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古屋敷 智之(フルヤシキ トモユキ) FURUYASHIKI Tomoyuki
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経歴(学外) 【 表示 / 非表示 】
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2001年04月-2003年03月京都大学 大学院医学研究科 日本学術振興会特別研究員(PD)
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2003年04月-2004年08月京都大学 大学院医学研究科 助手
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2004年09月-2008年03月ジョンズ・ホプキンス大学 心理脳科学部門 准研究員
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2008年04月-2012年10月京都大学 大学院医学研究科 助教
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2012年11月-2014年04月京都大学 大学院医学研究科 特定准教授
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2014年05月-2025年05月神戸大学 大学院医学研究科 教授
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2025年05月-2026年03月神戸大学 大学院医学研究科 特命教授
委員歴 【 表示 / 非表示 】
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2008年-2014年日本薬理学会 次世代の会
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2010年-2012年日本薬理学会 代議員
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2013年-2014年日本神経精神薬理学会 国際学術委員会
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2014年-2018年日本薬理学会 代議員
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2015年-2018年日本神経精神薬理学会 理事
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2015年-現在日本神経精神薬理学会 編集委員会
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2016年-2019年日本学術振興会 科学研究費委員会専門委員会
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2016年-2020年日本薬理学会 広報委員会
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2016年-2022年次世代脳プロジェクト 実行委員会
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2017年-2022年日本神経科学学会 ニュース編集委員会
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2017年-現在Neuropsychopharmacology Reports Associate Editor
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2018年-2025年理化学研究所神戸事業所 研究倫理第2委員会
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2018年-現在日本医療研究開発機構 課題評価委員会
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2018年-現在FEBS Open Bio Associate Editor
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2018年-現在文科省科学技術・学術政策研究所 専門調査員
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2019年-2020年日本学術振興会 国際科学研究費委員会
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2019年-2026年Kobe Journal of Medical Sciences Editor-in-Chief
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2020年-2022年日本薬理学会 企画教育委員会
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2020年-2024年日本薬理学会 理事
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2020年-2024年日本神経精神薬理学会 理事
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2020年-2027年日本薬理学会 百周年記念事業準備委員会
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2020年-現在日本薬理学会 国際対応委員会
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2020年-現在脳科学辞典 編集委員
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2020年-現在日本神経精神薬理学会 広報委員会
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2022年-2024年日本薬理学会 総務委員会
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2022年-2024年日本学術振興会 科学研究費委員会専門委員会
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2022年-2024年日本薬理学会 将来構想委員会
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2022年-2025年日本脳科学関連学会連合 会計幹事
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2023年-現在科学技術振興機構 創発アドバイザー
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2025年-2028年米国神経科学学会 プログラム委員会
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2026年日本神経精神薬理学会 年会
研究テーマ 【 表示 / 非表示 】
論文・総説 【 表示 / 非表示 】
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Danya Thayaparan, Takuo Emoto, Aniqa B. Khan, Rickvinder Besla, Homaira Hamidzada, Mahmoud El-Maklizi, Tharini Sivasubramaniyam, Shabana Vohra, Ash Hagerman, Sara Nejat, Charlotte E Needham-Robbins, Tao Wang, Moritz Lindquist Steven R. Botts, Stephanie A. Schroer, Masayuki Taniguchi, Taishi Inoue, Katsuhiro Yamanaka, Haotian Cui, Edouard Al-Chami, Hangjun Zhang, Marwan G. Althagafi, Aja Michalski, Joshua JC McGrath, Steven P Cass, David Luong, Yuya Suzuki, Angela Li, Amina Abow, Rachel Heo, Shaun Pacheco, Emily Chen, Felix Chiu, John Byrne, Tomoyuki Furuyashiki, Mansoor Husain, Peter Libby, Kenji Okada, Kathryn L. Howe, Scott P. Heximer, Tomoya Yamashita, Bo Wang, Barry B Rubin, Myron I Cybulsky, Joy Roy, Jesse W Williams, Sarah Q Crome, Slava Epelman, Ken-ichi Hirata, Martin R Stampfli, Clinton S. Robbins.. Atherosclerotic plaque macrophages drive abdominal aortic aneurysm formation. Nature Immunology. 2025; 26 (5): 706-721.
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Hiroki Ueno, Yusuke Iyanaga, Katsuyuki Kunida, Yuta Hara, Hiroki Miura, Yuka Nakai, Masato Tanuma, Misuzu Hayashida, Rei Yokoyama, Jin Ohkubo, Kaoru Seiriki, Atsuko Hayata-Takano, Tomoka Ao, Shun Yamaguchi, Shiho Kitaoka, Tomoyuki Furuyashiki, Yukio Ago, Takanobu Nakazawa, Kazuhiro Takuma, Junichiro Yoshimoto, Hitoshi Hashimoto, Atsushi Kasai.. Recovery of centralities in medial prefrontal and sensory-related cortices associated with social behavior improvements in an autism mouse model. Scientific Reports. 2025; 15 (1): 22895.
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Ryota Shinohara, Tomoyuki Furuyashiki.. Prefrontal contributions to mental resilience: Lessons from rodent studies of stress and antidepressant actions. Neuroscience Research. 2025; 211 16-23.
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Tomoyuki Furuyashiki, Scott J Russo.. Editorial: Neuroscience of resilience for mental health. Neuroscience Research. 2025; 211 1-2.
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Junko Kurokawa, Yuji Ikegaya, Tomoyuki Furuyashiki, Naohiko Anzai, Shuhei Tomita, Yasunari Kanda.. Formalizing and expanding our ethical framework: Introducing the comprehensive ethical guidelines for the Journal of Pharmacological Sciences. Journal of Pharmacological Sciences. 2025; 159 (1): 54-56.
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Yumika Motooka, Ryota Shinohara, Shiho Kitaoka, Ai Uryu, Dongrui Li, Hiroyuki Neyama, Yilong Cui, Tatsuya Kida, Wakiko Arakaki, Hisashi Doi, Yasuyoshi Watanabe, Tomoyuki Furuyashiki. . Alteration of COX-1 and TLR4 expression in the mouse brain during chronic social defeat stress revealed by Positron Emission Tomography study. Journal of Pharmacological Sciences. 2025; 157 (3): 156-166.
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Yuki Okuda, Dongrui Li, Yuzuki Maruyama, Hirokazu Sonobe, Tomoyuki Mano, Kazuki Tainaka, Ryota Shinohara, Tomoyuki Furuyashiki.. The activation of the piriform cortex to lateral septum pathway during chronic social defeat stress is crucial for the induction of behavioral disturbance in mice. Neuropsychopharmacology. 2025; 50 (5): 828-840.
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Rui Yamada, Hirotaka Nagai, Io Horikawa, Wenran Qiu, Yunhui Zhu, Kohei Ota, Tomoyuki Furuyashiki.. C57BL/6J and C57BL/6N mice show distinct aging-associated behavioral alterations. Journal of Pharmacological Sciences. 2025; 157 (2): 124-129.
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Yuya Suzuki, Takuo Emoto, Shunsuke Sato, Takeshi Yoshida, Mitsuhiko Shoda, Hiromi Endoh, Manabu Nagao, Tomoyo Hamana, Taishi Inoue, Tomohiro Hayashi, Eriko Nitta, Hiroki Konishi, Kunihiko Kiuchi, Mitsuru Takami, Kimitake Imamura, Masayuki Taniguchi, Masatoshi Inoue, Toshihiro Nakamura, Yusuke Sonoda, Hiroyuki Takahara, Kazutaka Nakasone, Kyoko Yamamoto, Kenichi Tani, Hidehiro Iwai, Yusuke Nakanishi, Shogo Yonehara, Atsushi Murakami, Ryuji Toh, Takenao Ohkawa, Tomoyuki Furuyashiki, Ryo Nitta, Tomoya Yamashita, Ken-ichi Hirata, Koji Fukuzawa.. Left atrial single-cell transcriptomics reveals amphiregulin as a surrogate marker for atrial fibrillation. Communications Biology. 2024; 7 (1): 1601.
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Io Horikawa, Hirotaka Nagai, Masayuki Taniguchi, Guowei Chen, Masakazu Shinohara, Tomohide Suzuki, Shinichi Ishii, Yoshio Katayama, Shiho Kitaoka, Tomoyuki Furuyashiki.. Chronic stress alters lipid mediator profiles associated with immune-related gene expressions and cell compositions in mouse bone marrow and spleen. Journal of Pharmacological Sciences. 2024; 154 (4): 279-293.
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Makoto Nishimori, Naomi Hayasaka, Kazunori Otsui, Nobutaka Inoue, Manabu Nagao, Ryuji Toh, Tatsuro Ishida, Ken-ichi Hirata, Tomoyuki Furuyashiki, Masakazu Shinohara.. Stress-induced stenotic vascular remodeling via reduction of plasma omega-3 fatty acid metabolite 4-oxoDHA by noradrenaline. Scientific Reports. 2024; 14 (1): 4178.
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Shintaro Takeda, Takuo Emoto, Tomoya Yamashita, Hiroyuki Yamamoto, Tomofumi Takaya, Takahiro Sawada, Takeshi Yoshida, Masatoshi Inoue, Yuya Suzuki, Tomoyo Hamana, Taishi Inoue, Masayuki Taniguchi, Naoto Sasaki, Hiromasa Otake, Takenao Ohkawa, Tomoyuki Furuyashiki, Hiroya Kawai, Ken-ichi Hirata.. Single-Cell RNA Sequencing reveals an Immune Landscape of CD4+ T cells in Coronary Culprit Plaques with Acute Coronary Syndrome. Arteriosclerosis, Thrombosis, and Vascular Biology. 2024; 44 (5): 1135-1143.
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Taishi Inoue, Takuo Emoto, Katsuhiro Yamanaka, Shunya Chomei, Shota Hasegawa, Yojiro Koda, Shunsuke Miyahara, Hiroaki Takahashi, Ryohei Shinohara, Takeshi Kondo, Yuya Suzuki, Tomoyo Hamana, Manabu Nagao, Masayuki Taniguchi, Tomoyuki Furuyashiki, Tomoya Yamashita, Ken-ichi Hirata, Kenji Okada.. Intense impact of IL-1β expressing inflammatory macrophages in acute aortic dissection. Scientific Reports. 2024; 14 (1): 14893.
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Tatsuhiro Ayabe, Masakazu Shinohara, Masahiro Kita, Chika Takahashi, Jiro Saito, Tomoyuki Furuyashiki, Kenji Toba, Satoshi Umeda, Yasuhisa Ano.. Supplementation with whey peptide rich in β-lactolin improves trait anxiety and subjective stress in healthy adults: a randomized, double-blind, placebo-controlled study. Scientific Reports. 2024; 14 (1): 23444.
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Takehiro Jimbo, Hidetoshi Matsuo, Yuya Imoto, Takumi Sodemura, Makoto Nishimori, Fukui Yoshinari, Takuya Hayashi, Tomoyuki Furuyashiki, Ryoichi Yokoyama.. Accelerated preprocessing of large numbers of brain images by parallel computing on supercomputers. Scientific Reports. 2023; 13 (1): 19901.
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Rei Mishima, Masayuki Taniguchi, Kazutoshi Matsushita, Bowen Tian, Tomoyuki Furuyashiki. . Microglial subpopulations with distinct transcriptome signatures vary across brain regions in the resting mouse brain. Journal of Pharmacological Sciences. 2023; 151 (3): 142-147.
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Mai Sakai, Zhiqian Yu, Masayuki Taniguchi, Nanami Oyama, David Stellwagen, Chiaki Ono, Yoshie Kikuchi, Ko Matsui, Rosanne Picotin, Miharu Nakanishi, Hatsumi Yoshii, Tomoyuki Furuyashiki, Takaaki Abe, Hiroaki Tomita.. N-acetylcysteine suppresses microglial inflammation and induces mortality dose-dependently via tumor necrosis factor-α signaling. International Journal of Molecular Sciences. 2023; 24 (4): 3798.
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Hisayoshi Kubota, Kazuo Kunisawa, Bolati Wulaer, Masaya Hasegawa, Hitomi Kurahashi, Takatoshi Sakata, Hiroyuki Tezuka, Masanori Kugita, Shizuko Nagao, Taku Nagai, Tomoyuki Furuyashiki, Shuh Narumiya, Kuniaki Saito, Toshitaka Nabeshima, Akihiro Mouri.. High salt induces cognitive impairment via the interaction of angiotensin II-AT1 and prostaglandin E2-EP1 systems. British Journal of Pharmacology. 2023; 180 (18): 2393-2411.
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Shiho Kitaoka, Ayaka Tomohiro, Shinya Ukeshima, Keyue Liu, Hidenori Wake, Shinya H Kimura, Yasuhiko Yamamoto, Masahiro Nishibori, Tomoyuki Furuyashiki.. Repeated Social Defeat Stress Induces HMGB1 Nuclear Export in Prefrontal Neurons, Leading to Social Avoidance in Mice. Cells. 2023; 12 (13): 1789.
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Nanami Kasakura, Yuka Murata, Asuka Shindo, Shiho Kitaoka, Tomoyuki Furuyashiki, Kanzo Suzuiki, Eri Segi-Nishida.. Overexpression of NT-3 in the hippocampus suppresses the early phase of the adult neurogenic process. Frontiers in Neuroscience. 2023; 17 1178555.
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Yuka Ishikawa, Tomoyuki Furuyashiki. . The impact of stress on immune systems and its relevance to mental illness. Neuroscience Research. 2022; 175 16-24.
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Mai Sakai, Zhiqian Yu, Ryo Hirayama, Masa Nakasato, Yoshie Kikuchi, Chiaki Ono, Hiroshi Komatsu, Miharu Nakanishi, Hatsumi Yoshii, David Stellwagen, Tomoyuki Furuyashiki, Masaaki Komatsu, Hiroaki Tomita.. Deficient Autophagy in Microglia Aggravates Repeated Social Defeat Stress-Induced Social Avoidance. Neural Plasticity. 2022; 2022 7503553.
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Takuo Emoto, Hiroyuki Yamamoto, Tomoya Yamashita, Tomofumi Takaya, Takahiro Sawada, Shintaro Takeda, Masayuki Taniguchi, Naoto Sasaki, Naofumi Yoshida, Yoshihiro Saito, Tharini Sivasubramaniyam, Hiromasa Otake, Tomoyuki Furuyashiki, Clinton S Robbins, Hiroya Kawai, Ken-ichi Hirata. . Single-Cell RNA Sequencing Reveals a Distinct Immune Landscape of Myeloid Cells in Coronary Culprit Plaques Causing Acute Coronary Syndrome. Circulation. 2022; 145 (18): 1434-1436.
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Yusuke Kawashima, Hirotaka Nagai, Ryo Konno, Masaki Ishikawa, Daisuke Nakajima, Hironori Sato, Ren Nakamura, Tomoyuki Furuyashiki, Osamu Ohara.. Single-Shot 10K Proteome Approach: Over 10,000 Protein Identifications by Data-Independent Acquisition-Based Single-Shot Proteomics with Ion Mobility Spectrometry. Journal of Proteome Research. 2022; 21 (6): 1418-1427.
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Risa Sakate; Masahiro Nishiyama; Yu Fukuda; Shiho Kitaoka; Tomoyuki Furuyashiki. . The transcription factor Hhex regulates inflammation-related genes in microglia. Journal of Pharmacological Sciences. 2022; 149 (3): 166-171.
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Satoshi Akiyama, Hirotaka Nagai, Shota Oike, Io Horikawa, Masakazu Shinohara, Yabin Lu, Takashi Futamura, Ryota Shinohara, Shiho Kitaoka, Tomoyuki Furuyashiki.. Chronic social defeat stress increases the amounts of 12-lipoxygenase lipid metabolites in the nucleus accumbens of stress-resilient mice. Scientific Reports. 2022; 12 (1): 11385.
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Namiko Kawamura, Goro Katsuura, Nobuko Yamada-Goto, Riho Nakama, Yuki Kambe, Atsuro Miyata, Tomoyuki Furuyashiki, Shuh Narumiya, Yoshihiro Ogawa, Akio Inui.. Brain fractalkine-CX3CR1 signalling is anti-obesity system as anorexigenic and anti-inflammatory actions in diet-induced obese mice. Scientific Reports. 2022; 12 (1): 12604.
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Zhiqian Yu, Mai Sakai, Hotaka Fukushima, Chiaki Ono, Yoshie Kikuchi, Ryuta Koyama, Ko Matsui, Tomoyuki Furuyashiki, Satoshi Kida, Hiroaki Tomita.. Contextual fear conditioning regulates synapse-related gene transcription in mouse microglia. Brain Research Bulletin. 2022; 189 57-68.
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Yoshiko Kato, Kazumi Nagano, Chenghong Hu, Tomoyuki Furuyashiki.. Relationship between dairy product intake and sense of coherence among middle and high school students in Japan. PLOS One. 2022; 17 (12): e0279232.
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Yoshiko Kato, Yukari Shimomura, Yoshihiro Takada, Tomoyuki Furuyashiki.. Correlation Between Lactic Acid Bacteria Beverage Intake and Stress Resilience. Kobe Journal of Medical Sciences. 2021; 67 (1): E1-E6.
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Yuka Ishikawa, Shiho Kitaoka, Yuko Kawano, Shinichi Ishii, Tomohide Suzuki, Kanako Wakahashi, Taro Kato, Yoshio Katayama, Tomoyuki Furuyashiki.. Repeated social defeat stress induces neutrophil mobilization in mice: maintenance after cessation of stress and strain-dependent difference in response. British Journal of Pharmacology. 2021; 178 (4): 827-844.
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Tomohide Suzuki, Shinichi Ishii, Masakazu Shinohara, Yuko Kawano, Kanako Wakahashi, Hiroki Kawano, Akiko Sada, Kentaro Minagawa, Michito Hamada, Satoru Takahashi, Tomoyuki Furuyashiki, Nguan Soon Tan, Toshimitsu Matsui, Yoshio Katayama. . Mobilization efficiency is critically regulated by fat via marrow PPARδ. Haematologica. 2021; 106 (6): 1671-1683.
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Hidekazu Sotoyama, Hisaaki Namba, Yutaro Kobayashi, Taku Hasegawa, Dai Watanabe, Ena Nakatsukasa, Kenji Sakimura, Tomoyuki Furuyashiki, Hiroyuki Nawa.. Resting-state dopaminergic cell firing in the ventral tegmental area negatively regulates affiliative social interactions in a developmental animal model of schizophrenia. Translational Psychiatry. 2021; 11 (1): 236.
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Midori Nagai, Hirotaka Nagai, Chisato Numa, Tomoyuki Furuyashiki.. Stress-induced sleep-like inactivity modulates stress susceptibility in mice. Scientific Reports. 2020; 10 (1): 19800.
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Yasuhisa Ano, Shiho Kitaoka, Rena Ohya, Keiji Kondo, Tomoyuki Furuyashiki. . Hop Bitter Acids Increase Hippocampal Dopaminergic Activity in a Mouse Model of Social Defeat Stress. International Journal of Molecular Sciences. 2020; 21 (24): 9612.
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Tomoyuki Furuyashiki, Shiho Kitaoka.. Neural mechanisms underlying adaptive and maladaptive consequences of stress: Roles of dopaminergic and inflammatory responses. Psychiatry and Clinical Neurosciences. 2019; 73 (11): 669-675.
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Yasuhisa Ano, Ayaka Hoshi, Tatsuhiro Ayabe, Rena Ohya, Shinichi Uchida, Koji Yamada, Keiji Kondo, Shiho Kitaoka, Tomoyuki Furuyashiki.. Iso-α-acids, the bitter components of beer, improve hippocampus-dependent memory through vagus nerve activation. FASEB Journal. 2019; 33 (4): 4987-4995.
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Yasuhisa Ano, Tatsuhiro Ayabe, Rena Ohya, Keiji Kondo, Shiho Kitaoka, Tomoyuki Furuyashiki.. Tryptophan-Tyrosine Dipeptide, the Core Sequence of β-Lactolin, Improves Memory by Modulating the Dopamine System. Nutrients. 2019; 11 (2): 348.
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Satoshi Okamura, Hirotaka Nagai, Chisato Numa, Midori Nagai, Ryota Shinohara, Tomoyuki Furuyashiki.. Social defeat stress induces phosphorylation of extracellular signal-regulated kinase in the leptomeninges in mice. Neuropsychopharmacology Reports. 2019; 39 (2): 134-139.
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Rie Ishikawa, Chiaki Uchida, Shiho Kitaoka, Tomoyuki Furuyashiki, Satoshi Kida. . Improvement of PTSD-like behavior by the forgetting effect of hippocampal neurogenesis enhancer memantine in a social defeat stress paradigm. Molecular Brain. 2019; 12 (1): 68.
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Yasuhisa Ano, Masahiro Kita, Shiho Kitaoka, Tomoyuki Furuyashiki.. Leucine-Histidine Dipeptide Attenuates Microglial Activation and Emotional Disturbances Induced by Brain Inflammation and Repeated Social Defeat Stress. Nutrients. 2019; 11 (9): 2161.
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Sudheesh K Rajput, Manoj Kumar, Xiangyu Quan, Mitsuhiro Morita, Tomoyuki Furuyashiki, Yasuhiro Awatsuji, Enrique Tajahuerce, Osamu Matoba.. Three-dimensional fluorescence imaging using the transport of intensity equation. Journal of Biomedical Optics. 2019; 25 (3): 1-7.
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Tatsuhiro Ayabe, Yasuhisa Ano, Rena Ohya, Shiho Kitaoka, Tomoyuki Furuyashiki.. The Lacto-Tetrapeptide Gly-Thr-Trp-Tyr, β-Lactolin, Improves Spatial Memory Functions via Dopamine Release and D1 Receptor Activation in the Hippocampus. Nutrients. 2019; 11 (10): 2469.
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Chisato Numa, Hirotaka Nagai, Masayuki Taniguchi, Midori Nagai, Ryota Shinohara, Tomoyuki Furuyashiki.. Social defeat stress-specific increase in c-Fos expression in the extended amygdala in mice: Involvement of dopamine D1 receptor in the medial prefrontal cortex. Scientific Reports. 2019; 9 (1): 16670.
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Xiang Nie, Shiho Kitaoka, Masakazu Shinohara, Akira Kakizuka, Shuh Narumiya, Tomoyuki Furuyashiki.. Roles of Toll-like receptor 2/4, monoacylglycerol lipase, and cyclooxygenase in social defeat stress-induced prostaglandin E 2 synthesis in the brain and their behavioral relevance. Scientific Reports. 2019; 9 (1): 17548.
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Tomoyuki Furuyashiki, Satoshi Akiyama, Shiho Kitaoka. Roles of multiple lipid mediators in stress and depression. International Immunology. 2019; 31 (9): 579-587.
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Xiang Nie, Shiho Kitaoka, Kohei Tanaka, Eri Segi-Nishida, Yuki Imoto, Atsubumi Ogawa, Fumitake Nakano, Ayaka Tomohiro, Kazuki Nakayama, Masayuki Taniguchi, Yuko Mimori-Kiyosue, Akira Kakizuka, Shuh Narumiya, Tomoyuki Furuyashiki.. The Innate Immune Receptors TLR2/4 Mediate Repeated Social Defeat Stress-Induced Social Avoidance through Prefrontal Microglial Activation. Neuron. 2018; 99 (3): 464-479.
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H Ota, K Katanosaka, S Murase, T Furuyashiki, S Narumiya, K Mizumura.. EP2 receptor plays pivotal roles in generating mechanical hyperalgesia after lengthening contractions. Scandinavian Journal of Medicine & Science in Sports. 2018; 28 (3): 826-833.
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R Shinohara, M Taniguchi, A T Ehrlich, K Yokogawa, Y Deguchi, Y Cherasse, M Lazarus, Y Urade, A Ogawa, S Kitaoka, A Sawa, S Narumiya, T Furuyashiki. . Dopamine D1 receptor subtype mediates acute stress-induced dendritic growth in excitatory neurons of the medial prefrontal cortex and contributes to suppression of stress susceptibility in mice. Molecular Psychiatry. 2018; 23 (8): 1717-1730.
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Akiko Sumitomo, Hiroshi Yukitake, Kazuko Hirai, Kouta Horike, Keisho Ueta, Youjin Chung, Eiji Warabi, Toru Yanagawa, Shiho Kitaoka, Tomoyuki Furuyashiki, Shuh Narumiya, Tomoo Hirano, Minae Niwa, Etienne Sibille, Takatoshi Hikida, Takeshi Sakurai, Koko Ishizuka, Akira Sawa, Toshifumi Tomoda.. Ulk2 controls cortical excitatory-inhibitory balance via autophagic regulation of p62 and GABAA receptor trafficking in pyramidal neurons. Human Molecular Genetics. 2018; 27 (18): 3165-3176.
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Shu Higashida, Hirotaka Nagai, Kazuki Nakayama, Ryota Shinohara, Masayuki Taniguchi, Midori Nagai, Takatoshi Hikida, Satoshi Yawata, Yukio Ago, Shiho Kitaoka, Shuh Narumiya, Tomoyuki Furuyashiki. . Repeated social defeat stress impairs attentional set shifting irrespective of social avoidance and increases female preference associated with heightened anxiety. Scientific Reports. 2018; 8 (1): 10454.
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Masakazu Ibi, Junjie Liu, Noriaki Arakawa, Shiho Kitaoka, Ai Kawaji, Ken-Ichi Matsuda, Kazumi Iwata, Misaki Matsumoto, Masato Katsuyama, Kai Zhu, Satoshi Teramukai, Tomoyuki Furuyashiki, Chihiro Yabe-Nishimura.. Depressive-Like Behaviors Are Regulated by NOX1/NADPH Oxidase by Redox Modification of NMDA Receptor 1. Journal of Neuroscience. 2017; 37 (15): 4200-4212.
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Yuko Kawano, Chie Fukui, Masakazu Shinohara, Kanako Wakahashi, Shinichi Ishii, Tomohide Suzuki, Mari Sato, Noboru Asada, Hiroki Kawano, Kentaro Minagawa, Akiko Sada, Tomoyuki Furuyashiki, Satoshi Uematsu, Shizuo Akira, Toshimitsu Uede, Shuh Narumiya, Toshimitsu Matsui, Yoshio Katayama.. G-CSF-induced sympathetic tone provokes fever and primes antimobilizing functions of neutrophils via PGE2. Blood. 2017; 129 (5): 587-597.
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Yuichi Deguchi, Masaya Harada, Ryota Shinohara, Michael Lazarus, Yoan Cherasse, Yoshihiro Urade, Daisuke Yamada, Masayuki Sekiguchi, Dai Watanabe, Tomoyuki Furuyashiki, Shuh Narumiya.. mDia and ROCK Mediate Actin-Dependent Presynaptic Remodeling Regulating Synaptic Efficacy and Anxiety. Cell Reports. 2016; 17 (9): 2405-2417.
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Qingyun, Yan Ma, Toshiaki Kato, Tomoyuki Furuyashiki. . Genetic Interactions among AMPK Catalytic Subunit Ssp2 and Glycogen Synthase Kinases Gsk3 and Gsk31 in Schizosaccharomyces Pombe. Kobe Journal of Medical Sciences. 2016; 62 (3): E70-E78.
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Ning Ma, Yan Ma, Akio Nakashima, Ushio Kikkawa, Tomoyuki Furuyashiki.. The Loss of Lam2 and Npr2-Npr3 Diminishes the Vacuolar Localization of Gtr1-Gtr2 and Disinhibits TORC1 Activity in Fission Yeast. PLoS One. 2016; 11 (5): e0156239.
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Chiung-Yuan Ko, Yu-Yi Chu, Shuh Narumiya, Jhih-Ying Chi, Tomoyuki Furuyashiki, Tomohiro Aoki, Shao-Ming Wang, Wen-Chang Chang, Ju-Ming Wang.. CCAAT/enhancer-binding protein delta/miR135a/thrombospondin 1 axis mediates PGE2-induced angiogenesis in Alzheimer's disease. Neurobiology of Aging. 2015; 36 (3): 1356-1368.
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Tetsushi Hirano, Shogo Yanai, Takuya Omotehara, Rie Hashimoto, Yuria Umemura, Naoto Kubota, Kiichi Minami, Daichi Nagahara, Eiko Matsuo, Yoshiko Aihara, Ryota Shinohara, Tomoyuki Furuyashiki, Youhei Mantani, Toshifumi Yokoyama, Hiroshi Kitagawa, Nobuhiko Hoshi. . The combined effect of clothianidin and environmental stress on the behavioral and reproductive function in male mice. Journal of Veterinary Science. 2015; 77 (10): 1207-1215.
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Lingling Hu, Yue Fang, Tsutomu Hayafuji, Yan Ma, Tomoyuki Furuyashiki.. Azoles activate Atf1-mediated transcription through MAP kinase pathway for antifungal effects in fission yeast. Genes to Cells. 2015; 20 (9): 695-705.
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Xibo Zhang, Yue Fang, Wurentuya Jaiseng, Lingling Hu, Yabin Lu, Yan Ma, Tomoyuki Furuyashiki. . Characterization of Tamoxifen as an Antifungal Agent Using the Yeast Schizosaccharomyces Pombe Model Organism. Kobe Journal of Medical Sciences. 2015; 61 (2): E54-E63.
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Qingbin Liu, Yan Ma, Xin Zhou, Tomoyuki Furuyashiki. . Constitutive Tor2 Activity Promotes Retention of the Amino Acid Transporter Agp3 at Trans-Golgi/Endosomes in Fission Yeast. PLoS One. 2015; 10 (10): e0139045.
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Yan Ma, Ning Ma, Qingbin Liu, Yao Qi, Ri-ichiroh Manabe, Tomoyuki Furuyashiki.. Tor Signaling Regulates Transcription of Amino Acid Permeases through a GATA Transcription Factor Gaf1 in Fission Yeast. PLOS One. 2015; 10 (12): e0144677.
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Wugangerile Sartagul, Xin Zhou, Yuki Yamada, Ning Ma, Katsunori Tanaka, Tomoyuki Furuyashiki, Yan Ma.. The MluI cell cycle box (MCB) motifs, but not damage-responsive elements (DREs), are responsible for the transcriptional induction of the rhp51+ gene in response to DNA replication stress. PLoS One. 2014; 9 (11): e111936.
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Aliza T Ehrlich, Tomoyuki Furuyashiki, Shiho Kitaoka, Akira Kakizuka, Shuh Narumiya. . Prostaglandin E receptor EP1 forms a complex with dopamine D1 receptor and directs D1-induced cAMP production to adenylyl cyclase 7 through mobilizing G(βγ) subunits in human embryonic kidney 293T cells. Molecular Pharmacology. 2013; 84 (3): 476-486.
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Yoshiko Matsumoto Ikushima, Fumio Arai, Kentaro Hosokawa, Hirofumi Toyama, Keiyo Takubo, Tomoyuki Furuyashiki, Shuh Narumiya, Toshio Suda. . Prostaglandin E(2) regulates murine hematopoietic stem/progenitor cells directly via EP4 receptor and indirectly through mesenchymal progenitor cells. Blood. 2013; 121 (11): 1995-2007.
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Yosuke Toyoda, Ryota Shinohara, Dean Thumkeo, Hiroshi Kamijo, Hiroshi Nishimaru, Hiroyuki Hioki, Takeshi Kaneko, Toshimasa Ishizaki, Tomoyuki Furuyashiki, Shuh Narumiya. . EphA4-dependent axon retraction and midline localization of Ephrin-B3 are disrupted in the spinal cord of mice lacking mDia1 and mDia3 in combination. Genes to Cells. 2013; 18 (10): 873-885.
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Tomoyuki Furuyashiki.. Roles of dopamine and inflammation-related molecules in behavioral alterations caused by repeated stress. Journal of Pharmacological Sciences. 2012; 120 (2): 63-69.
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Kentaro Kaneko, Michael Lazarus, Chihiro Miyamoto, Yo Oishi, Nanae Nagata, Shuzhang Yang, Masaaki Yoshikawa, Kosuke Aritake, Tomoyuki Furuyashiki, Shuh Narumiya, Yoshihiro Urade, Kousaku Ohinata.. Orally administered rubiscolin-6, a δ opioid peptide derived from Rubisco, stimulates food intake via leptomeningeal lipocallin-type prostaglandin D synthase in mice. Molecular Nutrition & Food Research. 2012; 56 (8): 1315-1323.
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Kiyomi Hamaguchi, Norio Yamamoto, Takayuki Nakagawa, Tomoyuki Furuyashiki, Shuh Narumiya, Juichi Ito.. Role of PGE-type receptor 4 in auditory function and noise-induced hearing loss in mice. Neuropharmacology. 2012; 62 (4): 1841-1847.
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Ryota Shinohara, Dean Thumkeo, Hiroshi Kamijo, Naoko Kaneko, Kazunobu Sawamoto, Keisuke Watanabe, Hirohide Takebayashi, Hiroshi Kiyonari, Toshimasa Ishizaki, Tomoyuki Furuyashiki, Shuh Narumiya.. A role for mDia, a Rho-regulated actin nucleator, in tangential migration of interneuron precursors. Nature Neuroscience. 2012; 15 (3): 373-380.
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Kohei Tanaka, Tomoyuki Furuyashiki, Shiho Kitaoka, Yuta Senzai, Yuki Imoto, Eri Segi-Nishida, Yuichi Deguchi, Richard M Breyer, Matthew D Breyer, Shuh Narumiya.. Prostaglandin E2-mediated attenuation of mesocortical dopaminergic pathway is critical for susceptibility to repeated social defeat stress in mice. Journal of Neuroscience. 2012; 32 (12): 4319-4329.
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Shuh Narumiya, Tomoyuki Furuyashiki.. Fever, inflammation, pain and beyond: prostanoid receptor research during these 25 years. FASEB Journal. 2011; 25 (3): 813-1847.
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T Aoki, M Nishimura, T Matsuoka, K Yamamoto, T Furuyashiki, H Kataoka, S Kitaoka, R Ishibashi, A Ishibazawa, S Miyamoto, R Morishita, J Ando, N Hashimoto, K Nozaki, S Narumiya. . PGE(2) -EP(2) signalling in endothelium is activated by haemodynamic stress and induces cerebral aneurysm through an amplifying loop via NF-κB. British Journal of Pharmacology. 2011; 163 (6): 1237-1249.
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Chihiro Suzuki, Chihiro Miyamoto, Tomoyuki Furuyashiki, Shuh Narumiya, Kousaku Ohinata. . Central PGE2 exhibits anxiolytic-like activity via EP1 and EP4 receptors in a manner dependent on serotonin 5-HT1A, dopamine D1 and GABAA receptors. FEBS Letters. 2011; 585 (14): 2357-2362.
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Tomoyuki Mitsumori, Tomoyuki Furuyashiki, Toshihiko Momiyama, Akinori Nishi, Takahide Shuto, Takashi Hayakawa, Fumitaka Ushikubi, Shiho Kitaoka, Tomohiro Aoki, Haruhisa Inoue, Toshiyuki Matsuoka, Shuh Narumiya.. Thromboxane receptor activation enhances striatal dopamine release, leading to suppression of GABAergic transmission and enhanced sugar intake. European Journal of Neuroscience. 2011; 34 (4): 594-604.
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Dean Thumkeo, Ryota Shinohara, Keisuke Watanabe, Hirohide Takebayashi, Yosuke Toyoda, Kiyoshi Tohyama, Toshimasa Ishizaki, Tomoyuki Furuyashiki, Shuh Narumiya.. Deficiency of mDia, an actin nucleator, disrupts integrity of neuroepithelium and causes periventricular dysplasia. PLoS One. 2011; 6 (9): e25465.
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Tomoyuki Furuyashiki, Shuh Narumiya.. Stress responses: the contribution of prostaglandin E(2) and its receptors. Nature Reviews Endocrinology. 2011; 7 (3): 163-175.
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Tomoyuki Furuyashiki, Shuh Narumiya.. Roles of prostaglandin E receptors in stress responses. Current Opinion in Pharmacology. 2009; 9 (1): 31-38.
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Yasuhiro Tanaka, Tomoyuki Furuyashiki, Toshihiko Momiyama, Hisaaki Namba, Akira Mizoguchi, Tomoyuki Mitsumori, Tetsuro Kayahara, Hitoshi Shichi, Kazushi Kimura, Toshiyuki Matsuoka, Hiroyuki Nawa, Shuh Narumiya. . Prostaglandin E receptor EP1 enhances GABA-mediated inhibition of dopaminergic neurons in the substantia nigra pars compacta and regulates dopamine level in the dorsal striatum. European Journal of Neuroscience. 2009; 30 (12): 2338-2346.
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Reiko Hanada, Andreas Leibbrandt, Toshikatsu Hanada, Shiho Kitaoka, Tomoyuki Furuyashiki, Hiroaki Fujihara, Jean Trichereau, Magdalena Paolino, Fatimunnisa Qadri, Ralph Plehm, Steffen Klaere, Vukoslav Komnenovic, Hiromitsu Mimata, Hironobu Yoshimatsu, Naoyuki Takahashi, Arndt von Haeseler, Michael Bader, Sara Sebnem Kilic, Yoichi Ueta, Christian Pifl, Shuh Narumiya, Josef M Penninger. . Central control of fever and female body temperature by RANKL/RANK. Nature. 2009; 462 505-509.
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Tomoyuki Furuyashiki, Peter C Holland, Michela Gallagher.. Rat orbitofrontal cortex separately encodes response and outcome information during performance of goal-directed behavior. Journal of Neuroscience. 2008; 28 (19): 5127-5138.
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Tomoyuki Furuyashiki, Michela Gallagher.. Neural encoding in the orbitofrontal cortex related to goal-directed behavior. Annals of the New York Academy of Sciences. 2007; 1121 193-215.
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Miyako Nagamachi, Daiji Sakata, Kenji Kabashima, Tomoyuki Furuyashiki, Takahiko Murata, Eri Segi-Nishida, Kitipong Soontrapa, Toshiyuki Matsuoka, Yoshiki Miyachi, Shuh Narumiya.. Facilitation of Th1-mediated immune response by prostaglandin E receptor EP1. Journal of Experimental Medicine. 2007; 204 (12): 2865-2874.
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Shiho Kitaoka, Tomoyuki Furuyashiki, Akinori Nishi, Takahide Shuto, Sho Koyasu, Toshiyuki Matsuoka, Masayuki Miyasaka, Paul Greengard, Shuh Narumiya.. Prostaglandin E2 acts on EP1 receptor and amplifies both dopamine D1 and D2 receptor signaling in the striatum. Journal of Neuroscience. 2007; 27 (47): 12900-12907.
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Shogo Ohmae, Sayaka Takemoto-Kimura, Michiko Okamura, Aki Adachi-Morishima, Mio Nonaka, Toshimitsu Fuse, Satoshi Kida, Masahiro Tanji, Tomoyuki Furuyashiki, Yoshiki Arakawa, Shuh Narumiya, Hiroyuki Okuno, Haruhiko Bito.. 74. Shogo Ohmae, Sayaka Takemoto-Kimura, Michiko Okamura, Aki Adachi-Morishima, Mio Nonaka, Toshimitsu Fuse, Satoshi Kida, Masahiro Tanji, Tomoyuki Furuyashiki, Yoshiki Arakawa, Shuh Narumiya, Hiroyuki Okuno, Haruhiko Bito. Journal of Biological Chemistry. 2006; 281 (29): 20427-20439.
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Yoko Matsuoka, Tomoyuki Furuyashiki, Kiyofumi Yamada, Taku Nagai, Haruhiko Bito, Yasuhiro Tanaka, Shiho Kitaoka, Fumitaka Ushikubi, Toshitaka Nabeshima, Shuh Narumiya.. Prostaglandin E receptor EP1 controls impulsive behavior under stress. Proceedings of the National Academy of Sciences. 2005; 102 (44): 16066-16071.
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Yosuke Morishima, Tsuyoshi Miyakawa, Tomoyuki Furuyashiki, Yasuhiro Tanaka, Hiroshi Mizuma, Shigetada Nakanishi.. Enhanced cocaine responsiveness and impaired motor coordination in metabotropic glutamate receptor subtype 2 knockout mice. Proceedings of the National Academy of Sciences. 2005; 102 (11): 4170-4175.
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Yoshiki Arakawa, Haruhiko Bito, Tomoyuki Furuyashiki, Takahiro Tsuji, Sayaka Takemoto-Kimura, Kazuhiro Kimura, Kazuhiko Nozaki, Nobuo Hashimoto, Shuh Narumiya.. Control of axon elongation via an SDF-1alpha/Rho/mDia pathway in cultured cerebellar granule neurons. Journal of Cell Biology. 2003; 161 (2): 381-391.
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Sayaka Takemoto-Kimura, Hisashi Terai, Maki Takamoto, Shogo Ohmae, Shoko Kikumura, Eri Segi, Yoshiki Arakawa, Tomoyuki Furuyashiki, Shuh Narumiya, Haruhiko Bito.. Molecular cloning and characterization of CLICK-III/CaMKIgamma, a novel membrane-anchored neuronal Ca2+/calmodulin-dependent protein kinase (CaMK). Journal of Biological Chemistry. 2003; 278 (20): 18597-18605.
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Yoko Matsuoka, Tomoyuki Furuyashiki, Haruhiko Bito, Fumitaka Ushikubi, Yasuhiro Tanaka, Takuya Kobayashi, Seiji Muro, Noriko Satoh, Tetsuro Kayahara, Mikito Higashi, Akira Mizoguchi, Hitoshi Shichi, Yoshihiro Fukuda, Kazuwa Nakao, Shuh Narumiya.. Impaired adrenocorticotropic hormone response to bacterial endotoxin in mice deficient in prostaglandin E receptor EP1 and EP3 subtypes. Proceedings of the National Academy of Sciences. 2003; 100 (7): 4132-4137.
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Takahiro Tsuji, Toshimasa Ishizaki, Muneo Okamoto, Chiharu Higashida, Kazuhiro Kimura, Tomoyuki Furuyashiki, Yoshiki Arakawa, Raymond B Birge, Tetsuya Nakamoto, Hisamaru Hirai, Shuh Narumiya.. ROCK and mDia1 antagonize in Rho-dependent Rac activation in Swiss 3T3 fibroblasts. Journal of Cell Biology. 2002; 157 (5): 819-830.
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Tomoyuki Furuyashiki, Yoshiki Arakawa, Sayaka Takemoto-Kimura, Haruhiko Bito, Shuh Narumiya. . Multiple spatiotemporal modes of actin reorganization by NMDA receptors and voltage-gated Ca2+ channels. Proceedings of the National Academy of Sciences. 2002; 99 (22): 14458-14463.
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T Ishizaki, Y Morishima, M Okamoto, T Furuyashiki, T Kato, S Narumiya.. Coordination of microtubules and the actin cytoskeleton by the Rho effector mDia1. Nature Cell Biology. 2001; 3 (1): 8-14.
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P Madaule, T Furuyashiki, M Eda, H Bito, T Ishizaki, S Narumiya.. Citron, a Rho target that affects contractility during cytokinesis. Microscopy Research and Technique. 2000; 49 (2): 123-126.
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H Bito, T Furuyashiki, H Ishihara, Y Shibasaki, K Ohashi, K Mizuno, M Maekawa, T Ishizaki, S Narumiya.. A critical role for a Rho-associated kinase, p160ROCK, in determining axon outgrowth in mammalian CNS neurons. Neuron. 2000; 26 (2): 431-441.
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T Furuyashiki, K Fujisawa, A Fujita, P Madaule, S Uchino, M Mishina, H Bito, S Narumiya. . Citron, a Rho-target, interacts with PSD-95/SAP-90 at glutamatergic synapses in the thalamus. Journal of Neuroscience. 1999; 19 (1): 109-118.
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T Reid, T Furuyashiki, T Ishizaki, G Watanabe, N Watanabe, K Fujisawa, N Morii, P Madaule, S Narumiya.. Rhotekin, a new putative target for Rho bearing homology to a serine/threonine kinase, PKN, and rhophilin in the rho-binding domain. Journal of Biological Chemistry. 1996; 271 (23): 13556-13560.
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P Madaule, T Furuyashiki, T Reid, T Ishizaki, G Watanabe, N Morii, S Narumiya.. A novel partner for the GTP-bound forms of rho and rac. FEBS Letters. 1995; 377 (2): 243-248.
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Furuyashiki T, Kitaoka S.. Part III Lipid Mediators and Diseases, 22. Roles and actions of arachidonic acid-derived bioactive lipids in stress-related behaviors. 315-328, Takehiko Yokomizo, Makoto Murakami eds., Bioactive Lipid Mediators Current Reviews and Protocols. Springer. 2015
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古屋敷 智之. 「慢性ストレスによる脳内炎症がうつ病を引き起こす?」,ブルーバックス「「心の病」の脳科学」(講談社),80頁~98頁.. 2023.02
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アジア神経精神薬理学会科学賞,アジア神経精神薬理学会,2025年06月
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国際神経精神薬理学会住友ファーマブレインヘルス基礎研究賞,国際神経精神薬理学会,2024年05月
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アステラス病態代謝研究会最優秀理事長賞,アステラス病態代謝研究会,2015年11月
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日本薬理学会学術奨励賞,日本薬理学会,2012年03月
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医学部医学科2年生「薬理学」,2025年 - 現在
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医学部医学科2年生「神経科学・基礎」,2025年 - 現在
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歯学部(歯学科・口腔保健学科)3年生「薬理学」,2026年 - 現在