論文・総説 - 井原　健介

1. Ikenouchi, T; Nitta, J; Inaba, O; Negishi, M; Amemiya, M; Kono, T; Yamamoto, T; Murata, K; Kawamura, I; Goto, K; Nishimura, T; Takamiya, T; Inamura, Y; Ihara, K; Tao, S; Sato, A; Takigawa, M; Ebana, Y; Miyazaki, S; Sasano, T; Furukawa, T. Embryological Classification of Arrhythmogenic Triggers Initiating Atrial Fibrillation JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 2024.11; 84 (21): 2116-2128. ( PubMed, DOI )

2. Satoshi Iwamiya, Kensuke Ihara, Giichi Nitta, Tetsuo Sasano . Atrial Fibrillation and Underlying Structural and Electrophysiological Heterogeneity International Journal of Molecular Sciences. 2024.09; 25 (18): 10193.

3. Hasegawa J, Nagata T, Ihara K, Tanihata J, Ebihara S, Yoshida-Tanaka K, Yanagidaira M, Ohara M, Nakayama M, Yamamoto S, Ishii T, Iwata-Hara R, Naito M, Miyata M, Sakaue F, Yokota T. . Heteroduplex oligonucleotide technology boosts oligonucleotide splice switching activity of morpholino oligomers in a Duchenne muscular dystrophy mouse model. Nature Communications. 2024.09; 15 7530.

4. Iwamiya, S; Ihara, K; Furukawa, T; Sasano, T. Sacubitril/valsartan attenuates atrial conduction disturbance and electrophysiological heterogeneity with ameliorating fibrosis in mice FRONTIERS IN CARDIOVASCULAR MEDICINE. 2024.01; 11 1341601. ( PubMed, DOI )

5. Sasano T, Ihara K, Tanaka T, Furukawa T. Risk stratification of atrial fibrillation and stroke using single nucleotide polymorphism and circulating biomarkers. PloS one. 2023.10; 18 (10): e0292118. ( PubMed, DOI )

6. Nakagama S, Maejima Y, Fan Q, Shiheido-Watanabe Y, Tamura N, Ihara K, Sasano T. Endoplasmic Reticulum Selective Autophagy Alleviates Anthracycline-Induced Cardiotoxicity. JACC. CardioOncology. 2023.10; 5 (5): 656-670. ( PubMed, DOI )

7. Ihara Kensuke, Sasano Tetsuo. Extracellular Vesicles for the Treatment of Atrial Fibrillation JACC-CLINICAL ELECTROPHYSIOLOGY. 2023.02; 9 (2): 159-160. ( PubMed, DOI )

8. Yamamoto Takuma, Sano Rie, Miura Aya, Imasaka Mai, Naito Yoshiro, Nishiguchi Minori, Ihara Kensuke, Otani Naruhito, Kominato Yoshihiko, Ohmuraya Masaki, Kuroyanagi Hidehito, Nishio Hajime. I536T variant of RBM20 affects splicing of cardiac structural proteins that are causative for developing dilated cardiomyopathy JOURNAL OF MOLECULAR MEDICINE-JMM. 2022.12; 100 (12): 1741-1754. ( PubMed, DOI )

9. Kaburagi Hidetoshi, Nagata Tetsuya, Enomoto Mitsuhiro, Hirai Takashi, Ohyagi Masaki, Ihara Kensuke, Yoshida-Tanaka Kie, Ebihara Satoe, Asada Ken, Yokoyama Hiroyuki, Okawa Atsushi, Yokota Takanori. Systemic DNA/RNA heteroduplex oligonucleotide administration for regulating the gene expression of dorsal root ganglion and sciatic nerve MOLECULAR THERAPY-NUCLEIC ACIDS. 2022.06; 28 910-919. ( PubMed, DOI )

10. Kawajiri K, Ihara K, Sasano T. Gene therapy to terminate tachyarrhythmias. Expert review of cardiovascular therapy. 2022.06; 20 (6): 431-442. ( PubMed, DOI )

11. Hamada Satomi, Sasaki Kanae, Kito Hotaka, Tooyama Yui, Ihara Kensuke, Aoyagi Eiko, Ichimura Naoya, Tohda Shuji, Sasano Tetsuo. Effect of the recording condition on the quality of a single-lead electrocardiogram HEART AND VESSELS. 2022.06; 37 (6): 1010-1026. ( PubMed, DOI )

12. Ihara Kensuke, Sasano Tetsuo. Role of Inflammation in the Pathogenesis of Atrial Fibrillation FRONTIERS IN PHYSIOLOGY. 2022.04; 13 862164. ( PubMed, DOI )

13. Ihara Kensuke, Sasano Tetsuo. Seeking a Better Experimental Model of Atrial Fibrillation CIRCULATION JOURNAL. 2022.02; 86 (2): 330-331. ( PubMed, DOI )

14. Yamaguchi J, Chiba R, Komuro H, Ihara K, Nozaki K, Nagai A, Furukawa T, Sasano T. Local Injection of Hydroxyapatite Electret Ameliorated Infarct Size After Myocardial Infarction. Circulation reports. 2022.01; 4 (1): 38-47. ( PubMed, DOI )

15. Ohyagi Masaki, Nagata Tetsuya, Ihara Kensuke, Yoshida-Tanaka Kie, Nishi Rieko, Miyata Haruka, Abe Aya, Mabuchi Yo, Akazawa Chihiro, Yokota Takanori. DNA/RNA heteroduplex oligonucleotide technology for regulating lymphocytes in vivo NATURE COMMUNICATIONS. 2021.12; 12 (1): 7344. ( PubMed, DOI )

16. Nagata Tetsuya, Dwyer Chrissa A., Yoshida-Tanaka Kie, Ihara Kensuke, Ohyagi Masaki, Kaburagi Hidetoshi, Miyata Haruka, Ebihara Satoe, Yoshioka Kotaro, Ishii Takashi, Miyata Kanjiro, Miyata Kenichi, Powers Berit, Igari Tomoko, Yamamoto Syunsuke, Arimura Naoto, Hirabayashi Hideki, Uchihara Toshiki, Hara Rintaro Iwata, Wada Takeshi, Bennett C. Frank, Seth Punit P., Rigo Frank, Yokota Takanori. Cholesterol-functionalized DNA/RNA heteroduplexes cross the blood-brain barrier and knock down genes in the rodent CNS NATURE BIOTECHNOLOGY. 2021.08; 39 (12): 1529-+. ( PubMed, DOI )

17. Yamazoe Masahiro, Sasano Tetsuo, Ihara Kensuke, Takahashi Kentaro, Nakamura Wakana, Takahashi Naomi, Komuro Hiroaki, Hamada Satomi, Furukawa Tetsushi. Sparsely methylated mitochondrial cell free DNA released from cardiomyocytes contributes to systemic inflammatory response accompanied by atrial fibrillation SCIENTIFIC REPORTS. 2021.03; 11 (1): 5837. ( PubMed, DOI )

18. Yang Xiaoxi, Sasano Tetsuo, Ebana Yusuke, Takeuchi Jun K., Ihara Kensuke, Yamazoe Masahiro, Furukawa Tetsushi. Functional Role of the L396R Mutation of Tks5 Identified by an Exome-Wide Association Study in Atrial Fibrillation CIRCULATION JOURNAL. 2020.12; 84 (12): 2148-+. ( PubMed, DOI )

19. Ihara K, Sasano T, Hiraoka Y, Togo-Ohno M, Soejima Y, Sawabe M, Tsuchiya M, Ogawa H, Furukawa T, Kuroyanagi H. A missense mutation in the RSRSP stretch of Rbm20 causes dilated cardiomyopathy and atrial fibrillation in mice. Scientific reports. 2020.10; 10 (1): 17894. ( PubMed, DOI )

20. Lee Jiyoung, Sutani Akito, Kaneko Rin, Takeuchi Jun, Sasano Tetsuo, Kohda Takashi, Ihara Kensuke, Takahashi Kentaro, Yamazoe Masahiro, Morio Tomohiro, Furukawa Tetsushi, Ishino Fumitoshi. In vitro generation of functional murine heart organoids via FGF4 and extracellular matrix NATURE COMMUNICATIONS. 2020.09; 11 (1): 4283. ( PubMed, DOI )

21. Yu Natsume, Kasumi Oaku, Kentaro Takahashi, Wakana Nakamura, Ai Oono, Satomi Hamada, Masahiro Yamazoe, Kensuke Ihara, Takeshi Sasaki, Masahiko Goya, Kenzo Hirao, Tetsushi Furukawa, Tetsuo Sasano. Combined Analysis of Human and Experimental Murine Samples Identified Novel Circulating MicroRNAs as Biomarkers for Atrial Fibrillation. Circ. J.. 2018.03; 82 (4): 965-973. ( PubMed, DOI )

22. Kensuke Ihara, Koji Sugiyama, Kentaro Takahashi, Masahiro Yamazoe, Tetsuo Sasano, Tetsushi Furukawa. Electrophysiological Assessment of Murine Atria with High-Resolution Optical Mapping Journal of Visualized Experiments. 2018.02;

23. Kaoru Okishige, Hideshi Aoyagi, Kensuke Ihara, Shinsuke Iwai, Tomofumi Nakamura, Mitsumi Yamashita, Nobutaka Katoh, Tomoaki Hasegawa, Naohiko Kawaguchi, Takehiko Keida, Tetsuo Sasano, Kenzo Hirao. Reappraisal of the clinical implications of adenosine triphosphate in terms of the prediction of reconnection sites in cases with electrical isolation of the pulmonary veins. J Interv Card Electrophysiol. 2015.11; 44 (2): 171-178. ( PubMed, DOI )

24. Shingo Maeda, Yoshihide Takahashi, Akihiko Nogami, Yasuteru Yamauchi, Yuki Osaka, Yasuhiro Shirai, Kensuke Ihara, Yasuhiro Yokoyama, Makoto Suzuki, Kaoru Okishige, Mitsuhiro Nishizaki, Kenzo Hirao. Seasonal, weekly, and circadian distribution of ventricular fibrillation in patients with J-wave syndrome from the J-PREVENT registry. J Arrhythm. 2015.10; 31 (5): 268-273. ( PubMed, DOI )

25. Kensuke Ihara, Takeshi Sasaki, Yasuhiro Shirai, Susumu Tao, Shingo Maeda, Mihoko Kawabata, Tetsuo Sasano, Yasuhiro Yokoyama, Mitsuaki Isobe, Kenzo Hirao. High Atrial Defibrillation Threshold With Internal Cardioversion Indicates Arrhythmogenicity of Superior Vena Cava in Non-Long-Standing Persistent Atrial Fibrillation. Circ. J.. 2015.06; 79 (7): 1479-1485. ( PubMed, DOI )

26. Mihoko Kawabata, Yasuhiro Yokoyama, Takeshi Sasaki, Susumu Tao, Kensuke Ihara, Yasuhiro Shirai, Tetsuo Sasano, Masahiko Goya, Tetsushi Furukawa, Mitsuaki Isobe, Kenzo Hirao. Severe iatrogenic bradycardia related to the combined use of beta-blocking agents and sodium channel blockers. Clin Pharmacol. 2015.02; 7 29-36. ( PubMed, DOI )

27. Shingo Maeda, Takeshi Sasaki, Yasuhiro Shirai, Kensuke Ihara, Mihoko Kawabata, Yasuhiro Yokoyama, Saman Nazarian, Stefan L Zimmerman, Kenzo Hirao. Association of intramural fat deposition in the interatrial septum with focal atrial tachyarrhythmias originating near the atrioventricular node. Heart Vessels. 2015.01; 30 (1): 143-145. ( PubMed, DOI )

28. The importance of the setting of the pacing cycle length in the para-Hisian pacing. J Interv Card Electrophysiol.. 2014.10; 39 S56-57.

29. Kensuke Ihara, Junichi Nitta, Kenzo Hirao, Mitsuaki Isobe. Atrial tachycardia originating from the hepatic segment of inferior vena cava in interruption of inferior vena cava with azygos continuation. J Interv Card Electrophysiol. 2013.04; 36 (3): 261-266. ( PubMed, DOI )

30. Manabu Kurabayashi, Kaoru Okishige, Mitsutoshi Asano, Hidetoshi Suzuki, Tsukasa Shimura, Shinsuke Iwai, Nobutaka Kato, Kensuke Ihara, Hideshi Aoyagi, Mitsuaki Isobe. Cardiopulmonary arrest caused by coronary spasm after coronary vasodilator withdrawal during the peri-operative period of gastrectomy. Intern. Med.. 2013.01; 52 (1): 81-84. ( PubMed )

31. Kensuke Ihara, Junichi Nitta, Akira Sato, Shinsuke Iwai, Mitsutoshi Asano, Miki Kanoh, Kenichi Muramatsu, Tsunehiro Yamato, Yutaka Matsumura, Kazuyasu Takei, Kihiro Asakawa, Kenzo Hirao, Mitsuaki Isobe. Coexistence of left-sided atrioventricular accessory pathways with a common inferior pulmonary vein ostium. Circ Arrhythm Electrophysiol. 2011.06; 4 (3): 310-317. ( PubMed, DOI )

32. Shingo Maeda, Mitsuhiro Nishizaki, Noriyoshi Yamawake, Takashi Ashikaga, Kensuke Ihara, Tadashi Murai, Hiroyuki Fujii, Harumizu Sakurada, Masayasu Hiraoka, Mitsuaki Isobe. Effect of High-dose Telmisartan on the Prevention of Recurrent Atrial Fibrillation in Hypertensive Patients. J Atr Fibrillation. 2010.10; 3 (3): 289. ( PubMed, DOI )

33. Shingo Maeda, Mitsuhiro Nishizaki, Noriyoshi Yamawake, Takashi Ashikaga, Hiroshi Shimada, Mitsutoshi Asano, Kensuke Ihara, Tadashi Murai, Hidetoshi Suzuki, Hiroyuki Fujii, Harumizu Sakurada, Masayasu Hiraoka, Mitsuaki Isobe. Ambulatory ECG-based T-wave alternans and heart rate turbulence predict high risk of arrhythmic events in patients with old myocardial infarction. Circ. J.. 2009.12; 73 (12): 2223-2228. ( PubMed )

34. Kensuke Ihara, Mitsuhiro Nishizaki, Harumizu Sakurada, Masayasu Hiraoka. Type 1 ST-segment elevation in the right precordial leads associated with acetylcholine-induced localized spasm of the conus branch of the right coronary artery. Heart Rhythm. 2009.11; 6 (11): 1681-1682. ( PubMed, DOI )

35. Takashi Ashikaga, Mitsuhiro Nishizaki, Hiroyuki Fujii, Kensuke Ihara, Saori Niki, Tadashi Murai, Shingo Maeda, Noriyoshi Yamawake, Yukio Kishi, Mitsuaki Isobe. Coronary endothelial dysfunction and impaired microcirculation response to atrial natriuretic peptide in hyperinsulinemia. J. Cardiovasc. Pharmacol. Ther.. 2008.03; 13 (1): 58-63. ( PubMed, DOI )

36. 井原 健介. 【不整脈学の新潮流-基礎研究・医工連携からAIの社会実装まで】基礎研究　遺伝子改変動物モデルによる病態生理へのアプローチ 医学のあゆみ. 2024.04; 289 (1): 24-30. ( 医中誌 )

37. Ebana Yusuke, Liu Lian, Ihara Kensuke, Abe Keiko, Terao Chikashi, Kamatani Yoichiro, Sasano Tetsuo, Furukawa Tetsushi. Genetic risk score of cerebral infarction in atrial fibrillation genome-wide association study EUROPEAN JOURNAL OF CLINICAL INVESTIGATION. 2023.08; 53 (12): e14084. ( PubMed, DOI )

38. 井原 健介, 古川 哲史. 【遺伝性不整脈疾患・心筋疾患の最新トピックス】遺伝性不整脈疾患・心筋疾患の遺伝子診断の現状と未来 循環器内科. 2022.03; 91 (3): 260-264. ( 医中誌 )

39. 井原 健介, 中釜 瞬. 【秒で見抜く　ヤバい心電図Q&A40】食事中に意識消失した50代男性 Emer Log. 2021.04; 34 (2): 183,229. ( 医中誌 )

40. 井原 健介, 中釜 瞬. 【秒で見抜く　ヤバい心電図Q&A40】起床時に突然の呼吸困難が出現した50代女性 Emer Log. 2021.04; 34 (2): 163,203. ( 医中誌 )

41. 井原 健介, 中釜 瞬. 【秒で見抜く　ヤバい心電図Q&A40】早朝に路上で倒れているところを発見された60代男性 Emer Log. 2021.04; 34 (2): 177,222. ( 医中誌 )

42. 井原 健介, 中釜 瞬. 【秒で見抜く　ヤバい心電図Q&A40】夫婦喧嘩後に胸痛を訴えた60代女性 Emer Log. 2021.04; 34 (2): 186,232-233. ( 医中誌 )

43. 井原 健介, 中釜 瞬. 【秒で見抜く　ヤバい心電図Q&A40】咽頭痛と胸痛を認めた70代女性 Emer Log. 2021.04; 34 (2): 187,233. ( 医中誌 )

44. 井原 健介, 古川 哲史. 【診断と治療の手技-診察室これ1冊-】(第1部)診断(第3章)　臨床検査　12誘導心電図 診断と治療. 2021.03; 109 (Suppl.): 147-151. ( 医中誌 )

45. 井原 健介, 笹野 哲郎. 【心不全と臓器連関】Exosomeを心不全の診断に生かす Cardiac Practice. 2021.03; 31 (2): 125-128. ( 医中誌 )

46. 古川哲史, 井原健介, 笹野哲郎. . 致死性不整脈とPurkinje線維. 循環器専門医. 2020.11; 29 70-77.

47. 古川 哲史, 井原 健介, 笹野 哲郎. 【基礎科学の進歩】致死性不整脈とPurkinje線維 循環器専門医. 2020.11; 29 70-77. ( 医中誌 )

48. 山添 正博, 井原 健介, 笹野 哲郎. 【臨床医が知っていてほしい循環器基礎研究最新の成果】不整脈　心房細動を分子生物学的に理解する 循環器内科. 2020.05; 87 (5): 601-606. ( 医中誌 )

49. 古川 哲史, 井原 健介, 山添 正博, 笹野 哲郎. 【心臓電気生理を理解して不整脈診療に活かす】識る　臨床医が知っておくべき抗不整脈薬の作用機序 Heart View. 2019.06; 23 (6): 559-565. ( 医中誌 )

50. 井原健介. 抗不整脈薬 臨床検査. 2016.10; 60 (11): 1285-1287.

51. 井原健介, 横山泰廣, 白井康大, 田尾進, 佐々木毅, 笹野哲郎, 川端美穂子, 平尾見三. . 大動脈無冠尖からの焼灼で副伝導路離断に成功した潜在性WPW症候群の２症例. 心臓. . 2014.09; 46 182-190.

52. 井原健介, 平尾見三. . 抗不整脈薬の分類・使い方, 何種類の薬を覚えればよいか. medicina. 2013.12; 50 (13): 2184-2188.

53. 井原健介, 新田順一, 根木謙, 黒柳享義, 村松賢一, 大和恒博, 佐藤明, 松村穣, 武居一康, 高橋良英, 高橋淳, 淺川喜裕.. 左房に広範な伝導障害と低電位領域を認めた拡張型心筋症の冠静脈洞内起源慢性心房頻拍. 臨床電気生理.. 2011.12; 34 269-277.

54. 村井典史, 山分規義, 島田博史, 浅野充寿, 井原健介、鈴木秀俊, 前田真吾, 藤井洋之, 足利貴志, 西崎光弘, 櫻田春水, 磯部光章, 平岡昌和.. Brugada症候群における頸動脈洞マッサージの反応性の検討. 心電図. . 2009.05; 29 (4): 32-37.