Published Papers & Misc - SASAKI Takehiko

81. Phosphoinositide 3-kinaseγ controls the intracellular localization of CpG to limit DNA-PKcs-dependent IL-10 production in macrophages. PloS one. 2011.10; 6 (10): ( PubMed, DOI )

82. Yasuo Horie, Shunsuke Takasuga, Takehiko Sasaki, Hirohide Ohnishi. Functional Analysis of Phosphatidylinositol 3,5-Bisphosphate in Enterocytes Using Pipk III Deficient Mice DIGESTIVE DISEASES AND SCIENCES. 2011.10; 56 (10): 2769-2770.

83. Masato Sasaki, Kohichi Kawahara, Miki Nishio, Koshi Mimori, Ryunosuke Kogo, Koichi Hamada, Bunsho Itoh, Jia Wang, Yukako Komatsu, Yong Ryoul Yang, Hiroki Hikasa, Yasuo Horie, Takayuki Yamashita, Takehiko Kamijo, Yanping Zhang, Yan Zhu, Carol Prives, Toru Nakano, Tak Wah Mak, Takehiko Sasaki, Tomohiko Maehama, Masaki Mori, Akira Suzuki. Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11. Nat. Med.. 2011.07; 17 (8): 944-951. ( PubMed, DOI )

84. Yasuo Horie, Shunsuke Takasuga, Takehiko Sasaki, Hirohide Ohnishi. Analysis of Intestinal Inflammation and Fibrosis Based on Impaired Production of Phosphatidylinositol 3,5-Bisphosphate on Enterocytes Using Type III Phosphatidylinositol Phosphate Kinase Deficient Mice GASTROENTEROLOGY. 2011.05; 140 (5): S85.

85. Naoki Kobayashi, Kohjiro Ueki, Yukiko Okazaki, Aya Iwane, Naoto Kubota, Mitsuru Ohsugi, Motoharu Awazawa, Masatoshi Kobayashi, Takayoshi Sasako, Kazuma Kaneko, Miho Suzuki, Yoshitaka Nishikawa, Kazuo Hara, Kotaro Yoshimura, Isao Koshima, Susumu Goyama, Koji Murakami, Junko Sasaki, Ryozo Nagai, Mineo Kurokawa, Takehiko Sasaki, Takashi Kadowaki. Blockade of class IB phosphoinositide-3 kinase ameliorates obesity-induced inflammation and insulin resistance. Proc. Natl. Acad. Sci. U.S.A.. 2011.04; 108 (14): 5753-5758. ( PubMed, DOI )

86. Nobukatsu Kinoshita, Yasuo Horie, Shigetoshi Ohshima, Yohei Hirai, Takahiro Dohmen, Mario Jin, Tamotsu Matsuhashi, Junko Sasaki, Takehiko Sasaki, Masahiro Iizuka, Hirohide Ohnishi. Epimorphin protects hepatocytes from oxidative stress by inhibiting mitochondrial injury JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY. 2011.01; 26 (1): 201-206. ( PubMed, DOI )

87. Yoichiro Fujioka, Masumi Tsuda, Tomoe Hattori, Junko Sasaki, Takehiko Sasaki, Tadaaki Miyazaki, Yusuke Ohba. The Ras-PI3K Signaling Pathway Is Involved in Clathrin-Independent Endocytosis and the Internalization of Influenza Viruses PLOS ONE. 2011.01; 6 (1): ( PubMed, DOI )

88. Laura A. Volpicelli-Daley, Louise Lucast, Liang-Wei Gong, Lijuan Liu, Junko Sasaki, Takehiko Sasaki, Charles S. Abrams, Yasunori Kanaho, Pietro De Camilli. Phosphatidylinositol-4-Phosphate 5-Kinases and Phosphatidylinositol 4,5-Bisphosphate Synthesis in the Brain JOURNAL OF BIOLOGICAL CHEMISTRY. 2010.09; 285 (37): 28708-28714. ( PubMed, DOI )

89. Honglu Zhang, Ju He, Tatiana G. Kutateladze, Takahiro Sakai, Takehiko Sasaki, Nicolas Markadieu, Christophe Erneux, Glenn D. Prestwich. 5-Stabilized Phosphatidylinositol 3,4,5-Trisphosphate Analogues Bind Grp1 PH, Inhibit Phosphoinositide Phosphatases, and Block Neutrophil Migration CHEMBIOCHEM. 2010.02; 11 (3): 388-395. ( PubMed, DOI )

90. Masahide Takeda, Wataru Ito, Masako Tanabe, Shigeharu Ueki, Junko Kihara, Hikari Kato, Tomomi Tanigai, Hiroyuki Kayaba, Takehiko Sasaki, Junichi Chihara. The Pathophysiological Roles of PI3Ks and Therapeutic Potential of Selective Inhibitors in Allergic Inflammation INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY. 2010; 152 90-95. ( PubMed, DOI )

91. Takehiko Sasaki, Junko Sasaki, Shunsuke Takasuga, Satoshi Eguchi, Satoshi Kofuji. Physiology of phosphoinositide metabolism JOURNAL OF PHYSIOLOGICAL SCIENCES. 2010; 60 S68.

92. Takehiko Sasaki, Shunsuke Takasuga, Junko Sasaki, Satoshi Kofuji, Satoshi Eguchi, Masakazu Yamazaki, Akira Suzuki. Mammalian phosphoinositide kinases and phosphatases. Prog. Lipid Res.. 2009.11; 48 (6): 307-343. ( PubMed, DOI )

93. Naoki Kobayashi, Kohjiro Ueki, Takehiko Sasaki, Takashi Kadowaki. Crucial Role of Class IB PI3-Kinase, PI3K gamma, in Obesity-Induced Insulin Resistance DIABETES. 2009.06; 58 A352.

94. Akihiko Nishikimi, Hideo Fukuhara, Wenjuan Su, Tsunaki Hongu, Shunsuke Takasuga, Hisashi Mihara, Qinhong Cao, Fumiyuki Sanematsu, Motomu Kanai, Hiroshi Hasegawa, Yoshihiko Tanaka, Masakatsu Shibasaki, Yasunori Kanaho, Takehiko Sasaki, Michael A Frohman, Yoshinori Fukui. Sequential regulation of DOCK2 dynamics by two phospholipids during neutrophil chemotaxis. Science. 2009.04; 324 (5925): 384-387. ( PubMed, DOI )

95. Chihiro Mogi, Masayuki Tobo, Hideaki Tomura, Naoya Murata, Xiao-Dong He, Koichi Sato, Takao Kimura, Tamotsu Ishizuka, Takehiko Sasaki, Takashi Sato, Yasuyuki Kihara, Satoshi Ishii, Akihiro Harada, Fumikazu Okajima. Involvement of Proton-Sensing TDAG8 in Extracellular Acidification-Induced Inhibition of Proinflammatory Cytokine Production in Peritoneal Macrophages JOURNAL OF IMMUNOLOGY. 2009.03; 182 (5): 3243-3251. ( PubMed, DOI )

96. Yanfeng Wang, Xinsheng Chen, Lurong Lian, Tang Tang, Timothy J. Stalker, Takehiko Sasaki, Yasunori Kanaho, Lawrence F. Brass, John K. Choi, John H. Hartwig, Charles S. Abrams. Loss of PIP5KI beta demonstrates that PIP5KI isoform-specific PIP2 synthesis is required for IP3 formation (vol 105, pg 14064, 2008) PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009.01; 106 (4): 1291. ( DOI )

97. Manando Nakasaki, Kiyoko Yoshioka, Yasuhide Miyamoto, Takehiko Sasaki, Hideki Yoshikawa, Kazuyuki Itoh. IGF-I secreted by osteoblasts acts as a potent chemotactic factor for osteoblasts BONE. 2008.11; 43 (5): 869-879. ( PubMed, DOI )

98. Yanfeng Wang, Xinsheng Chen, Lurong Lian, Tang Tang, Timothy J Stalker, Takehiko Sasaki, Yasunori Kanaho, Lawrence F Brass, John K Choi, John H Hartwig, Charles S Abrams. Loss of PIP5KIbeta demonstrates that PIP5KI isoform-specific PIP2 synthesis is required for IP3 formation. Proc. Natl. Acad. Sci. U.S.A.. 2008.09; 105 (37): 14064-14069. ( PubMed, DOI )

99. Tae Inoue-Narita, Koichi Hamada, Takehiko Sasaki, Sachiko Hatakeyama, Sachiko Fujita, Kohichi Kawahara, Masato Sasaki, Hiroyuki Kishimoto, Satoshi Eguchi, Itaru Kojima, Friedrich Beermann, Tetsunori Kimura, Masatake Osawa, Satoshi Itami, Tak Wah Mak, Toru Nakano, Motomu Manabe, Akira Suzuki. Pten deficiency in melanocytes results in resistance to hair graying and susceptibility to carcinogen-induced melanomagenesis. Cancer Res.. 2008.07; 68 (14): 5760-5768. ( PubMed, DOI )

100. Hirohide Iwasaki, Yoshimichi Murata, Youngjun Kim, Md Israil Hossain, Carolyn A Worby, Jack E Dixon, Thomas McCormack, Takehiko Sasaki, Yasushi Okamura. A voltage-sensing phosphatase, Ci-VSP, which shares sequence identity with PTEN, dephosphorylates phosphatidylinositol 4,5-bisphosphate. Proc. Natl. Acad. Sci. U.S.A.. 2008.06; 105 (23): 7970-7975. ( PubMed, DOI )