Personnel Information

写真a

OKITA Hikari


Job title

Assistant Professor

Homepage URL

https://softmater.energy.nagoya-u.ac.jp/index_en.html

Research Areas, Keywords

Artificial nucleic acid, Chemical ligation, Template-directed synthesis, DNA, Artificial life, Self-assembly, Origin of life

Field Introduction URL

https://softmater.energy.nagoya-u.ac.jp/index_en.html

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Graduating School 【 display / non-display 】

  • Shizuoka University, Faculty of Engineering, Applied Chemistry and Biochemical Engineering, 2020.03, Graduated

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Graduate School 【 display / non-display 】

  • Nagoya University, Graduate School, Division of Engineering, Biomolecular Engineering, Master's Course, 2022.03, Completed

  • Nagoya University, Graduate School, Division of Engineering, Biomolecular Engineering, Doctor's Course, 2025.03, Completed

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Degree 【 display / non-display 】

  • Ph. D. (Engineering), Nagoya University

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Campus Career 【 display / non-display 】

  • 2025.04
    -
    Now
    Institute of Science Tokyo， -， Institute of Integrated Research， Division of Biomedical Materials， Soft Matter and Biomedical Engineering， Assistant Professor
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External Career 【 display / non-display 】

  • 2024.06
    -
    2024.09
    MRC Laboratory of Molecular Biology,
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Academic Society Affiliations 【 display / non-display 】

  • The Society of Polymer Science, Japan (SPSJ)

  • Japanese Society for Origins of Life and Astrobiology

  • The Biophysical Society of Japan

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Research Areas 【 display / non-display 】

  • Bioorganic chemistry

  • Polymer chemistry

  • Chemical biology

  • Chemistry and chemical methodology of biomolecules

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Qualification Acquired 【 display / non-display 】

  • Usual Car License (AT limitation)

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Research Theme 【 display / non-display 】

  • Controlling template-directed synthesis and structure of artificial nucleic acid by liquid-liquid phase separation, 2023.10 - 2026.03

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Published Papers & Misc 【 display / non-display 】

  1. Sayuri Takeo , Maiko Tabata , Hikari Okita , Natsuki Shibata , Kohei Sato , Nobuyuki Mase , Takanori Oyoshi , Tetsuo Narumi. Identification of Guanine-Quadruplex-Binding Peptides from the RGG3 Domain of TLS/FUS Chemical and Pharmaceutical Bulletin. 2025.07;

  2. Hikari Okita , Keiji Murayama , Hiroyuki Asanuma. Chirality-Promoted Chemical Ligation and Reverse Transcription of Acyclic Threoninol Nucleic Acid Journal of the American Chemical Society. 2025.04; ( DOI )

  3. Hikari Okita , Keiji Murayama , Hiroyuki Asanuma. Highly Effective Chemical Ligation of DNA and L-aTNA Current Protocols. 2025.03; 5 (5): e70140. ( PubMed, DOI )

  4. Highly Functional Acyclic Xeno Nucleic Acids 2023.10; 96 (10): 1179-1187. ( DOI )

  5. Hikari Okita, Shuto Kondo, Keiji Murayama, Hiroyuki Asanuma. Rapid Chemical Ligation of DNA and Acyclic Threoninol Nucleic Acid (aTNA) for Effective Nonenzymatic Primer Extension JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 2023.07; 145 (32): 17872-17880. ( DOI )

  6. Keiji Murayama, Hikari Okita, Takumi Kuriki, Hiroyuki Asanuma. Nonenzymatic polymerase-like template-directed synthesis of acyclic l-threoninol nucleic acid Nature Communications. 2021.02; 12 (1): ( DOI )

  7. Hikari Okita, Yuna Kato, Tatsuki Masuzawa, Kosuke Arai, Sayuri Takeo, Kohei Sato, Nobuyuki Mase, Takanori Oyoshi, Tetsuo Narumi. Stereoselective synthesis of Gly-Gly-type (<i>E</i>)-methylalkene and (<i>Z</i>)-chloroalkene dipeptide isosteres and their application to 14-mer RGG peptidomimetics 2020.08; 10 (49): 29373-29377. ( DOI )

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Conference Activities & Talks 【 display / non-display 】

  1. Hikari Okita. Pseudo replication and transcription system for L-aTNA-based artificial Life. The 2nd US/Japan Joint Workshop between WSE/JHU and IBB/TMDU on Biosensing and Bioengineering 2025.08.07

  2. Hikari Okita. Pseudo replication and transcription system for L-aTNA-based artificial Life. The 2nd US/Japan Joint Workshop between WSE/JHU and IBB/TMDU on Biosensing and Bioengineering 2025.08.07

  3. Hikari Okita. Artificial Genetic Systems Based on Chemical Template-Directed Synthesis. International Symposium on Molecular Cybernetics 2025 2025.06.10

  4. 沖田ひかり. Nonenzymatic Replication and Transcription of Unnatural Nucleic Acid Derived from L-Threonine. ELSIセミナー 2025.03.12

  5. Hikari Okita, Keiji Murayama, Hiroyuki Asanuma. Transcription System of L-aTNA Based on Improvement of Chemical Template-Directed Synthesis by Chiral Scaffold. 第73回高分子討論会 2024.09.27

  6. Nonenzymatic Replication of Acyclic Artificial Nucleic Acid Derived from L-Threonine. 2024.04.24

  7. Hikari Okita, Keiji Murayama, Hiroyuki Asanuma. Chemical Template-Directed Synthesis for Replication of Acyclic L-Threoninol Nucleic Acids. ISMSC 2023 2023.06.01 アイスランド レイキャビク

  8. Hikari Okita, Keiji Murayama, Hiroyuki Asanuma. Elongation of long L-aTNA strand based on the kinetic analysis of chemical template-directed synthesis. ISNAC 2022 2022.11.01

  9. Hikari Okita, Keiji Murayama, Hiroyuki Asanuma. Nonenzymatic pseudo-primer extension reaction for replication and reverse transcription of acyclic L-threoninol nucleic acids. Pacifichem 2021 2021.12.01

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Awards & Honors 【 display / non-display 】

  • JSPS Ikushi Prize，Japan Society for the Promotion of Science (JSPS)，2025

  • CSJ Student Presentation Award 2024，2024.04

  • Student Presentation Award，2023.11

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Social Contribution 【 display / non-display 】

  • Editorial Forum "Chemistry Career Revolution: Redefining Job Hunting Essentials"，Chemical Society of Japan，2025.03.28

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