論文・総説 - 玉村　啓和

121. Nomura W, Mino T, Narumi T, Ohashi N, Masuda A, Hashimoto C, Tsutsumi H, Tamamura H. Development of crosslink-type tag-probe pairs for fluorescent imaging of proteins. Biopolymers. 2010; 94 843-852. ( PubMed, DOI )

122. Ohashi N, Nomura W, Kato M, Narumi T, Lewin NE, Blumberg PM, Tamamura H. Synthesis of protein kinase Cdelta C1b domain by native chemical ligation methodology and characterization of its folding and ligand binding. J Pept Sci. 2009.10; 15 (10): 642-646. ( PubMed, DOI )

123. Tanaka T, Nomura W, Narumi T, Esaka A, Oishi S, Ohashi N, Itotani K, Evans BJ, Wang ZX, Peiper SC, Fujii N, Tamamura H. Structure-activity relationship study on artificial CXCR4 ligands possessing the cyclic pentapeptide scaffold: the exploration of amino acid residues of pentapeptides by substitutions of several aromatic amino acids. Org Biomol Chem. 2009.09; 7 (18): 3805-3809. ( PubMed, DOI )

124. Inaba Y, Yoshimoto N, Sakamaki Y, Nakabayashi M, Ikura T, Tamamura H, Ito N, Shimizu M, Yamamoto K. A New Class of Vitamin D Analogues that Induce Structural Rearrangement of the Ligand-Binding Pocket of the Receptor. J Med Chem. 2009.02; ( PubMed, DOI )

125. Mizukoshi F, Baba K, Goto-Koshino Y, Setoguchi-Mukai A, Fujino Y, Ohno K, Tamamura H, Oishi S, Fujii N, Tsujimoto H. Inhibitory effect of newly developed CXC-chemokine receptor 4 antagonists on the infection with feline immunodeficiency virus. J Vet Med Sci. 2009.01; 71 (1): 121-124. ( PubMed )

126. Tsutsumi H, Nomura W, Abe S, Mino T, Masuda A, Ohashi N, Tanaka T, Ohba K, Yamamoto N, Akiyoshi K, Tamamura H. Fluorogenically active leucine zipper peptides as tag-probe pairs for protein imaging in living cells. Angew Chem Int Ed Engl. 2009; 48 (48): 9164-9166. ( PubMed, DOI )

127. Tamamura H, Tanaka T, Tsutsumi H, Ohashi N, Hiramatsu K, Araki T, Ojida A, Hamachi I, Wang Z, Peiper SC, Trent JO, Ueda S, Oishi S, Fujii N. Development of chemokine receptor CXCR4 antagonists using bio-mimetic strategy. Adv Exp Med Biol. 2009; 611 145-146. ( PubMed )

128. Tamamura H, Tanaka T, Tsutsumi H, Nemoto K, Mizokami S, Ohashi N, Oishi S, Fujii N. Stereoselective synthesis of peptidomimetics based on acid-catalyzed ring-opening of beta-aziridinyl-alpha,beta-enoates. Adv Exp Med Biol. 2009; 611 149-150. ( PubMed )

129. Tanaka T, Tsutsumi H, Nomura W, Tanabe Y, Ohashi N, Esaka A, Ochiai C, Sato J, Itotani K, Murakami T, Ohba K, Yamamoto N, Fujii N, Tamamura H. Structure-activity relationship study of CXCR4 antagonists bearing the cyclic pentapeptide scaffold: identification of the new pharmacophore. Org Biomol Chem. 2008.12; 6 (23): 4374-4377. ( PubMed, DOI )

130. Nomura W, Tanabe Y, Tsutsumi H, Tanaka T, Ohba K, Yamamoto N, Tamamura H. Fluorophore labeling enables imaging and evaluation of specific CXCR4-ligand interaction at the cell membrane for fluorescence-based screening. Bioconjug Chem. 2008.09; 19 (9): 1917-1920. ( PubMed, DOI )

131. Nakata H, Steinberg SM, Koh Y, Maeda K, Takaoka Y, Tamamura H, Fujii N, Mitsuya H. Potent synergistic anti-human immunodeficiency virus (HIV) effects using combinations of the CCR5 inhibitor aplaviroc with other anti-HIV drugs. Antimicrob Agents Chemother. 2008.06; 52 (6): 2111-2119. ( PubMed, DOI )

132. Driessen WH, Fujii N, Tamamura H, Sullivan SM. Development of peptide-targeted lipoplexes to CXCR4-expressing rat glioma cells and rat proliferating endothelial cells. Mol Ther. 2008.03; 16 (3): 516-524. ( PubMed, DOI )

133. Hirokazu Tamamura, Hiroshi Tsutsumi, Wataru Nomura, Tomohiro Tanaka & Nobutaka Fujii. A Future Perspective on the Development of Chemokine Receptor CXCR4 Antagonists. Expert Opin. Drug Discovery. 2008; 3 (10): 1150-1166.

134. Tamamura H, Tsutsumi H, Nomura W, Fujii N. Exploratory studies on development of the chemokine receptor CXCR4 antagonists toward downsizing. Perspect Medicin Chem. 2008; 2 1-9. ( PubMed )

135. Kasiyanov A, Fujii N, Tamamura H, Xiong H. Modulation of network-driven, GABA-mediated giant depolarizing potentials by SDF-1alpha in the developing hippocampus. Dev Neurosci. 2008; 30 (4): 285-292. ( PubMed, DOI )

136. Kabashima K, Shiraishi N, Sugita K, Mori T, Onoue A, Kobayashi M, Sakabe J, Yoshiki R, Tamamura H, Fujii N, Inaba K, Tokura Y. CXCL12-CXCR4 engagement is required for migration of cutaneous dendritic cells. Am J Pathol. 2007.10; 171 (4): 1249-1257. ( PubMed, DOI )

137. Kabashima K, Sugita K, Shiraishi N, Tamamura H, Fujii N, Tokura Y. CXCR4 engagement promotes dendritic cell survival and maturation. Biochem Biophys Res Commun. 2007.10; 361 (4): 1012-1016. ( PubMed, DOI )

138. Kubonishi S, Kikuchi T, Yamaguchi S, Tamamura H, Fujii N, Watanabe T, Arenzana-Seisdedos F, Ikeda K, Matsui T, Tanimoto M, Katayama Y. Rapid hematopoietic progenitor mobilization by sulfated colominic acid. Biochem Biophys Res Commun. 2007.04; 355 (4): 970-975. ( PubMed, DOI )

139. Berchiche YA, Chow KY, Lagane B, Leduc M, Percherancier Y, Fujii N, Tamamura H, Bachelerie F, Heveker N. Direct assessment of CXCR4 mutant conformations reveals complex link between receptor structure and G(alpha)(i) activation. J Biol Chem. 2007.02; 282 (8): 5111-5115. ( PubMed, DOI )

140. Ueda S, Oishi S, Wang ZX, Araki T, Tamamura H, Cluzeau J, Ohno H, Kusano S, Nakashima H, Trent JO, Peiper SC, Fujii N. Structure-activity relationships of cyclic peptide-based chemokine receptor CXCR4 antagonists: disclosing the importance of side-chain and backbone functionalities. J Med Chem. 2007.01; 50 (2): 192-198. ( PubMed, DOI )