論文・総説 - 永田　哲也

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  1. 横山 裕之, 平井 高志, 榎本 光裕, 永田 哲也, 横田 隆徳, 大川 淳. DNAマイクロアレイを用いた神経障害性疼痛関連分子の調査 日本整形外科学会雑誌. 2018.08; 92 (8): S1800. ( 医中誌 )

  2. 山田 大貴, 永田 哲也, 横田 隆徳. 【神経難病と創薬】神経難病と核酸医薬による分子標的治療の現状 医薬ジャーナル. 2018.07; 54 (7): 1613-1621. ( 医中誌 )

  3. 馬嶋 貴正, 永田 哲也, 仁科 一隆, 横田 隆徳. 【核酸医薬の現状と展望】ヘテロ核酸の現状 最新医学. 2018.06; 73 (6): 781-786. ( 医中誌 )

  4. 永田 哲也. 【核酸医薬の現状と展望】核酸医薬と神経変性疾患 最新医学. 2018.06; 73 (6): 807-814. ( 医中誌 )

  5. 大谷木 正貴, 永田 哲也, 横田 隆徳. 【核酸医薬】DNA/RNAヘテロ2本鎖核酸(HDO)の開発 BIO Clinica. 2018.01; 33 (1): 6-10. ( 医中誌 )

  6. 東 美和, 永田 哲也, 横田 隆徳. 【脊髄小脳変性症(SCD)-最新診療マニュアル】これからの治療への展望　核酸医薬 Clinical Neuroscience. 2017.09; 35 (9): 1124-1127. ( 医中誌 )

  7. Tanihata J, Nagata T, Ito N, Saito T, Nakamura A, Minamisawa S, Aoki Y, Ruegg UT, Takeda S. Truncated dystrophin ameliorates the dystrophic phenotype of mdx mice by reducing sarcolipin-mediated SERCA inhibition. Biochemical and biophysical research communications. 2018.09; ( PubMed, DOI )

  8. Zeniya S, Kuwahara H, Daizo K, Watari A, Kondoh M, Yoshida-Tanaka K, Kaburagi H, Asada K, Nagata T, Nagahama M, Yagi K, Yokota T. Angubindin-1 opens the blood-brain barrier in vivo for delivery of antisense oligonucleotide to the central nervous system. Journal of controlled release : official journal of the Controlled Release Society. 2018.05; 283 126-134. ( PubMed, DOI )

  9. Komaki H*, Nagata T*, Saito T*, Masuda S, Takeshita E, Sasaki M, Tachimori H, Nakamura H, Aoki Y, Takeda S *Equal Contribution. Systemic administration of the antisense oligonucleotide NS-065/NCNP-01 for skipping of exon 53 in patients with Duchenne muscular dystrophy. Science translational medicine. 2018.04; 10 (437): ( PubMed, DOI )

  10. Kuwahara H, Song J, Shimoura T, Yoshida-Tanaka K, Mizuno T, Mochizuki T, Zeniya S, Li F, Nishina K, Nagata T, Ito S, Kusuhara H, Yokota T. Modulation of blood-brain barrier function by a heteroduplex oligonucleotide in vivo. Scientific reports. 2018.03; 8 (1): 4377. ( PubMed, DOI )

  11. Kishimoto Y, Fujii A, Nakagawa O, Nagata T, Yokota T, Hari Y, Obika S. Synthesis and thermal stabilities of oligonucleotides containing 2'-O,4'-C-methylene bridged nucleic acid with a phenoxazine base. Organic & biomolecular chemistry. 2017.10; 15 (38): 8145-8152. ( PubMed, DOI )

  12. Echigoya Y, Nakamura A, Nagata T, Urasawa N, Lim KRQ, Trieu N, Panesar D, Kuraoka M, Moulton HM, Saito T, Aoki Y, Iversen P, Sazani P, Kole R, Maruyama R, Partridge T, Takeda S, Yokota T. Effects of systemic multiexon skipping with peptide-conjugated morpholinos in the heart of a dog model of Duchenne muscular dystrophy. Proceedings of the National Academy of Sciences of the United States of America. 2017.04; 114 (16): 4213-4218. ( PubMed, DOI )

  13. Kimura K, Morita H, Daimon M, Kawata T, Nakao T, Lee SL, Hirokawa M, Ebihara A, Nakajima T, Ozawa T, Yonemochi Y, Aida I, Motoyoshi Y, Mikata T, Uchida I, Komori T, Kitao R, Nagata T, Takeda S, Komaki H, Segawa K, Takenaka K, Komuro I. Prognostic impact of venous thromboembolism in patients with Duchenne muscular dystrophy: Prospective multicenter 5-year cohort study. International journal of cardiology. 2015.07; 191 178-180. ( PubMed, DOI )

  14. Yoshioka K, Kuwahara H, Nishina K, Nagata T, Yokota T. [Recent progress and prospect in oligonucleotide therapeutics]. Nihon rinsho. Japanese journal of clinical medicine. 2015.06; 73 (6): 1057-1065. ( PubMed )

  15. Echigoya Y, Aoki Y, Miskew B, Panesar D, Touznik A, Nagata T, Tanihata J, Nakamura A, Nagaraju K, Yokota T. Long-term efficacy of systemic multiexon skipping targeting dystrophin exons 45-55 with a cocktail of vivo-morpholinos in mdx52 mice. Mol Ther Nucleic Acids. 2015.02; 4 e225. ( PubMed, DOI )

  16. Re DB, Le Verche V, Yu C, Amoroso MW, Politi KA, Phani S, Ikiz B, Hoffmann L, Koolen M, Nagata T, Papadimitriou D, Nagy P, Mitsumoto H, Kariya S, Wichterle H, Henderson CE, Przedborski S. Necroptosis drives motor neuron death in models of both sporadic and familial ALS. Neuron. 2014.03; 81 (5): 1001-1008. ( PubMed, DOI )

  17. Aoki Y, Nagata T, Yokota T, Nakamura A, Wood MJ, Partridge T, Takeda S. Highly efficient in vivo delivery of PMO into regenerating myotubes and rescue in laminin-α2 chain-null congenital muscular dystrophy mice. Human molecular genetics. 2013.12; 22 (24): 4914-4928. ( PubMed, DOI )

  18. Kimura K, Takenaka K, Ebihara A, Uno K, Morita H, Nakajima T, Ozawa T, Aida I, Yonemochi Y, Higuchi S, Motoyoshi Y, Mikata T, Uchida I, Ishihara T, Komori T, Kitao R, Nagata T, Takeda S, Yatomi Y, Nagai R, Komuro I. Prognostic impact of left ventricular noncompaction in patients with Duchenne/Becker muscular dystrophy--prospective multicenter cohort study. International journal of cardiology. 2013.10; 168 (3): 1900-1904. ( PubMed, DOI )

  19. Echigoya Y, Lee J, Rodrigues M, Nagata T, Tanihata J, Nozohourmehrabad A, Panesar D, Miskew B, Aoki Y, Yokota T. Mutation types and aging differently affect revertant fiber expansion in dystrophic mdx and mdx52 mice. PloS one. 2013; 8 (7): e69194. ( PubMed, DOI )

  20. Yokota T, Nakamura A, Nagata T, Saito T, Kobayashi M, Aoki Y, Echigoya Y, Partridge T, Hoffman EP, Takeda S. Extensive and prolonged restoration of dystrophin expression with vivo-morpholino-mediated multiple exon skipping in dystrophic dogs. Nucleic acid therapeutics. 2012.10; 22 (5): 306-315. ( PubMed, DOI )

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