376  articles.  
* There may be some overlapped articles listed due to the difference of format.

  1. Hiroki Yamaguchi, Kazutoshi Takahashi, Nobutaka Numoto, Hiroshi Suzuki, Moemi Tatsumi, Akiko Kamegawa, Kouki Nishikawa, Yasuhisa Asano, Toshimi Mizukoshi, Hiroshi Miyano, Yoshinori Fujiyoshi, Masayuki Sugiki: Open and closed structures of L-arginine oxidase by cryo-electron microscopy and X-ray crystallography. J Biochem. 2024.10; ( PubMed , DOI )

  2. Leyva-Castillo JM, Das M, Strakosha M, McGurk A, Artru E, Kam C, Alasharee M, Wesemann DR, Tomura M, Karasuyama H, Brombacher F, Geha RS: IL-4 acts on skin derived dendritic cells to promote the Th2 response to cutaneous sensitization and the development of allergic skin inflammation. The Journal of allergy and clinical immunology. 2024.07; ( PubMed , DOI )

  3. Masaki Nagaya, Ayuko Uchikura, Kazuaki Nakano, Masahito Watanabe, Hitomi Matsunari, Kazuhiro Umeyama, Naoaki Mizuno, Toshiya Nishimura, Hiromitsu Nakauchi, Hiroshi Nagashima: Generation of insulin-like growth factor 1 receptor-knockout pigs as a potential system for interspecies organogenesis. Regen Ther. 2024.06; 26 783-791. ( PubMed , DOI )

  4. Hisato Nagano, Naoaki Mizuno, Hideyuki Sato, Eiji Mizutani, Ayaka Yanagida, Mayuko Kano, Mariko Kasai, Hiromi Yamamoto, Motoo Watanabe, Fabian Suchy, Hideki Masaki, Hiromitsu Nakauchi: Skin graft with dermis and appendages generated in vivo by cell competition. Nature Communications. 2024.04; 15 (1): 3366. ( PubMed , DOI )

  5. Tchen J, Simon Q, Chapart L, Thaminy MK, Vibhushan S, Saveanu L, Lamri Y, Saidoune F, Pacreau E, Pellefigues C, Bex-Coudrat J, Karasuyama H, Miyake K, Hidalgo J, Fallon PG, Papo T, Blank U, Benhamou M, Hanouna G, Sacre K, Daugas E, Charles N: PD-L1- and IL-4-expressing basophils promote pathogenic accumulation of T follicular helper cells in lupus. Nature communications. 2024.04; 15 (1): 3389. ( PubMed , DOI )

  6. Leyva-Castillo JM, Vega-Mendoza D, Strakosha M, Deng L, Choi S, Miyake K, Karasuyama H, Chiu IM, Phipatanakul W, Geha RS: Basophils are important for the development of allergic skin inflammation. The Journal of allergy and clinical immunology. 2024.02; 153 (5): 1344-1354.e5. ( PubMed , DOI )

  7. Miyake K, Ito J, Takahashi K, Nakabayashi J, Brombacher F, Shichino S, Yoshikawa S, Miyake S, Karasuyama H: Single-cell transcriptomics identifies the differentiation trajectory from inflammatory monocytes to pro-resolving macrophages in a mouse skin allergy model. Nature communications. 2024.02; 15 (1): 1666. ( PubMed , DOI )

  8. Strakosha M, Vega-Mendoza D, Kane J, Jain A, Sun L, Rockowitz S, Elkins M, Miyake K, Chou J, Karasuyama H, Geha RS, Leyva-Castillo JM: Basophils play a protective role in the recovery of skin barrier function from mechanical injury in mice. The Journal of investigative dermatology. 2024.01; 144 (8): 1784-1797.e4. ( PubMed , DOI )

  9. Nelson M LaMarche, Samarth Hegde, Matthew D Park, Barbara B Maier, Leanna Troncoso, Jessica Le Berichel, Pauline Hamon, Meriem Belabed, Raphaël Mattiuz, Clotilde Hennequin, Theodore Chin, Amanda M Reid, Iván Reyes-Torres, Erika Nemeth, Ruiyuan Zhang, Oakley C Olson, Deborah B Doroshow, Nicholas C Rohs, Jorge E Gomez, Rajwanth Veluswamy, Nicole Hall, Nicholas Venturini, Florent Ginhoux, Zhaoyuan Liu, Mark Buckup, Igor Figueiredo, Vladimir Roudko, Kensuke Miyake, Hajime Karasuyama, Edgar Gonzalez-Kozlova, Sacha Gnjatic, Emmanuelle Passegué, Seunghee Kim-Schulze, Brian D Brown, Fred R Hirsch, Brian S Kim, Thomas U Marron, Miriam Merad: An IL-4 signalling axis in bone marrow drives pro-tumorigenic myelopoiesis. Nature. 2024.01; 625 (7993): 166-174. ( PubMed , DOI )

  10. Miyake K, Ito J, Karasuyama H: Novel insights into the ontogeny of basophils. Frontiers in allergy. 2024; 5 1402841. ( PubMed , DOI )

  1. Nagashima N, Ugajin T, Miyake K, Walls AF, Namiki T, Yokozeki H, Karasuyama H, Okiyama N: Cutaneous basophil infiltration in atopic dermatitis is associated with abundant epidermal infiltration of helper T cells: A preliminary retrospective study. The Journal of dermatology. 2023.10; 51 (1): 130-134. ( PubMed , DOI )

  2. Kazufusa Takahashi, Kensuke Miyake, Junya Ito, Hinano Shimamura, Tadahiro Suenaga, Hajime Karasuyama, Kenichi Ohashi: Topical application of a PDE4 inhibitor ameliorates atopic dermatitis through inhibition of basophil IL-4 production. J Invest Dermatol. 2023.10; ( PubMed , DOI )

  3. Shota Suzuki, Kotaro Tanaka, Kouki Nishikawa, Hiroshi Suzuki, Atsunori Oshima, Yoshinori Fujiyoshi: Structural basis of hydroxycarboxylic acid receptor signaling mechanisms through ligand binding. Nat Commun. 2023.09; 14 (1): 5899. ( PubMed , DOI )

  4. Shunsuke Imai, Hiroshi Suzuki, Yoshinori Fujiyoshi, Ichio Shimada: Dynamically regulated two-site interaction of viral RNA to capture host translation initiation factor. Nat Commun. 2023.08; 14 (1): 4977. ( PubMed , DOI )

  5. Katsumasa Irie, Yoshinori Oda, Takashi Sumikama, Atsunori Oshima, Yoshinori Fujiyoshi: The structural basis of divalent cation block in a tetrameric prokaryotic sodium channel. Nat Commun. 2023.07; 14 (1): 4236. ( PubMed , DOI )

  6. Mayuko Kano, Naoaki Mizuno, Hideyuki Sato, Takaharu Kimura, Rei Hirochika, Yasumasa Iwasaki, Naoko Inoshita, Hisato Nagano, Mariko Kasai, Hiromi Yamamoto, Tomoyuki Yamaguchi, Hidetaka Suga, Hideki Masaki, Eiji Mizutani, Hiromitsu Nakauchi: Functional calcium-responsive parathyroid glands generated using single-step blastocyst complementation. Proc Natl Acad Sci U S A. 2023.07; 120 (28): e2216564120. ( PubMed , DOI )

  7. Akiko Kamegawa, Shota Suzuki, Hiroshi Suzuki, Kouki Nishikawa, Nobutaka Numoto, Yoshinori Fujiyoshi: Structural analysis of the water channel AQP2 by single-particle cryo-EM. J Struct Biol. 2023.06; 215 107984. ( PubMed , DOI )

  8. Kensuke Miyake, Junya Ito, Jun Nakabayashi, Shigeyuki Shichino, Kenji Ishiwata, Hajime Karasuyama: Single cell transcriptomics clarifies the basophil differentiation trajectory and identifies pre-basophils upstream of mature basophils. Nat Commun. 2023.05; 14 (1): 2694. ( PubMed , DOI )

  9. Daisuke Kozai, Nobutaka Numoto, Kouki Nishikawa, Akiko Kamegawa, Shohei Kawasaki, Yoko Hiroaki, Katsumasa Irie, Atsunori Oshima, Hiroyuki Hanzawa, Kousei Shimada, Yutaka Kitano, Yoshinori Fujiyoshi: Recognition Mechanism of a Novel Gabapentinoid Drug, Mirogabalin, for Recombinant Human α2δ1, a Voltage-Gated Calcium Channel Subunit J Mol Biol. 2023.03; 168049. ( PubMed , DOI )

  10. Pellefigues C, Karasuyama H: Editorial: The fundamental biology of basophils in health and disease. Frontiers in immunology. 2023; 14 1292279. ( PubMed , DOI )

  1. Hashimoto T, Yokozeki H, Karasuyama H, Satoh T: IL-31-generating network in atopic dermatitis comprising macrophages, basophils, thymic stromal lymphopoietin, and periostin. The Journal of allergy and clinical immunology. 2022.11; 151 (3): 737-746.e6. ( PubMed , DOI )

  2. Yukihiro Tanimura, Yoko Hiroaki, Masahiro Mori, Yoshinori Fujiyoshi: Cell-based flow cytometry assay for simultaneous detection of multiple autoantibodies in a single serum sample. Anal Biochem. 2022.08; 650 114721. ( PubMed , DOI )

  3. Katerina Naydenova, Akiko Kamegawa, Mathew J Peet, Richard Henderson, Yoshinori Fujiyoshi, Christopher J Russo: On the reduction in the effects of radiation damage to two-dimensional crystals of organic and biological molecules at liquid-helium temperature. Ultramicroscopy. 2022.07; 237 113512. ( PubMed , DOI )

  4. Inaba K, Higashiyama M, Watanabe C, Tomioka A, Ito S, Tanemoto R, Mizoguchi A, Nishii S, Wada A, Sugihara N, Hanawa Y, Horiuchi K, Akita Y, Okada Y, Kurihara C, Narimatsu K, Komoto S, Tomita K, Karasuyama H, Satoh T, Hokari R: Basophils play a proinflammatory role in oxazolone-induced chronic intestinal inflammation. Journal of gastroenterology and hepatology. 2022.07; 37 (9): 1768-1775. ( PubMed , DOI )

  5. Shota Suzuki, Momoko Iida, Yoko Hiroaki, Kotaro Tanaka, Akihiro Kawamoto, Takayuki Kato, Atsunori Oshima: Structural insight into the activation mechanism of MrgD with heterotrimeric Gi-protein revealed by cryo-EM. Commun Biol. 2022.07; 5 (1): 707. ( PubMed , DOI )

  6. Mami Oikawa, Hisato Kobayashi, Makoto Sanbo, Naoaki Mizuno, Kenyu Iwatsuki, Tomoya Takashima, Keiko Yamauchi, Fumika Yoshida, Takuya Yamamoto, Takashi Shinohara, Hiromitsu Nakauchi, Kazuki Kurimoto, Masumi Hirabayashi, Toshihiro Kobayashi: Functional primordial germ cell-like cells from pluripotent stem cells in rats. Science. 2022.04; 376 (6589): 176-179. ( PubMed , DOI )

  7. Mami Oikawa, Mayuko Nagae, Naoaki Mizuno, Kenyu Iwatsuki, Fumika Yoshida, Naoko Inoue, Yoshihisa Uenoyama, Hiroko Tsukamura, Hiromitsu Nakauchi, Masumi Hirabayashi, Toshihiro Kobayashi: Generation of Tfap2c-T2A-tdTomato knock-in reporter rats via adeno-associated virus-mediated efficient gene targeting. Mol Reprod Dev. 2022.03; 89 (3): 129-132. ( PubMed , DOI )

  8. Maki Kuzuya, Hidemi Hirano, Kenichi Hayashida, Masakatsu Watanabe, Kazumi Kobayashi, Tohru Terada, Md Iqbal Mahmood, Florence Tama, Kazutoshi Tani, Yoshinori Fujiyoshi, Atsunori Oshima: Structures of human pannexin-1 in nanodiscs reveal gating mediated by dynamic movement of the N terminus and phospholipids. Sci Signal. 2022.02; 15 (720): eabg6941. ( PubMed , DOI )

  9. Kazuto Yamazaki, Kenji Kubara, Satoko Ishii, Peng Li, Ryo Dairiki, Taro Hihara, Yuta Ishizuka, Yukina Izumi, Minoru Kumai, Tsutomu Kamisako, Hiroyoshi Ishizaki, Hideyuki Sato, Hideki Masaki, Naoaki Mizuno, Kaoru Mitsuhashi, Masashi Ito, Sanae Hamanaka, Tomoyuki Yamaguchi, Motoo Watanabe, Fumihiro Sugiyama, Hiromitsu Nakauchi: In vitro and in vivo functions of T cells produced in complemented thymi of chimeric mice generated by blastocyst complementation. Sci Rep. 2022.02; 12 (1): 3242. ( PubMed , DOI )

  10. Koki Kataoka, Shota Suzuki, Takeshi Tenno, Natsuko Goda, Emi Hibino, Atsunori Oshima, Hidekazu Hiroaki: A cryptic phosphate-binding pocket on the SPFH domain of human stomatin that regulates a novel fibril-like self-assembly. Curr Res Struct Biol. 2022; 4 158-166. ( PubMed , DOI )

  11. Kensuke Miyake, Junya Ito, Hajime Karasuyama: Role of Basophils in a Broad Spectrum of Disorders. Front Immunol. 2022; 13 902494. ( PubMed , DOI )

  12. Tchen J, Simon Q, Chapart L, Pellefigues C, Karasuyama H, Miyake K, Blank U, Benhamou M, Daugas E, Charles N: CT-M8 Mice: A New Mouse Model Demonstrates That Basophils Have a Nonredundant Role in Lupus-Like Disease Development. Frontiers in immunology. 2022; 13 900532. ( PubMed , DOI )

  1. van der Vlist M, Raoof R, Willemen HLDM, Prado J, Versteeg S, Martin Gil C, Vos M, Lokhorst RE, Pasterkamp RJ, Kojima T, Karasuyama H, Khoury-Hanold W, Meyaard L, Eijkelkamp N: Macrophages transfer mitochondria to sensory neurons to resolve inflammatory pain. Neuron. 2021.12; 110 (4): 613-+. ( PubMed , DOI )

  2. Karasuyama Hajime, Shibata Sho, Yoshikawa Soichiro, Miyake Kensuke: 免疫系において軽視されてきた非主流派の好塩基球はついに脚光を浴びる場所にやってきた(Basophils, a neglected minority in the immune system, have come into the limelight at last) International Immunology. 2021.12; 33 (12): 809-813. ( ichushi )

  3. Leyva-Castillo JM, Das M, Kane J, Strakosha M, Singh S, Wong DSH, Horswill AR, Karasuyama H, Brombacher F, Miller LS, Geha RS: Basophil-derived IL-4 promotes cutaneous Staphylococcus aureus infection. JCI insight. 2021.11; 6 (21): ( PubMed , DOI )

  4. Yukako Oda, Chisato Takahashi, Shota Harada, Shun Nakamura, Daxiao Sun, Kazumi Kiso, Yuko Urata, Hitoshi Miyachi, Yoshinori Fujiyoshi, Alf Honigmann, Seiichi Uchida, Yasushi Ishihama, Fumiko Toyoshima: Discovery of anti-inflammatory physiological peptides that promote tissue repair by reinforcing epithelial barrier formation. Sci Adv. 2021.11; 7 (47): eabj6895. ( PubMed , DOI )

  5. Toshihiro Kobayashi, Aracely Castillo-Venzor, Chris A Penfold, Michael Morgan, Naoaki Mizuno, Walfred W C Tang, Yasuyuki Osada, Masao Hirao, Fumika Yoshida, Hideyuki Sato, Hiromitsu Nakauchi, Masumi Hirabayashi, M Azim Surani: Tracing the emergence of primordial germ cells from bilaminar disc rabbit embryos and pluripotent stem cells. Cell Rep. 2021.10; 37 (2): 109812. ( PubMed , DOI )

  6. Kensuke Miyake, Sho Shibata, Soichiro Yoshikawa, Hajime Karasuyama: Basophils and their effector molecules in allergic disorders. Allergy. 2021.06; 76 (6): 1693-1706. ( PubMed , DOI )

  7. Nagaishi T, Watabe T, Kotake K, Kumazawa T, Aida T, Tanaka K, Ono R, Ishino F, Usami T, Miura T, Hirakata S, Kawasaki H, Tsugawa N, Yamada D, Hirayama K, Yoshikawa S, Karasuyama H, Okamoto R, Watanabe M, Blumberg RS, Adachi T: Immunoglobulin A-specific deficiency induces spontaneous inflammation specifically in the ileum. Gut. 2021.05; 71 (3): 487-496. ( PubMed , DOI )

  8. Karasuyama H, Shibata S, Yoshikawa S, Miyake K: Basophils, a neglected minority in the immune system, have come into the limelight at last. International immunology. 2021.05; 33 (12): 809-813. ( PubMed , DOI )

  9. Kensuke Miyake, Hajime Karasuyama: The Role of Trogocytosis in the Modulation of Immune Cell Functions. Cells. 2021.05; 10 (5): ( PubMed , DOI )

  10. Anaïs Wanet, Mahmoud A Bassal, Sweta B Patel, Francisco Marchi, Samanta A Mariani, Nouraiz Ahmed, Haoran Zhang, Marta Borchiellini, Sisi Chen, Junyan Zhang, Annalisa Di Ruscio, Kensuke Miyake, Mindy Tsai, Anuya Paranjape, Shin-Young Park, Hajime Karasuyama, Timm Schroeder, Elaine Dzierzak, Stephen J Galli, Daniel G Tenen, Robert S Welner: E-cadherin is regulated by GATA-2 and marks the early commitment of mouse hematopoietic progenitors to the basophil and mast cell fates. Sci Immunol. 2021.02; 6 (56): ( PubMed , DOI )

  11. Hiroki Yamaguchi, Akiko Kamegawa, Kunio Nakata, Tatsuki Kashiwagi, Yoshinori Fujiyoshi, Kazutoshi Tani, Toshimi Mizukoshi: Leucine Dehydrogenase: Structure and Thermostability. Subcell Biochem. 2021; 96 355-372. ( PubMed , DOI )

  1. Ito Junya, Miyake Kensuke, Shichino Shigeyuki, Yamanishi Yoshinori, Karasuyama Hajime: Identification of two distinct subpopulations among basophils in the bone marrow(和訳中) アレルギー. 2020.10; 69 (臨時増刊号): 133. ( ichushi )

  2. Miyake Kensuke, Ito Junya, Takahashi Kazufusa, Yoshikawa Soichiro, Yamanishi Yoshinori, Karasuyama Hajime: Regulation of immune cells　Monocyte-derived M2-like macrophages induced by activated basophils dampen IL-1α-mediated aggravation of allergic inflammation(和訳中) アレルギー. 2020.10; 69 (臨時増刊号): 91. ( ichushi )

  3. Aihara Yoshiko, Fukuda Yota, Takizawa Akiyoshi, Osakabe Naomi, Aida Tomomi, Tanaka Kohichi, Yoshikawa Soichiro, Karasuyama Hajime, Adachi Takahiro: 生体内イメージングを用いた腸管における機械的ストレス媒介Ca2+シグナル伝達の可視化(Visualization of mechanical stress-mediated Ca2+ signaling in the gut using intravital imaging) Bioscience of Microbiota, Food and Health. 2020.10; 39 (4): 209-218. ( ichushi )

  4. Karasuyama Hajime, Miyake Kensuke, Yoshikawa Soichiro: Immunobiology of Acquired Resistance to Ticks FRONTIERS IN IMMUNOLOGY. 2020.10; 11 601504. ( PubMed , DOI )

  5. Yamanishi Y, Mogi K, Takahashi K, Miyake K, Yoshikawa S, Karasuyama H: Skin-infiltrating basophils promote atopic dermatitis-like inflammation via IL-4 production in mice. Allergy. 2020.10; 75 (10): 2613-2622. ( PubMed , DOI )

  6. Yoshikawa S, Miyake K, Kamiya A, Karasuyama H: The role of basophils in acquired protective immunity to tick infestation. Parasite immunology. 2020.10; 43 (5): e12804. ( PubMed , DOI )

  7. Hanayo Nakanishi, Tomohiro Nishizawa, Katsumori Segawa, Osamu Nureki, Yoshinori Fujiyoshi, Shigekazu Nagata, Kazuhiro Abe: Transport Cycle of Plasma Membrane Flippase ATP11C by Cryo-EM. Cell Rep. 2020.09; 32 (13): 108208. ( PubMed , DOI )

  8. Yang Yue, Nagai Shigenori, Kang Siwen, Xia Yulong, Kawano Yohei, Miyake Kensuke, Karasuyama Hajime, Azuma Miyuki: Tolerogenic properties of CD206+ macrophages appeared in the sublingual mucosa after repeated antigen-painting International Immunology. 2020.08; 32 (8): 509-518. ( ichushi )

  9. Irie Katsumasa, Shimomura Takushi, Yonekawa Yoshiki, Nagura Hitoshi, Tateyama Michihiro, Fujiyoshi Yoshinori: 天然の原核生物由来カルシウムチャネルにおけるイオン透過選択性の進化とその決定残基の同定(The selectivity determinant and evolution of a native prokaryotic voltage-dependent calcium channel) 生物物理. 2020.08; 60 (Suppl.1-2): S248. ( ichushi )

  10. Shimada Atsuhiro, Kozai Daisuke, Nishikawa Kouki, Fujiyoshi Yoshinori, Sho Gyokucho, Mizutani Takumi, Tani Kazutoshi: クライオ電子顕微鏡を用いたシトクロム酸化酵素とシトクロムcの複合体構造解析(The structural analysis of cytochrome c oxidase complexed with cytochrome c using cryo-electron microscopy) 生物物理. 2020.08; 60 (Suppl.1-2): S158. ( ichushi )

  11. Hanayo Nakanishi, Katsumasa Irie, Katsumori Segawa, Kazuya Hasegawa, Yoshinori Fujiyoshi, Shigekazu Nagata, Kazuhiro Abe: Crystal structure of a human plasma membrane phospholipid flippase. J Biol Chem. 2020.07; 295 (30): 10180-10194. ( PubMed , DOI )

  12. Koki Ikeda, Shota Suzuki, Yoshiki Shigemitsu, Takeshi Tenno, Natsuko Goda, Atsunori Oshima, Hidekazu Hiroaki: Presence of intrinsically disordered proteins can inhibit the nucleation phase of amyloid fibril formation of Aβ(1-42) in amino acid sequence independent manner. Sci Rep. 2020.07; 10 (1): 12334. ( PubMed , DOI )

  13. Nishimura Yuya, Fukuda Yota, Okonogi Toya, Yoshikawa Soichiro, Karasuyama Hajime, Osakabe Naomi, Ikegaya Yuji, Sasaki Takuya, Adachi Takahiro: Dual real-time in vivo monitoring system of the brain-gut axis BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2020.04; 524 (2): 340-345. ( PubMed , DOI )

  14. Development of a deep learning-based method to identify "good" regions of a cryo-electron microscopy grid. 2020.04; 12 (2): 349-354. ( PubMed , DOI )

  15. Yue Yang, Shigenori Nagai, Siwen Kang, Yulong Xia, Yohei Kawano, Kensuke Miyake, Hajime Karasuyama, Miyuki Azuma: Tolerogenic properties of CD206+ macrophages appeared in the sublingual mucosa after repeated antigen-painting. Int. Immunol.. 2020.03; ( PubMed , DOI )

  16. Lin Yu-Hsien, Tahara-Hanaoka Satoko, Nagai Kei, Yoshikawa Soichiro, Kubo Masato, Shibayama Shiro, Karasuyama Hajime, Shibuya Akira: マウスにおける好塩基球上のAllergin-1による経口アレルゲン誘導アナフィラキシーの選択的抑制(Selective suppression of oral allergen-induced anaphylaxis by Allergin-1 on basophils in mice) International Immunology. 2020.03; 32 (3): 213-219. ( ichushi )

  17. B. Burendei, R. Shinozaki, M. Watanabe, T. Terada, K. Tani, Y. Fujiyoshi and A. Oshima: Cryo-EM structures of undocked innexin-6 hemichannels in phospholipids. Sci. Adv.. 2020.02; 6 (7): ( DOI )

  18. Takushi Shimomura, Yoshiki Yonekawa, Hitoshi Nagura, Michihiro Tateyama, Yoshinori Fujiyoshi, Katsumasa Irie: A native prokaryotic voltage-dependent calcium channel with a novel selectivity filter sequence. Elife. 2020.02; 9 ( PubMed , DOI )

  19. Aihara Yoshiko, Fukuda Yota, Takizawa Akiyoshi, Osakabe Naomi, Aida Tomomi, Tanaka Kohichi, Yoshikawa Soichiro, Karasuyama Hajime, Adachi Takahiro: Visualization of mechanical stress-mediated Ca2+ signaling in the gut using intravital imaging BIOSCIENCE OF MICROBIOTA FOOD AND HEALTH. 2020; 39 (4): 209-218. ( PubMed , DOI )

  1. Lin YH, Tahara-Hanaoka S, Nagai K, Yoshikawa S, Kubo M, Shibayama S, Karasuyama H, Shibuya A: Selective suppression of oral allergen-induced anaphylaxis by Allergin-1 on basophils in mice. International Immunology. 2019.12; 32 (3): 213-219. ( PubMed , DOI )

  2. Yoshikawa S., Oh-hora M., Hashimoto R., Miyake K., Adachi T., Kawano Y., Yamanishi Y., Kamiya A., Karasuyama H.: Pivotal role of STIM2, but not STIM1, in IL-4 production by IL-3-stimulated basophils EUROPEAN JOURNAL OF IMMUNOLOGY. 2019.10; 49 584-585.

  3. Kashiwakura J, Ando T, Karasuyama H, Kubo M, Matsumoto K, Matsuda T, Kawakami T: The basophil-IL-4-mast cell axis is required for food allergy. Allergy. 2019.10; 74 (10): 1992-1996. ( PubMed , DOI )

  4. Adachi Takahiro, Yoshikawa Soichiro, Tezuka Hiroyuki, Tsuji Noriko M., Ohteki Toshiaki, Karasuyama Hajime, Kumazawa Toshihiko: プロポリスは免疫細胞におけるCa2+シグナル伝達を誘導する(Propolis induces Ca2+ signaling in immune cells) Bioscience of Microbiota, Food and Health. 2019.10; 38 (4): 141-149. ( ichushi )

  5. K. Yamamoto, V. Dubey, K. Irie, H. Nakanishi, H. Khandelia, Y. Fujiyoshi and K. Abe: A single K+-binding site in the crystal structure of the gastric proton pump. eLife. 2019.08; 8 ( DOI )

  6. Arata Honda, Ryoma Tachibana, Kazuya Hamada, Kohtaro Morita, Naoaki Mizuno, Kento Morita, Masahide Asano: Efficient derivation of knock-out and knock-in rats using embryos obtained by in vitro fertilization. Sci Rep. 2019.08; 9 (1): 11571. ( PubMed , DOI )

  7. Naoaki Mizuno, Eiji Mizutani, Hideyuki Sato, Mariko Kasai, Hiromitsu Nakauchi, Tomoyuki Yamaguchi: CRISPR/Cas9 + AAV-mediated Intra-embryonic Gene Knocking in Mice. Bio Protoc. 2019.07; 9 (13): e3295. ( PubMed , DOI )

  8. Balam S, Schiechl-Brachner G, Buchtler S, Halbritter D, Schmidbauer K, Talke Y, Neumayer S, Salewski NJ, Winter F, Karasuyama H, Yamanishi Y, Renner K, Geissler EK, Mack M: IL-3 Triggers Chronic Rejection of Cardiac Allografts by Activation of Infiltrating Basophils. Journal of Immunology. 2019.06; 202 (12): 3514-3523. ( PubMed , DOI )

  9. Soichiro Yoshikawa, Masatsugu Oh-Hora, Ryota Hashimoto, Toshihisa Nagao, Louis Peters, Mayumi Egawa, Takuya Ohta, Kensuke Miyake, Takahiro Adachi, Yohei Kawano, Yoshinori Yamanishi, Hajime Karasuyama: Pivotal role of STIM2, but not STIM1, in IL-4 production by IL-3-stimulated murine basophils. Sci Signal. 2019.04; 12 (576): ( PubMed , DOI )

  10. Hashimoto T, Satoh T, Karasuyama H, Yokozeki H: Amphiregulin from basophils amplifies basophil-mediated chronic skin inflammation. The Journal of investigative dermatology. 2019.03; ( PubMed , DOI )

  11. Shun Nakamura, Katsumasa Irie, Hiroo Tanaka, Kouki Nishikawa, Hiroshi Suzuki, Yasunori Saitoh, Atsushi Tamura, Sachiko Tsukita & Yoshinori Fujiyoshi: Morphologic determinant of tight junctions revealed by claudin-3 structures Nature Communications. 2019.02; 10 816. ( DOI )

  12. Toshihisa Nagao, Yoshinori Yamanishi, Kensuke Miyake, Mio Teranishi, Saori Takahashi, Soichiro Yoshikawa, Yohei Kawano, Hajime Karasuyama: Aggregation makes a protein allergenic at the challenge phase of basophil-mediated allergy in mice. Int. Immunol.. 2019.02; 31 (1): 41-49. ( PubMed , DOI )

  13. Piliponsky AM, Shubin NJ, Lahiri AK, Truong P, Clauson M, Niino K, Tsuha AL, Nedospasov SA, Karasuyama H, Reber LL, Tsai M, Mukai K, Galli SJ: Basophil-derived tumor necrosis factor can enhance survival in a sepsis model in mice. Nature Immunology. 2019.02; 20 (2): 129-140. ( PubMed , DOI )

  14. Yamaguchi Hiroki, Kamegawa Akiko, Nakata Kunio, Kashiwagi Tatsuki, Mizukoshi Toshimi, Fujiyoshi Yoshinori, Tani Kazutoshi: Structural insights into thermostabilization of leucine dehydrogenase from its atomic structure by cryo-electron microscopy JOURNAL OF STRUCTURAL BIOLOGY. 2019.01; 205 (1): 11-21. ( PubMed , DOI )

  15. Nagao Toshihisa, Yamanishi Yoshinori, Miyake Kensuke, Teranishi Mio, Takahashi Saori, Yoshikawa Soichiro, Kawano Yohei, Karasuyama Hajime: マウスにて好塩基球媒介性アレルギー誘発相において、蛋白質の凝集によって蛋白質がアレルゲン化する(Aggregation makes a protein allergenic at the challenge phase of basophil-mediated allergy in mice) International Immunology. 2019.01; 31 (1): 41-49. ( ichushi )

  16. Tateishi T., Shibata S., Karasuyama H., Miyazaki Y.: Basophil Depletion Leads to Promotion of the Lung Fibrosis in Bleomycin-Mouse Model AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2019; 199

  17. Adachi Takahiro, Yoshikawa Soichiro, Tezuka Hiroyuki, Tsuji Noriko M., Ohteki Toshiaki, Karasuyama Hajime, Kumazawa Toshihiko: Propolis induces Ca2+ signaling in immune cells BIOSCIENCE OF MICROBIOTA FOOD AND HEALTH. 2019; 38 (4): 141-149. ( DOI )

  1. Sho Shibata, Kensuke Miyake, Tomoya Tateishi, Soichiro Yoshikawa, Yoshinori Yamanishi, Yasunari Miyazaki, Naohiko Inase, Hajime Karasuyama: Basophils trigger emphysema development in a murine model of COPD through IL-4-mediated generation of MMP-12-producing macrophages. Proc. Natl. Acad. Sci. U.S.A.. 2018.12; 115 (51): 13057-13062. ( PubMed , DOI )

  2. Hajime Karasuyama, Yuya Tabakawa, Takuya Ohta, Takeshi Wada, Soichiro Yoshikawa: Crucial Role for Basophils in Acquired Protective Immunity to Tick Infestation. Front Physiol. 2018.12; 9 1769. ( PubMed , DOI )

  3. Naoaki Mizuno, Eiji Mizutani, Hideyuki Sato, Mariko Kasai, Aki Ogawa, Fabian Suchy, Tomoyuki Yamaguchi, Hiromitsu Nakauchi: Intra-embryo Gene Cassette Knockin by CRISPR/Cas9-Mediated Genome Editing with Adeno-Associated Viral Vector. iScience. 2018.11; 9 286-297. ( PubMed , DOI )

  4. Sanae Hamanaka, Ayumi Umino, Hideyuki Sato, Tomonari Hayama, Ayaka Yanagida, Naoaki Mizuno, Toshihiro Kobayashi, Mariko Kasai, Fabian Patrik Suchy, Satoshi Yamazaki, Hideki Masaki, Tomoyuki Yamaguchi, Hiromitsu Nakauchi: Generation of Vascular Endothelial Cells and Hematopoietic Cells by Blastocyst Complementation. Stem Cell Reports. 2018.10; 11 (4): 988-997. ( PubMed , DOI )

  5. Tomoyuki Yamaguchi, Hideyuki Sato, Toshihiro Kobayashi, Megumi Kato-Itoh, Teppei Goto, Hiromasa Hara, Naoaki Mizuno, Ayaka Yanagida, Ayumi Umino, Sanae Hamanaka, Fabian Suchy, Hideki Masaki, Yasunori Ota, Masumi Hirabayashi, Hiromitsu Nakauchi: An interspecies barrier to tetraploid complementation and chimera formation. Sci Rep. 2018.10; 8 (1): 15289. ( PubMed , DOI )

  6. Karasuyama Hajime, Miyake Kensuke, Yoshikawa Soichiro, Kawano Yohei, Yamanishi Yoshinori: How do basophils contribute to T(h)2 cell differentiation and allergic responses? INTERNATIONAL IMMUNOLOGY. 2018.09; 30 (9): 391-396. ( PubMed , DOI )

  7. Karasuyama Hajime, Miyake Kensuke, Yoshikawa Soichiro, Kawano Yohei, Yamanishi Yoshinori: 好塩基球はいかにしてTh2細胞分化およびアレルギー反応に寄与するか?(How do basophils contribute to Th2 cell differentiation and allergic responses?) International Immunology. 2018.09; 30 (9): 391-396. ( ichushi )

  8. Hajime Karasuyama, Kensuke Miyake, Soichiro Yoshikawa, Yoshinori Yamanishi: Multifaceted roles of basophils in health and disease. J. Allergy Clin. Immunol.. 2018.08; 142 (2): 370-380. ( PubMed , DOI )

  9. Yuya Tabakawa, Takuya Ohta, Soichiro Yoshikawa, Elisabeth J Robinson, Kayoko Yamaji, Kenji Ishiwata, Yohei Kawano, Kensuke Miyake, Yoshinori Yamanishi, Hiroshi Ohtsu, Takahiro Adachi, Naohiro Watanabe, Hirotaka Kanuka, Hajime Karasuyama: Histamine Released From Skin-Infiltrating Basophils but Not Mast Cells Is Crucial for Acquired Tick Resistance in Mice. Front Immunol. 2018.07; 9 1540. ( PubMed , DOI )

  10. Yohei Kawano, Georg Petkau, Christina Stehle, Pawel Durek, Gitta Anne Heinz, Kousuke Tanimoto, Hajime Karasuyama, Mir-Farzin Mashreghi, Chiara Romagnani, Fritz Melchers: Stable lines and clones of long-term proliferating normal, genetically unmodified murine common lymphoid progenitors. Blood. 2018.05; 131 (18): 2026-2035. ( PubMed , DOI )

  11. Taro Watabe, Takashi Nagaishi, Naoya Tsugawa, Yudai Kojima, Nisha Jose, Akinori Hosoya, Michio Onizawa, Yasuhiro Nemoto, Shigeru Oshima, Tetsuya Nakamura, Hajime Karasuyama, Takahiro Adachi, Mamoru Watanabe: B cell activation in the cecal patches during the development of an experimental colitis model. Biochem. Biophys. Res. Commun.. 2018.02; 496 (2): 367-373. ( PubMed , DOI )

  12. Christophe Pellefigues, Barbara Dema, Yasmine Lamri, Fanny Saidoune, Nathalie Chavarot, Charlotte Lohéac, Emeline Pacreau, Michael Dussiot, Caroline Bidault, Florian Marquet, Mathieu Jablonski, Jonathan M Chemouny, Fanny Jouan, Antoine Dossier, Marie-Paule Chauveheid, Delphine Gobert, Thomas Papo, Hajime Karasuyama, Karim Sacré, Eric Daugas, Nicolas Charles: Prostaglandin D2 amplifies lupus disease through basophil accumulation in lymphoid organs. Nat Commun. 2018.02; 9 (1): 725. ( PubMed , DOI )

  1. Kojima Toshiyuki, Yoshikawa Soichiro, Yamanishi Yoshinori, Karasuyama Hajime: Mucosal-Skin Immunity(2) Novel CD200 homologues iSEC1 and iSEC2 are gastrointestinal secretory cell-specific ligands of inhibitory receptor CD200R(和訳中) 日本免疫学会総会・学術集会記録. 2017.12; 46 (Proceedings): 3-F. ( ichushi )

  2. Takahiro Adachi, Yoshikawa Soichiro, Karasuyama Hajime: B cell development and function Intravital imaging of Ca2+ signals in lymphocytes of the Ca2+ biosensor YC3.60 transgenic mice(和訳中) 日本免疫学会総会・学術集会記録. 2017.12; 46 (Proceedings): 3-E. ( ichushi )

  3. Karasuyama Hajime: Allergy: state-of-the-art Emerging roles of basophils in allergic inflammation and immune regulation(和訳中) 日本免疫学会総会・学術集会記録. 2017.12; 46 (Proceedings): S1-4. ( ichushi )

  4. Miyake Kensuke, Shiozawa Nozomu, Nagao Toshihisa, Yoshikawa Soichiro, Yamanishi Yoshinori, Karasuyama Hajime: Granulocyte & Mast cells Basophils exert antigen presentation via trogocytosis-mediated acquisition of peptide-MHC class II complexes from dendritic cells(DCs)(和訳中) 日本免疫学会総会・学術集会記録. 2017.12; 46 (Proceedings): 3-H. ( ichushi )

  5. SHIBATA Sho, MIYAKE Kensuke, YOSHIKAWA Soichiro, KAWANO Yohei, YAMANISHI Yoshinori, KARASUYAMA Hajime: Allergy: Lower airway allergic inflammation Monocyte-derived macrophages in the lung contribute to the development of pulmonary emphysema through MMP-12 production in a mouse model of COPD(和訳中) 日本免疫学会総会・学術集会記録. 2017.12; 46 (Proceedings): 1-A. ( ichushi )

  6. Yamanishi Yoshinori, Iki Misako, Tanaka Kensei, Deki Hayato, Fujimaki Mio, Miyake Kensuke, Yoshikawa Soichiro, Kawano Yohei, Sato Shingo, Karasuyama Hajime: Allergy: Allergic dermatitis, food allergy and allergic conjunctivitis Basophil tryptase mMCP-11 plays a crucial role in IgE-mediated, delayed-onset allergic inflammation(和訳中) 日本免疫学会総会・学術集会記録. 2017.12; 46 (Proceedings): 2-G. ( ichushi )

  7. Takuya Ohta, Soichiro Yoshikawa, Yuya Tabakawa, Kayoko Yamaji, Kenji Ishiwata, Hiroshi Shitara, Choji Taya, Masatsugu Oh-Hora, Yohei Kawano, Kensuke Miyake, Yoshinori Yamanishi, Hiromichi Yonekawa, Naohiro Watanabe, Hirotaka Kanuka, Hajime Karasuyama: Skin CD4+ Memory T Cells Play an Essential Role in Acquired Anti-Tick Immunity through Interleukin-3-Mediated Basophil Recruitment to Tick-Feeding Sites. Front Immunol. 2017.10; 8 1348. ( PubMed , DOI )

  8. Barbara Dema, Yasmine Lamri, Christophe Pellefigues, Emeline Pacreau, Fanny Saidoune, Caroline Bidault, Hajime Karasuyama, Karim Sacré, Eric Daugas, Nicolas Charles: Basophils contribute to pristane-induced Lupus-like nephritis model. Sci Rep. 2017.08; 7 (1): 7969. ( PubMed , DOI )

  9. Miyake Kensuke, Karasuyama Hajime: アレルギー性炎症における好塩基球の新たな役割(Beyond Th2, More than ILC2　Emerging roles of basophils in allergic inflammation) Allergology International. 2017.07; 66 (3): 382-391. ( ichushi )

  10. Sumika Toyama, Naoko Okada, Akio Matsuda, Hideaki Morita, Hirohisa Saito, Takao Fujisawa, Susumu Nakae, Hajime Karasuyama, Kenji Matsumoto: Human eosinophils constitutively express a unique serine protease, PRSS33. Allergol Int. 2017.07; 66 (3): 463-471. ( PubMed , DOI )

  11. Tomoyuki Bando, Setsuko Fujita, Naoko Nagano, Soichiro Yoshikawa, Yoshinori Yamanishi, Masashi Minami, Hajime Karasuyama: Differential usage of COX-1 and COX-2 in prostaglandin production by mast cells and basophils. Biochem Biophys Rep. 2017.07; 10 82-87. ( PubMed , DOI )

  12. Yoshinori Yamanishi, Kensuke Miyake, Misako Iki, Hidemitsu Tsutsui, Hajime Karasuyama: Recent advances in understanding basophil-mediated Th2 immune responses. Immunol. Rev.. 2017.07; 278 (1): 237-245. ( PubMed , DOI )

  13. Kensuke Miyake, Hajime Karasuyama: Emerging roles of basophils in allergic inflammation. Allergol. Int.. 2017.07; 66 (3): 382-391. ( PubMed , DOI )

  14. Yamanishi Yoshinori, Iki Misako, Tanaka Kensei, Deki Hayato, Fujimaki Mio, Sato Shingo, Yoshikawa Soichiro, Karasuyama Hajime: IgE介在性慢性アレルギー性炎症において好塩基球性トリプターゼmMCP-11は重要な役割を果たす(Basophil tryptase mMCP-11 plays a crucial role in the IgE-mediated chronic allergic inflammation) アレルギー. 2017.05; 66 (4-5): 520. ( ichushi )

  15. Kaori Mukai, Hajime Karasuyama, Kenji Kabashima, Masato Kubo, Stephen J Galli: Differences in the Importance of Mast Cells, Basophils, IgE, and IgG versus That of CD4+ T Cells and ILC2 Cells in Primary and Secondary Immunity to Strongyloides venezuelensis. Infect. Immun.. 2017.04; 85 (5): e00053-17. ( PubMed , DOI )

  16. Bianca Balbino, Riccardo Sibilano, Philipp Starkl, Thomas Marichal, Nicolas Gaudenzio, Hajime Karasuyama, Pierre Bruhns, Mindy Tsai, Laurent L Reber, Stephen J Galli: Pathways of immediate hypothermia and leukocyte infiltration in an adjuvant-free mouse model of anaphylaxis. J. Allergy Clin. Immunol.. 2017.02; 139 (2): 584-596.e10. ( PubMed , DOI )

  17. Tomoyuki Yamaguchi, Hideyuki Sato, Megumi Kato-Itoh, Teppei Goto, Hiromasa Hara, Makoto Sanbo, Naoaki Mizuno, Toshihiro Kobayashi, Ayaka Yanagida, Ayumi Umino, Yasunori Ota, Sanae Hamanaka, Hideki Masaki, Sheikh Tamir Rashid, Masumi Hirabayashi, Hiromitsu Nakauchi: Interspecies organogenesis generates autologous functional islets. Nature. 2017.02; 542 (7640): 191-196. ( PubMed , DOI )

  18. Hidemitsu Tsutsui, Yoshinori Yamanishi, Hiromi Ohtsuka, Shingo Sato, Soichiro Yoshikawa, Hajime Karasuyama: The Basophil-specific Protease mMCP-8 Provokes an Inflammatory Response in the Skin with Microvascular Hyperpermeability and Leukocyte Infiltration. J. Biol. Chem.. 2017.01; 292 (3): 1061-1067. ( PubMed , DOI )

  19. Kensuke Miyake, Nozomu Shiozawa, Toshihisa Nagao, Soichiro Yoshikawa, Yoshinori Yamanishi, Hajime Karasuyama: Trogocytosis of peptide-MHC class II complexes from dendritic cells confers antigen-presenting ability on basophils. Proc. Natl. Acad. Sci. U.S.A.. 2017.01; 114 (5): 1111-1116. ( PubMed , DOI )

  1. Iki, M., Tanaka, K., Deki, H. Fujimaki, M., Sato, S., Yoshikawa, S., Yamanishi, Y., Karasuyama, K.: Basophil tryptase mMCP-11 plays a crucial role in IgE-mediated, delayed-onset allergic inflammation in mice. Blood. 2016.12; 128 (25): 2909-2918. ( PubMed , DOI )

  2. Toshiyuki Kojima, Kiichiro Tsuchiya, Shinji Ikemizu, Soichiro Yoshikawa, Yoshinori Yamanishi, Mamoru Watanabe, Hajime Karasuyama: Novel CD200 homologues iSEC1 and iSEC2 are gastrointestinal secretory cell-specific ligands of inhibitory receptor CD200R. Sci Rep. 2016.11; 6 36457. ( PubMed , DOI )

  3. Venturelli, N., Lexmond, W. S., Ohsaki, A., Nurko, S., Karasuyama, H., Fiebiger, E., Oyoshi, M. K.: Allergic skin sensitization promotes eosinophilic esophagitis through the IL-33-basophil axis in mice. J. Allergy Clin. Immunol.. 2016.11; 138 (5): 1367-1380.e5. ( PubMed , DOI )

  4. Horiguchi, K., Yoshikawa, S., Saito, A., Haddad, S., Ohta, T., Miyake, K., Yamanishi, Y., Karasuyama, H.: Real-time imaging of mast cell degranulation in vitro and in vivo. Biochem. Biophys. Res. Commun.. 2016.10; 479 (3): 517-522. ( PubMed , DOI )

  5. Schiechl, G., Hermann, F.J., Rodriguez Gomez, M., Kutzi, S., Schmidbauer, K., Talke, Y., Neumayer, S., Goebel, N., Renner, K., Brühl, H., Karasuyama, H., Obata-Ninomiya, K., K Utpatel, K., Evert, M., Hirt, S.W., Geissler, E.K., Fichtner-Feigl, S., Mack, M.: Basophils Trigger Fibroblast Activation in Cardiac Allograft Fibrosis Development. Am. J. Transplant.. 2016.09; 16 (9): 2574-2588. ( PubMed , DOI )

  6. Yamanishi, Y., Karasuyama, H.: Basophils and mast cells in immunity and inflammation. Semin Immunopathol. 2016.09; 38 (5): 535-537. ( PubMed , DOI )

  7. Yamanishi, Y., Karasuyama, H.: Basophil-derived IL-4 plays versatile roles in immunity. Semin Immunopathol. 2016.09; 38 (5): 615-622. ( PubMed , DOI )

  8. Ayaka Yanagida, Naoak Mizuno, Yuji Yamazaki, Megumi Kato-Itoh, Ayumi Umino, Hideyuki Sato, Keiichi Ito, Tomoyuki Yamaguchi, Hiromitsu Nakauchi, Akihide Kamiya: Investigation of bipotent differentiation of hepatoblasts using inducible diphtheria toxin receptor-transgenic mice. Hepatol Res. 2016.07; 46 (8): 816-828. ( PubMed , DOI )

  9. Hayama T, Yamaguchi T, Kato-Itoh M, Ishii Y, Mizuno N, Umino A, Sato H, Sanbo M, Hamanaka S, Masaki H, Hirabayashi M, Nakauchi H.: Practical selection methods for rat and mouse round spermatids without DNA staining by flow cytometric cell sorting. Mol Reprod Dev.. 2016.06;

  10. Baba, T., Tanabe, Y., Yoshikawa, S., Yamanishi, Y., Morishita, S., Komatsu, N., Karasuyama, H., Hirao, A., Mukaida N.: MIP-1α/CCL3-expressing basophil-lineage cells drive the leukemic hematopoiesis of chronic myeloid leukemia in mice. Blood. 2016.05; 127 (21): 2607-2617. ( PubMed , DOI )

  11. Yoshikawa, S., Usami, T., Kikuta, J., Ishii, M., Sasano, T., Sugiyama, K., Furukawa, T., Nakasho, E., Takayanagi, H., Tedder, T. F., Karasuyama, H., Miyawaki, A., Adachi, T.: Intravital imaging of Ca(2+) signals in lymphocytes of Ca(2+) biosensor transgenic mice: indication of autoimmune diseases before the pathological onset. Sci Rep. 2016.01; 6 18738. ( PubMed , DOI )

  12. Adachi, T., Kakuta, S., Aihara, Y., Kamiya, T., Watanabe, Y., Osakabe, N., Hazato, N., Miyawaki, A., Yoshikawa, S., Usami, T., Karasuyama, H., Kimoto-Nira, H., Hirayama, K., M Tsuji, N.: Visualization of Probiotic-Mediated Ca(2+) Signaling in Intestinal Epithelial Cells In Vivo. Front Immunol. 2016; 7 601. ( PubMed , DOI )

  1. LiHua, L., Yoshikawa, S., Ohta, T., Horiguchi, K., Kawano, Y., Ohtsu, H., Yamanishi, Y., and Karasuyama, H.: Large particulate allergens can elicit mast cell-mediated anaphylaxis without exit from blood vessels as efficiently as do small soluble allergens. Biochem. Biophys. Res. Commun. . 2015.11; 467 (6 (1)): 70-75. ( PubMed )

  2. Morita, H., Arae, K., Unno, H., Nambu, A, Oboki, K., Ohno, T., Matsuda, A., Toyama, S., Miyauchi, K., Yamaguchi, S., Narushima, S., Kajiwara, N., Iikura, M., Suto, H., McKenzie, A., Takahashi, T., Karasuyama, H., Okumara, K., Azuma, M., Galli, SJ., Moro, K., Akdis, C., Koyasu, S., Kubo, M., Sudo, K., Saito, H., Matsumoto, K., and Nakae, S.: An Interleukin-33-Mast Cell-Interleukin-2 Axis Suppresses Papain-Induced Allergic Inflammation by Promoting Regulatory T Cell Numbers. Immunity. 2015.07; 43 (1): 175-186. ( PubMed , DOI )

  3. Tsai, S.H., Kinoshita, M., Kusu, T., Kayama, H., Okumura, R., Ikeda, K., Shimada Y., Takeda A., Yoshikawa, S., Obata-Ninomiya, K., Kurashima, Y., Sato, S., Umemoto, E., Kiyono, H., Karasuyama, H., and Takeda, K.: The ectoenzyme E-NPP3 negatively regulates ATP-dependent chronic allergic responses by basophils and mast cells. Immunity. 2015.02; 42 (2): 279-293. ( PubMed , DOI )

  1. Hajime Karasuyama, Yoshinori Yamanishi: Basophils have emerged as a key player in immunity. Curr. Opin. Immunol.. 2014.12; 31 1-7. ( PubMed , DOI )

  2. Tomonari Hayama, Tomoyuki Yamaguchi, Megumi Kato-Itoh, Sanae Hamanaka, Mami Kawarai, Makoto Sanbo, Chihiro Tamura, Youn-Su Lee, Ayaka Yanagida, Hideyuki Murayama, Naoaki Mizuno, Ayumi Umino, Hideyuki Sato, Satoshi Yamazaki, Hideki Masaki, Toshihiro Kobayashi, Masumi Hirabayashi, Hiromitsu Nakauchi: Generation of mouse functional oocytes in rat by xeno-ectopic transplantation of primordial germ cells. Biol Reprod. 2014.10; 91 (4): 89. ( PubMed , DOI )

  3. Laurent L Reber, Thomas Marichal, Jeremy Sokolove, Philipp Starkl, Nicolas Gaudenzio, Yoichiro Iwakura, Hajime Karasuyama, Lawrence B Schwartz, William H Robinson, Mindy Tsai, Stephen J Galli: Contribution of mast cell-derived interleukin-1β to uric acid crystal-induced acute arthritis in mice. Arthritis and Rheumatology (Hoboken, N.J.). 2014.10; 66 (10): 2881-2891. ( PubMed , DOI )

  4. Ryota Inokuchi, Kensuke Nakamura, Naoaki Mizuno, Hajime Sato, Kazuaki Shinohara, Takehiro Matsubara, Kent Doi, Takeshi Ishii, Masataka Gunshin, Susumu Nakajima, Naoki Yahagi: Adult-onset seizures in a patient with Down syndrome and portosystemic shunt. Brain Dev. 2014.08; 36 (7): 626-629. ( PubMed , DOI )

  5. Mahbubul Morshed, Ruslan Hlushchuk, Dagmar Simon, Andrew F Walls, Kazushige Obata-Ninomiya, Hajime Karasuyama, Valentin Djonov, Alexander Eggel, Thomas Kaufmann, Hans-Uwe Simon, Shida Yousefi: NADPH oxidase-independent formation of extracellular DNA traps by basophils. J. Immunol.. 2014.06; 192 (11): 5314-5323. ( PubMed , DOI )

  6. Nadja Bakocevic, Carla Claser, Soichiro Yoshikawa, Leigh Ann Jones, Samantha Chew, Chi Ching Goh, Benoit Malleret, Anis Larbi, Florent Ginhoux, Maria Curotto de Lafaille, Hajime Karasuyama, Laurent Renia, Lai Guan Ng: CD41 is a reliable identification and activation marker for murine basophils in the steady state and during helminth and malarial infections. Eur. J. Immunol.. 2014.06; 44 (6): 1823-1834. ( PubMed , DOI )

  7. Egawa, M., Mukai, K., and Karasuyama, H.: Basophil-derived IL-4 induces the differentiation of inflammatory monocytes into M2-type macrophages to dampen allergic inflammation. Allergic diseases: from mechanisms to cures.. 2014; 59-62.

  8. Karasuyama H.: Basophils. Global Atlas of Allergy. 2014; 56-57.

  1. Shiraishi Y, Jia Y, Domenico J, Joetham A, Karasuyama H, Takeda K, Gelfand E.W: Sequential engagement of FcεRI on mast cells and basophil histamine H4 receptor and FcεRI in allergic rhinitis Journal of Immunology. 2013.01; 190 (2): 539-548. ( PubMed , DOI )

  1. Ken Morita, Fumihiko Nakamura, Yasuhiko Kamikubo, Naoaki Mizuno, Masashi Miyauchi, Go Yamamoto, Yasuhito Nannya, Motoshi Ichikawa, Mineo Kurokawa: Pituitary lymphoma developing within pituitary adenoma. Int J Hematol. 2012.06; 95 (6): 721-724. ( PubMed , DOI )

  2. Ogawa H, Mukai K, Kawano Y, Minegishi Y, Karasuyama H: Th2-inducing cytokines IL-4 and IL-33 synergistically elicit the expression of transmembrane TNF-α on macrophages through the autocrine action of IL-6. Biochemical and biophysical research communications. 2012.03; 420 (1): 114-118. ( PubMed , DOI )

  3. Junji Kawada, Hisashi Wada, Midori Isobe, Sacha Gnjatic, Hiroyoshi Nishikawa, Achim A Jungbluth, Nami Okazaki, Akiko Uenaka, Yurika Nakamura, Shinichi Fujiwara, Naoaki Mizuno, Takashi Saika, Erika Ritter, Makoto Yamasaki, Hiroshi Miyata, Gerd Ritter, Roger Murphy, Ralph Venhaus, Linda Pan, Lloyd J Old, Yuichiro Doki, Eiichi Nakayama: Heteroclitic serological response in esophageal and prostate cancer patients after NY-ESO-1 protein vaccination. Int J Cancer. 2012.02; 130 (3): 584-592. ( PubMed , DOI )

  1. Ishikawa Y, Kobayashi K, Yamamoto M, Nakata K, Takagawa T, Funada Y, Kotani Y, Karasuyama H, Yoshida M, Nishimura Y: Antigen-Specific IgG ameliorates allergic airway inflammation via Fcγ receptor IIB on dendritic cells. Respiratory research. 2011.04; 12 42. ( PubMed , DOI )

  1. Hara-Chikuma M., Chikuma S., Kabashima K., Nakahigashi K., Kamegawa A., Fujiyoshi Y., Verkman A. S., Sugiyama Y., Inoue S., Miyachi Y.: A controlled aquaporin-3 expression in T lymphocytes regulate their migration and trafficking in cutaneous immune reaction JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2010.04; 130 S116.

  1. Takai T, Karasuyama H: The study of allergy by Japanese researchers: a historical perspective. Int Immunol. 2009.12; 21 (12): 1311-1316. ( PubMed , DOI )

  2. Ugajin T, Kojima T, Mukai K, Obata K, Kawano Y, Minegishi Y, Eishi Y, Yokozeki H, Karasuyama H: Basophils preferentially express mouse mast cell protease 11 among the mast cell tryptase family in contrast to mast cells. J Leukoc Biol. 2009.08; ( PubMed , DOI )

  3. Minegishi Y, Saito M, Nagasawa M, Takada H, Hara T, Tsuchiya S, Agematsu K, Yamada M, Kawamura N, Ariga T, Tsuge I, Karasuyama H: Molecular explanation for the contradiction between systemic Th17 defect and localized bacterial infection in hyper-IgE syndrome. J Exp Med. 2009.06; 206 (6): 1291-1301. ( PubMed , DOI )

  4. Karasuyama H: [An exciting new era of basophil research: newly discovered roles for basophils in acute and chronic allergic reactions] Arerugi. 2009.06; 58 (6): 635-637. ( PubMed )

  5. Mukai K, Obata K, Tsujimura Y, Karasuyama H: New insights into the roles for basophils in acute and chronic allergy. Allergol Int. 2009.03; 58 (1): 11-19. ( PubMed , DOI )

  6. Belkina NV, Liu Y, Hao JJ, Karasuyama H, Shaw S: LOK is a major ERM kinase in resting lymphocytes and regulates cytoskeletal rearrangement through ERM phosphorylation. Proc Natl Acad Sci U S A. 2009.03; 106 (12): 4707-4712. ( PubMed , DOI )

  7. Minegishi Y, Karasuyama H: Defects in Jak-STAT-mediated cytokine signals cause hyper-IgE syndrome: lessons from a primary immunodeficiency. Int Immunol. 2009.02; 21 (2): 105-112. ( PubMed , DOI )

  8. Hida S, Yamasaki S, Sakamoto Y, Takamoto M, Obata K, Takai T, Karasuyama H, Sugane K, Saito T, Taki S: Fc receptor gamma-chain, a constitutive component of the IL-3 receptor, is required for IL-3-induced IL-4 production in basophils. Nat Immunol. 2009.02; 10 (2): 214-222. ( PubMed , DOI )

  9. Khodoun M, Strait R, Orekov T, Hogan S, Karasuyama H, Herbert DR, Kohl J, Finkelman FD: Peanuts can contribute to anaphylactic shock by activating complement. J Allergy Clin Immunol. 2009.02; 123 (2): 342-351. ( PubMed , DOI )

  10. Karasuyama H, Mukai K, Tsujimura Y, Obata K: Newly discovered roles for basophils: a neglected minority gains new respect. Nat Rev Immunol. 2009.01; 9 (1): 9-13. ( PubMed , DOI )

  11. Yoshikawa S, Kawano Y, Minegishi Y, Karasuyama H: The skewed heavy-chain repertoire in peritoneal B-1 cells is predetermined by the selection via pre-B cell receptor during B cell ontogeny in the fetal liver. Int Immunol. 2009.01; 21 (1): 43-52. ( PubMed , DOI )

  1. Takada T, Shitara H, Matsuoka K, Kojima E, Ishii R, Kikkawa Y, Taya C, Karasuyama H, Kohno K, Yonekawa H: A novel hairless mouse model on an atopic dermatitis-prone genetic background generated by receptor-mediated transgenesis. Transgenic Res. 2008.12; 17 (6): 1155-1162. ( PubMed , DOI )

  2. Watanabe M, Satoh T, Yamamoto Y, Kanai Y, Karasuyama H, Yokozeki H: Overproduction of IgE induces macrophage-derived chemokine (CCL22) secretion from basophils. J Immunol. 2008.10; 181 (8): 5653-5659. ( PubMed )

  3. Minegishi Y, Karasuyama H: Genetic origins of hyper-IgE syndrome. Curr Allergy Asthma Rep. 2008.09; 8 (5): 386-391. ( PubMed )

  4. Tsujimura Y, Obata K, Mukai K, Shindou H, Yoshida M, Nishikado H, Kawano Y, Minegishi Y, Shimizu T, Karasuyama H: Basophils play a pivotal role in immunoglobulin-G-mediated but not immunoglobulin-E-mediated systemic anaphylaxis. Immunity. 2008.04; 28 (4): 581-589. ( PubMed , DOI )

  5. Yasuda T, Sanjo H, Pages G, Kawano Y, Karasuyama H, Pouyssegur J, Ogata M, Kurosaki T: Erk kinases link pre-B cell receptor signaling to transcriptional events required for early B cell expansion. Immunity. 2008.04; 28 (4): 499-508. ( PubMed , DOI )

  1. Minegishi Y, Karasuyama H: Hyperimmunoglobulin E syndrome and tyrosine kinase 2 deficiency. Curr Opin Allergy Clin Immunol. 2007.12; 7 (6): 506-509. ( PubMed , DOI )

  2. Kojima T, Obata K, Mukai K, Sato S, Takai T, Minegishi Y, Karasuyama H: Mast cells and basophils are selectively activated in vitro and in vivo through CD200R3 in an IgE-independent manner. J Immunol. 2007.11; 179 (10): 7093-7100. ( PubMed )

  3. Obata K, Mukai K, Tsujimura Y, Ishiwata K, Kawano Y, Minegishi Y, Watanabe N, Karasuyama H: Basophils are essential initiators of a novel type of chronic allergic inflammation. Blood. 2007.08; 110 (3): 913-920. ( PubMed , DOI )

  4. Minegishi Y, Saito M, Tsuchiya S, Tsuge I, Takada H, Hara T, Kawamura N, Ariga T, Pasic S, Stojkovic O, Metin A, Karasuyama H: Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome. Nature. 2007.08; 448 (7157): 1058-1062. ( PubMed , DOI )

  5. Yakata Kaya, Hiroaki Yoko, Ishibashi Kenichi, Sohara Eisei, Sasaki Sei, Mitsuoka Kaoru, Fujiyoshi Yoshinori: Aquaporin-11 containing a divergent NPA motif has normal water channel activity. Biochim Biophys Acta. 2007.03; 1768 (3): 688-693. ( PubMed , DOI )

  1. Ochiai K, Katoh Y, Ikura T, Hoshikawa Y, Noda T, Karasuyama H, Tashiro S, Muto A, Igarashi K: Plasmacytic transcription factor Blimp-1 is repressed by Bach2 in B cells. J Biol Chem. 2006.12; 281 (50): 38226-38234. ( PubMed , DOI )

  2. Minegishi Y, Saito M, Morio T, Watanabe K, Agematsu K, Tsuchiya S, Takada H, Hara T, Kawamura N, Ariga T, Kaneko H, Kondo N, Tsuge I, Yachie A, Sakiyama Y, Iwata T, Bessho F, Ohishi T, Joh K, Imai K, Kogawa K, Shinohara M, Fujieda M, Wakiguchi H, Pasic S, Abinun M, Ochs HD, Renner ED, Jansson A, Belohradsky BH, Metin A, Shimizu N, Mizutani S, Miyawaki T, Nonoyama S, Karasuyama H: Human tyrosine kinase 2 deficiency reveals its requisite roles in multiple cytokine signals involved in innate and acquired immunity. Immunity. 2006.11; 25 (5): 745-755. ( PubMed , DOI )

  3. Yamamoto M, Hayashi K, Nojima T, Matsuzaki Y, Kawano Y, Karasuyama H, Goitsuka R, Kitamura D: BASH-novel PKC-Raf-1 pathway of pre-BCR signaling induces kappa gene rearrangement. Blood. 2006.10; 108 (8): 2703-2711. ( PubMed , DOI )

  4. Kawano Y, Yoshikawa S, Minegishi Y, Karasuyama H: Pre-B cell receptor assesses the quality of IgH chains and tunes the pre-B cell repertoire by delivering differential signals. J Immunol. 2006.08; 177 (4): 2242-2249. ( PubMed )

  5. Kubota T, Mukai K, Minegishi Y, Karasuyama H: Different stabilities of the structurally related receptors for IgE and IgG on the cell surface are determined by length of the stalk region in their alpha-chains. J Immunol. 2006.06; 176 (11): 7008-7014. ( PubMed )

  1. Mukai K, Matsuoka K, Taya C, Suzuki H, Yokozeki H, Nishioka K, Hirokawa K, Etori M, Yamashita M, Kubota T, Minegishi Y, Yonekawa H, Karasuyama H: Basophils play a critical role in the development of IgE-mediated chronic allergic inflammation independently of T cells and mast cells. Immunity. 2005.08; 23 (2): 191-202. ( PubMed , DOI )

  2. Kawano Y, Yoshikawa S, Minegishi Y, Karasuyama H: Selection of stereotyped VH81X-{micro}H chains via pre-B cell receptor early in ontogeny and their conservation in adults by marginal zone B cells. Int Immunol. 2005.07; 17 (7): 857-867. ( PubMed , DOI )

  3. Jimi E, Phillips RJ, Rincon M, Voll R, Karasuyama H, Flavell R, Ghosh S: Activation of NF-kappaB promotes the transition of large, CD43+ pre-B cells to small, CD43- pre-B cells. Int Immunol. 2005.06; 17 (6): 815-825. ( PubMed , DOI )

  4. Omata N, Ohshima Y, Yasutomi M, Yamada A, Karasuyama H, Mayumi M: Ovalbumin-specific IgE modulates ovalbumin-specific T-cell response after repetitive oral antigen administration. J Allergy Clin Immunol. 2005.04; 115 (4): 822-827. ( PubMed , DOI )

  5. Toyama-Sorimachi N, Omatsu Y, Onoda A, Tsujimura Y, Iyoda T, Kikuchi-Maki A, Sorimachi H, Dohi T, Taki S, Inaba K, Karasuyama H: Inhibitory NK receptor Ly49Q is expressed on subsets of dendritic cells in a cellular maturation- and cytokine stimulation-dependent manner. J Immunol. 2005.04; 174 (8): 4621-4629. ( PubMed )

  6. Shinohara H, Inoue A, Toyama-Sorimachi N, Nagai Y, Yasuda T, Suzuki H, Horai R, Iwakura Y, Yamamoto T, Karasuyama H, Miyake K, Yamanashi Y: Dok-1 and Dok-2 are negative regulators of lipopolysaccharide-induced signaling. J Exp Med. 2005.02; 201 (3): 333-339. ( PubMed , DOI )

  1. Taguchi T, Kiyokawa N, Takenouch H, Matsui J, Tang WR, Nakajima H, Suzuki K, Shiozawa Y, Saito M, Katagiri YU, Takahashi T, Karasuyama H, Matsuo Y, Okita H, Fujimoto J: Deficiency of BLNK hampers PLC-gamma2 phosphorylation and Ca2+ influx induced by the pre-B-cell receptor in human pre-B cells. Immunology. 2004.08; 112 (4): 575-582. ( PubMed , DOI )

  2. Kiyokawa N, Sekino T, Matsui T, Takenouchi H, Mimori K, Tang WR, Matsui J, Taguchi T, Katagiri YU, Okita H, Matsuo Y, Karasuyama H, Fujimoto J: Diagnostic importance of CD179a/b as markers of precursor B-cell lymphoblastic lymphoma. Mod Pathol. 2004.04; 17 (4): 423-429. ( PubMed , DOI )

  3. Maezawa Y, Nakajima H, Seto Y, Suto A, Kumano K, Kubo S, Karasuyama H, Saito Y, Iwamoto I: IgE-dependent enhancement of Th2 cell-mediated allergic inflammation in the airways. Clin Exp Immunol. 2004.01; 135 (1): 12-18. ( PubMed )

  4. Toyama-Sorimachi N, Tsujimura Y, Maruya M, Onoda A, Kubota T, Koyasu S, Inaba K, Karasuyama H: Ly49Q, a member of the Ly49 family that is selectively expressed on myeloid lineage cells and involved in regulation of cytoskeletal architecture. Proc Natl Acad Sci U S A. 2004.01; 101 (4): 1016-1021. ( PubMed , DOI )

  1. Minami J, Eishi Y, Ishige Y, Kobayashi I, Ishige I, Kobayashi D, Ando N, Uchida K, Ikeda S, Sorimachi N, Karasuyama H, Takemura T, Takizawa T, Koike M: Pulmonary granulomas caused experimentally in mice by a recombinant trigger-factor protein of Propionibacterium acnes. J Med Dent Sci. 2003.12; 50 (4): 265-274. ( PubMed )

  2. Kawashima I, Yoshida Y, Taya C, Shitara H, Yonekawa H, Karasuyama H, Tada N, Furukawa K, Tai T: Expansion of natural killer cells in mice transgenic for IgM antibody to ganglioside GD2: demonstration of prolonged survival after challenge with syngeneic tumor cells. Int J Oncol. 2003.08; 23 (2): 381-388. ( PubMed )

  3. Terauchi M, Koi H, Hayano C, Toyama-Sorimachi N, Karasuyama H, Yamanashi Y, Aso T, Shirakata M: Placental extravillous cytotrophoblasts persistently express class I major histocompatibility complex molecules after human cytomegalovirus infection. J Virol. 2003.08; 77 (15): 8187-8195. ( PubMed )

  4. Maezawa Y, Nakajima H, Kumano K, Kubo S, Karasuyama H, Iwamoto I: Role of IgE in Th2 cell-mediated allergic airway inflammation. Int Arch Allergy Immunol. 2003.06; 131 Suppl 1 2-6. ( PubMed , DOI )

  5. Saijo K, Schmedt C, Su IH, Karasuyama H, Lowell CA, Reth M, Adachi T, Patke A, Santana A, Tarakhovsky A: Essential role of Src-family protein tyrosine kinases in NF-kappaB activation during B cell development. Nat Immunol. 2003.03; 4 (3): 274-279. ( PubMed , DOI )

  6. Tsuchiya K, Kawano Y, Kojima T, Nagata K, Takao T, Okada M, Shinohara H, Maki K, Toyama-Sorimachi N, Miyasaka N, Watanabe M, Karasuyama H: Molecular cloning and characterization of TPP36 and its isoform TPP32, novel substrates of Abl tyrosine kinase. FEBS Lett. 2003.02; 537 (1-3): 203-209. ( PubMed )

  7. Sato E, Hirahara K, Wada Y, Yoshitomi T, Azuma T, Matsuoka K, Kubo S, Taya C, Yonekawa H, Karasuyama H, Shiraishi A: Chronic inflammation of the skin can be induced in IgE transgenic mice by means of a single challenge of multivalent antigen. J Allergy Clin Immunol. 2003.01; 111 (1): 143-148. ( PubMed )

  8. Kubo S, Nakayama T, Matsuoka K, Yonekawa H, Karasuyama H: Long term maintenance of IgE-mediated memory in mast cells in the absence of detectable serum IgE. J Immunol. 2003.01; 170 (2): 775-780. ( PubMed )

  9. Taguchi T, Kiyokawa N, Mimori K, Suzuki T, Sekino T, Nakajima H, Saito M, Katagiri YU, Matsuo N, Matsuo Y, Karasuyama H, Fujimoto J: Pre-B cell antigen receptor-mediated signal inhibits CD24-induced apoptosis in human pre-B cells. J Immunol. 2003.01; 170 (1): 252-260. ( PubMed )

  1. Wang YH, Stephan RP, Scheffold A, Kunkel D, Karasuyama H, Radbruch A, Cooper MD: Differential surrogate light chain expression governs B-cell differentiation. Blood. 2002.04; 99 (7): 2459-2467. ( PubMed )

  1. Stephan RP, Elgavish E, Karasuyama H, Kubagawa H, Cooper MD: Analysis of VpreB expression during B lineage differentiation in lambda5-deficient mice. J Immunol. 2001.10; 167 (7): 3734-3739. ( PubMed )

  2. Kinoshita T, Nagata K, Sorimachi N, Karasuyama H, Sekiguchi T, Miyajima A: Oncostatin M suppresses generation of lymphoid progenitors in fetal liver by inhibiting the hepatic microenvironment. Exp Hematol. 2001.09; 29 (9): 1091-1097. ( PubMed )

  3. Kubo S, Matsuoka K, Taya C, Kitamura F, Takai T, Yonekawa H, Karasuyama H: Drastic up-regulation of Fcepsilonri on mast cells is induced by IgE binding through stabilization and accumulation of Fcepsilonri on the cell surface. J Immunol. 2001.09; 167 (6): 3427-3434. ( PubMed )

  4. Agematsu K, Nagumo H, Hokibara S, Mori T, Wada T, Yachie A, Kanegane H, Miyawaki T, Sugita K, Karasuyama H, Komiyama A: Complete arrest from pro- to pre-B cells in a case of B cell-negative severe combined immunodeficiency (SCID) without recombinase activating gene (RAG) mutations. Clin Exp Immunol. 2001.06; 124 (3): 461-464. ( PubMed )

  5. Kouro T, Nagata K, Takaki S, Nisitani S, Hirano M, Wahl MI, Witte ON, Karasuyama H, Takatsu K: Bruton's tyrosine kinase is required for signaling the CD79b-mediated pro-B to pre-B cell transition. Int Immunol. 2001.04; 13 (4): 485-493. ( PubMed )

  6. Toyama-Sorimachi N, Taguchi Y, Yagita H, Kitamura F, Kawasaki A, Koyasu S, Karasuyama H: Mouse CD94 participates in Qa-1-mediated self recognition by NK cells and delivers inhibitory signals independent of Ly-49. J Immunol. 2001.03; 166 (6): 3771-3779. ( PubMed )

  7. Kohara Y, Tanabe K, Matsuoka K, Kanda N, Matsuda H, Karasuyama H, Yonekawa H: A major determinant quantitative-trait locus responsible for atopic dermatitis-like skin lesions in NC/Nga mice is located on Chromosome 9. Immunogenetics. 2001.02; 53 (1): 15-21. ( PubMed )

  8. Shuichi Kubo, Kunie Matsuoka, Choji Taya, Fujiko Kitmura, Hiromichi Yonekawa, Hajime Karasuyama: IgE stabilizes its high affinity receptor (FcεRI) on mast cells in vitro and ex vivo Activating and inhibitory immunoglobulin-like receptors. 2001; 183-188.

  1. Ohnishi K, Shimizu T, Karasuyama H, Melchers F: The identification of a nonclassical cadherin expressed during B cell development and its interaction with surrogate light chain. J Biol Chem. 2000.10; 275 (40): 31134-31144. ( PubMed , DOI )

  2. Nomura K, Kanegane H, Karasuyama H, Tsukada S, Agematsu K, Murakami G, Sakazume S, Sako M, Tanaka R, Kuniya Y, Komeno T, Ishihara S, Hayashi K, Kishimoto T, Miyawaki T: Genetic defect in human X-linked agammaglobulinemia impedes a maturational evolution of pro-B cells into a later stage of pre-B cells in the B-cell differentiation pathway. Blood. 2000.07; 96 (2): 610-617. ( PubMed )

  3. Nagaoka H, Takahashi Y, Hayashi R, Nakamura T, Ishii K, Matsuda J, Ogura A, Shirakata Y, Karasuyama H, Sudo T, Nishikawa S, Tsubata T, Mizuochi T, Asano T, Sakano H, Takemori T: Ras mediates effector pathways responsible for pre-B cell survival, which is essential for the developmental progression to the late pre-B cell stage. J Exp Med. 2000.07; 192 (2): 171-182. ( PubMed )

  4. Ellinger-Ziegelbauer H, Karasuyama H, Yamada E, Tsujikawa K, Todokoro K, Nishida E: Ste20-like kinase (SLK), a regulatory kinase for polo-like kinase (Plk) during the G2/M transition in somatic cells. Genes Cells. 2000.06; 5 (6): 491-498. ( PubMed )

  5. Donohoe ME, Beck-Engeser GB, Lonberg N, Karasuyama H, Riley RL, Jack HM, Blomberg BB: Transgenic human lambda 5 rescues the murine lambda 5 nullizygous phenotype. J Immunol. 2000.05; 164 (10): 5269-5276. ( PubMed )

  6. Tagawa K, Taya C, Hayashi Y, Nakagawa M, Ono Y, Fukuda R, Karasuyama H, Toyama-Sorimachi N, Katsui Y, Hata S, Ishiura S, Nonaka I, Seyama Y, Arahata K, Yonekawa H, Sorimachi H, Suzuki K: Myopathy phenotype of transgenic mice expressing active site-mutated inactive p94 skeletal muscle-specific calpain, the gene product responsible for limb girdle muscular dystrophy type 2A. Hum Mol Genet. 2000.05; 9 (9): 1393-1402. ( PubMed )

  7. Maki K, Nagata K, Kitamura F, Takemori T, Karasuyama H: Immunoglobulin beta signaling regulates locus accessibility for ordered immunoglobulin gene rearrangements. J Exp Med. 2000.04; 191 (8): 1333-1340. ( PubMed )

  8. Endo J, Toyama-Sorimachi N, Taya C, Kuramochi-Miyagawa S, Nagata K, Kuida K, Takashi T, Yonekawa H, Yoshizawa Y, Miyasaka N, Karasuyama H: Deficiency of a STE20/PAK family kinase LOK leads to the acceleration of LFA-1 clustering and cell adhesion of activated lymphocytes. FEBS Lett. 2000.02; 468 (2-3): 234-238. ( PubMed )

  1. Bosma GC, Chang Y, Karasuyama H, Bosma MJ: Differential effect of an Ig mu transgene on development of pre-B cells in fetal and adult SCID mice. Proc Natl Acad Sci U S A. 1999.10; 96 (21): 11952-11957. ( PubMed )

  2. Miyazaki T, Kato I, Takeshita S, Karasuyama H, Kudo A: Lambda5 is required for rearrangement of the Ig kappa light chain gene in pro-B cell lines. Int Immunol. 1999.08; 11 (8): 1195-1202. ( PubMed )

  3. Matsuoka K, Taya C, Kubo S, Toyama-Sorimachi N, Kitamura F, Ra C, Yonekawa H, Karasuyama H: Establishment of antigen-specific IgE transgenic mice to study pathological and immunobiological roles of IgE in vivo. Int Immunol. 1999.06; 11 (6): 987-994. ( PubMed )

  4. Kuramochi S, Matsuda Y, Okamoto M, Kitamura F, Yonekawa H, Karasuyama H: Molecular cloning of the human gene STK10 encoding lymphocyte-oriented kinase, and comparative chromosomal mapping of the human, mouse, and rat homologues. Immunogenetics. 1999.05; 49 (5): 369-375. ( PubMed )

  1. Tsuganezawa K, Kiyokawa N, Matsuo Y, Kitamura F, Toyama-Sorimachi N, Kuida K, Fujimoto J, Karasuyama H: Flow cytometric diagnosis of the cell lineage and developmental stage of acute lymphoblastic leukemia by novel monoclonal antibodies specific to human pre-B-cell receptor. Blood. 1998.12; 92 (11): 4317-4324. ( PubMed )

  2. Muto A, Hoshino H, Madisen L, Yanai N, Obinata M, Karasuyama H, Hayashi N, Nakauchi H, Yamamoto M, Groudine M, Igarashi K: Identification of Bach2 as a B-cell-specific partner for small maf proteins that negatively regulate the immunoglobulin heavy chain gene 3' enhancer. EMBO J. 1998.10; 17 (19): 5734-5743. ( PubMed , DOI )

  3. Meffre E, Papavasiliou F, Cohen P, de Bouteiller O, Bell D, Karasuyama H, Schiff C, Banchereau J, Liu YJ, Nussenzweig MC: Antigen receptor engagement turns off the V(D)J recombination machinery in human tonsil B cells. J Exp Med. 1998.08; 188 (4): 765-772. ( PubMed )

  4. Kuida K, Haydar TF, Kuan CY, Gu Y, Taya C, Karasuyama H, Su MS, Rakic P, Flavell RA: Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9. Cell. 1998.08; 94 (3): 325-337. ( PubMed )

  1. Koyama M, Ishihara K, Karasuyama H, Cordell JL, Iwamoto A, Nakamura T: CD79 alpha/CD79 beta heterodimers are expressed on pro-B cell surfaces without associated mu heavy chain. Int Immunol. 1997.11; 9 (11): 1767-1772. ( PubMed )

  2. Nagata K, Nakamura T, Kitamura F, Kuramochi S, Taki S, Campbell KS, Karasuyama H: The Ig alpha/Igbeta heterodimer on mu-negative proB cells is competent for transducing signals to induce early B cell differentiation. Immunity. 1997.10; 7 (4): 559-570. ( PubMed )

  3. Kuramochi S, Moriguchi T, Kuida K, Endo J, Semba K, Nishida E, Karasuyama H: LOK is a novel mouse STE20-like protein kinase that is expressed predominantly in lymphocytes. J Biol Chem. 1997.09; 272 (36): 22679-22684. ( PubMed )

  4. Emoto K, Toyama-Sorimachi N, Karasuyama H, Inoue K, Umeda M: Exposure of phosphatidylethanolamine on the surface of apoptotic cells. Exp Cell Res. 1997.05; 232 (2): 430-434. ( PubMed , DOI )

  5. Karasuyama H, Nakamura T, Nagata K, Kuramochi T, Kitamura F, Kuida K: The roles of preB cell receptor in early B cell development and its signal transduction. Immunol Cell Biol. 1997.04; 75 (2): 209-216. ( PubMed , DOI )

  1. Kuida K, Zheng TS, Na S, Kuan C, Yang D, Karasuyama H, Rakic P, Flavell RA: Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice. Nature. 1996.11; 384 (6607): 368-372. ( PubMed , DOI )

  2. Maki K, Sunaga S, Komagata Y, Kodaira Y, Mabuchi A, Karasuyama H, Yokomuro K, Miyazaki JI, Ikuta K: Interleukin 7 receptor-deficient mice lack gammadelta T cells. Proc Natl Acad Sci U S A. 1996.07; 93 (14): 7172-7177. ( PubMed )

  3. Karasuyama H, Rolink A, Melchers F: Surrogate light chain in B cell development. Adv Immunol. 1996; 63 1-41. ( PubMed )

  1. Sawai H, Yamasaki N, Shigeta M, Komori S, Karasuyama H, Koyama K, Isojima S: Direct production of the Fab fragment derived from the sperm immobilizing antibody using polymerase chain reaction and cDNA expression vectors. Am J Reprod Immunol. 1995.07; 34 (1): 26-34. ( PubMed )

  2. Rolink A, Ghia P, Grawunder U, Haasner D, Karasuyama H, Kalberer C, Winkler T, Melchers F: In-vitro analyses of mechanisms of B-cell development. Semin Immunol. 1995.06; 7 (3): 155-167. ( PubMed )

  3. Melchers F, Rolink A, Grawunder U, Winkler TH, Karasuyama H, Ghia P, Andersson J: Positive and negative selection events during B lymphopoiesis. Curr Opin Immunol. 1995.04; 7 (2): 214-227. ( PubMed )

  4. Winkler TH, Rolink A, Melchers F, Karasuyama H: Precursor B cells of mouse bone marrow express two different complexes with the surrogate light chain on the surface. Eur J Immunol. 1995.02; 25 (2): 446-450. ( PubMed )

  1. Rolink A, Grawunder U, Winkler TH, Karasuyama H, Melchers F: IL-2 receptor alpha chain (CD25, TAC) expression defines a crucial stage in pre-B cell development. Int Immunol. 1994.08; 6 (8): 1257-1264. ( PubMed )

  2. Karasuyama H, Rolink A, Shinkai Y, Young F, Alt FW, Melchers F: The expression of Vpre-B/lambda 5 surrogate light chain in early bone marrow precursor B cells of normal and B cell-deficient mutant mice. Cell. 1994.04; 77 (1): 133-143. ( PubMed )

  3. Rolink A, Karasuyama H, Haasner D, Grawunder U, Martensson IL, Kudo A, Melchers F: Two pathways of B-lymphocyte development in mouse bone marrow and the roles of surrogate L chain in this development. Immunol Rev. 1994.02; 137 185-201. ( PubMed )

  4. Melchers F, Haasner D, Grawunder U, Kalberer C, Karasuyama H, Winkler T, Rolink AG: Roles of IgH and L chains and of surrogate H and L chains in the development of cells of the B lymphocyte lineage. Annu Rev Immunol. 1994; 12 209-225. ( PubMed , DOI )

  1. Karasuyama H, Rolink A, Melchers F: A complex of glycoproteins is associated with VpreB/lambda 5 surrogate light chain on the surface of mu heavy chain-negative early precursor B cell lines. J Exp Med. 1993.08; 178 (2): 469-478. ( PubMed )

  2. Rolink A, Karasuyama H, Grawunder U, Haasner D, Kudo A, Melchers F: B cell development in mice with a defective lambda 5 gene. Eur J Immunol. 1993.06; 23 (6): 1284-1288. ( PubMed )

  3. Sawai H, Yamasaki N, Komori S, Karasuyama H, Isojima S: Stable production of recombinant human sperm immobilizing antibody using cDNA expression vectors. Am J Reprod Immunol. 1993.03; 29 (2): 100-108. ( PubMed )

  4. Melchers F, Karasuyama H, Haasner D, Bauer S, Kudo A, Sakaguchi N, Jameson B, Rolink A: The surrogate light chain in B-cell development. Immunol Today. 1993.02; 14 (2): 60-68. ( PubMed )

  1. Uemura N, Ozawa K, Tojo A, Takahashi K, Okano A, Karasuyama H, Tani K, Asano S: Acquisition of interleukin-3 independence in FDC-P2 cells after transfection with the activated c-H-ras gene using a bovine papillomavirus-based plasmid vector. Blood. 1992.12; 80 (12): 3198-3204. ( PubMed )

  2. Melchers F, Haasner D, Karasuyama H, Reininger L, Rolink A: Progenitor and precursor B lymphocytes of mice. Proliferation and differentiation in vitro and population, differentiation and turnover in SCID mice in vivo of normal and abnormal cells. Curr Top Microbiol Immunol. 1992; 182 3-12. ( PubMed )

  1. Golumbek PT, Lazenby AJ, Levitsky HI, Jaffee LM, Karasuyama H, Baker M, Pardoll DM: Treatment of established renal cancer by tumor cells engineered to secrete interleukin-4. Science. 1991.11; 254 (5032): 713-716. ( PubMed )

  2. Yamamura Y, Kotani M, Chowdhury MI, Yamamoto N, Yamaguchi K, Karasuyama H, Katsura Y, Miyasaka M: Infection of human CD4+ rabbit cells with HIV-1: the possibility of the rabbit as a model for HIV-1 infection. Int Immunol. 1991.11; 3 (11): 1183-1187. ( PubMed )

  3. Tanaka T, Tsudo M, Karasuyama H, Kitamura F, Kono T, Hatakeyama M, Taniguchi T, Miyasaka M: A novel monoclonal antibody against murine IL-2 receptor beta-chain. Characterization of receptor expression in normal lymphoid cells and EL-4 cells. J Immunol. 1991.10; 147 (7): 2222-2228. ( PubMed )

  4. Rolink A, Kudo A, Karasuyama H, Kikuchi Y, Melchers F: Long-term proliferating early pre B cell lines and clones with the potential to develop to surface Ig-positive, mitogen reactive B cells in vitro and in vivo. EMBO J. 1991.02; 10 (2): 327-336. ( PubMed )

  5. Tanaka T, Tsudo M, Karasuyama H, Toyama N, Hatakeyama M, Taniguchi T, Miyasaka M: Signal transduction through the human IL-2 receptor beta-chain expressed in IL-6-dependent mouse B cell hybridoma. Int Immunol. 1991.01; 3 (1): 105-108. ( PubMed )

  6. Miyajima H, Hirano T, Hirose S, Karasuyama H, Okumura K, Ovary Z: Suppression by IL-2 of IgE production by B cells stimulated by IL-4. J Immunol. 1991.01; 146 (2): 457-462. ( PubMed )

  1. Yamamura Y, Kotani M, Tsudo M, Karasuyama H, Seto A, Miyasaka M: IL-2 receptors on rabbit T-cell lines and their transfectants expressing the human IL-2 receptor alpha chain. Immunology. 1990.12; 71 (4): 502-507. ( PubMed )

  2. Karasuyama H, Kudo A, Melchers F: The proteins encoded by the VpreB and lambda 5 pre-B cell-specific genes can associate with each other and with mu heavy chain. J Exp Med. 1990.09; 172 (3): 969-972. ( PubMed )

  3. Tsudo M, Karasuyama H, Kitamura F, Tanaka T, Kubo S, Yamamura Y, Tamatani T, Hatakeyama M, Taniguchi T, Miyasaka M: The IL-2 receptor beta-chain (p70). Ligand binding ability of the cDNA-encoding membrane and secreted forms. J Immunol. 1990.07; 145 (2): 599-606. ( PubMed )

  4. Tohyama N, Karasuyama H, Tada T: Growth autonomy and tumorigenicity of interleukin 6-dependent B cells transfected with interleukin 6 cDNA. J Exp Med. 1990.02; 171 (2): 389-400. ( PubMed )

  5. Fearon ER, Pardoll DM, Itaya T, Golumbek P, Levitsky HI, Simons JW, Karasuyama H, Vogelstein B, Frost P: Interleukin-2 production by tumor cells bypasses T helper function in the generation of an antitumor response. Cell. 1990.02; 60 (3): 397-403. ( PubMed )

  6. Sano K, Kishimoto H, Karasuyama H, Asano Y, Tada T: Cell division-associated expression of an epitope, KH17, on early developing thymocytes. Int Immunol. 1990; 2 (8): 725-733. ( PubMed )

  1. Tsudo M, Karasuyama H, Kitamura F, Nagasaka Y, Tanaka T, Miyasaka M: Reconstitution of a functional IL-2 receptor by the beta-chain cDNA. A newly acquired receptor transduces negative signal. J Immunol. 1989.12; 143 (12): 4039-4043. ( PubMed )

  2. Sato T, Kohno S, Kobayashi H, Yoshida K, Karasuyama H, Tabata T: [Prosthetic application of a new measuring instrument of the dynamic periodontal function] Nihon Hotetsu Shika Gakkai Zasshi. 1989.10; 33 (5): 1202-1211. ( PubMed )

  3. Tani K, Ozawa K, Ogura H, Takahashi T, Okano A, Watari K, Matsudaira T, Tajika K, Karasuyama H, Nagata S, et al.: Implantation of fibroblasts transfected with human granulocyte colony-stimulating factor cDNA into mice as a model of cytokine-supplement gene therapy. Blood. 1989.09; 74 (4): 1274-1280. ( PubMed )

  4. Tonouchi N, Miwa K, Karasuyama H, Matsui H: Deletion of 3' untranslated region of human BSF-2 mRNA causes stabilization of the mRNA and high-level expression in mouse NIH3T3 cells. Biochem Biophys Res Commun. 1989.09; 163 (2): 1056-1062. ( PubMed )

  5. Karasuyama H, Tohyama N, Tada T: Autocrine growth and tumorigenicity of interleukin 2-dependent helper T cells transfected with IL-2 gene. J Exp Med. 1989.01; 169 (1): 13-25. ( PubMed )

  6. Yagita H, Nakamura T, Karasuyama H, Okumura K: Monoclonal antibodies specific for murine CD2 reveal its presence on B as well as T cells. Proc Natl Acad Sci U S A. 1989.01; 86 (2): 645-649. ( PubMed )

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  1. Abe K, Irie K, Nakanishi H, Suzuki H, Fujiyoshi Y: Crystal structures of the gastric proton pump. Nature. 2018.04; 556 (7700): 214-218. ( PubMed , DOI )

  2. Nakamura S, Fujiyoshi Y, Irie K: Enhancement of the thermostability of mouse claudin-3 on complex formation with the carboxyl-terminal region of Clostridium perfringens enterotoxin improves crystal quality. Acta crystallographica. Section F, Structural biology communications. 2018.03; 74 (Pt 3): 150-155. ( PubMed , DOI )

  3. Irie K, Haga Y, Shimomura T, Fujiyoshi Y: Optimized expression and purification of NavAb provide the structural insight into the voltage dependence. FEBS letters. 2018.01; 592 (2): 274-283. ( PubMed , DOI )

  1. Shihoya W, Nishizawa T, Yamashita K, Inoue A, Hirata K, Kadji FMN, Okuta A, Tani K, Aoki J, Fujiyoshi Y, Doi T, Nureki O: X-ray structures of endothelin ETB receptor bound to clinical antagonist bosentan and its analog. Nature structural & molecular biology. 2017.09; 24 (9): 758-764. ( PubMed , DOI )

  2. Abe K, Shimokawa J, Naito M, Munson K, Vagin O, Sachs G, Suzuki H, Tani K, Fujiyoshi Y: The cryo-EM structure of gastric H+,K+-ATPase with bound BYK99, a high-affinity member of K+-competitive, imidazo[1,2-a]pyridine inhibitors. Scientific reports. 2017.07; 7 (1): 6632. ( PubMed , DOI )

  3. Suzuki H, Tani K, Fujiyoshi Y: Crystal structures of claudins: insights into their intermolecular interactions. Annals of the New York Academy of Sciences. 2017.06; 1397 (1): 25-34. ( PubMed , DOI )

  1. Oshima A, Tani K, Fujiyoshi Y: Atomic structure of the innexin-6 gap junction channel determined by cryo-EM. Nature communications. 2016.12; 7 13681. ( PubMed , DOI )

  2. Shihoya W, Nishizawa T, Okuta A, Tani K, Dohmae N, Fujiyoshi Y, Nureki O, Doi T: Activation mechanism of endothelin ETB receptor by endothelin-1. Nature. 2016.09; 537 (7620): 363-368. ( PubMed , DOI )

  3. Shimomura T, Irie K, Fujiyoshi Y: Molecular determinants of prokaryotic voltage-gated sodium channels for recognition of local anesthetics. The FEBS journal. 2016.08; 283 (15): 2881-2895. ( PubMed , DOI )

  4. Abe K, Fujiyoshi Y: Cryo-electron microscopy for structure analyses of membrane proteins in the lipid bilayer. Current opinion in structural biology. 2016.08; 39 71-78. ( PubMed , DOI )

  5. Okuta A, Tani K, Nishimura S, Fujiyoshi Y, Doi T: Thermostabilization of the Human Endothelin Type B Receptor. Journal of molecular biology. 2016.06; 428 (11): 2265-2274. ( PubMed , DOI )

  6. Kamegawa A, Hiroaki Y, Tani K, Fujiyoshi Y: Two-dimensional crystal structure of aquaporin-4 bound to the inhibitor acetazolamide. Microscopy (Oxford, England). 2016.04; 65 (2): 177-184. ( PubMed , DOI )

  7. Nagura H, Doi T, Fujiyoshi Y: Characterization of physiological phenotypes of dentate gyrus synapses of PDZ1/2 domain-deficient PSD-95-knockin mice. The European journal of neuroscience. 2016.03; 43 (5): 618-625. ( PubMed , DOI )

  8. Oshima A, Matsuzawa T, Murata K, Tani K, Fujiyoshi Y: Hexadecameric structure of an invertebrate gap junction channel. Journal of molecular biology. 2016.03; 428 (6): 1227-1236. ( PubMed , DOI )

  9. Tanaka H, Yamamoto Y, Kashihara H, Yamazaki Y, Tani K, Fujiyoshi Y, Mineta K, Takeuchi K, Tamura A, Tsukita S: Claudin-21 Has a Paracellular Channel Role at Tight Junctions. Molecular and cellular biology. 2016.01; 36 (6): 954-964. ( PubMed , DOI )

  10. Bando Y, Irie K, Shimomura T, Umeshima H, Kushida Y, Kengaku M, Fujiyoshi Y, Hirano T, Tagawa Y: Control of Spontaneous Ca2+ Transients Is Critical for Neuronal Maturation in the Developing Neocortex. Cerebral cortex (New York, N.Y. : 1991). 2016.01; 26 (1): 106-117. ( PubMed , DOI )

  1. Hauer F, Gerle C, Fischer N, Oshima A, Shinzawa-Itoh K, Shimada S, Yokoyama K, Fujiyoshi Y, Stark H: GraDeR: Membrane Protein Complex Preparation for Single-Particle Cryo-EM. Structure (London, England : 1993). 2015.09; 23 (9): 1769-1775. ( PubMed , DOI )

  2. Minatohara K, Murata Y, Fujiyoshi Y, Doi T: An intracellular domain with a novel sequence regulates cell surface expression and synaptic clustering of leucine-rich repeat transmembrane proteins in hippocampal neurons. Journal of neurochemistry. 2015.08; 134 (4): 618-628. ( PubMed , DOI )

  3. Jiko C, Davies KM, Shinzawa-Itoh K, Tani K, Maeda S, Mills DJ, Tsukihara T, Fujiyoshi Y, Kühlbrandt W, Gerle C: Bovine F1Fo ATP synthase monomers bend the lipid bilayer in 2D membrane crystals. eLife. 2015.03; 4 e06119. ( PubMed , DOI )

  4. Saitoh Y, Suzuki H, Tani K, Nishikawa K, Irie K, Ogura Y, Tamura A, Tsukita S, Fujiyoshi Y: Tight junctions. Structural insight into tight junction disassembly by Clostridium perfringens enterotoxin. Science (New York, N.Y.). 2015.02; 347 (6223): 775-778. ( PubMed , DOI )

  5. Suzuki H, Tani K, Tamura A, Tsukita S, Fujiyoshi Y: Model for the architecture of claudin-based paracellular ion channels through tight junctions. Journal of molecular biology. 2015.01; 427 (2): 291-297. ( PubMed , DOI )

  6. Fujiyoshi Y: Development of the field of structural physiology. Proceedings of the Japan Academy. Series B, Physical and biological sciences. 2015; 91 (9): 447-468. ( PubMed , DOI )

  1. Abe K, Tani K, Fujiyoshi Y: Systematic comparison of molecular conformations of H+,K+-ATPase reveals an important contribution of the A-M2 linker for the luminal gating. The Journal of biological chemistry. 2014.10; 289 (44): 30590-30601. ( PubMed , DOI )

  2. Tani K, Fujiyoshi Y: Water channel structures analysed by electron crystallography. Biochimica et biophysica acta. 2014.05; 1840 (5): 1605-1613. ( PubMed , DOI )

  3. Suzuki H, Nishizawa T, Tani K, Yamazaki Y, Tamura A, Ishitani R, Dohmae N, Tsukita S, Nureki O, Fujiyoshi Y: Crystal structure of a claudin provides insight into the architecture of tight junctions. Science (New York, N.Y.). 2014.04; 344 (6181): 304-307. ( PubMed , DOI )

  4. Morito D, Nishikawa K, Hoseki J, Kitamura A, Kotani Y, Kiso K, Kinjo M, Fujiyoshi Y, Nagata K: Moyamoya disease-associated protein mysterin/RNF213 is a novel AAA+ ATPase, which dynamically changes its oligomeric state. Scientific reports. 2014.03; 4 4442. ( PubMed , DOI )

  1. Yang F, Abe K, Tani K, Fujiyoshi Y: Carbon sandwich preparation preserves quality of two-dimensional crystals for cryo-electron microscopy. Microscopy (Oxford, England). 2013.12; 62 (6): 597-606. ( PubMed , DOI )

  2. Tsai CJ, Tani K, Irie K, Hiroaki Y, Shimomura T, McMillan DG, Cook GM, Schertler GF, Fujiyoshi Y, Li XD: Two alternative conformations of a voltage-gated sodium channel. Journal of molecular biology. 2013.11; 425 (22): 4074-4088. ( PubMed , DOI )

  3. Tani K, Arthur CP, Tamakoshi M, Yokoyama K, Mitsuoka K, Fujiyoshi Y, Gerle C: Visualization of two distinct states of disassembly in the bacterial V-ATPase from Thermus thermophilus. Microscopy (Oxford, England). 2013.08; 62 (4): 467-474. ( PubMed , DOI )

  4. Fujiyoshi Y, Tanji T, Osakabe N, Hirayama T: Special Issue: "Tribute to Akira Tonomura". Foreword. Microscopy (Oxford, England). 2013.06; 62 Suppl 1 S1. ( PubMed , DOI )

  5. Oshima A, Matsuzawa T, Nishikawa K, Fujiyoshi Y: Oligomeric structure and functional characterization of Caenorhabditis elegans Innexin-6 gap junction protein. The Journal of biological chemistry. 2013.04; 288 (15): 10513-10521. ( PubMed , DOI )

  6. Mori H, Fujiyoshi Y: Preface on the occasion of the inauguration issue of Microscopy. Microscopy (Oxford, England). 2013.02; 62 (1): 1-2. ( PubMed , DOI )

  7. Goda M, Fujiyoshi Y, Sugimoto M, Fujii R: Novel dichromatic chromatophores in the integument of the mandarin fish Synchiropus splendidus. The Biological bulletin. 2013.02; 224 (1): 14-17. ( PubMed , DOI )

  8. Minatohara K, Ichikawa SH, Seki T, Fujiyoshi Y, Doi T: Ligand binding of PDZ domains has various roles in the synaptic clustering of SAP102 and PSD-95. Neuroscience letters. 2013.01; 533 44-49. ( PubMed , DOI )

  9. Fujiyoshi Y: Low dose techniques and cryo-electron microscopy. Methods in molecular biology (Clifton, N.J.). 2013; 955 103-118. ( PubMed , DOI )

  10. Fujiyoshi Y: Future directions of electron crystallography. Methods in molecular biology (Clifton, N.J.). 2013; 955 551-568. ( PubMed , DOI )

  11. Suzuki H, Ito Y, Yamazaki Y, Mineta K, Uji M, Abe K, Tani K, Fujiyoshi Y, Tsukita S: The four-transmembrane protein IP39 of Euglena forms strands by a trimeric unit repeat. Nature communications. 2013; 4 1766. ( PubMed , DOI )

  1. Nagura H, Ishikawa Y, Kobayashi K, Takao K, Tanaka T, Nishikawa K, Tamura H, Shiosaka S, Suzuki H, Miyakawa T, Fujiyoshi Y, Doi T: Impaired synaptic clustering of postsynaptic density proteins and altered signal transmission in hippocampal neurons, and disrupted learning behavior in PDZ1 and PDZ2 ligand binding-deficient PSD-95 knockin mice. Molecular brain. 2012.12; 5 43. ( PubMed , DOI )

  2. Abe K, Tani K, Friedrich T, Fujiyoshi Y: Cryo-EM structure of gastric H+,K+-ATPase with a single occupied cation-binding site. Proceedings of the National Academy of Sciences of the United States of America. 2012.11; 109 (45): 18401-18406. ( PubMed , DOI )

  3. Unwin N, Fujiyoshi Y: Gating movement of acetylcholine receptor caught by plunge-freezing. Journal of molecular biology. 2012.10; 422 (5): 617-634. ( PubMed , DOI )

  4. Irie K, Shimomura T, Fujiyoshi Y: The C-terminal helical bundle of the tetrameric prokaryotic sodium channel accelerates the inactivation rate. Nature communications. 2012.04; 3 793. ( PubMed , DOI )

  1. Rico F, Oshima A, Hinterdorfer P, Fujiyoshi Y, Scheuring S: Two-dimensional kinetics of inter-connexin interactions from single-molecule force spectroscopy. Journal of molecular biology. 2011.09; 412 (1): 72-79. ( PubMed , DOI )

  2. Goda M, Ohata M, Ikoma H, Fujiyoshi Y, Sugimoto M, Fujii R: Integumental reddish-violet coloration owing to novel dichromatic chromatophores in the teleost fish, Pseudochromis diadema. Pigment cell & melanoma research. 2011.08; 24 (4): 614-617. ( PubMed , DOI )

  3. Ohta Y, Nishikawa K, Hiroaki Y, Fujiyoshi Y: Electron tomographic analysis of gap junctions in lateral giant fibers of crayfish. Journal of structural biology. 2011.07; 175 (1): 49-61. ( PubMed , DOI )

  4. Wakao S, Kitada M, Kuroda Y, Shigemoto T, Matsuse D, Akashi H, Tanimura Y, Tsuchiyama K, Kikuchi T, Goda M, Nakahata T, Fujiyoshi Y, Dezawa M: Multilineage-differentiating stress-enduring (Muse) cells are a primary source of induced pluripotent stem cells in human fibroblasts. Proceedings of the National Academy of Sciences of the United States of America. 2011.06; 108 (24): 9875-9880. ( PubMed , DOI )

  5. Yakata K, Tani K, Fujiyoshi Y: Water permeability and characterization of aquaporin-11. Journal of structural biology. 2011.05; 174 (2): 315-320. ( PubMed , DOI )

  6. Fujiyoshi Y: Structural physiology based on electron crystallography. Protein science : a publication of the Protein Society. 2011.05; 20 (5): 806-817. ( PubMed , DOI )

  7. Shimomura T, Irie K, Nagura H, Imai T, Fujiyoshi Y: Arrangement and mobility of the voltage sensor domain in prokaryotic voltage-gated sodium channels. The Journal of biological chemistry. 2011.03; 286 (9): 7409-7417. ( PubMed , DOI )

  8. Abe K, Tani K, Fujiyoshi Y: Conformational rearrangement of gastric H(+),K(+)-ATPase induced by an acid suppressant. Nature communications. 2011.01; 2 155. ( PubMed , DOI )

  9. Oshima A, Tani K, Toloue MM, Hiroaki Y, Smock A, Inukai S, Cone A, Nicholson BJ, Sosinsky GE, Fujiyoshi Y: Asymmetric configurations and N-terminal rearrangements in connexin26 gap junction channels. Journal of molecular biology. 2011.01; 405 (3): 724-735. ( PubMed , DOI )

  10. Fujiyoshi Y: Electron crystallography for structural and functional studies of membrane proteins. Journal of electron microscopy. 2011; 60 Suppl 1 S149-59. ( PubMed , DOI )

  1. Mitsuma T, Tani K, Hiroaki Y, Kamegawa A, Suzuki H, Hibino H, Kurachi Y, Fujiyoshi Y: Influence of the cytoplasmic domains of aquaporin-4 on water conduction and array formation. Journal of molecular biology. 2010.10; 402 (4): 669-681. ( PubMed , DOI )

  2. Matsuse D, Kitada M, Kohama M, Nishikawa K, Makinoshima H, Wakao S, Fujiyoshi Y, Heike T, Nakahata T, Akutsu H, Umezawa A, Harigae H, Kira J, Dezawa M: Human umbilical cord-derived mesenchymal stromal cells differentiate into functional Schwann cells that sustain peripheral nerve regeneration. Journal of neuropathology and experimental neurology. 2010.09; 69 (9): 973-985. ( PubMed , DOI )

  3. Nagura H, Irie K, Imai T, Shimomura T, Hige T, Fujiyoshi Y: Evidence for lateral mobility of voltage sensors in prokaryotic voltage-gated sodium channels. Biochemical and biophysical research communications. 2010.08; 399 (3): 341-346. ( PubMed , DOI )

  4. Kuroda Y, Kitada M, Wakao S, Nishikawa K, Tanimura Y, Makinoshima H, Goda M, Akashi H, Inutsuka A, Niwa A, Shigemoto T, Nabeshima Y, Nakahata T, Nabeshima Y, Fujiyoshi Y, Dezawa M: Unique multipotent cells in adult human mesenchymal cell populations. Proceedings of the National Academy of Sciences of the United States of America. 2010.05; 107 (19): 8639-8643. ( PubMed , DOI )

  5. Abe K, Tani K, Fujiyoshi Y: Structural and functional characterization of H+, K+-ATPase with bound fluorinated phosphate analogs. Journal of structural biology. 2010.04; 170 (1): 60-68. ( PubMed , DOI )

  6. Irie K, Kitagawa K, Nagura H, Imai T, Shimomura T, Fujiyoshi Y: Comparative study of the gating motif and C-type inactivation in prokaryotic voltage-gated sodium channels. The Journal of biological chemistry. 2010.02; 285 (6): 3685-3694. ( PubMed , DOI )

  7. Abe K, Tani K, Nishizawa T, Fujiyoshi Y: [Novel ratchet mechanism of gastric H(+), K(+)-ATPase revealed by electron crystallography of two-dimensional crystals]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 2010.02; 130 (2): 205-210. ( PubMed , DOI )

  8. Schenk AD, Hite RK, Engel A, Fujiyoshi Y, Walz T: Electron crystallography and aquaporins. Methods in enzymology. 2010; 483 91-119. ( PubMed , DOI )

  1. Inutsuka A, Goda M, Fujiyoshi Y: Calyculin A-induced neurite retraction is critically dependent on actomyosin activation but not on polymerization state of microtubules. Biochemical and biophysical research communications. 2009.12; 390 (4): 1160-1166. ( PubMed , DOI )

  2. Noma K, Kimura K, Minatohara K, Nakashima H, Nagao Y, Mizoguchi A, Fujiyoshi Y: Triple N-glycosylation in the long S5-P loop regulates the activation and trafficking of the Kv12.2 potassium channel. The Journal of biological chemistry. 2009.11; 284 (48): 33139-33150. ( PubMed , DOI )

  3. Kuwahara Y, Unzai S, Nagata T, Hiroaki Y, Yokoyama H, Matsui I, Ikegami T, Fujiyoshi Y, Hiroaki H: Unusual thermal disassembly of the SPFH domain oligomer from Pyrococcus horikoshii. Biophysical journal. 2009.10; 97 (7): 2034-2043. ( PubMed , DOI )

  4. Fujiyoshi Y: [Observation of molecular structure of membrane proteins]. Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme. 2009.08; 54 (10): 1300-1306. ( PubMed )

  5. Abe K, Tani K, Nishizawa T, Fujiyoshi Y: Inter-subunit interaction of gastric H+,K+-ATPase prevents reverse reaction of the transport cycle. The EMBO journal. 2009.06; 28 (11): 1637-1643. ( PubMed , DOI )

  6. Tani K, Mitsuma T, Hiroaki Y, Kamegawa A, Nishikawa K, Tanimura Y, Fujiyoshi Y: Mechanism of aquaporin-4's fast and highly selective water conduction and proton exclusion. Journal of molecular biology. 2009.06; 389 (4): 694-706. ( PubMed , DOI )

  7. Tanimura Y, Hiroaki Y, Fujiyoshi Y: Acetazolamide reversibly inhibits water conduction by aquaporin-4. Journal of structural biology. 2009.04; 166 (1): 16-21. ( PubMed , DOI )

  8. Maeda S, Nakagawa S, Suga M, Yamashita E, Oshima A, Fujiyoshi Y, Tsukihara T: Structure of the connexin 26 gap junction channel at 3.5 A resolution. Nature. 2009.04; 458 (7238): 597-602. ( PubMed , DOI )

  9. Mio K, Ogura T, Yamamoto T, Hiroaki Y, Fujiyoshi Y, Kubo Y, Sato C: Reconstruction of the P2X(2) receptor reveals a vase-shaped structure with lateral tunnels above the membrane. Structure (London, England : 1993). 2009.02; 17 (2): 266-275. ( PubMed , DOI )

  10. Walz T, Fujiyoshi Y, Engel A: The AQP structure and functional implications. Handbook of experimental pharmacology. 2009; (190): 31-56. ( PubMed , DOI )

  1. Tani K, Hiroaki Y, Fujiyoshi Y: [Aquaporin-4]. Rinsho shinkeigaku = Clinical neurology. 2008.11; 48 (11): 941-944. ( PubMed )

  2. Iwasaki K, Miyazaki N, Hammar L, Zhu Y, Omura T, Wu B, Sjöborg F, Yonekura K, Murata K, Namba K, Caspar DL, Fujiyoshi Y, Cheng RH: Pleomorphic configuration of the trimeric capsid proteins of Rice dwarf virus that allows formation of both the outer capsid and tubular crystals. Journal of molecular biology. 2008.10; 383 (1): 252-265. ( PubMed , DOI )

  3. Sakisaka T, Yamamoto Y, Mochida S, Nakamura M, Nishikawa K, Ishizaki H, Okamoto-Tanaka M, Miyoshi J, Fujiyoshi Y, Manabe T, Takai Y: Dual inhibition of SNARE complex formation by tomosyn ensures controlled neurotransmitter release. The Journal of cell biology. 2008.10; 183 (2): 323-337. ( PubMed , DOI )

  4. Fujiyoshi Y, Unwin N: Electron crystallography of proteins in membranes. Current opinion in structural biology. 2008.10; 18 (5): 587-592. ( PubMed , DOI )

  5. Hayakawa S, Mori M, Okuta A, Kamegawa A, Fujiyoshi Y, Yoshiyama Y, Mitsuoka K, Ishibashi K, Sasaki S, Hattori T, Kuwabara S: Neuromyelitis optica and anti-aquaporin-4 antibodies measured by an enzyme-linked immunosorbent assay. Journal of neuroimmunology. 2008.05; 196 (1-2): 181-187. ( PubMed , DOI )

  6. Oshima A, Tani K, Hiroaki Y, Fujiyoshi Y, Sosinsky GE: Projection structure of a N-terminal deletion mutant of connexin 26 channel with decreased central pore density. Cell communication & adhesion. 2008.05; 15 (1): 85-93. ( PubMed , DOI )

  7. Nishizawa T, Abe K, Tani K, Fujiyoshi Y: Structural analysis of 2D crystals of gastric H+,K+-ATPase in different states of the transport cycle. Journal of structural biology. 2008.05; 162 (2): 219-228. ( PubMed , DOI )

  8. Suzuki H, Kurooka M, Hiroaki Y, Fujiyoshi Y, Kaneda Y: Sendai virus F glycoprotein induces IL-6 production in dendritic cells in a fusion-independent manner. FEBS letters. 2008.04; 582 (9): 1325-1329. ( PubMed , DOI )

  9. Suzuki H, Nishikawa K, Hiroaki Y, Fujiyoshi Y: Formation of aquaporin-4 arrays is inhibited by palmitoylation of N-terminal cysteine residues. Biochimica et biophysica acta. 2008.04; 1778 (4): 1181-1189. ( PubMed , DOI )

  10. Engel A, Fujiyoshi Y, Gonen T, Walz T: Junction-forming aquaporins. Current opinion in structural biology. 2008.04; 18 (2): 229-235. ( PubMed , DOI )

  1. Toei M, Gerle C, Nakano M, Tani K, Gyobu N, Tamakoshi M, Sone N, Yoshida M, Fujiyoshi Y, Mitsuoka K, Yokoyama K: Dodecamer rotor ring defines H+/ATP ratio for ATP synthesis of prokaryotic V-ATPase from Thermus thermophilus. Proceedings of the National Academy of Sciences of the United States of America. 2007.12; 104 (51): 20256-20261. ( PubMed , DOI )

  2. Hirai T, Mitsuoka K, Kidera A, Fujiyoshi Y: Simulation of charge effects on density maps obtained by high-resolution electron crystallography. Journal of electron microscopy. 2007.08; 56 (4): 131-140. ( PubMed , DOI )

  3. Oshima A, Tani K, Hiroaki Y, Fujiyoshi Y, Sosinsky GE: Three-dimensional structure of a human connexin26 gap junction channel reveals a plug in the vestibule. Proceedings of the National Academy of Sciences of the United States of America. 2007.06; 104 (24): 10034-10039. ( PubMed , DOI )

  4. Mio K, Ogura T, Kiyonaka S, Hiroaki Y, Tanimura Y, Fujiyoshi Y, Mori Y, Sato C: The TRPC3 channel has a large internal chamber surrounded by signal sensing antennas. Journal of molecular biology. 2007.03; 367 (2): 373-383. ( PubMed , DOI )

  1. Fujiyoshi Y: [Structures and functions of ion channels--for accumulation of basic knowledge helpful in medical studies]. Masui. The Japanese journal of anesthesiology. 2006.11; 55 Suppl S1-10. ( PubMed )

  2. Hige T, Fujiyoshi Y, Takahashi T: Neurosteroid pregnenolone sulfate enhances glutamatergic synaptic transmission by facilitating presynaptic calcium currents at the calyx of Held of immature rats. The European journal of neuroscience. 2006.10; 24 (7): 1955-1966. ( PubMed , DOI )

  3. Holm PJ, Bhakat P, Jegerschöld C, Gyobu N, Mitsuoka K, Fujiyoshi Y, Morgenstern R, Hebert H: Structural basis for detoxification and oxidative stress protection in membranes. Journal of molecular biology. 2006.07; 360 (5): 934-945. ( PubMed , DOI )

  4. Nonaka M, Doi T, Fujiyoshi Y, Takemoto-Kimura S, Bito H: Essential contribution of the ligand-binding beta B/beta C loop of PDZ1 and PDZ2 in the regulation of postsynaptic clustering, scaffolding, and localization of postsynaptic density-95. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2006.01; 26 (3): 763-774. ( PubMed , DOI )

  1. Gonen T, Cheng Y, Sliz P, Hiroaki Y, Fujiyoshi Y, Harrison SC, Walz T: Lipid-protein interactions in double-layered two-dimensional AQP0 crystals. Nature. 2005.12; 438 (7068): 633-638. ( PubMed , DOI )

  2. Fujiyoshi Y: [Structure and function of water channels]. Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme. 2005.08; 50 (10 Suppl): 1278-1283. ( PubMed )

  1. Mitsuoka K, Fujiyoshi Y: [Three-dimensional structural analysis of biological molecules by cryo-electron microscopy]. Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme. 2004.08; 49 (11 Suppl): 1794-1799. ( PubMed )

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