論文・総説 - 井原　健介

1. Ikenouchi, T; Nitta, J; Inaba, O; Negishi, M; Amemiya, M; Kono, T; Yamamoto, T; Murata, K; Kawamura, I; Goto, K; Nishimura, T; Takamiya, T; Inamura, Y; Ihara, K; Tao, S; Sato, A; Takigawa, M; Ebana, Y; Miyazaki, S; Sasano, T; Furukawa, T. Embryological Classification of Arrhythmogenic Triggers Initiating Atrial Fibrillation JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 2024.11; 84 (21): 2116-2128. ( PubMed, DOI )

2. Satoshi Iwamiya, Kensuke Ihara, Giichi Nitta, Tetsuo Sasano . Atrial Fibrillation and Underlying Structural and Electrophysiological Heterogeneity International Journal of Molecular Sciences. 2024.09; 25 (18): 10193.

3. Hasegawa J, Nagata T, Ihara K, Tanihata J, Ebihara S, Yoshida-Tanaka K, Yanagidaira M, Ohara M, Nakayama M, Yamamoto S, Ishii T, Iwata-Hara R, Naito M, Miyata M, Sakaue F, Yokota T. . Heteroduplex oligonucleotide technology boosts oligonucleotide splice switching activity of morpholino oligomers in a Duchenne muscular dystrophy mouse model. Nature Communications. 2024.09; 15 7530.

4. Iwamiya, S; Ihara, K; Furukawa, T; Sasano, T. Sacubitril/valsartan attenuates atrial conduction disturbance and electrophysiological heterogeneity with ameliorating fibrosis in mice FRONTIERS IN CARDIOVASCULAR MEDICINE. 2024.01; 11 1341601. ( PubMed, DOI )

5. Sasano T, Ihara K, Tanaka T, Furukawa T. Risk stratification of atrial fibrillation and stroke using single nucleotide polymorphism and circulating biomarkers. PloS one. 2023.10; 18 (10): e0292118. ( PubMed, DOI )

6. Nakagama S, Maejima Y, Fan Q, Shiheido-Watanabe Y, Tamura N, Ihara K, Sasano T. Endoplasmic Reticulum Selective Autophagy Alleviates Anthracycline-Induced Cardiotoxicity. JACC. CardioOncology. 2023.10; 5 (5): 656-670. ( PubMed, DOI )

7. Ihara Kensuke, Sasano Tetsuo. Extracellular Vesicles for the Treatment of Atrial Fibrillation JACC-CLINICAL ELECTROPHYSIOLOGY. 2023.02; 9 (2): 159-160. ( PubMed, DOI )

8. Yamamoto Takuma, Sano Rie, Miura Aya, Imasaka Mai, Naito Yoshiro, Nishiguchi Minori, Ihara Kensuke, Otani Naruhito, Kominato Yoshihiko, Ohmuraya Masaki, Kuroyanagi Hidehito, Nishio Hajime. I536T variant of RBM20 affects splicing of cardiac structural proteins that are causative for developing dilated cardiomyopathy JOURNAL OF MOLECULAR MEDICINE-JMM. 2022.12; 100 (12): 1741-1754. ( PubMed, DOI )

9. Kaburagi Hidetoshi, Nagata Tetsuya, Enomoto Mitsuhiro, Hirai Takashi, Ohyagi Masaki, Ihara Kensuke, Yoshida-Tanaka Kie, Ebihara Satoe, Asada Ken, Yokoyama Hiroyuki, Okawa Atsushi, Yokota Takanori. Systemic DNA/RNA heteroduplex oligonucleotide administration for regulating the gene expression of dorsal root ganglion and sciatic nerve MOLECULAR THERAPY-NUCLEIC ACIDS. 2022.06; 28 910-919. ( PubMed, DOI )

10. Kawajiri K, Ihara K, Sasano T. Gene therapy to terminate tachyarrhythmias. Expert review of cardiovascular therapy. 2022.06; 20 (6): 431-442. ( PubMed, DOI )

11. Hamada Satomi, Sasaki Kanae, Kito Hotaka, Tooyama Yui, Ihara Kensuke, Aoyagi Eiko, Ichimura Naoya, Tohda Shuji, Sasano Tetsuo. Effect of the recording condition on the quality of a single-lead electrocardiogram HEART AND VESSELS. 2022.06; 37 (6): 1010-1026. ( PubMed, DOI )

12. Ihara Kensuke, Sasano Tetsuo. Role of Inflammation in the Pathogenesis of Atrial Fibrillation FRONTIERS IN PHYSIOLOGY. 2022.04; 13 862164. ( PubMed, DOI )

13. Ihara Kensuke, Sasano Tetsuo. Seeking a Better Experimental Model of Atrial Fibrillation CIRCULATION JOURNAL. 2022.02; 86 (2): 330-331. ( PubMed, DOI )

14. Yamaguchi J, Chiba R, Komuro H, Ihara K, Nozaki K, Nagai A, Furukawa T, Sasano T. Local Injection of Hydroxyapatite Electret Ameliorated Infarct Size After Myocardial Infarction. Circulation reports. 2022.01; 4 (1): 38-47. ( PubMed, DOI )

15. Ohyagi Masaki, Nagata Tetsuya, Ihara Kensuke, Yoshida-Tanaka Kie, Nishi Rieko, Miyata Haruka, Abe Aya, Mabuchi Yo, Akazawa Chihiro, Yokota Takanori. DNA/RNA heteroduplex oligonucleotide technology for regulating lymphocytes in vivo NATURE COMMUNICATIONS. 2021.12; 12 (1): 7344. ( PubMed, DOI )

16. Nagata Tetsuya, Dwyer Chrissa A., Yoshida-Tanaka Kie, Ihara Kensuke, Ohyagi Masaki, Kaburagi Hidetoshi, Miyata Haruka, Ebihara Satoe, Yoshioka Kotaro, Ishii Takashi, Miyata Kanjiro, Miyata Kenichi, Powers Berit, Igari Tomoko, Yamamoto Syunsuke, Arimura Naoto, Hirabayashi Hideki, Uchihara Toshiki, Hara Rintaro Iwata, Wada Takeshi, Bennett C. Frank, Seth Punit P., Rigo Frank, Yokota Takanori. Cholesterol-functionalized DNA/RNA heteroduplexes cross the blood-brain barrier and knock down genes in the rodent CNS NATURE BIOTECHNOLOGY. 2021.08; 39 (12): 1529-+. ( PubMed, DOI )

17. Yamazoe Masahiro, Sasano Tetsuo, Ihara Kensuke, Takahashi Kentaro, Nakamura Wakana, Takahashi Naomi, Komuro Hiroaki, Hamada Satomi, Furukawa Tetsushi. Sparsely methylated mitochondrial cell free DNA released from cardiomyocytes contributes to systemic inflammatory response accompanied by atrial fibrillation SCIENTIFIC REPORTS. 2021.03; 11 (1): 5837. ( PubMed, DOI )

18. Yang Xiaoxi, Sasano Tetsuo, Ebana Yusuke, Takeuchi Jun K., Ihara Kensuke, Yamazoe Masahiro, Furukawa Tetsushi. Functional Role of the L396R Mutation of Tks5 Identified by an Exome-Wide Association Study in Atrial Fibrillation CIRCULATION JOURNAL. 2020.12; 84 (12): 2148-+. ( PubMed, DOI )

19. Ihara K, Sasano T, Hiraoka Y, Togo-Ohno M, Soejima Y, Sawabe M, Tsuchiya M, Ogawa H, Furukawa T, Kuroyanagi H. A missense mutation in the RSRSP stretch of Rbm20 causes dilated cardiomyopathy and atrial fibrillation in mice. Scientific reports. 2020.10; 10 (1): 17894. ( PubMed, DOI )

20. Lee Jiyoung, Sutani Akito, Kaneko Rin, Takeuchi Jun, Sasano Tetsuo, Kohda Takashi, Ihara Kensuke, Takahashi Kentaro, Yamazoe Masahiro, Morio Tomohiro, Furukawa Tetsushi, Ishino Fumitoshi. In vitro generation of functional murine heart organoids via FGF4 and extracellular matrix NATURE COMMUNICATIONS. 2020.09; 11 (1): 4283. ( PubMed, DOI )