Published Papers & Misc - OKAZAWA Hitoshi

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  1. Homma H, Ngo KX, Yoshioka Y, Tanaka H, Inotsume M, Fujita K, Ando T, Okazawa H. PQBP3/NOL7 is an intrinsically disordered protein. Biochem Biophys Res Commun. 2024.12; 736 150453. ( PubMed, DOI )

  2. Tsumaki K, Bertens CJF, Nakayama M, Kato S, Jonao Y, Kuribayashi A, Sato K, Ishiyama S, Asakawa M, Aihara R, Yoshioka Y, Homma H, Tanaka H, Fujita K, Okazawa H, Sone M. Loss of function of VCP/TER94 causes neurodegeneration. Dis Model Mech. 2024.12; 17 (12): dmm050359. ( PubMed, DOI )

  3. Yoshioka Y, Huang Y, Jin X, Ngo KX, Kumaki T, Jin M, Toyoda S, Takayama S, Inotsume M, Fujita K, Homma H, Ando T, Tanaka H, Okazawa H. PQBP3 prevents senescence by suppressing PSME3-mediated proteasomal Lamin B1 degradation. EMBO J. 2024.09; 43 (18): 3968-3999. ( PubMed, DOI )

  4. Homma H, Yoshioka Y, Fujita K, Shirai S, Hama Y, Komano H, Saito Y, Yabe I, Okano H, Sasaki H, Tanaka H, Okazawa H. Dynamic molecular network analysis of iPSC-Purkinje cells differentiation delineates roles of ISG15 in SCA1 at the earliest stage. Commun Biol. 2024.04; 7 (1): 413. ( PubMed, DOI )

  5. Homma H, Tanaka H, Fujita K, Okazawa H. Necrosis Links Neurodegeneration and Neuroinflammation in Neurodegenerative Disease. Int J Mol Sci. 2024.03; 25 (7): 3636. ( PubMed, DOI )

  6. Yoshioka Y, Taniguchi JB, Homma H, Tamura T, Fujita K, Inotsume M, Tagawa K, Misawa K, Matsumoto N, Nakagawa M, Inoue H, Tanaka H, Okazawa H. AAV-mediated editing of PMP22 rescues Charcot-Marie-Tooth disease type 1A features in patient-derived iPS Schwann cells. Commun Med (Lond). 2023.11; 3 (1): 170. ( PubMed, DOI )

  7. Gall-Duncan T, Luo J, Jurkovic CM, Fischer LA, Fujita K, Deshmukh AL, Harding RJ, Tran S, Mehkary M, Li V, Leib DE, Chen R, Tanaka H, Mason AG, Lévesque D, Khan M, Razzaghi M, Prasolava T, Lanni S, Sato N, Caron MC, Panigrahi GB, Wang P, Lau R, Castel AL, Masson JY, Tippett L, Turner C, Spies M, La Spada AR, Campos EI, Curtis MA, Boisvert FM, Faull RLM, Davidson BL, Nakamori M, Okazawa H, Wold MS, Pearson CE. Antagonistic roles of canonical and Alternative-RPA in disease-associated tandem CAG repeat instability. Cell. 2023.10; 186 (22): 4898-4919.e25. ( PubMed, DOI )

  8. Fujita K, Homma H, Jin M, Yoshioka Y, Jin X, Saito Y, Tanaka H, Okazawa H. Mutant α-synuclein propagates via the lymphatic system of the brain in the monomeric state. Cell Rep. 2023.08; 42 (8): 112962. ( PubMed, DOI )

  9. Shiwaku H, Katayama S, Gao M, Kondo K, Nakano Y, Motokawa Y, Toyoda S, Yoshida F, Hori H, Kubota T, Ishikawa K, Kunugi H, Ikegaya Y, Okazawa H, Takahashi H. Analyzing schizophrenia-related phenotypes in mice caused by autoantibodies against NRXN1α in schizophrenia. Brain Behav Immun. 2023.07; 111 32-45. ( PubMed, DOI )

  10. Jin X, Tanaka H, Jin M, Fujita K, Homma H, Inotsume M, Yong H, Umeda K, Kodera N, Ando T, Okazawa H. PQBP5/NOL10 maintains and anchors the nucleolus under physiological and osmotic stress conditions. Nat Commun. 2023.01; 14 (1): 9. ( PubMed, DOI )

  11. Tanaka H, Okazawa H. PQBP1: The Key to Intellectual Disability, Neurodegenerative Diseases, and Innate Immunity. Int J Mol Sci. 2022.06; 23 (11): 6227. ( PubMed, DOI )

  12. Shiwaku H, Katayama S, Kondo K, Nakano Y, Tanaka H, Yoshioka Y, Fujita K, Tamaki H, Takebayashi H, Terasaki O, Nagase Y, Nagase T, Kubota T, Ishikawa K, Okazawa H, Takahashi H. Autoantibodies against NCAM1 from patients with schizophrenia cause schizophrenia-related behavior and changes in synapses in mice. Cell Rep Med. 2022.04; 3 (4): 100597. ( PubMed, DOI )

  13. Jin M, Shiwaku H, Tanaka H, Obita T, Ohuchi S, Yoshioka Y, Jin X, Kondo K, Fujita K, Homma H, Nakajima K, Mizuguchi M, Okazawa H. Tau activates microglia via the PQBP1-cGAS-STING pathway to promote brain inflammation. Nat Commun. 2021.11; 12 (1): 6565. ( PubMed, DOI )

  14. Okazawa H, Tanaka H. Molecular Dissection and Therapeutic Application of SCA1 Pathologies Revealed by Comprehensive Approaches. Cerebellum as a CNS Hub. 2021.11; 479-486.

  15. Tanaka H, Kondo K, Fujita K, Homma H, Tagawa K, Jin X, Jin M, Yoshioka Y, Takayama S, Masuda H, Tokuyama R, Nakazaki Y, Saito T, Saido T, Murayama S, Ikura T, Ito N, Yamamori Y, Tomii K, Bianchi ME, Okazawa H. HMGB1 signaling phosphorylates Ku70 and impairs DNA damage repair in Alzheimer's disease pathology. Commun Biol. 2021.10; 4 (1): 1175. ( PubMed, DOI )

  16. Kondo K, Ikura T, Tanaka H, Fujita K, Takayama S, Yoshioka Y, Tagawa K, Homma H, Liu S, Kawasaki R, Huang Y, Ito N, Tate SI, Okazawa H. Hepta-Histidine Inhibits Tau Aggregation. ACS Chem Neurosci. 2021.08; 12 (16): 3015-3027. ( PubMed, DOI )

  17. Jin M, Jin X, Homma H, Fujita K, Tanaka H, Murayama S, Akatsu H, Tagawa K, Okazawa H. Prediction and verification of the AD-FTLD common pathomechanism based on dynamic molecular network analysis. Commun Biol. 2021.08; 4 (1): 961. ( PubMed, DOI )

  18. Homma H, Tanaka H, Jin M, Jin X, Huang Y, Yoshioka Y, Bertens CJ, Tsumaki K, Kondo K, Shiwaku H, Tagawa K, Akatsu H, Atsuta N, Katsuno M, Furukawa K, Ishiki A, Waragai M, Ohtomo G, Iwata A, Yokota T, Inoue H, Arai H, Sobue G, Sone M, Fujita K, Okazawa H. DNA damage in embryonic neural stem cell determines FTLDs' fate via early-stage neuronal necrosis. Life Sci Alliance. 2021.06; 4 (7): e202101022. ( PubMed, DOI )

  19. Hitoshi Okazawa. Intracellular amyloid hypothesis for ultra-early phase pathology of Alzheimer's disease. Neuropathology. 2021.04; 41 (2): 93-98. ( PubMed, DOI )

  20. Saito M, Nakayama M, Fujita K, Uchida A, Yano H, Goto S, Okazawa H, Sone M. Role of the Drosophila YATA protein in the proper subcellular localization of COPI revealed by in vivo analysis. Genes Genet Syst. 2021.03; 95 (6): 303-314. ( PubMed, DOI )

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