論文・総説 - 玉村　啓和

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  1. Hirokazu Tamamura, Tadakazu Hori, Akira Otaka & Nobutaka Fujii. Efficient Stereoselective Synthesis of Peptidomimetics Containing Hydroxyethylamine Dipeptide Isosteres Utilizing the Aza-Payne Rearrangement and O, N-Acyl Transfer Reactions. J. Chem. Soc., Perkin Trans.. 2002; 1 (2002(5)): 577-580.

  2. Shinya Oishi, Ayumu Niida, Takae Kamano, Yoshihisa Miwa, Tooru Taga, Yoshihiko Odagaki, Nobuyuki Hamanaka, Mikio Yamamoto, Keiichi Ajito, Hirokazu Tamamura, Akira Otaka & Nobutaka Fujii. Regio- and Stereoselective Ring-opening of Chiral 1,3-Oxazolidin-2-one Derivatives by Organocopper Reagents Provides Novel Access to Di-, tri- and tetra-substituted Alkene Dipeptide Isosteres. J. Chem. Soc., Perkin Trans.. 2002; 1 (2002(15)): 1786-1793.

  3. Tamamura H. [Development of selective antagonists against an HIV second receptor] Yakugaku Zasshi. 2001.11; 121 (11): 781-792. ( PubMed )

  4. Fujii N, Tamamura H. Peptide-lead CXCR4 antagonists with high anti-HIV activity. Curr Opin Investig Drugs. 2001.09; 2 (9): 1198-1202. ( PubMed )

  5. Tamamura H, Omagari A, Hiramatsu K, Kanamoto T, Gotoh K, Kanbara K, Yamamoto N, Nakashima H, Otaka A, Fujii N. Synthesis and evaluation of bifunctional anti-HIV agents based on specific CXCR4 antagonists-AZT conjugation. Bioorg Med Chem. 2001.08; 9 (8): 2179-2187. ( PubMed )

  6. Tamamura H, Omagari A, Hiramatsu K, Gotoh K, Kanamoto T, Xu Y, Kodama E, Matsuoka M, Hattori T, Yamamoto N, Nakashima H, Otaka A, Fujii N. Development of specific CXCR4 inhibitors possessing high selectivity indexes as well as complete stability in serum based on an anti-HIV peptide T140. Bioorg Med Chem Lett. 2001.07; 11 (14): 1897-1902. ( PubMed )

  7. Gotoh K, Yoshimori M, Kanbara K, Tamamura H, Kanamoto T, Mochizuki K, Fujii N, Nakashima H. Increase of R5 HIV-1 infection and CCR5 expression in T cells treated with high concentrations of CXCR4 antagonists and SDF-1. J Infect Chemother. 2001.03; 7 (1): 28-36. ( PubMed, DOI )

  8. Tamamura H, Sugioka M, Odagaki Y, Omagari A, Kan Y, Oishi S, Nakashima H, Yamamoto N, Peiper SC, Hamanaka N, Otaka A, Fujii N. Conformational study of a highly specific CXCR4 inhibitor, T140, disclosing the close proximity of its intrinsic pharmacophores associated with strong anti-HIV activity. Bioorg Med Chem Lett. 2001.02; 11 (3): 359-362. ( PubMed )

  9. Akira Otaka, Hideaki Watanabe, Akira Yukimasa, Shinya Oishi, Hirokazu Tamamura & Nobutaka Fujii. New Access to α-Substituted (Z)-Fluoroalkene Dipeptide Isosteres Utilizing Organocopper Reagents under 'Reduction-oxidative Alkylation (R-OA)' Conditions. Tetrahedron Lett.. 2001; 42 (2): 5443-5446.

  10. Shinya Oishi, Hirokazu Tamamura, Masaki Yamashita, Yoshihiko Odagaki, Nobuyuki Hamanaka, Akira Otaka & Nobutaka Fujii. Stereoselective Synthesis of a Set of Two Functionalized (E)-Alkene Dipeptide Isosteres of L-Amino Acid-L-Glu and L-Amino acid-D-Glu. J. Chem. Soc., Perkin Trans.. 2001; 1 (19): 2445-2451.

  11. Kenji Kanbara, Setsuko Sato, Jun-ichi Tanuma, Hirokazu Tamamura, Kazuyo Gotoh, Manabu Yoshimori, Taisei Kanamoto, Motoo Kitano, Nobutaka Fujii & Hideki Nakashima. Biological and Genetic Characterization of a Human Immunodeficiency Virus Strain Resistant to CXCR4 Antagonist T134. AIDS Res. Hum. Retroviruses. 2001; 17 (7): 615-622.

  12. 玉村　啓和. HIV侵入の第二受容体に対する特異的拮抗剤の発見と応用に関する研究 薬学雑誌. 2001; 121 (11): 781-792.

  13. Tamamura H, Omagari A, Oishi S, Kanamoto T, Yamamoto N, Peiper SC, Nakashima H, Otaka A, Fujii N. Pharmacophore identification of a specific CXCR4 inhibitor, T140, leads to development of effective anti-HIV agents with very high selectivity indexes. Bioorg Med Chem Lett. 2000.12; 10 (23): 2633-2637. ( PubMed )

  14. Miyoshi K, Otaka A, Kaneko M, Tamamura H, Fujii N. A new practical strategy for the synthesis of long-chain phosphopeptide. Chem Pharm Bull (Tokyo). 2000.08; 48 (8): 1230-1233. ( PubMed )

  15. Udaka K, Wiesmuller KH, Kienle S, Jung G, Tamamura H, Yamagishi H, Okumura K, Walden P, Suto T, Kawasaki T. An automated prediction of MHC class I-binding peptides based on positional scanning with peptide libraries. Immunogenetics. 2000.08; 51 (10): 816-828. ( PubMed )

  16. Otaka A, Mitsuyama E, Kinoshita T, Tamamura H, Fujii N. Stereoselective synthesis of CF(2)-substituted phosphothreonine mimetics and their incorporation into peptides using newly developed deprotection procedures. J Org Chem. 2000.08; 65 (16): 4888-4899. ( PubMed )

  17. Tamamura H, Bienfait B, Nacro K, Lewin NE, Blumberg PM, Marquez VE. Conformationally constrained analogues of diacylglycerol (DAG). 17. Contrast between sn-1 and sn-2 DAG lactones in binding to protein kinase C. J Med Chem. 2000.08; 43 (17): 3209-3217. ( PubMed )

  18. Kakugawa K, Udaka K, Nakashima K, Inaba K, Oka Y, Sugiyama H, Tamamura H, Yamagishi H. Efficient induction of peptide-specific cytotoxic T lymphocytes by LPS-activated spleen cells. Microbiol Immunol. 2000; 44 (2): 123-133. ( PubMed )

  19. Akira Otaka, Etsuko Mitsuyama, Hideaki Watanabe, Hirokazu Tamamura & Nobutaka Fujii. Development of New Methodology for the Synthesis of Functionalized α-Fluorophosphonates and Its Practical Application to the Preparation of Phosphopeptide Mimetics. Chem. Commun.. 2000; 1081-1082.

  20. Murakami T, Zhang TY, Koyanagi Y, Tanaka Y, Kim J, Suzuki Y, Minoguchi S, Tamamura H, Waki M, Matsumoto A, Fujii N, Shida H, Hoxie JA, Peiper SC, Yamamoto N. Inhibitory mechanism of the CXCR4 antagonist T22 against human immunodeficiency virus type 1 infection. J Virol. 1999.09; 73 (9): 7489-7496. ( PubMed )

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