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FURUYASHIKI Tomoyuki
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Graduating School 【 display / non-display 】
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Kyoto University, Faculty of Medicine, Faculty of Medicine, 1997.03, Graduated
Graduate School 【 display / non-display 】
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Kyoto University, Graduate School, Division of Medicine, Doctor's Course, 2001.03, Completed
Campus Career 【 display / non-display 】
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2025.06-NowInstitute of Science Tokyo, -, Graduate Schools, Cognitive and Behavioral Medicine, Department of Pharmacology, Professor
External Career 【 display / non-display 】
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2001.04-2003.03Kyoto University, Graduate School of Medicine, JSPS postdoctoral fellow
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2003.04-2004.08Kyoto University, Graduate School of Medicine, Assistant Professor
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2004.09-2008.03Johns Hopkins University, Department of Psychological and Brain Sciences, Associate Research Scientist
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2008.04-2012.10Kyoto University, Graduate School of Medicine, Assistant Professor
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2012.11-2014.04Kyoto University, Graduate School of Medicine, Associate Professor
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2014.05-2025.05Kobe University, Graduate School of Medicine, Professor and chair of pharmacology
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2014.05-2025.05Kobe University, Graduate School of Medicine, Professor
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2025.05-2026.03Kobe University, Graduate School of Medicine, Specially Appointed Professor
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2025.06-2026.03Kobe University, Graduate School of Medicine, Specially Appointed Professor
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2025.06-NowInstitute of Science Tokyo, Graduate School of Medical and Dental Sciences, Professor and chair of pharmacology
Academic Society Affiliations 【 display / non-display 】
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Japanese Pharmacological Society
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Japanese Society of Neuropsychopharmacology
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Japan Neuroscience Society
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American College of Neuropsychopharmacology
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Society for Neuroscience (U.S.A.)
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THE JAPANESE PHARMACOLOGICAL SOCIETY
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SOCIETY FOR NEUROSCIENCE
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American College of Neuropsychopharmacology
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INTERNATIONAL COLLEGE OF NEUROPSYCHOPHARMACOLOGY
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THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
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THE JAPANESE SOCIETY OF INFLAMMATION AND REGENERATION
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THE JAPANESE BIOCHEMICAL SOCIETY
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JAPANESE SOCIETY OF BIOLOGICAL PSYCHIATRY
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JAPANESE ASSOCIATION FOR THE STUDY OF PAIN
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THE JAPANESE SOCIETY FOR NEUROCHEMISTRY
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THE JAPAN NEUROSCIENCE SOCIETY
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THE JAPANESE SOCIETY OF NEUROPSYCHOPHARMACOLOGY
Research Areas 【 display / non-display 】
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Pharmacology
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Pathophysiologic neuroscience
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Function of nervous system
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Pathophysiologic neuroscience
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Neuroscience-general
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Pharmacology
Research Theme 【 display / non-display 】
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Elucidation of molecular and cellular mechanisms underlying neural pathology and resilience in stress and aging
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Elucidation of neural circuits and brain information processing underlying neural pathology and resilience in stress and aging
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Elucidation of brain-peripheral interactions underlying neural pathology and resilience in stress and aging
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Integrative analysis of multi-hierarchical data related to neural pathology and resilience in stress and aging
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Elucidation of pathophysiological significance of molecular and neural circuit abnormalities in neuropsychiatric disorders and their application to drug discovery
Published Papers & Misc 【 display / non-display 】
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Sotani, N; Kusuhara, S; Nishisho, R; Kuno, H; Shima, H; Haruwaka, K; Mori, Y; Kishi, M; Furuyashiki, T; Kobayashi, K; Wake, H; Takumi, T; Nakamura, M; Tachibana, Y. Transpupillary in vivo two- photon imaging reveals enhanced surveillance of retinal microglia in diabetic mice PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2025.10; 122 (41): e2426241122. ( PubMed, DOI )
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Imai Y, Kinugasa Y, Nukiwa R, Covarrubias MAL, Thwin KK, Yonezaki K, Shimizu T, Yamasaki S, Shintani Y, Hashimoto H, Suzuki Y, Fujino Y, Kubodera K, Kotani T, Furuyashiki T, Penninger J, Slutsky AS. Protective Role of Apelin in a Mouse Model of Post-Intensive Care Syndrome. American journal of respiratory cell and molecular biology. 2025.09; ( PubMed, DOI )
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Kurokawa J, Ikegaya Y, Furuyashiki T, Anzai N, Tomita S, Kanda Y. Formalizing and expanding our ethical framework: Introducing the comprehensive ethical guidelines for the Journal of Pharmacological Sciences. Journal of pharmacological sciences. 2025.09; 159 (1): 54-56. ( PubMed, DOI )
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Ueno, H; Iyanaga, Y; Kunida, K; Hara, Y; Miura, H; Nakai, Y; Tanuma, M; Hayashida, M; Yokoyama, R; Ohkubo, J; Seiriki, K; Hayata-Takano, A; Ao, T; Yamaguchi, S; Kitaoka, S; Furuyashiki, T; Ago, Y; Nakazawa, T; Takuma, K; Yoshimoto, J; Hashimoto, H; Kasai, A. Recovery of centralities in medial prefrontal and sensory-related cortices associated with social behavior improvements in an autism mouse model SCIENTIFIC REPORTS. 2025.07; 15 (1): 22895. ( PubMed, DOI )
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Thayaparan, D; Emoto, T; Khan, AB; Besla, R; Hamidzada, H; El-Maklizi, M; Sivasubramaniyam, T; Vohra, S; Hagerman, A; Nejat, S; Needham-Robbins, CE; Wang, T; Lindquist, M; Botts, SR; Schroer, SA; Taniguchi, M; Inoue, T; Yamanaka, K; Cui, HT; Al-Chami, E; Zhang, HJ; Althagafi, MG; Michalski, A; Mcgrath, JJC; Cass, SP; Luong, D; Suzuki, Y; Li, A; Abow, A; Heo, R; Pacheco, S; Chen, E; Chiu, F; Byrne, J; Furuyashiki, T; Husain, M; Libby, P; Okada, K; Howe, KL; Heximer, SP; Yamashita, T; Wang, B; Rubin, BB; Cybulsky, MI; Roy, J; Williams, JW; Crome, SQ; Epelman, S; Hirata, KI; Stampfli, MR; Robbins, CS. Endothelial dysfunction drives atherosclerotic plaque macrophage-dependent abdominal aortic aneurysm formation NATURE IMMUNOLOGY. 2025.05; 26 (5): 706-721. ( PubMed, DOI )
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Suzuki, Y; Emoto, T; Sato, S; Yoshida, T; Shoda, M; Endoh, H; Nagao, M; Hamana, T; Inoue, T; Hayashi, T; Nitta, E; Konishi, H; Kiuchi, K; Takami, M; Imamura, K; Taniguchi, M; Inoue, M; Nakamura, T; Sonoda, Y; Takahara, H; Nakasone, K; Yamamoto, K; Tani, K; Iwai, H; Nakanishi, Y; Yonehara, S; Murakami, A; Toh, R; Ohkawa, T; Furuyashiki, T; Nitta, R; Yamashita, T; Hirata, K; Fukuzawa, K. Left atrial single-cell transcriptomics reveals amphiregulin as a surrogate marker for atrial fibrillation (vol 7, 1601, 2024) COMMUNICATIONS BIOLOGY. 2025.05; 8 (1): 803. ( PubMed, DOI )
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Okuda, Y; Li, DR; Maruyama, Y; Sonobe, H; Mano, T; Tainaka, K; Shinohara, R; Furuyashiki, T. The activation of the piriform cortex to lateral septum pathway during chronic social defeat stress is crucial for the induction of behavioral disturbance in mice NEUROPSYCHOPHARMACOLOGY. 2025.04; 50 (5): 828-840. ( PubMed, DOI )
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Motooka, Y; Shinohara, R; Kitaoka, S; Uryu, A; Li, DR; Neyama, H; Cui, YL; Kida, T; Arakaki, W; Doi, H; Watanabe, Y; Furuyashiki, T. Alteration of COX-1 and TLR4 expression in the mouse brain during chronic social defeat stress revealed by Positron Emission Tomography study JOURNAL OF PHARMACOLOGICAL SCIENCES. 2025.03; 157 (3): 156-166. ( PubMed, DOI )
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Furuyashiki, T; Russo, SJ. Editorial: Neuroscience of resilience for mental health NEUROSCIENCE RESEARCH. 2025.02; 211 1-2. ( PubMed, DOI )
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Shinohara, R; Furuyashiki, T. Prefrontal contributions to mental resilience: Lessons from rodent studies of stress and antidepressant actions NEUROSCIENCE RESEARCH. 2025.02; 211 16-23. ( PubMed, DOI )
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Rui Yamada, Hirotaka Nagai, Io Horikawa, Wenran Qiu, Yunhui Zhu, Kohei Ota, Tomoyuki Furuyashiki.. C57BL/6J and C57BL/6N mice show distinct aging-associated behavioral alterations. Journal of Pharmacological Sciences. 2025; 157 (2): 124-129.
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Danya Thayaparan, Takuo Emoto, Aniqa B. Khan, Rickvinder Besla, Homaira Hamidzada, Mahmoud El-Maklizi, Tharini Sivasubramaniyam, Shabana Vohra, Ash Hagerman, Sara Nejat, Charlotte E Needham-Robbins, Tao Wang, Moritz Lindquist Steven R. Botts, Stephanie A. Schroer, Masayuki Taniguchi, Taishi Inoue, Katsuhiro Yamanaka, Haotian Cui, Edouard Al-Chami, Hangjun Zhang, Marwan G. Althagafi, Aja Michalski, Joshua JC McGrath, Steven P Cass, David Luong, Yuya Suzuki, Angela Li, Amina Abow, Rachel Heo, Shaun Pacheco, Emily Chen, Felix Chiu, John Byrne, Tomoyuki Furuyashiki, Mansoor Husain, Peter Libby, Kenji Okada, Kathryn L. Howe, Scott P. Heximer, Tomoya Yamashita, Bo Wang, Barry B Rubin, Myron I Cybulsky, Joy Roy, Jesse W Williams, Sarah Q Crome, Slava Epelman, Ken-ichi Hirata, Martin R Stampfli, Clinton S. Robbins.. Atherosclerotic plaque macrophages drive abdominal aortic aneurysm formation. Nature Immunology. 2025; 26 (5): 706-721.
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Okuda, Y; Li, DR; Maruyama, Y; Sonobe, H; Mano, T; Tainaka, K; Shinohara, R; Furuyashiki, T. OLFACTORY PROCESSING DURING CHRONIC SOCIAL DEFEAT STRESS IS CRUCIAL FOR THE INDUCTION OF BEHAVIORAL DISTURBANCE IN MICE NEUROPSYCHOPHARMACOLOGY. 2024.12; 49 583-584.
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Suzuki, Y; Emoto, T; Sato, S; Yoshida, T; Shoda, M; Endoh, H; Nagao, M; Hamana, T; Inoue, T; Hayashi, T; Nitta, E; Konishi, H; Kiuchi, K; Takami, M; Imamura, K; Taniguchi, M; Inoue, M; Nakamura, T; Sonoda, Y; Takahara, H; Nakasone, K; Yamamoto, K; Tani, K; Iwai, H; Nakanishi, Y; Yonehara, S; Murakami, A; Toh, R; Ohkawa, T; Furuyashiki, T; Nitta, R; Yamashita, T; Hirata, KI; Fukuzawa, K. Left atrial single-cell transcriptomics reveals amphiregulin as a surrogate marker for atrial fibrillation COMMUNICATIONS BIOLOGY. 2024.12; 7 (1): 1601. ( PubMed, DOI )
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Ayabe, T; Shinohara, M; Kita, M; Takahashi, C; Saito, J; Furuyashiki, T; Toba, K; Umeda, S; Ano, Y. Supplementation with whey peptide rich in β-lactolin improves trait anxiety and subjective stress in healthy adults: a randomized, double-blind, placebo-controlled study SCIENTIFIC REPORTS. 2024.10; 14 (1): 23444. ( PubMed, DOI )
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Inoue, T; Emoto, T; Yamanaka, K; Chomei, S; Miyahara, S; Takahashi, H; Shinohara, R; Kondo, T; Taniguchi, M; Furuyashiki, T; Yamashita, T; Hirata, KI; Okada, K. Intense impact of IL-1β expressing inflammatory macrophages in acute aortic dissection SCIENTIFIC REPORTS. 2024.06; 14 (1): 14893. ( PubMed, DOI )
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Takeda, S; Emoto, T; Yamashita, T; Yamamoto, H; Takaya, T; Sawada, T; Yoshida, T; Inoue, M; Suzuki, Y; Hamana, T; Inoue, T; Taniguchi, M; Sasaki, N; Otake, H; Ohkawa, T; Furuyashiki, T; Kawai, H; Hirata, K. Single-Cell RNA Sequencing Reveals an Immune Landscape of CD4<SUP>+</SUP> T Cells in Coronary Culprit Plaques With Acute Coronary Syndrome in Humans-Brief Report ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2024.05; 44 (5): 1135-1143. ( PubMed, DOI )
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Horikawa Io, Nagai Hirotaka, Taniguchi Masayuki, Chen Guowei, Shinohara Masakazu, Suzuki Tomohide, Ishii Shinichi, Katayama Yoshio, Kitaoka Shiho, Furuyashiki Tomoyuki. 慢性ストレスはマウスの骨髄と脾臓における免疫関連遺伝子発現と細胞構成に関連する脂質メディエータープロファイルを変化させる(Chronic stress alters lipid mediator profiles associated with immune-related gene expressions and cell compositions in mouse bone marrow and spleen) Journal of Pharmacological Sciences. 2024.04; 154 (4): 279-293. ( ichushi )
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Horikawa, I; Nagai, H; Taniguchi, M; Chen, GW; Shinohara, M; Suzuki, T; Ishii, S; Katayama, Y; Kitaoka, S; Furuyashiki, T. Chronic stress alters lipid mediator profiles associated with immune-related gene expressions and cell compositions in mouse bone marrow and spleen JOURNAL OF PHARMACOLOGICAL SCIENCES. 2024.04; 154 (4): 279-293. ( PubMed, DOI )
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Nishimori, M; Hayasaka, N; Otsui, K; Inoue, N; Asakura, J; Nagao, M; Toh, R; Ishida, T; Hirata, KI; Furuyashiki, T; Shinohara, M. Stress-induced stenotic vascular remodeling via reduction of plasma omega-3 fatty acid metabolite 4-oxoDHA by noradrenaline SCIENTIFIC REPORTS. 2024.02; 14 (1): 4178. ( PubMed, DOI )
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Jimbo, T; Matsuo, H; Imoto, Y; Sodemura, T; Nishimori, M; Fukui, Y; Hayashi, T; Furuyashiki, T; Yokoyama, R. Accelerated preprocessing of large numbers of brain images by parallel computing on supercomputers (vol 13, 19901, 2023) SCIENTIFIC REPORTS. 2024.01; 14 (1): 2233. ( PubMed, DOI )
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Shintaro Takeda, Takuo Emoto, Tomoya Yamashita, Hiroyuki Yamamoto, Tomofumi Takaya, Takahiro Sawada, Takeshi Yoshida, Masatoshi Inoue, Yuya Suzuki, Tomoyo Hamana, Taishi Inoue, Masayuki Taniguchi, Naoto Sasaki, Hiromasa Otake, Takenao Ohkawa, Tomoyuki Furuyashiki, Hiroya Kawai, Ken-ichi Hirata.. Single-Cell RNA Sequencing reveals an Immune Landscape of CD4+ T cells in Coronary Culprit Plaques with Acute Coronary Syndrome. Arteriosclerosis, Thrombosis, and Vascular Biology. 2024; 44 (5): 1135-1143.
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Taniguchi, M; Matsushita, K; Mishima, R; Kadota, M; Kuraku, S; Furuyashiki, T. Microglia Integrates Multiple Stress Signals Via Distinct Molecular Pathways for Behavioral Dysfunctions NEUROPSYCHOPHARMACOLOGY. 2023.12; 48 250.
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Jimbo, T; Matsuo, H; Imoto, Y; Sodemura, T; Nishimori, M; Fukui, Y; Hayashi, T; Furuyashiki, T; Yokoyama, R. Accelerated preprocessing of large numbers of brain images by parallel computing on supercomputers SCIENTIFIC REPORTS. 2023.11; 13 (1): 19901. ( PubMed, DOI )
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Kubota, H; Kunisawa, K; Wulaer, B; Hasegawa, M; Kurahashi, H; Sakata, T; Tezuka, H; Kugita, M; Nagao, S; Nagai, T; Furuyashiki, T; Narumiya, S; Saito, K; Nabeshima, T; Mouri, A. High salt induces cognitive impairment via the interaction of the angiotensin II-AT<sub>1</sub> and prostaglandin E2-EP<sub>1</sub> systems BRITISH JOURNAL OF PHARMACOLOGY. 2023.09; 180 (18): 2393-2411. ( PubMed, DOI )
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Kasakura, N; Murata, Y; Shindo, A; Kitaoka, S; Furuyashiki, T; Suzuki, K; Segi-Nishida, E. Overexpression of NT-3 in the hippocampus suppresses the early phase of the adult neurogenic process FRONTIERS IN NEUROSCIENCE. 2023.07; 17 1178555. ( PubMed, DOI )
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Kitaoka, S; Tomohiro, A; Ukeshima, S; Liu, KY; Wake, H; Kimura, SH; Yamamoto, Y; Nishibori, M; Furuyashiki, T. Repeated Social Defeat Stress Induces HMGB1 Nuclear Export in Prefrontal Neurons, Leading to Social Avoidance in Mice CELLS. 2023.07; 12 (13): 1789. ( PubMed, DOI )
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Mishima Rei, Taniguchi Masayuki, Matsushita Kazutoshi, Tian Bowen, Furuyashiki Tomoyuki. 明確なトランスクリプトームシグネチャーを持つミクログリア亜集団は安静マウス脳の脳領域によって異なる(Microglial subpopulations with distinct transcriptome signatures vary across brain regions in the resting mouse brain) Journal of Pharmacological Sciences. 2023.03; 151 (3): 142-147. ( ichushi )
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Mishima, R; Taniguchi, M; Matsushita, K; Tian, BW; Furuyashiki, T. Microglial subpopulations with distinct transcriptome signatures vary across brain regions in the resting mouse brain JOURNAL OF PHARMACOLOGICAL SCIENCES. 2023.03; 151 (3): 142-147. ( PubMed, DOI )
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Yu, ZQ; Sakai, M; Fukushima, H; Ono, C; Kikuchi, Y; Koyama, R; Matsui, K; Furuyashiki, T; Kida, S; Tomita, H. Microarray dataset of gene transcription in mouse microglia and peripheral monocytes in contextual fear conditioning DATA IN BRIEF. 2023.02; 46 108862. ( PubMed, DOI )
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Sakai, M; Yu, ZQ; Taniguchi, M; Picotin, R; Oyama, N; Stellwagen, D; Ono, C; Kikuchi, Y; Matsui, K; Nakanishi, M; Yoshii, H; Furuyashiki, T; Abe, T; Tomita, H. N-Acetylcysteine Suppresses Microglial Inflammation and Induces Mortality Dose-Dependently via Tumor Necrosis Factor-α Signaling INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2023.02; 24 (4): ( PubMed, DOI )
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Yamaguchi, Y; Hase, T; Shirakami, A; Shinohara, R; Kitaoka, S; Furuyashiki, T; Shimono, M. Network properties of the medial prefrontal cortex altered by chronic social stress in mice JOURNAL OF COMPUTATIONAL NEUROSCIENCE. 2023.01; 51 S86-S87.
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Nanami Kasakura, Yuka Murata, Asuka Shindo, Shiho Kitaoka, Tomoyuki Furuyashiki, Kanzo Suzuiki, Eri Segi-Nishida.. Overexpression of NT-3 in the hippocampus suppresses the early phase of the adult neurogenic process. Frontiers in Neuroscience. 2023; 17 1178555.
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Mai Sakai, Zhiqian Yu, Masayuki Taniguchi, Nanami Oyama, David Stellwagen, Chiaki Ono, Yoshie Kikuchi, Ko Matsui, Rosanne Picotin, Miharu Nakanishi, Hatsumi Yoshii, Tomoyuki Furuyashiki, Takaaki Abe, Hiroaki Tomita.. N-acetylcysteine suppresses microglial inflammation and induces mortality dose-dependently via tumor necrosis factor-α signaling. International Journal of Molecular Sciences. 2023; 24 (4): 3798.
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Hisayoshi Kubota, Kazuo Kunisawa, Bolati Wulaer, Masaya Hasegawa, Hitomi Kurahashi, Takatoshi Sakata, Hiroyuki Tezuka, Masanori Kugita, Shizuko Nagao, Taku Nagai, Tomoyuki Furuyashiki, Shuh Narumiya, Kuniaki Saito, Toshitaka Nabeshima, Akihiro Mouri.. High salt induces cognitive impairment via the interaction of angiotensin II-AT1 and prostaglandin E2-EP1 systems. British Journal of Pharmacology. 2023; 180 (18): 2393-2411.
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Shiho Kitaoka, Ayaka Tomohiro, Shinya Ukeshima, Keyue Liu, Hidenori Wake, Shinya H Kimura, Yasuhiko Yamamoto, Masahiro Nishibori, Tomoyuki Furuyashiki.. Repeated Social Defeat Stress Induces HMGB1 Nuclear Export in Prefrontal Neurons, Leading to Social Avoidance in Mice. Cells. 2023; 12 (13): 1789.
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Taniguchi, M; Matsushita, K; Mishima, R; Kadota, M; Kuraku, S; Furuyashiki, T. Transcriptional Machinery of Microglial Stress Response for Mental Illness Pathology NEUROPSYCHOPHARMACOLOGY. 2022.12; 47 246.
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Yoshiko, K; Nagano, K; Hu, CH; Furuyashiki, T. Relationship between dairy product intake and sense of coherence among middle and high school students in Japan PLOS ONE. 2022.12; 17 (12): e0279232. ( PubMed, DOI )
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Yu, ZQ; Sakai, M; Fukushima, H; Ono, C; Kikuchi, Y; Koyama, R; Matsui, K; Furuyashiki, T; Kida, S; Tomita, H. Contextual fear conditioning regulates synapse-related gene transcription in mouse microglia BRAIN RESEARCH BULLETIN. 2022.10; 189 57-68. ( PubMed, DOI )
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Sakate Risa, Nishiyama Masahiro, Fukuda Yu, Kitaoka Shiho, Furuyashiki Tomoyuki. 転写因子Hhexはミクログリアの炎症関連遺伝子を調節する(The transcription factor Hhex regulates inflammation-related genes in microglia) Journal of Pharmacological Sciences. 2022.07; 149 (3): 166-171. ( ichushi )
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Kawamura, N; Katsuura, G; Yamada-Goto, N; Nakama, R; Kambe, Y; Miyata, A; Furuyashiki, T; Narumiya, S; Ogawa, Y; Inui, A. Brain fractalkine-CX3CR1 signalling is anti-obesity system as anorexigenic and anti-inflammatory actions in diet-induced obese mice SCIENTIFIC REPORTS. 2022.07; 12 (1): 12604. ( PubMed, DOI )
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Akiyama, S; Nagai, H; Oike, S; Horikawa, I; Shinohara, M; Lu, YB; Futamura, T; Shinohara, R; Kitaoka, S; Furuyashiki, T. Chronic social defeat stress increases the amounts of 12-lipoxygenase lipid metabolites in the nucleus accumbens of stress-resilient mice SCIENTIFIC REPORTS. 2022.07; 12 (1): 11385. ( PubMed, DOI )
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Sakate R, Nishiyama M, Fukuda Y, Kitaoka S, Furuyashiki T. The transcription factor Hhex regulates inflammation-related genes in microglia. Journal of pharmacological sciences. 2022.07; 149 (3): 166-171. ( PubMed, DOI )
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Kawashima, Y; Nagai, H; Konno, R; Ishikawa, M; Nakajima, D; Sato, H; Nakamura, R; Furuyashiki, T; Ohara, O. Single-Shot 10K Proteome Approach: Over 10,000 Protein Identifications by Data-Independent Acquisition-Based Single-Shot Proteomics with Ion Mobility Spectrometry JOURNAL OF PROTEOME RESEARCH. 2022.06; 21 (6): 1418-1427. ( PubMed, DOI )
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Emoto, T; Yamamoto, H; Yamashita, T; Takaya, T; Sawada, T; Takeda, S; Taniguchi, M; Sasaki, N; Yoshida, N; Saito, Y; Sivasubramaniyam, T; Otake, H; Furuyashiki, T; Robbins, CS; Kawai, H; Hirata, K. Single-Cell RNA Sequencing Reveals a Distinct Immune Landscape of Myeloid Cells in Coronary Culprit Plaques Causing Acute Coronary Syndrome CIRCULATION. 2022.05; 145 (18): 1434-1436. ( PubMed, DOI )
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Ishikawa Yuka, Furuyashiki Tomoyuki. 【マルチスケール精神病態の構成的理解】ストレスが免疫系に及ぼす影響およびその精神疾患との関連(【Constructive Understanding of Multi-scale Dynamism of Neuropsychiatric Disorders】The impact of stress on immune systems and its relevance to mental illness) Neuroscience Research. 2022.02; 175 16-24. ( ichushi )
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Sakai, M; Yu, ZQ; Hirayama, R; Nakasato, M; Kikuchi, Y; Ono, C; Komatsu, H; Nakanishi, M; Yoshii, H; Stellwagen, D; Furuyashiki, T; Komatsu, M; Tomita, H. Deficient Autophagy in Microglia Aggravates Repeated Social Defeat Stress-Induced Social Avoidance NEURAL PLASTICITY. 2022.02; 2022 7503553. ( PubMed, DOI )
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Ishikawa, Y; Furuyashiki, T. The impact of stress on immune systems and its relevance to mental illness NEUROSCIENCE RESEARCH. 2022.02; 175 16-24. ( PubMed, DOI )
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Yuka Ishikawa, Tomoyuki Furuyashiki. . The impact of stress on immune systems and its relevance to mental illness. Neuroscience Research. 2022; 175 16-24.
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Mai Sakai, Zhiqian Yu, Ryo Hirayama, Masa Nakasato, Yoshie Kikuchi, Chiaki Ono, Hiroshi Komatsu, Miharu Nakanishi, Hatsumi Yoshii, David Stellwagen, Tomoyuki Furuyashiki, Masaaki Komatsu, Hiroaki Tomita.. Deficient Autophagy in Microglia Aggravates Repeated Social Defeat Stress-Induced Social Avoidance. Neural Plasticity. 2022; 2022 7503553.
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Takuo Emoto, Hiroyuki Yamamoto, Tomoya Yamashita, Tomofumi Takaya, Takahiro Sawada, Shintaro Takeda, Masayuki Taniguchi, Naoto Sasaki, Naofumi Yoshida, Yoshihiro Saito, Tharini Sivasubramaniyam, Hiromasa Otake, Tomoyuki Furuyashiki, Clinton S Robbins, Hiroya Kawai, Ken-ichi Hirata. . Single-Cell RNA Sequencing Reveals a Distinct Immune Landscape of Myeloid Cells in Coronary Culprit Plaques Causing Acute Coronary Syndrome. Circulation. 2022; 145 (18): 1434-1436.
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Yusuke Kawashima, Hirotaka Nagai, Ryo Konno, Masaki Ishikawa, Daisuke Nakajima, Hironori Sato, Ren Nakamura, Tomoyuki Furuyashiki, Osamu Ohara.. Single-Shot 10K Proteome Approach: Over 10,000 Protein Identifications by Data-Independent Acquisition-Based Single-Shot Proteomics with Ion Mobility Spectrometry. Journal of Proteome Research. 2022; 21 (6): 1418-1427.
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Satoshi Akiyama, Hirotaka Nagai, Shota Oike, Io Horikawa, Masakazu Shinohara, Yabin Lu, Takashi Futamura, Ryota Shinohara, Shiho Kitaoka, Tomoyuki Furuyashiki.. Chronic social defeat stress increases the amounts of 12-lipoxygenase lipid metabolites in the nucleus accumbens of stress-resilient mice. Scientific Reports. 2022; 12 (1): 11385.
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Namiko Kawamura, Goro Katsuura, Nobuko Yamada-Goto, Riho Nakama, Yuki Kambe, Atsuro Miyata, Tomoyuki Furuyashiki, Shuh Narumiya, Yoshihiro Ogawa, Akio Inui.. Brain fractalkine-CX3CR1 signalling is anti-obesity system as anorexigenic and anti-inflammatory actions in diet-induced obese mice. Scientific Reports. 2022; 12 (1): 12604.
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Zhiqian Yu, Mai Sakai, Hotaka Fukushima, Chiaki Ono, Yoshie Kikuchi, Ryuta Koyama, Ko Matsui, Tomoyuki Furuyashiki, Satoshi Kida, Hiroaki Tomita.. Contextual fear conditioning regulates synapse-related gene transcription in mouse microglia. Brain Research Bulletin. 2022; 189 57-68.
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Yoshiko Kato, Kazumi Nagano, Chenghong Hu, Tomoyuki Furuyashiki.. Relationship between dairy product intake and sense of coherence among middle and high school students in Japan. PLOS One. 2022; 17 (12): e0279232.
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Suzuki, T; Ishii, S; Shinohara, M; Kawano, Y; Wakahashi, K; Kawano, H; Sada, A; Minagawa, K; Hamada, M; Takahashi, S; Furuyashiki, T; Tan, NS; Matsui, T; Katayama, Y. Mobilization efficiency is critically regulated by fat via marrow PPARδ HAEMATOLOGICA. 2021.06; 106 (6): 1671-1683. ( PubMed, DOI )
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Kato Y, Shimomura Y, Takada Y, Furuyashiki T. Correlation Between Lactic Acid Bacteria Beverage Intake and Stress Resilience. The Kobe journal of medical sciences. 2021.04; 67 (1): E1-E6. ( PubMed )
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Sotoyama, H; Namba, H; Kobayashi, Y; Hasegawa, T; Watanabe, D; Nakatsukasa, E; Sakimura, K; Furuyashiki, T; Nawa, H. Resting-state dopaminergic cell firing in the ventral tegmental area negatively regulates affiliative social interactions in a developmental animal model of schizophrenia TRANSLATIONAL PSYCHIATRY. 2021.04; 11 (1): 236. ( PubMed, DOI )
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Ishikawa, Y; Kitaoka, S; Kawano, Y; Ishii, S; Suzuki, T; Wakahashi, K; Kato, T; Katayama, Y; Furuyashiki, T. Repeated social defeat stress induces neutrophil mobilization in mice: maintenance after cessation of stress and strain-dependent difference in response BRITISH JOURNAL OF PHARMACOLOGY. 2021.02; 178 (4): 827-844. ( PubMed, DOI )
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Hidekazu Sotoyama, Hisaaki Namba, Yutaro Kobayashi, Taku Hasegawa, Dai Watanabe, Ena Nakatsukasa, Kenji Sakimura, Tomoyuki Furuyashiki, Hiroyuki Nawa.. Resting-state dopaminergic cell firing in the ventral tegmental area negatively regulates affiliative social interactions in a developmental animal model of schizophrenia. Translational Psychiatry. 2021; 11 (1): 236.
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Tomohide Suzuki, Shinichi Ishii, Masakazu Shinohara, Yuko Kawano, Kanako Wakahashi, Hiroki Kawano, Akiko Sada, Kentaro Minagawa, Michito Hamada, Satoru Takahashi, Tomoyuki Furuyashiki, Nguan Soon Tan, Toshimitsu Matsui, Yoshio Katayama. . Mobilization efficiency is critically regulated by fat via marrow PPARδ. Haematologica. 2021; 106 (6): 1671-1683.
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Kato Yoshiko, Shimomura Yukari, Takada Yoshihiro, Furuyashiki Tomoyuki. 乳酸菌飲料摂取とストレス・レジリエンスとの相互関係(Correlation Between Lactic Acid Bacteria Beverage Intake and Stress Resilience) Kobe Journal of Medical Sciences. 2021; 67 (1): E1-E6. ( ichushi )
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Taniguchi, M; Matsushita, K; Kadota, M; Kuraku, S; Furuyashiki, T. Chronic Stress-Induced Epigenetic Changes of Microglia NEUROPSYCHOPHARMACOLOGY. 2020.12; 45 (SUPPL 1): 107-108.
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Chronic Stress-Induced Epigenetic Changes of Microglia 2020.12; 45 (SUPPL 1): 107-108.
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Ano, Y; Kitaoka, S; Ohya, R; Kondo, K; Furuyashiki, T. Hop Bitter Acids Increase Hippocampal Dopaminergic Activity in a Mouse Model of Social Defeat Stress INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2020.12; 21 (24): ( PubMed, DOI )
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Nagai, M; Nagai, H; Numa, C; Furuyashiki, T. Stress-induced sleep-like inactivity modulates stress susceptibility in mice SCIENTIFIC REPORTS. 2020.11; 10 (1): 19800. ( PubMed, DOI )
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Yoshioka Y, Inoue M, Yoshioka H, Kitakaze T, Furuyashiki T, Abe N, Ashida H. Enzymatically synthesized glycogen inhibited degranulation and inflammatory responses through stimulation of intestine. Journal of clinical biochemistry and nutrition. 2020.07; 67 (1): 67-73. ( PubMed, DOI )
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Kitakaze T, Yoshioka Y, Furuyashiki T, Ashida H. Enzymatically synthesized glycogen protects inflammation induced by urban particulate matter in normal human epidermal keratinocytes. Journal of clinical biochemistry and nutrition. 2020.07; 67 (1): 29-35. ( PubMed, DOI )
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Yoshioka Y, Kitakaze T, Mitani T, Furuyashiki T, Ashida H. Enzymatically synthesized glycogen prevents ultraviolet B-induced cell damage in normal human epidermal keratinocytes. Journal of clinical biochemistry and nutrition. 2020.07; 67 (1): 36-42. ( PubMed, DOI )
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Rajput, SK; Kumar, M; Quan, XY; Morita, M; Furuyashiki, T; Awatsuji, Y; Tajahuerce, E; Matoba, O. Three-dimensional fluorescence imaging using the transport of intensity equation JOURNAL OF BIOMEDICAL OPTICS. 2020.03; 25 (3): 1. ( PubMed, DOI )
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Tomohiro, A; Ukeshima, S; Kitaoka, S; Nie, X; Liu, KY; Wake, H; Teshigawara, K; Nishibori, M; Furuyashiki, T. Roles and Mechanisms of Neuroinflammation in Stress and Depression NEUROPSYCHOPHARMACOLOGY. 2019.12; 44 (SUPPL 1): 120-121.
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Roles and Mechanisms of Neuroinflammation in Stress and Depression 2019.12; 44 (SUPPL 1): 120-121.
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Furuyashiki, T; Kitaoka, S. Neural mechanisms underlying adaptive and maladaptive consequences of stress: Roles of dopaminergic and inflammatory responses PSYCHIATRY AND CLINICAL NEUROSCIENCES. 2019.11; 73 (11): 669-675. ( PubMed, DOI )
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Numa, C; Nagai, H; Taniguchi, M; Nagai, M; Shinohara, R; Furuyashiki, T. Social defeat stress-specific increase in c-Fos expression in the extended amygdala in mice: Involvement of dopamine D1 receptor in the medial prefrontal cortex SCIENTIFIC REPORTS. 2019.11; 9 (1): 16670. ( PubMed, DOI )
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Nie, X; Kitaoka, S; Shinohara, M; Kakizuka, A; Narumiya, S; Furuyashiki, T. Roles of Toll-like receptor 2/4, monoacylglycerol lipase, and cyclooxygenase in social defeat stress-induced prostaglandin E<sub>2</sub> synthesis in the brain and their behavioral relevance SCIENTIFIC REPORTS. 2019.11; 9 (1): 17548. ( PubMed, DOI )
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Ayabe, T; Ano, Y; Ohya, R; Kitaoka, S; Furuyashiki, T. The Lacto-Tetrapeptide Gly-Thr-Trp-Tyr, β-Lactolin, Improves Spatial Memory Functions via Dopamine Release and D1 Receptor Activation in the Hippocampus NUTRIENTS. 2019.10; 11 (10): ( PubMed, DOI )
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Furuyashiki Tomoyuki, Akiyama Satoshi, Kitaoka Shiho. ストレスと抑うつにおける複数の脂質仲介因子の役割(Roles of multiple lipid mediators in stress and depression) International Immunology. 2019.09; 31 (9): 579-587. ( ichushi )
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Ano, Y; Kita, M; Kitaoka, S; Furuyashiki, T. Leucine-Histidine Dipeptide Attenuates Microglial Activation and Emotional Disturbances Induced by Brain Inflammation and Repeated Social Defeat Stress NUTRIENTS. 2019.09; 11 (9): 2161. ( PubMed, DOI )
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Furuyashiki, T; Akiyama, S; Kitaoka, S. Roles of multiple lipid mediators in stress and depression INTERNATIONAL IMMUNOLOGY. 2019.09; 31 (9): 579-587. ( PubMed, DOI )
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Ishikawa, R; Uchida, C; Kitaoka, S; Furuyashiki, T; Kida, S. Improvement of PTSD-like behavior by the forgetting effect of hippocampal neurogenesis enhancer memantine in a social defeat stress paradigm MOLECULAR BRAIN. 2019.08; 12 (1): 68. ( PubMed, DOI )
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Okamura Satoshi, Nagai Hirotaka, Numa Chisato, Nagai Midori, Shinohara Ryota, Furuyashiki Tomoyuki. 社会的敗北ストレスはマウスの軟膜におけるextracellular signal-regulated kinaseのリン酸化を誘導する(Social defeat stress induces phosphorylation of extracellular signal-regulated kinase in the leptomeninges in mice) Neuropsychopharmacology Reports. 2019.06; 39 (2): 134-139. ( ichushi )
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Okamura S, Nagai H, Numa C, Nagai M, Shinohara R, Furuyashiki T. Social defeat stress induces phosphorylation of extracellular signal-regulated kinase in the leptomeninges in mice. Neuropsychopharmacology reports. 2019.06; 39 (2): 134-139. ( PubMed, DOI )
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Ano, Y; Hoshi, A; Ayabe, T; Ohya, R; Uchida, S; Yamada, K; Kondo, K; Kitaoka, S; Furuyashiki, T. Iso-α-acids, the bitter components of beer, improve hippocampus-dependent memory through vagus nerve activation FASEB JOURNAL. 2019.04; 33 (4): 4987-4995. ( PubMed, DOI )
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Ano, Y; Ayabe, T; Ohya, R; Kondo, K; Kitaoka, S; Furuyashiki, T. Tryptophan-Tyrosine Dipeptide, the Core Sequence of -Lactolin, Improves Memory by Modulating the Dopamine System NUTRIENTS. 2019.02; 11 (2): E348. ( PubMed, DOI )
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Chisato Numa, Hirotaka Nagai, Masayuki Taniguchi, Midori Nagai, Ryota Shinohara, Tomoyuki Furuyashiki.. Social defeat stress-specific increase in c-Fos expression in the extended amygdala in mice: Involvement of dopamine D1 receptor in the medial prefrontal cortex. Scientific Reports. 2019; 9 (1): 16670.
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Yasuhisa Ano, Tatsuhiro Ayabe, Rena Ohya, Keiji Kondo, Shiho Kitaoka, Tomoyuki Furuyashiki.. Tryptophan-Tyrosine Dipeptide, the Core Sequence of β-Lactolin, Improves Memory by Modulating the Dopamine System. Nutrients. 2019; 11 (2): 348.
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Rie Ishikawa, Chiaki Uchida, Shiho Kitaoka, Tomoyuki Furuyashiki, Satoshi Kida. . Improvement of PTSD-like behavior by the forgetting effect of hippocampal neurogenesis enhancer memantine in a social defeat stress paradigm. Molecular Brain. 2019; 12 (1): 68.
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Sudheesh K Rajput, Manoj Kumar, Xiangyu Quan, Mitsuhiro Morita, Tomoyuki Furuyashiki, Yasuhiro Awatsuji, Enrique Tajahuerce, Osamu Matoba.. Three-dimensional fluorescence imaging using the transport of intensity equation. Journal of Biomedical Optics. 2019; 25 (3): 1-7.
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Tatsuhiro Ayabe, Yasuhisa Ano, Rena Ohya, Shiho Kitaoka, Tomoyuki Furuyashiki.. The Lacto-Tetrapeptide Gly-Thr-Trp-Tyr, β-Lactolin, Improves Spatial Memory Functions via Dopamine Release and D1 Receptor Activation in the Hippocampus. Nutrients. 2019; 11 (10): 2469.
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Sumitomo, A; Yukitake, H; Hirai, K; Horike, K; Ueta, K; Chung, YJ; Warabi, E; Yanagawa, T; Kitaoka, S; Furuyashiki, T; Narumiya, S; Hirano, T; Niwa, M; Sibille, E; Hikida, T; Sakurai, T; Ishizuka, K; Sawa, A; Tomoda, T. <i>Ulk2</i> controls cortical excitatory-inhibitory balance via autophagic regulation of p62 and GABA<sub>A</sub> receptor trafficking in pyramidal neurons HUMAN MOLECULAR GENETICS. 2018.09; 27 (18): 3165-3176. ( PubMed, DOI )
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Shinohara, R; Taniguchi, M; Ehrlich, AT; Yokogawa, K; Deguchi, Y; Cherasse, Y; Lazarus, M; Urade, Y; Ogawa, A; Kitaoka, S; Sawas, A; Narumiya, S; Furuyashiki, T. Dopamine D1 receptor subtype mediates acute stress-induced dendritic growth in excitatory neurons of the medial prefrontal cortex and contributes to suppression of stress susceptibility in mice MOLECULAR PSYCHIATRY. 2018.08; 23 (8): 1717-1730. ( PubMed, DOI )
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Nie, X; Kitaoka, S; Tanaka, K; Segi-Nishida, E; Imoto, Y; Ogawa, A; Nakano, F; Tomohiro, A; Nakayama, K; Taniguchi, M; Mimori-Kiyosue, Y; Kakizuka, A; Narumiya, S; Furuyashiki, T. The Innate Immune Receptors TLR2/4 Mediate Repeated Social Defeat Stress-Induced Social Avoidance through Prefrontal Microglial Activation NEURON. 2018.08; 99 (3): 464-+. ( PubMed, DOI )
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Higashida, S; Nagai, H; Nakayama, K; Shinohara, R; Taniguchi, M; Nagai, M; Hikida, T; Yawata, S; Ago, Y; Kitaoka, S; Narumiya, S; Furuyashiki, T. Repeated social defeat stress impairs attentional set shifting irrespective of social avoidance and increases female preference associated with heightened anxiety SCIENTIFIC REPORTS. 2018.07; 8 (1): 10454. ( PubMed, DOI )
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Ota, H; Katanosaka, K; Murase, S; Furuyashiki, T; Narumiya, S; Mizumura, K. EP2 receptor plays pivotal roles in generating mechanical hyperalgesia after lengthening contractions SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS. 2018.03; 28 (3): 826-833. ( PubMed, DOI )
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Shu Higashida, Hirotaka Nagai, Kazuki Nakayama, Ryota Shinohara, Masayuki Taniguchi, Midori Nagai, Takatoshi Hikida, Satoshi Yawata, Yukio Ago, Shiho Kitaoka, Shuh Narumiya, Tomoyuki Furuyashiki. . Repeated social defeat stress impairs attentional set shifting irrespective of social avoidance and increases female preference associated with heightened anxiety. Scientific Reports. 2018; 8 (1): 10454.
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H Ota, K Katanosaka, S Murase, T Furuyashiki, S Narumiya, K Mizumura.. EP2 receptor plays pivotal roles in generating mechanical hyperalgesia after lengthening contractions. Scandinavian Journal of Medicine & Science in Sports. 2018; 28 (3): 826-833.
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Akiko Sumitomo, Hiroshi Yukitake, Kazuko Hirai, Kouta Horike, Keisho Ueta, Youjin Chung, Eiji Warabi, Toru Yanagawa, Shiho Kitaoka, Tomoyuki Furuyashiki, Shuh Narumiya, Tomoo Hirano, Minae Niwa, Etienne Sibille, Takatoshi Hikida, Takeshi Sakurai, Koko Ishizuka, Akira Sawa, Toshifumi Tomoda.. Ulk2 controls cortical excitatory-inhibitory balance via autophagic regulation of p62 and GABAA receptor trafficking in pyramidal neurons. Human Molecular Genetics. 2018; 27 (18): 3165-3176.
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Mitani T, Yoshioka Y, Furuyashiki T, Yamashita Y, Shirai Y, Ashida H. Enzymatically synthesized glycogen inhibits colitis through decreasing oxidative stress. Free radical biology & medicine. 2017.05; 106 355-367. ( PubMed, DOI )
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Ibi, M; Liu, JJ; Arakawa, N; Kitaoka, S; Kawaji, A; Matsuda, K; Iwata, K; Matsumoto, M; Katsuyama, M; Zhu, K; Teramukai, S; Furuyashiki, T; Yabe-Nishimura, C. Depressive-Like Behaviors Are Regulated by NOX1/NADPH Oxidase by Redox Modification of NMDA Receptor 1 JOURNAL OF NEUROSCIENCE. 2017.04; 37 (15): 4200-4212. ( PubMed, DOI )
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Elevated p62 and attenuated autophagy cause GABA receptor downregulation and underlie the pathophysiology of neuropsychiatric manifestation 2017.03; 133 (3): S221.
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Sumitomo, A; Ueta, K; Horike, K; Kitaoka, S; Furuyashiki, T; Hikida, T; Sakurai, T; Sawa, A; Tomoda, T; Narumiya, S. Elevated p62 and attenuated autophagy cause GABA receptor downregulation and underlie the pathophysiology of neuropsychiatric manifestation JOURNAL OF PHARMACOLOGICAL SCIENCES. 2017.03; 133 (3): S221.
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Kawano, Y; Fukui, C; Shinohara, M; Wakahashi, K; Ishii, S; Suzuki, T; Sato, M; Asada, N; Kawano, H; Minagawa, K; Sada, A; Furuyashiki, T; Uematsu, S; Akira, S; Uede, T; Narumiya, S; Matsui, T; Katayama, Y. G-CSF-induced sympathetic tone provokes fever and primes antimobilizing functions of neutrophils via PGE<sub>2</sub> BLOOD. 2017.02; 129 (5): 587-597. ( PubMed, DOI )
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Masakazu Ibi, Junjie Liu, Noriaki Arakawa, Shiho Kitaoka, Ai Kawaji, Ken-Ichi Matsuda, Kazumi Iwata, Misaki Matsumoto, Masato Katsuyama, Kai Zhu, Satoshi Teramukai, Tomoyuki Furuyashiki, Chihiro Yabe-Nishimura.. Depressive-Like Behaviors Are Regulated by NOX1/NADPH Oxidase by Redox Modification of NMDA Receptor 1. Journal of Neuroscience. 2017; 37 (15): 4200-4212.
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Yuko Kawano, Chie Fukui, Masakazu Shinohara, Kanako Wakahashi, Shinichi Ishii, Tomohide Suzuki, Mari Sato, Noboru Asada, Hiroki Kawano, Kentaro Minagawa, Akiko Sada, Tomoyuki Furuyashiki, Satoshi Uematsu, Shizuo Akira, Toshimitsu Uede, Shuh Narumiya, Toshimitsu Matsui, Yoshio Katayama.. G-CSF-induced sympathetic tone provokes fever and primes antimobilizing functions of neutrophils via PGE2. Blood. 2017; 129 (5): 587-597.
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Yuichi Deguchi, Masaya Harada, Ryota Shinohara, Michael Lazarus, Yoan Cherasse, Yoshihiro Urade, Daisuke Yamada, Masayuki Sekiguchi, Dai Watanabe, Tomoyuki Furuyashiki, Shuh Narumiya.. mDia and ROCK Mediate Actin-Dependent Presynaptic Remodeling Regulating Synaptic Efficacy and Anxiety. Cell Reports. 2016; 17 (9): 2405-2417.
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Qingyun, Yan Ma, Toshiaki Kato, Tomoyuki Furuyashiki. . Genetic Interactions among AMPK Catalytic Subunit Ssp2 and Glycogen Synthase Kinases Gsk3 and Gsk31 in Schizosaccharomyces Pombe. Kobe Journal of Medical Sciences. 2016; 62 (3): E70-E78.
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Ning Ma, Yan Ma, Akio Nakashima, Ushio Kikkawa, Tomoyuki Furuyashiki.. The Loss of Lam2 and Npr2-Npr3 Diminishes the Vacuolar Localization of Gtr1-Gtr2 and Disinhibits TORC1 Activity in Fission Yeast. PLoS One. 2016; 11 (5): e0156239.
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Chiung-Yuan Ko, Yu-Yi Chu, Shuh Narumiya, Jhih-Ying Chi, Tomoyuki Furuyashiki, Tomohiro Aoki, Shao-Ming Wang, Wen-Chang Chang, Ju-Ming Wang.. CCAAT/enhancer-binding protein delta/miR135a/thrombospondin 1 axis mediates PGE2-induced angiogenesis in Alzheimer's disease. Neurobiology of Aging. 2015; 36 (3): 1356-1368.
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Lingling Hu, Yue Fang, Tsutomu Hayafuji, Yan Ma, Tomoyuki Furuyashiki.. Azoles activate Atf1-mediated transcription through MAP kinase pathway for antifungal effects in fission yeast. Genes to Cells. 2015; 20 (9): 695-705.
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Xibo Zhang, Yue Fang, Wurentuya Jaiseng, Lingling Hu, Yabin Lu, Yan Ma, Tomoyuki Furuyashiki. . Characterization of Tamoxifen as an Antifungal Agent Using the Yeast Schizosaccharomyces Pombe Model Organism. Kobe Journal of Medical Sciences. 2015; 61 (2): E54-E63.
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Qingbin Liu, Yan Ma, Xin Zhou, Tomoyuki Furuyashiki. . Constitutive Tor2 Activity Promotes Retention of the Amino Acid Transporter Agp3 at Trans-Golgi/Endosomes in Fission Yeast. PLoS One. 2015; 10 (10): e0139045.
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Yan Ma, Ning Ma, Qingbin Liu, Yao Qi, Ri-ichiroh Manabe, Tomoyuki Furuyashiki.. Tor Signaling Regulates Transcription of Amino Acid Permeases through a GATA Transcription Factor Gaf1 in Fission Yeast. PLOS One. 2015; 10 (12): e0144677.
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Tetsushi Hirano, Shogo Yanai, Takuya Omotehara, Rie Hashimoto, Yuria Umemura, Naoto Kubota, Kiichi Minami, Daichi Nagahara, Eiko Matsuo, Yoshiko Aihara, Ryota Shinohara, Tomoyuki Furuyashiki, Youhei Mantani, Toshifumi Yokoyama, Hiroshi Kitagawa, Nobuhiko Hoshi. . The combined effect of clothianidin and environmental stress on the behavioral and reproductive function in male mice. Journal of Veterinary Science. 2015; 77 (10): 1207-1215.
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Wugangerile Sartagul, Xin Zhou, Yuki Yamada, Ning Ma, Katsunori Tanaka, Tomoyuki Furuyashiki, Yan Ma.. The MluI cell cycle box (MCB) motifs, but not damage-responsive elements (DREs), are responsible for the transcriptional induction of the rhp51+ gene in response to DNA replication stress. PLoS One. 2014; 9 (11): e111936.
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Aliza T Ehrlich, Tomoyuki Furuyashiki, Shiho Kitaoka, Akira Kakizuka, Shuh Narumiya. . Prostaglandin E receptor EP1 forms a complex with dopamine D1 receptor and directs D1-induced cAMP production to adenylyl cyclase 7 through mobilizing G(βγ) subunits in human embryonic kidney 293T cells. Molecular Pharmacology. 2013; 84 (3): 476-486.
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Yoshiko Matsumoto Ikushima, Fumio Arai, Kentaro Hosokawa, Hirofumi Toyama, Keiyo Takubo, Tomoyuki Furuyashiki, Shuh Narumiya, Toshio Suda. . Prostaglandin E(2) regulates murine hematopoietic stem/progenitor cells directly via EP4 receptor and indirectly through mesenchymal progenitor cells. Blood. 2013; 121 (11): 1995-2007.
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Yosuke Toyoda, Ryota Shinohara, Dean Thumkeo, Hiroshi Kamijo, Hiroshi Nishimaru, Hiroyuki Hioki, Takeshi Kaneko, Toshimasa Ishizaki, Tomoyuki Furuyashiki, Shuh Narumiya. . EphA4-dependent axon retraction and midline localization of Ephrin-B3 are disrupted in the spinal cord of mice lacking mDia1 and mDia3 in combination. Genes to Cells. 2013; 18 (10): 873-885.
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Tomoyuki Furuyashiki.. Roles of dopamine and inflammation-related molecules in behavioral alterations caused by repeated stress. Journal of Pharmacological Sciences. 2012; 120 (2): 63-69.
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Kiyomi Hamaguchi, Norio Yamamoto, Takayuki Nakagawa, Tomoyuki Furuyashiki, Shuh Narumiya, Juichi Ito.. Role of PGE-type receptor 4 in auditory function and noise-induced hearing loss in mice. Neuropharmacology. 2012; 62 (4): 1841-1847.
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Ryota Shinohara, Dean Thumkeo, Hiroshi Kamijo, Naoko Kaneko, Kazunobu Sawamoto, Keisuke Watanabe, Hirohide Takebayashi, Hiroshi Kiyonari, Toshimasa Ishizaki, Tomoyuki Furuyashiki, Shuh Narumiya.. A role for mDia, a Rho-regulated actin nucleator, in tangential migration of interneuron precursors. Nature Neuroscience. 2012; 15 (3): 373-380.
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Kohei Tanaka, Tomoyuki Furuyashiki, Shiho Kitaoka, Yuta Senzai, Yuki Imoto, Eri Segi-Nishida, Yuichi Deguchi, Richard M Breyer, Matthew D Breyer, Shuh Narumiya.. Prostaglandin E2-mediated attenuation of mesocortical dopaminergic pathway is critical for susceptibility to repeated social defeat stress in mice. Journal of Neuroscience. 2012; 32 (12): 4319-4329.
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Kentaro Kaneko, Michael Lazarus, Chihiro Miyamoto, Yo Oishi, Nanae Nagata, Shuzhang Yang, Masaaki Yoshikawa, Kosuke Aritake, Tomoyuki Furuyashiki, Shuh Narumiya, Yoshihiro Urade, Kousaku Ohinata.. Orally administered rubiscolin-6, a δ opioid peptide derived from Rubisco, stimulates food intake via leptomeningeal lipocallin-type prostaglandin D synthase in mice. Molecular Nutrition & Food Research. 2012; 56 (8): 1315-1323.
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Shuh Narumiya, Tomoyuki Furuyashiki.. Fever, inflammation, pain and beyond: prostanoid receptor research during these 25 years. FASEB Journal. 2011; 25 (3): 813-1847.
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T Aoki, M Nishimura, T Matsuoka, K Yamamoto, T Furuyashiki, H Kataoka, S Kitaoka, R Ishibashi, A Ishibazawa, S Miyamoto, R Morishita, J Ando, N Hashimoto, K Nozaki, S Narumiya. . PGE(2) -EP(2) signalling in endothelium is activated by haemodynamic stress and induces cerebral aneurysm through an amplifying loop via NF-κB. British Journal of Pharmacology. 2011; 163 (6): 1237-1249.
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Chihiro Suzuki, Chihiro Miyamoto, Tomoyuki Furuyashiki, Shuh Narumiya, Kousaku Ohinata. . Central PGE2 exhibits anxiolytic-like activity via EP1 and EP4 receptors in a manner dependent on serotonin 5-HT1A, dopamine D1 and GABAA receptors. FEBS Letters. 2011; 585 (14): 2357-2362.
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Tomoyuki Mitsumori, Tomoyuki Furuyashiki, Toshihiko Momiyama, Akinori Nishi, Takahide Shuto, Takashi Hayakawa, Fumitaka Ushikubi, Shiho Kitaoka, Tomohiro Aoki, Haruhisa Inoue, Toshiyuki Matsuoka, Shuh Narumiya.. Thromboxane receptor activation enhances striatal dopamine release, leading to suppression of GABAergic transmission and enhanced sugar intake. European Journal of Neuroscience. 2011; 34 (4): 594-604.
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Dean Thumkeo, Ryota Shinohara, Keisuke Watanabe, Hirohide Takebayashi, Yosuke Toyoda, Kiyoshi Tohyama, Toshimasa Ishizaki, Tomoyuki Furuyashiki, Shuh Narumiya.. Deficiency of mDia, an actin nucleator, disrupts integrity of neuroepithelium and causes periventricular dysplasia. PLoS One. 2011; 6 (9): e25465.
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Tomoyuki Furuyashiki, Shuh Narumiya.. Stress responses: the contribution of prostaglandin E(2) and its receptors. Nature Reviews Endocrinology. 2011; 7 (3): 163-175.
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Tomoyuki Furuyashiki, Shuh Narumiya.. Roles of prostaglandin E receptors in stress responses. Current Opinion in Pharmacology. 2009; 9 (1): 31-38.
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Yasuhiro Tanaka, Tomoyuki Furuyashiki, Toshihiko Momiyama, Hisaaki Namba, Akira Mizoguchi, Tomoyuki Mitsumori, Tetsuro Kayahara, Hitoshi Shichi, Kazushi Kimura, Toshiyuki Matsuoka, Hiroyuki Nawa, Shuh Narumiya. . Prostaglandin E receptor EP1 enhances GABA-mediated inhibition of dopaminergic neurons in the substantia nigra pars compacta and regulates dopamine level in the dorsal striatum. European Journal of Neuroscience. 2009; 30 (12): 2338-2346.
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Reiko Hanada, Andreas Leibbrandt, Toshikatsu Hanada, Shiho Kitaoka, Tomoyuki Furuyashiki, Hiroaki Fujihara, Jean Trichereau, Magdalena Paolino, Fatimunnisa Qadri, Ralph Plehm, Steffen Klaere, Vukoslav Komnenovic, Hiromitsu Mimata, Hironobu Yoshimatsu, Naoyuki Takahashi, Arndt von Haeseler, Michael Bader, Sara Sebnem Kilic, Yoichi Ueta, Christian Pifl, Shuh Narumiya, Josef M Penninger. . Central control of fever and female body temperature by RANKL/RANK. Nature. 2009; 462 505-509.
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Tomoyuki Furuyashiki, Peter C Holland, Michela Gallagher.. Rat orbitofrontal cortex separately encodes response and outcome information during performance of goal-directed behavior. Journal of Neuroscience. 2008; 28 (19): 5127-5138.
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Tomoyuki Furuyashiki, Michela Gallagher.. Neural encoding in the orbitofrontal cortex related to goal-directed behavior. Annals of the New York Academy of Sciences. 2007; 1121 193-215.
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Miyako Nagamachi, Daiji Sakata, Kenji Kabashima, Tomoyuki Furuyashiki, Takahiko Murata, Eri Segi-Nishida, Kitipong Soontrapa, Toshiyuki Matsuoka, Yoshiki Miyachi, Shuh Narumiya.. Facilitation of Th1-mediated immune response by prostaglandin E receptor EP1. Journal of Experimental Medicine. 2007; 204 (12): 2865-2874.
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Shiho Kitaoka, Tomoyuki Furuyashiki, Akinori Nishi, Takahide Shuto, Sho Koyasu, Toshiyuki Matsuoka, Masayuki Miyasaka, Paul Greengard, Shuh Narumiya.. Prostaglandin E2 acts on EP1 receptor and amplifies both dopamine D1 and D2 receptor signaling in the striatum. Journal of Neuroscience. 2007; 27 (47): 12900-12907.
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Shogo Ohmae, Sayaka Takemoto-Kimura, Michiko Okamura, Aki Adachi-Morishima, Mio Nonaka, Toshimitsu Fuse, Satoshi Kida, Masahiro Tanji, Tomoyuki Furuyashiki, Yoshiki Arakawa, Shuh Narumiya, Hiroyuki Okuno, Haruhiko Bito.. 74. Shogo Ohmae, Sayaka Takemoto-Kimura, Michiko Okamura, Aki Adachi-Morishima, Mio Nonaka, Toshimitsu Fuse, Satoshi Kida, Masahiro Tanji, Tomoyuki Furuyashiki, Yoshiki Arakawa, Shuh Narumiya, Hiroyuki Okuno, Haruhiko Bito. Journal of Biological Chemistry. 2006; 281 (29): 20427-20439.
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Yoko Matsuoka, Tomoyuki Furuyashiki, Kiyofumi Yamada, Taku Nagai, Haruhiko Bito, Yasuhiro Tanaka, Shiho Kitaoka, Fumitaka Ushikubi, Toshitaka Nabeshima, Shuh Narumiya.. Prostaglandin E receptor EP1 controls impulsive behavior under stress. Proceedings of the National Academy of Sciences. 2005; 102 (44): 16066-16071.
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Yosuke Morishima, Tsuyoshi Miyakawa, Tomoyuki Furuyashiki, Yasuhiro Tanaka, Hiroshi Mizuma, Shigetada Nakanishi.. Enhanced cocaine responsiveness and impaired motor coordination in metabotropic glutamate receptor subtype 2 knockout mice. Proceedings of the National Academy of Sciences. 2005; 102 (11): 4170-4175.
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Yoshiki Arakawa, Haruhiko Bito, Tomoyuki Furuyashiki, Takahiro Tsuji, Sayaka Takemoto-Kimura, Kazuhiro Kimura, Kazuhiko Nozaki, Nobuo Hashimoto, Shuh Narumiya.. Control of axon elongation via an SDF-1alpha/Rho/mDia pathway in cultured cerebellar granule neurons. Journal of Cell Biology. 2003; 161 (2): 381-391.
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Sayaka Takemoto-Kimura, Hisashi Terai, Maki Takamoto, Shogo Ohmae, Shoko Kikumura, Eri Segi, Yoshiki Arakawa, Tomoyuki Furuyashiki, Shuh Narumiya, Haruhiko Bito.. Molecular cloning and characterization of CLICK-III/CaMKIgamma, a novel membrane-anchored neuronal Ca2+/calmodulin-dependent protein kinase (CaMK). Journal of Biological Chemistry. 2003; 278 (20): 18597-18605.
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Yoko Matsuoka, Tomoyuki Furuyashiki, Haruhiko Bito, Fumitaka Ushikubi, Yasuhiro Tanaka, Takuya Kobayashi, Seiji Muro, Noriko Satoh, Tetsuro Kayahara, Mikito Higashi, Akira Mizoguchi, Hitoshi Shichi, Yoshihiro Fukuda, Kazuwa Nakao, Shuh Narumiya.. Impaired adrenocorticotropic hormone response to bacterial endotoxin in mice deficient in prostaglandin E receptor EP1 and EP3 subtypes. Proceedings of the National Academy of Sciences. 2003; 100 (7): 4132-4137.
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Takahiro Tsuji, Toshimasa Ishizaki, Muneo Okamoto, Chiharu Higashida, Kazuhiro Kimura, Tomoyuki Furuyashiki, Yoshiki Arakawa, Raymond B Birge, Tetsuya Nakamoto, Hisamaru Hirai, Shuh Narumiya.. ROCK and mDia1 antagonize in Rho-dependent Rac activation in Swiss 3T3 fibroblasts. Journal of Cell Biology. 2002; 157 (5): 819-830.
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Tomoyuki Furuyashiki, Yoshiki Arakawa, Sayaka Takemoto-Kimura, Haruhiko Bito, Shuh Narumiya. . Multiple spatiotemporal modes of actin reorganization by NMDA receptors and voltage-gated Ca2+ channels. Proceedings of the National Academy of Sciences. 2002; 99 (22): 14458-14463.
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T Ishizaki, Y Morishima, M Okamoto, T Furuyashiki, T Kato, S Narumiya.. Coordination of microtubules and the actin cytoskeleton by the Rho effector mDia1. Nature Cell Biology. 2001; 3 (1): 8-14.
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P Madaule, T Furuyashiki, M Eda, H Bito, T Ishizaki, S Narumiya.. Citron, a Rho target that affects contractility during cytokinesis. Microscopy Research and Technique. 2000; 49 (2): 123-126.
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H Bito, T Furuyashiki, H Ishihara, Y Shibasaki, K Ohashi, K Mizuno, M Maekawa, T Ishizaki, S Narumiya.. A critical role for a Rho-associated kinase, p160ROCK, in determining axon outgrowth in mammalian CNS neurons. Neuron. 2000; 26 (2): 431-441.
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T Furuyashiki, K Fujisawa, A Fujita, P Madaule, S Uchino, M Mishina, H Bito, S Narumiya. . Citron, a Rho-target, interacts with PSD-95/SAP-90 at glutamatergic synapses in the thalamus. Journal of Neuroscience. 1999; 19 (1): 109-118.
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T Reid, T Furuyashiki, T Ishizaki, G Watanabe, N Watanabe, K Fujisawa, N Morii, P Madaule, S Narumiya.. Rhotekin, a new putative target for Rho bearing homology to a serine/threonine kinase, PKN, and rhophilin in the rho-binding domain. Journal of Biological Chemistry. 1996; 271 (23): 13556-13560.
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P Madaule, T Furuyashiki, T Reid, T Ishizaki, G Watanabe, N Morii, S Narumiya.. A novel partner for the GTP-bound forms of rho and rac. FEBS Letters. 1995; 377 (2): 243-248.
Books etc 【 display / non-display 】
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Furuyashiki T, Kitaoka S.. Part III Lipid Mediators and Diseases, 22. Roles and actions of arachidonic acid-derived bioactive lipids in stress-related behaviors. 315-328, Takehiko Yokomizo, Makoto Murakami eds., Bioactive Lipid Mediators Current Reviews and Protocols. Springer. 2015
Conference Activities & Talks 【 display / non-display 】
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1. Hirotaka Nagai, Kohei Ota, Chisato Numa, Midori Nagai, Wenran Qiu, Masayuki Taniguchi, Tomomi Yamashita, Kotaro Mizuta, Yusuke Kawashima, Nobuhiko Ohno, Yosky Kataoka, Shuichi Shimma, Yuko Mimori-Kiyosue, Taro Kato, Yasunori Hayashi, Tomoyoshi Soga, Tomoyuki Furuyashiki . Stress-induced alterations in synaptic metabolism and their behavioral relevance. American College of Neuropsychopharmacology 2026 2026.01.14
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Tomoyuki Furuyashiki. Neuro-Immune-Metabolic Crosstalk Underlying Stress-Related Brain Pathology. Symposium,International Symposium of Neuroimmunology 2025 2025.10.06
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Tomoyuki Furuyashiki. Neuroimmunology of Stress. Global Schools of Neuroimmunology (GSNI),International Symposium of Neuroimmunology 2025 2025.10.05
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Tomoyuki Furuyashiki. Roles and Mechanisms of Stress-Induced Neuroinflammation in Mental Illness. Pre-congress symposium, International Symposium of Neuroimmunology 2025 2025.10.04
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Tomoyuki Furuyashiki. Microglia integrates multiple stress signals via distinct molecular pathways for behavioral dysfunctions. CINP-AsCNP (International and Asian College of Neuropsychopharmacology) 2025 2025.06.18
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Tomoyuki Furuyashiki. Decoding Neuroimmune Mechanisms in Stress-Related Neuropsychiatric Disorders. CINP-AsCNP (International and Asian College of Neuropsychopharmacology) 2025 2025.06.16
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鈴木 雄也, 江本 拓央, 佐藤 俊輔, 遠藤 広美, 井上 大志, 林 友鴻, 仁田 英里子, 小西 弘樹, 木内 邦彦, 高見 充, 谷口 将之, 古屋敷 智之, 仁田 亮, 山下 智也, 平田 健一, 福沢 公二. Single cell RNA sequencing解析によって明らかになる心房細動患者における左房の異なる免疫ランドスケープ(Single Cell RNA Sequencing Reveals a Distinct Immune Landscape in the Left Atria in Atrial Fibrillation Patients). 日本心臓病学会学術集会抄録 2023.09.01
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Ishida Shunto, Kitaoka Shiho, Furuyashiki Tomoyuki, Narumiya Shu, Matsumura Kiyoshi. 脳出血発熱におよぼすミクログリア特異的COX-1ノックアウトの影響(Effect of microglia-specific cyclooxygenase-1 knockout on fever induced by cerebral hemorrhage). The Journal of Physiological Sciences 2023.05.01
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古屋敷 智之. Neuroscienceの最前線 ストレスによる脳病態の生物学的基盤(Biological basis of stress-induced brain pathology). 日本眼科学会雑誌 2023.03.01
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古屋敷 智之. Integrative control of physiological responses by neuropeptides 慢性ストレスと複数のinflammatory axes(Chronic stress and multiple inflammatory axes). 日本内分泌学会雑誌 2022.03.01
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Furuyashiki Tomoyuki. 心理ストレスの神経機構 分子機序、回路から病態の理解へ 社会ストレスによる脳内炎症反応の多様な役割(Neural Mechanism of Psychological Stress: Molecules, Circuits and Disorders Multiple roles of social stress-induced inflammatory responses in the brain). The Journal of Physiological Sciences 2020.03.01
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Numa Chisato, Nagai Hirotaka, Furuyashiki Tomoyuki. マウスの社会的な敗北ストレスに対する復元力に重要な役割を果たす内側前前頭皮質からのニューロン投射の解明(Elucidating neuronal projections from the medial prefrontal cortex responsible for the resilience to social defeat stress in mice). 日本組織細胞化学会総会・学術集会講演プログラム・予稿集 2019.09.01
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Sumitomo Akiko, Ueta Keisho, Horike Kouta, Kitaoka Shiho, Furuyashiki Tomoyuki, Hikida Takatoshi, Sakurai Takeshi, Sawa Akira, Tomoda Toshifumi, Narumiya Shuh. p62増大とオートファジー減弱はGABA受容体ダウンレギュレーションをもたらし、神経精神症状の病態生理の根底をなす(Elevated p62 and attenuated autophagy cause GABA receptor downregulation and underlie the pathophysiology of neuropsychiatric manifestation). Journal of Pharmacological Sciences 2017.03.01
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Furuyashiki Tomoyuki. ストレスおよび抑うつにおけるprostaglandinと自然免疫分子の間のクロストーク(A crosstalk between prostaglandins and innate immune molecules in stress and depression). Journal of Pharmacological Sciences 2017.03.01
Awards & Honors 【 display / non-display 】
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Ebashi-Setsuro Award,Japanese Pharmacological Society,2026.03
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AsCNP Science Award,Asian College of Neuropsychopharmacology,2025.06
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CINP Sumitomo Pharma Brain Health Basic Research Award,CINP (The International College of Neuropsychopharmacology),2024.05
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President's award,Kobe University,2018.10
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The Astellas Foundation for Research on Metabolic Disorders The Best President's Award,The Astellas Foundation for Research on Metabolic Disorders,2015.11
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Japanese Pharmacological Society The Young Investigator Award,Japanese Pharmacological Society,2012.03
Campus class subject 【 display / non-display 】
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Second-year, Faculty of Medicine, "Pharmacology",2025 - Now
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Second year, Faculty of Medicine, "Neuroscience / Basic",2025 - Now
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"Pharmacology" for third year students of the Faulty of Dentistry,2026 - Now
Ability of educational 【 display / non-display 】
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New Pharmacology 8th edition (Nankodo)