論文・総説 - 淺原　弘嗣

1. Lin Liu, Tomoki Chiba, Takahide Matsushima, Maiko Inotsume, Tomomi Kato, Yuichi Hiraoka, Hiroshi Asahara. Gene dosage-dependent roles of Mkx in postnatal tendon development and maintenance revealed by conditional deletion. Dev Biol. 2025.10; 526 15-25. ( PubMed, DOI )

2. Yuta Tsuchiya, Hikaru Matsuo, Hiroshi Asahara, Masafumi Inui. Matrix stiffness regulates Mkx expression in rat tenocyte through TRPM7. Biochem Biophys Rep. 2025.09; 43 102178. ( PubMed, DOI )

3. Atsushi Goto, Shingo Komura, Koki Kato, Rie Maki, Akihiro Hirakawa, Hitomi Aoki, Hiroyuki Tomita, Jumpei Taguchi, Manabu Ozawa, Takahide Matsushima, Akio Kishida, Tsuyoshi Kimura, Hiroshi Asahara, Yuuki Imai, Yasuhiro Yamada, Haruhiko Akiyama. PI3K-Akt signalling regulates Scx-lineage tenocytes and Tppp3-lineage paratenon sheath cells in neonatal tendon regeneration. Nat Commun. 2025.04; 16 (1): 3734. ( PubMed, DOI )

4. Takahide Matsushima, Yuki Naito, Tomoki Chiba, Ryota Kurimoto, Keiko Itano, Koji Ochiai, Koichi Takahashi, Naoki Goshima, Hiroshi Asahara. Localizatome: a database for stress-dependent subcellular localization changes in proteins. Database (Oxford). 2025.04; 2025 ( PubMed, DOI )

5. Ryota Sato, Kaiwen Liu, Takuma Shibata, Katsuaki Hoshino, Kiyoshi Yamaguchi, Toru Miyazaki, Ryosuke Hiranuma, Ryutaro Fukui, Yuji Motoi, Yuri Fukuda-Ohta, Yun Zhang, Tatjana Reuter, Yuko Ishida, Toshikazu Kondo, Tomoki Chiba, Hiroshi Asahara, Masato Taoka, Yoshio Yamauchi, Toshiaki Isobe, Tsuneyasu Kaisho, Yoichi Furukawa, Eicke Latz, Kohta Nakatani, Yoshihiro Izumi, Yunzhong Nie, Hideki Taniguchi, Kensuke Miyake. RNase T2 deficiency promotes TLR13-dependent replenishment of tissue-protective Kupffer cells. J Exp Med. 2025.03; 222 (3): ( PubMed, DOI )

6. Suzu Chida, Tomoki Chiba, Yutaro Uchida, Takahide Matsushima, Ryota Kurimoto, Takayuki Miyazaki, Lisa Yagasaki, Satoshi Nakamura, Emiko Mihara, Junichi Takagi, Keiji Moriyama, Hiroshi Asahara. Impact of mechanotransduction on gene expression changes in periodontal ligament during orthodontic tooth movement. J Bone Miner Metab. 2025.02; ( PubMed, DOI )

7. Yutaro Uchida, Ryota Kurimoto, Tomoki Chiba, Takahide Matsushima, Goshi Oda, Iichiroh Onishi, Yasuto Takeuchi, Noriko Gotoh, Hiroshi Asahara. RNA binding protein ZCCHC24 promotes tumorigenicity in triple-negative breast cancer. EMBO Rep. 2024.12; 25 (12): 5352-5382. ( PubMed, DOI )

8. Junya Ito, Kensuke Miyake, Tomoki Chiba, Kazufusa Takahashi, Yutaro Uchida, Perry J Blackshear, Hiroshi Asahara, Hajime Karasuyama. Tristetraprolin-mediated mRNA destabilization regulates basophil inflammatory responses. Allergol Int. 2024.11; ( PubMed, DOI )

9. Hiroki Tsutsumi, Tomoki Chiba, Yuta Fujii, Takahide Matsushima, Tsuyoshi Kimura, Akinori Kanai, Akio Kishida, Yutaka Suzuki, Hiroshi Asahara. Single-nucleus transcriptional and chromatin accessibility analyses of maturing mouse Achilles tendon uncover the molecular landscape of tendon stem/progenitor cells. bioRxiv. 2024.10; ( PubMed, DOI )

10. Ryo Nakamichi, Hiroshi Asahara. The role of mechanotransduction in tendon. J Bone Miner Res. 2024.08; 39 (7): 814-820. ( PubMed, DOI )

11. Takahide Matsushima, Asahara Hiroshi. Molecular mechanisms of mechanosensing and plasticity of tendons and ligaments. J Biochem. 2024.05; ( PubMed, DOI )

12. Lisa Yagasaki, Tomoki Chiba, Ryota Kurimoto, Mitsuyo Nakajima, Takanori Iwata, Hiroshi Asahara. The essential role of Mkx in periodontal ligament on the metabolism of alveolar bone and cementum Regen Ther. 2024.03; 25 186-193. ( PubMed, DOI )

13. Naoto Washihira, Mika Murakami, Miho Nakamura, Sho Fujii, Takahide Matsushima, Hiroshi Asahara, Akio Kishida, Tadao Tanabe, Tsuyoshi Kimura, Mako Kobayashi, Masaya Yamamoto. Application of a genetically engineered macrophage cell line for evaluating cellular effects of UV/US-treated poly(ethylene terephthalate) microplastics. Colloids Surf B Biointerfaces. 2024.02; 234 113735. ( PubMed, DOI )

14. Mengjiao Li, Tatsunori Nishimura, Yasuto Takeuchi, Tsunaki Hongu, Yuming Wang, Daisuke Shiokawa, Kang Wang, Haruka Hirose, Asako Sasahara, Masao Yano, Satoko Ishikawa, Masafumi Inokuchi, Tetsuo Ota, Masahiko Tanabe, Kei-Ichiro Tada, Tetsu Akiyama, Xi Cheng, Chia-Chi Liu, Toshinari Yamashita, Sumio Sugano, Yutaro Uchida, Tomoki Chiba, Hiroshi Asahara, Masahiro Nakagawa, Shinya Sato, Yohei Miyagi, Teppei Shimamura, Luis Augusto E Nagai, Akinori Kanai, Manami Katoh, Seitaro Nomura, Ryuichiro Nakato, Yutaka Suzuki, Arinobu Tojo, Dominic C Voon, Seishi Ogawa, Koji Okamoto, Theodoros Foukakis, Noriko Gotoh. FXYD3 functionally demarcates an ancestral breast cancer stem cell subpopulation with features of drug-tolerant persisters. J Clin Invest. 2023.11; 133 (22): ( PubMed, DOI )

15. Jaehoon Shin, Shigeru Miyaki, Hiroshi Asahara, Takayuki Akimoto. MicroRNA-140 is not involved in sepsis-induced muscle atrophy. Am J Physiol Cell Physiol. 2023.08; 325 (2): C509-C518. ( PubMed, DOI )

16. Yudai Ono, Saundra Schlesinger, Kanako Fukunaga, Shinsei Yambe, Tempei Sato, Takako Sasaki, Chisa Shukunami, Hiroshi Asahara, Masafumi Inui. Scleraxis-lineage cells are required for correct muscle patterning. Development. 2023.05; 150 (10): ( PubMed, DOI )

17. Maiko Inotsume, Tomoki Chiba, Takahide Matsushima, Ryota Kurimoto, Mitsuyo Nakajima, Tomomi Kato, Kana Shishido, Lin Liu, Koichi Kawakami, Hiroshi Asahara. One-step generation of mice with gene editing by Tol2 transposon-dependent gRNA delivery. FEBS Lett. 2023.03; ( PubMed, DOI )

18. Hiroto Yamamoto, Yutaro Uchida, Ryota Kurimoto, Tomoki Chiba, Takahide Matsushima, Yoshiaki Ito, Maiko Inotsume, Kohei Miyata, Kenta Watanabe, Masaki Inada, Naoki Goshima, Tokujiro Uchida, Hiroshi Asahara. RNA-binding protein LIN28A upregulates transcription factor HIF1α by posttranscriptional regulation via direct binding to UGAU motifs. J Biol Chem. 2023.01; 299 (1): 102791. ( PubMed, DOI )

19. Ryo Nakamichi, Hiroshi Asahara. Motion-capture Analysis of Mice Using a Video Recorded on an iPhone Camera. Bio Protoc. 2022.11; 12 (21): ( PubMed, DOI )

20. Tomohiko Murakami, Yoshifumi Takahata, Kenji Hata, Kosuke Ebina, Katsutoshi Hirose, Lerdluck Ruengsinpinya, Yuri Nakaminami, Yuki Etani, Sachi Kobayashi, Takashi Maruyama, Hiroyasu Nakano, Takehito Kaneko, Satoru Toyosawa, Hiroshi Asahara, Riko Nishimura. Semaphorin 4D induces articular cartilage destruction and inflammation in joints by transcriptionally reprogramming chondrocytes. Sci Signal. 2022.11; 15 (758): eabl5304. ( PubMed, DOI )