Department of Medical Chemistry

48  articles.  
* There may be some overlapped articles listed due to the difference of format.

  1. Miyata Y, Segawa K: Protocol to analyze lipid asymmetry in the plasma membrane. STAR protocols. 2022.12; 3 (4): 101870. ( PubMed , DOI )

  2. Ochiai Y, Suzuki C, Segawa K, Uchiyama Y, Nagata S: Inefficient development of syncytiotrophoblasts in the Atp11a-deficient mouse placenta. Proceedings of the National Academy of Sciences of the United States of America. 2022.05; 119 (18): e2200582119. ( PubMed , DOI )

  3. Miyata Yugo, Tokumoto Shoko, Arai Tomohiko, Shaikhutdinov Nurislam, Deviatiiarov Ruslan, Fuse Hiroto, Gogoleva Natalia, Garushyants Sofya, Cherkasov Alexander, Ryabova Alina, Gazizova Guzel, Cornette Richard, Shagimardanova Elena, Gusev Oleg, Kikawada Takahiro: Identification of Genomic Safe Harbors in the Anhydrobiotic Cell Line, Pv11 GENES. 2022.03; 13 (3): ( PubMed , DOI )

  4. High quality genome assembly of the anhydrobiotic midge provides insights on a single chromosome-based emergence of extreme desiccation tolerance 2022.03; 4 (2): ( DOI )

  1. Cas9-mediated genome editing reveals a significant contribution of calcium signaling pathways to anhydrobiosis in Pv11 cells 2021.12; 11 (1): ( DOI )

  2. Genome-Wide Role of HSF1 in Transcriptional Regulation of Desiccation Tolerance in the Anhydrobiotic Cell Line, Pv11. 2021.05; 22 (11): ( PubMed , DOI )

  1. Hanayo Nakanishi, Tomohiro Nishizawa, Katsumori Segawa, Osamu Nureki, Yoshinori Fujiyoshi, Shigekazu Nagata, Kazuhiro Abe: Transport Cycle of Plasma Membrane Flippase ATP11C by Cryo-EM. Cell Rep. 2020.09; 32 (13): 108208. ( PubMed , DOI )

  2. Hanayo Nakanishi, Katsumasa Irie, Katsumori Segawa, Kazuya Hasegawa, Yoshinori Fujiyoshi, Shigekazu Nagata, Kazuhiro Abe: Crystal structure of a human plasma membrane phospholipid flippase. J Biol Chem. 2020.07; 295 (30): 10180-10194. ( PubMed , DOI )

  3. Low melting point agarose (LMPA)-immobilization method to improve functional assay of olfactory receptors in Sf9 cells 2020; ( DOI )

  1. The Physiological Functions of a Model Peptide of G3LEA in Living Cells 2019; ( DOI )

  1. Establishment of gene transfer and gene silencing methods in a desiccation-tolerant cell line, Pv11 2017; 21 (1): 65-72. ( PubMed , DOI )

  1. Katsumori Segawa, Sachiko Kurata, Shigekazu Nagata: Human Type IV P-type ATPases That Work as Plasma Membrane Phospholipid Flippases and Their Regulation by Caspase and Calcium. J Biol Chem. 2016.01; 291 (2): 762-772. ( PubMed , DOI )

  1. Katsumori Segawa, Shigekazu Nagata: An Apoptotic 'Eat Me' Signal: Phosphatidylserine Exposure. Trends Cell Biol. 2015.11; 25 (11): 639-650. ( PubMed , DOI )

  2. Satoshi Toda, Chihiro Nishi, Yuichi Yanagihashi, Katsumori Segawa, Shigekazu Nagata: Clearance of Apoptotic Cells and Pyrenocytes. Curr Top Dev Biol. 2015; 114 267-295. ( PubMed , DOI )

  1. Hiroyuki Takatsu, Gaku Tanaka, Katsumori Segawa, Jun Suzuki, Shigekazu Nagata, Kazuhisa Nakayama, Hye-Won Shin: Phospholipid flippase activities and substrate specificities of human type IV P-type ATPases localized to the plasma membrane. J Biol Chem. 2014.11; 289 (48): 33543-33556. ( PubMed , DOI )

  2. Katsumori Segawa, Sachiko Kurata, Yuichi Yanagihashi, Thijn R Brummelkamp, Fumihiko Matsuda, Shigekazu Nagata: Caspase-mediated cleavage of phospholipid flippase for apoptotic phosphatidylserine exposure. Science. 2014.06; 344 (6188): 1164-1168. ( PubMed , DOI )

  3. Satoshi Toda, Katsumori Segawa, Shigekazu Nagata: MerTK-mediated engulfment of pyrenocytes by central macrophages in erythroblastic islands. Blood. 2014.06; 123 (25): 3963-3971. ( PubMed , DOI )

  4. Chihiro Nishi, Satoshi Toda, Katsumori Segawa, Shigekazu Nagata: Tim4- and MerTK-mediated engulfment of apoptotic cells by mouse resident peritoneal macrophages. Mol Cell Biol. 2014.04; 34 (8): 1512-1520. ( PubMed , DOI )

  5. Katsumori Segawa, Jun Suzuki, Shigekazu Nagata: Flippases and scramblases in the plasma membrane. Cell Cycle. 2014; 13 (19): 2990-2991. ( PubMed , DOI )

  1. Masanori Miyanishi, Katsumori Segawa, Shigekazu Nagata: Synergistic effect of Tim4 and MFG-E8 null mutations on the development of autoimmunity. Int Immunol. 2012.09; 24 (9): 551-559. ( PubMed , DOI )

  1. Katsumori Segawa, Jun Suzuki, Shigekazu Nagata: Constitutive exposure of phosphatidylserine on viable cells. Proc Natl Acad Sci U S A. 2011.11; 108 (48): 19246-19251. ( PubMed , DOI )

  1. Katsumori Segawa, Morihiro Matsuda, Atsunori Fukuhara, Kentaro Morita, Yosuke Okuno, Ryutaro Komuro, Iichiro Shimomura: Identification of a novel distal enhancer in human adiponectin gene. J Endocrinol. 2009.01; 200 (1): 107-116. ( PubMed , DOI )

  1. Maiko Nozaki, Atsunori Fukuhara, Katsumori Segawa, Yosuke Okuno, Manabu Abe, Naomi Hosogai, Morihiro Matsuda, Ryutaro Komuro, Iichiro Shimomura: Nitric oxide dysregulates adipocytokine expression in 3T3-L1 adipocytes. Biochem Biophys Res Commun. 2007.12; 364 (1): 33-39. ( PubMed , DOI )

  2. Masaki Tanaka, Maiko Nozaki, Atsunori Fukuhara, Katsumori Segawa, Naohito Aoki, Morihiro Matsuda, Ryutaro Komuro, Iichiro Shimomura: Visfatin is released from 3T3-L1 adipocytes via a non-classical pathway. Biochem Biophys Res Commun. 2007.07; 359 (2): 194-201. ( PubMed , DOI )

  3. Naomi Hosogai, Atsunori Fukuhara, Kazuya Oshima, Yugo Miyata, Sachiyo Tanaka, Katsumori Segawa, Shigetada Furukawa, Yoshihiro Tochino, Ryutaro Komuro, Morihiro Matsuda, Iichiro Shimomura: Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation. Diabetes. 2007.04; 56 (4): 901-911. ( PubMed , DOI )

  1. Katsumori Segawa, Atsunori Fukuhara, Naomi Hosogai, Kentaro Morita, Yosuke Okuno, Masaki Tanaka, Yasuhiko Nakagawa, Shinji Kihara, Tohru Funahashi, Ryutaro Komuro, Morihiro Matsuda, Iichiro Shimomura: Visfatin in adipocytes is upregulated by hypoxia through HIF1alpha-dependent mechanism. Biochem Biophys Res Commun. 2006.10; 349 (3): 875-882. ( PubMed , DOI )

  1. Yugo Miyata,Katsumori Segawa, : Asymmetry and vulnerability on phospholipids in the plasma membrane 2023.04; 32 (2): 11-16. ( ichushi )

  1. Yugo Miyata, Kyoko Yamada, Shigekazu Nagata, Katsumori Segawa: Two types of type IV P-type ATPases independently re-establish the asymmetrical distribution of phosphatidylserine in plasma membranes. The Journal of biological chemistry. 2022.11; 298 (11): 102527. ( PubMed , DOI )

  2. Sabina A. Kondratyeva, Taisiya A. Voronina, Alexander A. Nesmelov, Yugo Miyata, Shoko Tokumoto, Richard Cornette, Maria V. Vorontsova, Takahiro Kikawada, Oleg A. Gusev, Elena I. Shagimardanova: Intracellular Localization and Gene Expression Analysis Provides New Insights on LEA Proteins' Diversity in Anhydrobiotic Cell Line Biology. 2022.04; 11 (4): ( PubMed , DOI )

  3. Yuta Ryoden, Katsumori Segawa, Shigekazu Nagata: Requirement of Xk and Vps13a for the P2X7-mediated phospholipid scrambling and cell lysis in mouse T cells. Proceedings of the National Academy of Sciences of the United States of America. 2022.02; 119 (7): ( PubMed , DOI )

  1. Katsumori Segawa, Atsuo Kikuchi, Tomoyasu Noji, Yuki Sugiura, Keita Hiraga, Chigure Suzuki, Kazuhiro Haginoya, Yasuko Kobayashi, Mitsuhiro Matsunaga, Yuki Ochiai, Kyoko Yamada, Takuo Nishimura, Shinya Iwasawa, Wataru Shoji, Fuminori Sugihara, Kohei Nishino, Hidetaka Kosako, Masahito Ikawa, Yasuo Uchiyama, Makoto Suematsu, Hiroshi Ishikita, Shigeo Kure, Shigekazu Nagata: A sublethal ATP11A mutation associated with neurological deterioration causes aberrant phosphatidylcholine flipping in plasma membranes. The Journal of clinical investigation. 2021.09; 131 (18): ( PubMed , DOI )

  2. Shigekazu Nagata, Katsumori Segawa: Sensing and clearance of apoptotic cells. Current opinion in immunology. 2021.02; 68 1-8. ( PubMed , DOI )

  1. Yuta Ryoden, Toshihiro Fujii, Katsumori Segawa, Shigekazu Nagata: Functional Expression of the P2X7 ATP Receptor Requires Eros. Journal of immunology (Baltimore, Md. : 1950). 2020.02; 204 (3): 559-568. ( PubMed , DOI )

  2. Shigekazu Nagata, Takaharu Sakuragi, Katsumori Segawa: Flippase and scramblase for phosphatidylserine exposure. Current opinion in immunology. 2020.02; 62 31-38. ( PubMed , DOI )

  1. Takuma Tsuji, Jinglei Cheng, Tsuyako Tatematsu, Aoi Ebata, Hiroki Kamikawa, Akikazu Fujita, Sayuri Gyobu, Katsumori Segawa, Hiroyuki Arai, Tomohiko Taguchi, Shigekazu Nagata, Toyoshi Fujimoto: Predominant localization of phosphatidylserine at the cytoplasmic leaflet of the ER, and its TMEM16K-dependent redistribution PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019.07; 116 (27): 13368-13373. ( PubMed , DOI )

  2. Chihiro Nishi, Yuichi Yanagihashi, Katsumori Segawa, Shigekazu Nagata: MERTK tyrosine kinase receptor together with TIM4 phosphatidylserine receptor mediates distinct signal transduction pathways for efferocytosis and cell proliferation. The Journal of biological chemistry. 2019.05; 294 (18): 7221-7230. ( PubMed , DOI )

  1. Katsumori Segawa, Yuichi Yanagihashi, Kyoko Yamada, Chigure Suzuki, Yasuo Uchiyama, Shigekazu Nagata: Phospholipid flippases enable precursor B cells to flee engulfment by macrophages. Proceedings of the National Academy of Sciences of the United States of America. 2018.11; 115 (48): 12212-12217. ( PubMed , DOI )

  2. Katsumori Segawa, Sachiko Kurata, Shigekazu Nagata: The CDC50A extracellular domain is required for forming a functional complex with and chaperoning phospholipid flippases to the plasma membrane Journal of Biological Chemistry. 2018.02; 293 (6): 2172-2182. ( PubMed , DOI )

  1. Yuichi Yanagihashi, Katsumori Segawa, Ryota Maeda, Yo-ichi Nabeshima, Shigekazu Nagata: Mouse macrophages show different requirements for phosphatidylserine receptor Tim4 in efferocytosis PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017.08; 114 (33): 8800-8805. ( PubMed , DOI )

  2. Sayuri Gyobu, Kenji Ishihara, Jun Suzuki, Katsumori Segawa, Shigekazu Nagata: Characterization of the scrambling domain of the TMEM16 family PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017.06; 114 (24): 6274-6279. ( PubMed , DOI )

  1. Kosuke Mizutani, Yuki Yoshida, Eita Nakanishi, Yugo Miyata, Shoko Tokumoto, Hiroto Fuse, Oleg Gusev, Shingo Kikuta, Takahiro Kikawada: A sodium-dependent trehalose transporter contributes to anhydrobiosis in insect cell line, Pv11 Proceedings of the National Academy of Sciences. 2024.04; 121 (14): e2317254121. ( PubMed , DOI )

  1. 中西瑛太, CORNETTE Richard, 吉田祐貴, 新井智彦, 徳本翔子, 宮田佑吾, GUSEV Oleg, GUSEV Oleg, GUSEV Oleg, 黄川田隆洋, 黄川田隆洋: Genomic analysis of an acid-tolerant chironomid, Polypedilum sp. cf. tamanigrum, to reveal adaptation mechanisms to extremely acidic environments 日本分子生物学会年会プログラム・要旨集(Web). 2021; 44th

  1. Shoko Tokumoto, Yugo Miyata, Kengo Usui, Ruslan Deviatiiarov, Takahiro Ohkawa, Sabina Kondratieva, Elena Shagimardanova, Oleg Gusev, Richard Cornette, Masayoshi Itoh, Yoshihide Hayashizaki, Takahiro Kikawada: Development of a Tet-On Inducible Expression System for the Anhydrobiotic Cell Line, Pv11 Insects. 2020.11; 11 (11): 781. ( DOI )

  2. 布施寛人, 宮田佑吾, CORNETTE Richard, 黄川田隆洋, 黄川田隆洋: Development of Real-time Ca2+ Imaging Method in Pv11 Cells Using Perfusion System 低温生物工学会誌. 2020; 66 (2):

  3. Voronina, T.A., Nesmelov, A.A., Kondratyeva, S.A., Deviatiiarov, R.M., Miyata, Y., Tokumoto, S., Cornette, R., Gusev, O.A., Kikawada, T., Shagimardanova, E.I.: New group of transmembrane proteins associated with desiccation tolerance in the anhydrobiotic midge Polypedilum vanderplanki Scientific Reports. 2020; 10 (1): ( PubMed , DOI )

  1. Sabina A. Kondratyeva, Alexander A. Nesmelov, Alexander V. Cherkasov, Yugo Miyata, Shoko Tokumoto, Takahiro Kikawada, Oleg A. Gusev, Elena I. Shagimardanova: Intracellular localization and gene expression analysis provide new insights on LEA proteins' diversity in anhydrobiotic midge bioRxiv. 2019.10; ( DOI )

  2. Miyata, Y., Tokumoto, S., Sogame, Y., Deviatiiarov, R., Okada, J., Cornette, R., Gusev, O., Shagimardanova, E., Sakurai, M., Kikawada, T.: Identification of a novel strong promoter from the anhydrobiotic midge, Polypedilum vanderplanki, with conserved function in various insect cell lines Scientific Reports. 2019; 9 (1): ( PubMed , DOI )

  1. Mazin, P.V., Shagimardanova, E., Kozlova, O., Cherkasov, A., Sutormin, R., Stepanova, V.V., Stupnikov, A., Logacheva, M., Penin, A., Sogame, Y., Cornette, R., Tokumoto, S., Miyata, Y., Kikawada, T., Gelfand, M.S., Gusev, O.: Cooption of heat shock regulatory system for anhydrobiosis in the sleeping chironomid Polypedilum vanderplanki Proceedings of the National Academy of Sciences of the United States of America. 2018; 115 (10): E2477-E2486. ( PubMed , DOI )

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