteki, T Sasaki, T Kaisho, Y Kimura, R Yoshida, A Wakeham, T Higuchi, M Fukumoto, T Tsubata, P S Ohashi, S Koyasu, J M Penninger, T Nakano, T W Mak. T cell-specific loss of Pten leads to defects in central and peripheral tolerance. Immunity. 2001.05; 14 (5): 523-534. ( PubMed )
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J M Penninger, J Irie-Sasaki, T Sasaki, A J Oliveira-dos-Santos. CD45: new jobs for an old acquaintance. Nat. Immunol.. 2001.05; 2 (5): 389-396. ( PubMed, DOI )
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N Joza, S A Susin, E Daugas, W L Stanford, S K Cho, C Y Li, T Sasaki, A J Elia, H Y Cheng, L Ravagnan, K F Ferri, N Zamzami, A Wakeham, R Hakem, H Yoshida, Y Y Kong, T W Mak, J C Zúñiga-Pflücker, G Kroemer, J M Penninger. Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death. Nature. 2001.03; 410 (6828): 549-554. ( PubMed, DOI )
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C Bony, S Roche, U Shuichi, T Sasaki, M A Crackower, J Penninger, H Mano, M Pucéat. A specific role of phosphatidylinositol 3-kinase gamma. A regulation of autonomic Ca(2)+ oscillations in cardiac cells. J. Cell Biol.. 2001.02; 152 (4): 717-728. ( PubMed )
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S Clément, U Krause, F Desmedt, J F Tanti, J Behrends, X Pesesse, T Sasaki, J Penninger, M Doherty, W Malaisse, J E Dumont, Y Le Marchand-Brustel, C Erneux, L Hue, S Schurmans. The lipid phosphatase SHIP2 controls insulin sensitivity. Nature. 2001.01; 409 (6816): 92-97. ( PubMed, DOI )
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C Krawczyk, K Bachmaier, T Sasaki, R G Jones, S B Snapper, D Bouchard, I Kozieradzki, P S Ohashi, F W Alt, J M Penninger. Cbl-b is a negative regulator of receptor clustering and raft aggregation in T cells. Immunity. 2000.10; 13 (4): 463-473. ( PubMed )
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AJ Oliveira-dos-Santos, G Matsumoto, BE Snow, DL Bai, FP Houston, IQ Whishaw, S Mariathasan, T Sasaki, A Wakeham, PS Ohashi, JC Roder, CA Barnes, DP Siderovski, JM Penninger. Regulation of T cell activation, anxiety, and male aggression by RGS2 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2000.10; 97 (22): 12272-12277. ( PubMed, DOI )
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J E Fata, Y Y Kong, J Li, T Sasaki, J Irie-Sasaki, R A Moorehead, R Elliott, S Scully, E B Voura, D L Lacey, W J Boyle, R Khokha, J M Penninger. The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development. Cell. 2000.09; 103 (1): 41-50. ( PubMed )
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T Sasaki, J Irie-Sasaki, Y Horie, K Bachmaier, JE Fata, M Li, A Suzuki, D Bouchard, A Ho, M Redston, S Gallinger, R Khokha, TW Mak, PT Hawkins, L Stephens, SW Scherer, M Tsao, JM Penninger. Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)K gamma NATURE. 2000.08; 406 (6798): 897-902. ( PubMed, DOI )
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K Bachmaier, C Krawczyk, I Kozieradzki, Y Y Kong, T Sasaki, A Oliveira-dos-Santos, S Mariathasan, D Bouchard, A Wakeham, A Itie, J Le, P S Ohashi, I Sarosi, H Nishina, S Lipkowitz, J M Penninger. Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b. Nature. 2000.01; 403 (6766): 211-216. ( PubMed, DOI )
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H Watanabe, M Miura, T Sasaki. Differential effects of the insulin-like growth factor I receptor on radiosensitivity and spontaneous necrosis formation of human glioblastoma cells grown in multicellular spheroids EXPERIMENTAL CELL RESEARCH. 1999.07; 250 (1): 99-111.
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JM Penninger, KD Fischer, T Sasaki, Kozieradzki, I, J Le, K Tedford, K Bachmaier, PS Ohashi, MF Bachmann. The oncogene product Vav is a crucial regulator of primary cytotoxic T cell responses but has no apparent role in CD28-mediated co-stimulation EUROPEAN JOURNAL OF IMMUNOLOGY. 1999.05; 29 (5): 1709-1718. ( PubMed, DOI )
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Q Liu, T Sasaki, I Kozieradzki, A Wakeham, A Itie, D J Dumont, J M Penninger. SHIP is a negative regulator of growth factor receptor-mediated PKB/Akt activation and myeloid cell survival. Genes Dev.. 1999.04; 13 (7): 786-791. ( PubMed )
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MA Lomaga, WC Yeh, Sarosi, I, GS Duncan, C Furlonger, A Ho, S Morony, C Capparelli, G Van, S Kaufman, A van der Heiden, A Itie, A Wakeham, W Khoo, T Sasaki, ZD Cao, JM Penninger, CJ Paige, DL Lacey, CR Dunstan, WJ Boyle, DV Goeddel, TW Mak. TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling GENES & DEVELOPMENT. 1999.04; 13 (8): 1015-1024. ( PubMed, DOI )
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A Hakem, T Sasaki, I Kozieradzki, J M Penninger. The cyclin-dependent kinase Cdk2 regulates thymocyte apoptosis. J. Exp. Med.. 1999.03; 189 (6): 957-968. ( PubMed )
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H Nishina, C Vaz, P Billia, M Nghiem, T Sasaki, JL De la Pompa, K Furlonger, C Paige, CC Hui, KD Fischer, H Kishimoto, T Iwatsubo, T Katada, Woodgett, JR, JM Penninger. Defective liver formation and liver cell apoptosis in mice lacking the stress signaling kinase SEK1/MKK4 DEVELOPMENT. 1999.02; 126 (3): 505-516. ( PubMed )