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UCHIDA Shusaku
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Campus Career 【 display / non-display 】
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2025.03-NowInstitute of Science Tokyo, -, Institute of Integrated Research, Advanced Pathophysiological Science, -, Professor
External Career 【 display / non-display 】
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2008-2011, Assistant Professor
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2013.12-2018.03Yamaguchi University, Hospital, Junior Associate Professor
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2018.04-2023.10Kyoto University Graduate School of Medicine, Medical Innovation Center,
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2023.11-2025.02Nagoya City University, Associate Professor
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2025.03-NowInstitute of Science Tokyo, Professor
Academic Society Affiliations 【 display / non-display 】
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THE JAPANESE SOCIETY FOR NEUROCHEMISTRY
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JAPANESE SOCIETY OF BIOLOGICAL PSYCHIATRY
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THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
Research Areas 【 display / non-display 】
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Experimental psychology
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Psychiatry
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Neuroscience-general
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Nutrition science and health science
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Sports sciences
Research Theme 【 display / non-display 】
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Molecula and neral mechanisms of individual- and -sex differences in behavioral resposne to stress, 2018.04 - 2021.03
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Identification of glycoproteins as markers of depression, 2016.04 - 2019.03
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Elucidating molecular mechanisms underlying stress vulnerability, 2015.04 - 2018.03
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Molecular and neural mechanisms of depression, 2015.04 - 2018.03
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Disrupted cortico-limbic network and molecular mechanism in bipolar disorder, 2012.04 - 2015.03
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Neural correlates of plasma acylated ghrelin level in individuals with mood disorders, 2009 - 2011
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Role of splicing factors in the pathogenesis of mood disorders, 2008 - 2009
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Role of alternative splicing in the pathophysiology of mood disorders, 2007 - 2008
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Study for stress-induced morphological alterations of neural dendrites in Fisher344 rats, an animal model for stress-vulnerability, 2005 - 2006
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Serotonergic neuronal plasticity in the depression model animal, 2004 - 2005
Published Papers & Misc 【 display / non-display 】
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Inaba S, Hasegawa T, Nakano Y, Naito S, Suzukawa R, Koide T, Sekiya H, Matsuki H, Fujiki T, Kikuchi H, Arai Y, Mori Y, Ando F, Mori T, Susa K, Iimori S, Sohara E, Uchida S, Mandai S. Circulating Extracellular Vesicle MicroRNAs as Predictive Biomarkers for Kidney and Cardiovascular Events. Journal of the American Heart Association. 2026.01; 15 (1): e045148. ( PubMed, DOI )
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Uchida S. Technological advances in mRNA delivery and engineering for therapeutic cancer vaccines. Japanese journal of clinical oncology. 2025.12; ( PubMed, DOI )
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Dirisala A, Uchida S, Toh K, Li J, Liu X, Wen P, Fukushima S, Kataoka K. Structural stability and RNase resistance of mRNA Polyplex micelles for systemic delivery. Journal of controlled release : official journal of the Controlled Release Society. 2025.08; 384 113935. ( PubMed, DOI )
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Uchida S, Liu YS, Yamaguchi A, Sekine Y, Yamaguchi K, Tanabe T, Miyauchi M. Synthesis of Orthorhombic Sn(3)O(4) Film and Its Photocatalytic Visible-Light Activity. ACS applied materials & interfaces. 2025.08; 17 (32): 45696-45703. ( PubMed, DOI )
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Nakao Y, Mori Y, Kunieda J, Taguchi T, Mori K, Yamamura A, Naito S, Ando F, Mandai S, Iimori S, Susa K, Mori T, Ohashi K, Sohara E, Uchida S. Successful Remission of Nephrotic Syndrome Caused by IgA Nephropathy with Membranoproliferative Glomerulonephritis-pattern Lesion Treated by Cyclosporine and Oral Corticosteroids. Internal medicine (Tokyo, Japan). 2025.07; ( PubMed, DOI )
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Morishita Y, Fuentes I, Gonzalez-Salinas S, Favate J, Mejaes J, Zushida K, Nishi A, Hevi C, Goldsmith N, Buyske S, Sillivan SE, Miller CA, Kandel ER, Uchida S, Shah P, Alarcon JM, Barker DJ, Shumyatsky GP. Dopamine release and dopamine-related gene expression in the amygdala are modulated by the gastrin-releasing peptide in opposite directions during stress-enhanced fear learning and extinction. Molecular psychiatry. 2024.11; 30 (6): 2381-2394. ( PubMed, DOI )
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Iwano T, Akutsu D, Ubukata H, Ogiwara N, Kikukawa Y, Wang S, Yan LK, Kageyama H, Uchida S. Tuning Proton Conduction by Staggered Arrays of Polar Preyssler-Type Oxoclusters. Journal of the American Chemical Society. 2024.09; 146 (38): 26113-26120. ( PubMed, DOI )
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Itoh Y, Zhan P, Tojo T, Jaikhan P, Ota Y, Suzuki M, Li Y, Hui Z, Moriyama Y, Takada Y, Yamashita Y, Oba M, Uchida S, Masuda M, Ito S, Sowa Y, Sakai T, Suzuki T. Discovery of Selective Histone Deacetylase 1 and 2 Inhibitors: Screening of a Focused Library Constructed by Click Chemistry, Kinetic Binding Analysis, and Biological Evaluation. Journal of medicinal chemistry. 2023.10; 66 (22): 15171-15188. ( PubMed, DOI )
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Fujimaru, T; Mori, T; Chiga, M; Mandai, S; Ando, F; Mori, Y; Susa, K; Nakano, Y; Shoji, T; Fukudome, Y; Inaba, N; Kitamura, K; Nakanishi, T; Kimura, T; Tamura, T; Ozawa, K; Uchida, S; Sohara, E. Underlying Genetic Causes of Adult Patients With ESKD Undergoing Hemodialysis Therapy JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2022.11; 33 (11): 755-756.
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Sinha, AS; Wang, TY; Watanabe, M; Hosoi, Y; Sohara, E; Akita, T; Uchida, S; Fukuda, A. WNK3 kinase maintains neuronal excitability by reducing inwardly rectifying K<SUP>+</SUP> conductance in layer V pyramidal neurons of mouse medial prefrontal cortex FRONTIERS IN MOLECULAR NEUROSCIENCE. 2022.10; 15 ( PubMed, DOI )
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Wang, QBS; Edahiro, R; Namkoong, H; Hasegawa, T; Shirai, Y; Sonehara, K; Tanaka, H; Lee, H; Saiki, R; Hyugaji, T; Shimizu, E; Katayama, K; Kanai, M; Naito, T; Sasa, N; Yamamoto, K; Kato, Y; Morita, T; Takahashi, K; Harada, N; Naito, T; Hiki, M; Matsushita, Y; Takagi, H; Ichikawa, M; Nakamura, A; Harada, S; Sandhu, Y; Kabata, H; Masaki, K; Kamata, H; Ikemura, S; Chubachi, S; Okamori, S; Terai, H; Morita, A; Asakura, T; Sasaki, J; Morisaki, H; Uwamino, Y; Nanki, K; Uchida, S; Uno, S; Nishimura, T; Ishiguro, T; Isono, T; Shibata, S; Matsui, Y; Hosoda, C; Takano, K; Nishida, T; Kobayashi, Y; Takaku, Y; Takayanagi, N; Ueda, S; Tada, A; Miyawaki, M; Yamamoto, M; Yoshida, E; Hayashi, R; Nagasaka, T; Arai, S; Kaneko, Y; Sasaki, K; Tagaya, E; Kawana, M; Arimura, K; Takahashi, K; Anzai, T; Ito, S; Endo, A; Uchimura, Y; Miyazaki, Y; Honda, T; Tateishi, T; Tohda, S; Ichimura, N; Sonobe, K; Sassa, CT; Nakajima, J; Nakano, Y; Nakajima, Y; Anan, R; Arai, R; Kurihara, Y; Harada, Y; Nishio, K; Ueda, T; Azuma, M; Saito, R; Sado, T; Miyazaki, Y; Sato, R; Haruta, Y; Nagasaki, T; Yasui, Y; Hasegawa, Y; Mutoh, Y; Kimura, T; Sato, T; Takei, R; Hagimoto, S; Noguchi, Y; Yamano, Y; Sasano, H; Ota, S; Nakamori, Y; Yoshiya, K; Saito, F; Yoshihara, T; Wada, D; Iwamura, H; Kanayama, S; Maruyama, S; Yoshiyama, T; Ohta, K; Kokuto, H; Ogata, H; Tanaka, Y; Arakawa, K; Shimoda, M; Osawa, T; Tateno, H; Hase, I; Yoshida, S; Suzuki, S; Kawada, M; Horinouchi, H; Saito, F; Mitamura, K; Hagihara, M; Ochi, J; Uchida, T; Baba, R; Arai, D; Ogura, T; Takahashi, H; Hagiwara, S; Nagao, G; Konishi, S; Nakachi, I; Murakami, K; Yamada, M; Sugiura, H; Sano, H; Matsumoto, S; Kimura, N; Ono, Y; Baba, H; Suzuki, Y; Nakayama, S; Masuzawa, K; Namba, S; Shiroyama, T; Noda, Y; Niitsu, T; Adachi, Y; Enomoto, T; Amiya, S; Hara, R; Yamaguchi, Y; Murakami, T; Kuge, T; Matsumoto, K; Yamamoto, Y; Yamamoto, M; Yoneda, M; Tomono, K; Kato, K; Hirata, H; Takeda, Y; Koh, H; Manabe, T; Funatsu, Y; Ito, F; Fukui, T; Shinozuka, K; Kohashi, S; Miyazaki, M; Shoko, T; Kojima, M; Adachi, T; Ishikawa, M; Takahashi, K; Inoue, T; Hirano, T; Kobayashi, K; Takaoka, H; Watanabe, K; Miyazawa, N; Kimura, Y; Sado, R; Sugimoto, H; Kamiya, A; Kuwahara, N; Fujiwara, A; Matsunaga, T; Sato, Y; Okada, T; Hirai, Y; Kawashima, H; Narita, A; Niwa, K; Sekikawa, Y; Nishi, K; Nishitsuji, M; Tani, M; Suzuki, J; Nakatsumi, H; Ogura, T; Kitamura, H; Hagiwara, E; Murohashi, K; Okabayashi, H; Mochimaru, T; Nukaga, S; Satomi, R; Oyamada, Y; Mori, N; Baba, T; Fukui, Y; Odate, M; Mashimo, S; Makino, Y; Yagi, K; Hashiguchi, M; Kagyo, J; Shiomi, T; Fuke, S; Saito, H; Tsuchida, T; Fujitani, S; Takita, M; Morikawa, D; Yoshida, T; Izumo, T; Inomata, M; Kuse, N; Awano, N; Tone, M; Ito, A; Nakamura, Y; Hoshino, K; Maruyama, J; Ishikura, H; Takata, T; Odani, T; Amishima, M; Hattori, T; Shichinohe, Y; Kagaya, T; Kita, T; Ohta, K; Sakagami, S; Koshida, K; Hayashi, K; Shimizu, T; Kozu, Y; Hiranuma, H; Gon, Y; Izumi, N; Nagata, K; Ueda, K; Taki, R; Hanada, S; Kawamura, K; Ichikado, K; Nishiyama, K; Muranaka, H; Nakamura, K; Hashimoto, N; Wakahara, K; Koji, S; Omote, N; Ando, A; Kodama, N; Kaneyama, Y; Maeda, S; Kuraki, T; Matsumoto, T; Yokote, K; Nakada, TA; Abe, R; Oshima, T; Shimada, T; Harada, M; Takahashi, T; Ono, H; Sakurai, T; Shibusawa, T; Kimizuka, Y; Kawana, A; Sano, T; Watanabe, C; Suematsu, R; Sageshima, H; Yoshifuji, A; Ito, K; Takahashi, S; Ishioka, K; Nakamura, M; Masuda, M; Wakabayashi, A; Watanabe, H; Ueda, S; Nishikawa, M; Chihara, Y; Takeuchi, M; Onoi, K; Shinozuka, J; Sueyoshi, A; Nagasaki, Y; Okamoto, M; Ishihara, S; Shimo, M; Tokunaga, Y; Kusaka, Y; Ohba, T; Isogai, S; Ogawa, A; Inoue, T; Fukuyama, S; Eriguchi, Y; Yonekawa, A; Kan-o, K; Matsumoto, K; Kanaoka, K; Ihara, S; Komuta, K; Inoue, Y; Chiba, S; Yamagata, K; Hiramatsu, Y; Kai, H; Asano, K; Oguma, T; Ito, Y; Hashimoto, S; Yamasaki, M; Kasamatsu, Y; Komase, Y; Hida, N; Tsuburai, T; Oyama, B; Takada, M; Kanda, H; Kitagawa, Y; Fukuta, T; Miyake, T; Yoshida, S; Ogura, S; Abe, S; Kono, Y; Togashi, Y; Takoi, H; Kikuchi, R; Ogawa, S; Ogata, T; Ishihara, S; Kanehiro, A; Ozaki, S; Fuchimoto, Y; Wada, S; Fujimoto, N; Nishiyama, K; Terashima, M; Beppu, S; Yoshida, K; Narumoto, O; Nagai, H; Ooshima, N; Motegi, M; Umeda, A; Miyagawa, K; Shimada, H; Endo, M; Ohira, Y; Watanabe, M; Inoue, S; Igarashi, A; Sato, M; Sagara, H; Tanaka, A; Ohta, S; Kimura, T; Shibata, Y; Tanino, Y; Nikaido, T; Minemura, H; Sato, Y; Yamada, Y; Hashino, T; Shinoki, M; Iwagoe, H; Takahashi, H; Fujii, K; Kishi, H; Kanai, M; Imamura, T; Yamashita, T; Yatomi, M; Maeno, T; Hayashi, S; Takahashi, M; Kuramochi, M; Kamimaki, I; Tominaga, Y; Ishii, T; Utsugi, M; Ono, A; Tanaka, T; Kashiwada, T; Fujita, K; Saito, Y; Seike, M; Watanabe, H; Matsuse, H; Kodaka, N; Nakano, C; Oshio, T; Hirouchi, T; Makino, S; Egi, M; Omae, Y; Nannya, Y; Ueno, T; Takano, T; Katayama, K; Ai, M; Kumanogoh, A; Sato, T; Hasegawa, N; Tokunaga, K; Ishii, M; Koike, R; Kitagawa, Y; Kimura, A; Imoto, S; Miyano, S; Ogawa, S; Kanai, T; Fukunaga, K; Okada, Y. The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force NATURE COMMUNICATIONS. 2022.08; 13 (1): 4830. ( PubMed, DOI )
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Saito, T; Fujimoto, K; Uchida, S; Yamazaki, D; Hirano, T; Sano, I; Ye, B; Kagawa, O; Shariar, MS; Do, V; Morii, Y; Prozorova, L; Chiba, S. Uncovering overlooked diversity using molecular phylogenetic approach: A case of Japanese sphaeriid clams (Bivalvia: Sphaeriidae) MOLECULAR PHYLOGENETICS AND EVOLUTION. 2022.08; 173 107508. ( PubMed, DOI )
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Fuentes, I; Morishita, Y; Gonzalez-Salinas, S; Champagne, FA; Uchida, S; Shumyatsky, GP. Experience-Regulated Neuronal Signaling in Maternal Behavior FRONTIERS IN MOLECULAR NEUROSCIENCE. 2022.03; 15 844295. ( PubMed, DOI )
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Seki, T; Yamagata, H; Uchida, S; Kobayashi, A; Watanabe, Y; Nakagawa, S. A novel mouse model of postpartum depression using emotional stress as evaluated by nesting behavior SCIENTIFIC REPORTS. 2021.11; 11 (1): 22615. ( PubMed, DOI )
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Sato, H; Aoki, D; Marubayashi, H; Uchida, S; Sogawa, H; Nojima, S; Liang, XB; Nakajima, K; Hayakawa, T; Takata, T. Topology-transformable block copolymers based on a rotaxane structure: change in bulk properties with same composition NATURE COMMUNICATIONS. 2021.10; 12 (1): ( PubMed, DOI )
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Nanamatsu, A; Mori, T; Ando, F; Furusho, T; Mandai, S; Susa, K; Sohara, E; Rai, T; Uchida, S. Vasopressin Induces Urinary Uromodulin Secretion by Activating Protein Kinase A JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2021.10; 32 (10): 420.
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Kawatake-Kuno, A; Murai, T; Uchida, S. A Multiscale View of the Mechanisms Underlying Ketamine's Antidepressant Effects: An Update on Neuronal Calcium Signaling FRONTIERS IN BEHAVIORAL NEUROSCIENCE. 2021.09; 15 749180. ( PubMed, DOI )
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Neidell, M; Uchida, S; Veronesi, M. The unintended effects from halting nuclear power production: Evidence from Fukushima Daiichi accident JOURNAL OF HEALTH ECONOMICS. 2021.09; 79 102507. ( PubMed, DOI )
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Fujii, S; Kikuchi, E; Suzuyama, H; Watanabe, Y; Ishigami-Yuasa, M; Masuno, H; Mori, T; Isobe, K; Uchida, S; Kagechika, H. Structural Development of Salicylanilide-Based SPAK Inhibitors as Candidate Antihypertensive Agents CHEMMEDCHEM. 2021.09; 16 (18): 2817-2822. ( PubMed, DOI )
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Kawatake-Kuno, A; Murai, T; Uchida, S. The Molecular Basis of Depression: Implications of Sex-Related Differences in Epigenetic Regulation FRONTIERS IN MOLECULAR NEUROSCIENCE. 2021.07; 14 708004. ( PubMed, DOI )
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Nanamatsu, A; Mori, T; Ando, F; Furusho, T; Mandai, S; Susa, K; Sohara, E; Rai, T; Uchida, S. Vasopressin Induces Urinary Uromodulin Secretion By Activating PKA (Protein Kinase A) HYPERTENSION. 2021.06; 77 (6): 1953-1963. ( PubMed, DOI )
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Sakai, Y; Li, HY; Inaba, H; Funayama, Y; Ishimori, E; Kawatake-Kuno, A; Yamagata, H; Seki, T; Hobara, T; Nakagawa, S; Watanabe, Y; Tomita, S; Murai, T; Uchida, S. Gene-environment interactions mediate stress susceptibility and resilience through the CaMKIIβ/TARPγ-8/AMPAR pathway ISCIENCE. 2021.05; 24 (5): 102504. ( PubMed, DOI )
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Fukushima, Y; Uchida, S; Imai, H; Nakatomi, H; Kataoka, K; Saito, N; Itaka, K. Treatment of ischemic neuronal death by introducing brain-derived neurotrophic factor mRNA using polyplex nanomicelle BIOMATERIALS. 2021.03; 270 ( PubMed, DOI )
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Yamagata, H; Ogihara, H; Matsuo, K; Uchida, S; Kobayashi, A; Seki, T; Kobayashi, M; Harada, K; Chen, C; Miyata, S; Fukuda, M; Mikuni, M; Hamamoto, Y; Watanabe, Y; Nakagawa, S. Distinct epigenetic signatures between adult-onset and late-onset depression SCIENTIFIC REPORTS. 2021.01; 11 (1): 2296. ( PubMed, DOI )
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Arai, Y; Asano, K; Mandai, S; Ando, F; Susa, K; Mori, T; Nomura, N; Rai, T; Tanaka, M; Uchida, S; Sohara, E. WNK1-TAK1 signaling suppresses lipopolysaccharide-induced cytokine production and classical activation in macrophages BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2020.12; 533 (4): 1290-1297. ( PubMed, DOI )
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Fujii, S; Kikuchi, E; Watanabe, Y; Suzuyama, H; Ishigami-Yuasa, M; Mori, T; Isobe, K; Uchida, S; Kagechika, H. Structural development of <i>N</i>-(4-phenoxyphenyl)benzamide derivatives as novel SPAK inhibitors blocking WNK kinase signaling BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2020.09; 30 (17): ( PubMed, DOI )
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Furusho, T; Uchida, S; Sohara, E. The WNK signaling pathway and salt-sensitive hypertension HYPERTENSION RESEARCH. 2020.08; 43 (8): 733-743. ( PubMed, DOI )
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Watanabe, N; Murakami, S; Uchida, S; Tateishi, S; Ohara, H; Yamamoto, Y; Kojima, T. Validity of the Japanese Orthopaedic Association Hip Disease Evaluation Questionnaire (JHEQ) for Japanese patients with labral tear JOURNAL OF HIP PRESERVATION SURGERY. 2020.08; 7 (3): 466-473. ( PubMed, DOI )
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Tsuji, K; Kitamura, M; Muta, K; Mochizuki, Y; Mori, T; Sohara, E; Uchida, S; Sakai, H; Mukae, H; Nishino, T. Transplantation of a kidney with a heterozygous mutation in the <i>SLC22A12</i> (URAT1) gene causing renal hypouricemia: a case report BMC NEPHROLOGY. 2020.07; 21 (1): ( PubMed, DOI )
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Shoda, W; Nomura, N; Ando, F; Tagashira, H; Iwamoto, T; Ohta, A; Isobe, K; Mori, T; Susa, K; Sohara, E; Rai, T; Uchida, S. Sodium-calcium exchanger 1 is the key molecule for urinary potassium excretion against acute hyperkalemia PLOS ONE. 2020.06; 15 (6): ( PubMed, DOI )
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Miyake, Y; Itoh, Y; Suzuma, Y; Kodama, H; Kurohara, T; Yamashita, Y; Narozny, R; Hanatani, Y; Uchida, S; Suzuki, T. Metalloprotein-Catalyzed Click Reaction for In Situ Generation of a Potent Inhibitor ACS CATALYSIS. 2020.05; 10 (10): 5383-5392. ( DOI )
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Wang, CG; Cheawchan, S; Qiagedeer, A; Monjiyama, S; Uchida, S; Koyama, Y; Takata, T. Simple Chemical Modification Using Perfluoroalkyl-Substituted Stable Nitrile <i>N</i>-Oxide on Bulk Surface via Catalyst-Free Click Reaction CHEMISTRYSELECT. 2020.05; 5 (17): 5312-5315. ( DOI )
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Uchida, S; Yanagihara, K; Matsui, A; Kataoka, K; Itaka, K. mRNA as a Tool for Gene Transfection in 3D Cell Culture for Future Regenerative Therapy MICROMACHINES. 2020.04; 11 (4): ( PubMed, DOI )
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Goseki, R; Miyao, S; Uchida, S; Yokoyama, H; Ito, K; Ishizone, T. Surface characterization of amphiphilic block copolymers possessing polyisoprene and poly [tri(ethylene glycol) methacrylate] segments and the effect of side chain ω-function on surface energy POLYMER. 2020.03; 190 ( DOI )
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Uchida, S. Epigenetic Mechanisms of Stress Susceptibility and Resilience NEUROPSYCHOPHARMACOLOGY. 2019.12; 44 (SUPPL 1): 116.
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Goseki, R; Zhang, F; Takahata, K; Uchida, S; Ishizone, T. Synthesis of a well-defined alternating copolymer of 1,1-diphenylethylene and <i>tert</i>-butyldimethyl-silyloxymethyl substituted styrene by anionic copolymerization: toward tailored graft copolymers with controlled side chain densities POLYMER CHEMISTRY. 2019.12; 10 (47): 6413-6422. ( DOI )
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Seki, T; Yamagata, H; Uchida, S; Chen, C; Kobayashi, A; Kobayashi, M; Harada, K; Matsuo, K; Watanabe, Y; Nakagawa, S. Altered expression of long noncoding RNAs in patients with major depressive disorder JOURNAL OF PSYCHIATRIC RESEARCH. 2019.10; 117 92-99. ( PubMed, DOI )
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Matsuura, Y; Nomura, N; Shoda, W; Mori, T; Isobe, K; Susa, K; Ando, F; Sohara, E; Rai, T; Uchida, S. Tacrolimus ameliorates the phenotypes of type 4 Bartter syndrome model mice through activation of sodium-potassium-2 chloride cotransporter and sodium-chloride cotransporter BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2019.09; 517 (2): 364-368. ( PubMed, DOI )
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Yamada, T; Kamata, K; Hayashi, E; Hara, M; Uchida, S. Structure-Function Relationships in Fructose Dehydration to 5-Hydroxymethylfurfural under Mild Conditions by Porous Ionic Crystals Constructed with Analogous Building Blocks CHEMCATCHEM. 2019.08; 11 (16): 3743-3747. ( DOI )
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Takahata, K; Uchida, S; Goseki, R; Ishizone, T. Synthesis of chain end acyl-functionalized polymers by living anionic polymerization: versatile precursors for H-shaped polymers POLYMER CHEMISTRY. 2019.08; 10 (29): 3951-3959. ( DOI )
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Fujiki, T; Ando, F; Murakami, K; Isobe, K; Mori, T; Susa, K; Nomura, N; Sohara, E; Rai, T; Uchida, S. Tolvaptan activates the Nrf2/HO-1 antioxidant pathway through PERK phosphorylation SCIENTIFIC REPORTS. 2019.06; 9 ( PubMed, DOI )
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Lin, CY; Crowley, ST; Uchida, S; Komaki, Y; Kataoka, K; Itaka, K. Treatment of Intervertebral Disk Disease by the Administration of mRNA Encoding a Cartilage-Anabolic Transcription Factor MOLECULAR THERAPY-NUCLEIC ACIDS. 2019.06; 16 162-171. ( PubMed, DOI )
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Takahashi, M; Izawa, K; Urai, M; Yamanishi, Y; Maehara, A; Isobe, M; Matsukawa, T; Kaitani, A; Takamori, A; Uchida, S; Yamada, H; Nagamine, M; Ando, T; Shimizu, T; Ogawa, H; Okumura, K; Kinjo, Y; Kitamura, T; Kitaura, J. The phytosphingosine-CD300b interaction promotes zymosan-induced, nitric oxide-dependent neutrophil recruitment SCIENCE SIGNALING. 2019.01; 12 (564): ( PubMed, DOI )
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Sato, F; Choi, M; Wang, Z; Imamura, K; Horiuchi, T; Quan, W; Fujita, I; Uchida, S; Kato, M; Tanigaki, F; Higashibata, A; Muratani, M; Kobayashi, J; Takahashi, A; Sugano, S; Matsuzaki, F; Suzuki, Y; Kawakami, K; Sehara-Fujisawa, A. Study on gravity-dependent skeletal muscle maintenance mechanisms using Zebrafish, aquatic organisms. MOLECULAR BIOLOGY OF THE CELL. 2018.12; 29 (26):
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Kikuchi, H; Kanda, E; Mori, T; Sato, H; Iimori, S; Nomura, N; Naito, S; Sohara, E; Okado, T; Uchida, S; Fushimi, K; Rai, T. Short-term prognosis of emergently hospitalized dialysis-independent chronic kidney disease patients: A nationwide retrospective cohort study in Japan PLOS ONE. 2018.11; 13 (11): ( PubMed, DOI )
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Murata, Y; Uchida, S; Utsunomiya, H; Hatakeyama, A; Nakashima, H; Chang, A; Sekiya, I; Sakai, A. Synovial Mesenchymal Stem Cells Derived From the Cotyloid Fossa Synovium Have Higher Self-renewal and Differentiation Potential Than Those From the Paralabral Synovium in the Hip Joint AMERICAN JOURNAL OF SPORTS MEDICINE. 2018.10; 46 (12): 2942-2953. ( PubMed, DOI )
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Uchida, S; Shumyatsky, GP. Epigenetic regulation of <i>Fgf</i>1 transcription by CRTC1 and memory enhancement BRAIN RESEARCH BULLETIN. 2018.07; 141 3-12. ( PubMed, DOI )
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Yamagata, H; Uchida, S; Matsuo, K; Harada, K; Kobayashi, A; Nakashima, M; Higuchi, F; Watanuki, T; Matsubara, T; Watanabe, Y. Altered plasma protein glycosylation in a mouse model of depression and in patients with major depression JOURNAL OF AFFECTIVE DISORDERS. 2018.06; 233 79-85. ( PubMed, DOI )
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Yanagihara, K; Uchida, S; Ohba, S; Kataoka, K; Itaka, K. Treatment of Bone Defects by Transplantation of Genetically Modified Mesenchymal Stem Cell Spheroids MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT. 2018.06; 9 358-366. ( PubMed, DOI )
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Mandai, S; Mori, T; Nomura, N; Furusho, T; Arai, Y; Kikuchi, H; Sasaki, E; Sohara, E; Rai, T; Uchida, S. WNK1 regulates skeletal muscle cell hypertrophy by modulating the nuclear localization and transcriptional activity of FOXO4 SCIENTIFIC REPORTS. 2018.06; 8 ( PubMed, DOI )
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Uchida, S; Yamagata, H; Seki, T; Kobayashi, A; Hara, K; Matsuo, K; Nakagawa, S; Watanabe, Y. HDAC2 Modulates Behavioral Response to Chronic Stress Through Glucocorticoid Receptor BIOLOGICAL PSYCHIATRY. 2018.05; 83 (9): S276. ( DOI )
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Uchida, S; Yamagata, H; Seki, T; Watanabe, Y. Epigenetic mechanisms of major depression: Targeting neuronal plasticity PSYCHIATRY AND CLINICAL NEUROSCIENCES. 2018.04; 72 (4): 212-227. ( PubMed, DOI )
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Isobe, M; Izawa, K; Sugiuchi, M; Sakanishi, T; Kaitani, A; Takamori, A; Maehara, A; Matsukawa, T; Takahashi, M; Yamanishi, Y; Oki, T; Uchida, S; Uchida, K; Ando, T; Maeda, K; Nakano, N; Yagita, H; Takai, T; Ogawa, H; Okumura, K; Kitamura, T; Kitaura, J. The CD300e molecule in mice is an immune-activating receptor JOURNAL OF BIOLOGICAL CHEMISTRY. 2018.03; 293 (10): 3793-3805. ( PubMed, DOI )
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Uchida, S; Shumyatsky, GP. Synaptically Localized Transcriptional Regulators in Memory Formation NEUROSCIENCE. 2018.02; 370 4-13. ( PubMed, DOI )
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Nomura, N; Shoda, W; Wang, YL; Mandai, S; Furusho, T; Takahashi, D; Zeniya, M; Sohara, E; Rai, T; Uchida, S. Role of ClC-K and barttin in low potassium-induced sodium chloride cotransporter activation and hypertension in mouse kidney BIOSCIENCE REPORTS. 2018.02; 38 ( PubMed, DOI )
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Toriu N, Hoshino J, Kobori S, Watanabe S, Oguro M, Oshima Y, Hiramatsu R, Mizuno H, Ikuma D, Sekine A, Hayami N, Sumida K, Yamanouchi M, Hasegawa E, Sawa N, Takaichi K, Yanagita M, Fujimaru T, Sohara E, Uchida S, Ubara Y. Transcatheter Arterial Embolization Therapy for Huge Renal Cysts: Two Case Reports. Case reports in nephrology and dialysis. 2018.01; 8 (1): 82-89. ( PubMed, DOI )
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Matsumoto, A; Matsui, I; Mori, T; Sakaguchi, Y; Mizui, M; Ueda, Y; Takahashi, A; Doi, Y; Shimada, K; Yamaguchi, S; Kubota, K; Hashimoto, N; Oka, T; Takabatake, Y; Sohara, E; Hamano, T; Uchida, S; Isaka, Y. Severe Osteomalacia with Dent Disease Caused by a Novel Intronic Mutation of the <i>CLCN5</i> gene INTERNAL MEDICINE. 2018; 57 (24): 3603-3610. ( PubMed, DOI )
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Jang, K; Iijima, K; Koyama, Y; Uchida, S; Asai, S; Takata, T. Synthesis and properties of rotaxane-cross-linked polymers using a double-stranded γ-CD-based inclusion complex as a supramolecular cross-linker POLYMER. 2017.10; 128 379-385. ( DOI )
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Zeniya, M; Mori, T; Yui, N; Nomura, N; Mandai, S; Isobe, K; Chiga, M; Sohara, E; Rai, T; Uchida, S. The proteasome inhibitor bortezomib attenuates renal fibrosis in mice via the suppression of TGF-β1 SCIENTIFIC REPORTS. 2017.10; 7 ( PubMed, DOI )
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樋口 文宏, 内田 周作, 山形 弘隆, 關 友恵, 渡辺 義文. ストレス適応機構におけるヒストン脱アセチル化酵素の役割の解析(The role of histone deacetylase in stress-induced depression-like behavior in mice) 日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集. 2017.09; 39回・47回 165. ( ichushi )
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關 友恵, 山形 弘隆, 内田 周作, 原田 健一郎, 松尾 幸治, 渡邉 義文. 大うつ病性障害患者における長鎖非コードRNAの発現解析(Expression profiling of long, noncoding RNAs in patients with major depression) 日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集. 2017.09; 39回・47回 170. ( ichushi )
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Susa, K; Sohara, E; Takahashi, D; Okado, T; Rai, T; Uchida, S. WNK4 is indispensable for the pathogenesis of pseudohypoaldosteronism type II caused by mutant KLHL3 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2017.09; 491 (3): 727-732. ( PubMed, DOI )
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Yui, N; Ando, F; Sasaki, S; Uchida, S. Ser-261 phospho-regulation is involved in pS256 and pS269-mediated aquaporin-2 apical translocation BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2017.08; 490 (3): 1039-1044. ( PubMed, DOI )
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Yamagata, H; Uchida, S; Matsuo, K; Harada, K; Kobayashi, A; Nakashima, M; Nakano, M; Otsuki, K; Abe-Higuchi, N; Higuchi, F; Watanuki, T; Matsubara, T; Miyata, S; Fukuda, M; Mikuni, M; Watanabe, Y. Identification of commonly altered genes between in major depressive disorder and a mouse model of depression SCIENTIFIC REPORTS. 2017.06; 7 (1): 3044. ( PubMed, DOI )
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Arai, Y; Kanda, E; Iimori, S; Naito, S; Noda, Y; Kawasaki, T; Sato, H; Ando, R; Sasaki, S; Sohara, E; Okado, T; Rai, T; Uchida, S. The use of vitamin D analogs is independently associated with the favorable renal prognosis in chronic kidney disease stages 4-5: the CKD-ROUTE study CLINICAL AND EXPERIMENTAL NEPHROLOGY. 2017.06; 21 (3): 481-487. ( PubMed, DOI )
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Miyamoto, S; Ohkubo, A; Seshima, H; Komori, S; Yamamoto, M; Maeda, T; Itagaki, A; Yamamoto, H; Nojima, K; Iimori, S; Naito, S; Kurashima, N; Sohara, E; Rai, T; Uchida, S; Okado, T. Selective Plasma Exchange for the Removal of Pemphigus Autoantibodies, Fibrinogen, and Factor XIII in Pemphigus Vulgaris THERAPEUTIC APHERESIS AND DIALYSIS. 2017.06; 21 (3): 226-231. ( PubMed, DOI )
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Arai, Y; Takahashi, D; Asano, K; Tanaka, M; Oda, M; Ko, SBH; Ko, MSH; Mandai, S; Nomura, N; Rai, T; Uchida, S; Sohara, E. Salt suppresses IFNγ inducible chemokines through the IFNγ-JAK1-STAT1 signaling pathway in proximal tubular cells SCIENTIFIC REPORTS. 2017.04; 7 ( PubMed, DOI )
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Takahashi, D; Mori, T; Sohara, E; Tanaka, M; Chiga, M; Inoue, Y; Nomura, N; Zeniya, M; Ochi, H; Takeda, S; Suganami, T; Rai, T; Uchida, S. WNK4 is an Adipogenic Factor and Its Deletion Reduces Diet-Induced Obesity in Mice EBIOMEDICINE. 2017.04; 18 118-127. ( PubMed, DOI )
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Kawahara, R; Osuga, R; Kondo, JN; Mizuno, N; Uchida, S. Synergetic effect in heterogeneous acid catalysis by a porous ionic crystal based on Al(III)-salphen and polyoxometalate DALTON TRANSACTIONS. 2017.03; 46 (10): ( PubMed, DOI )
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Ito-Ihara, T; Furuta, S; Komagata, Y; Muso, E; Endo, T; Uchida, S; Kono, H; Hamano, Y; Tsukamoto, T; Endo, S; Yamagata, K; Walsh, M; Merkel, P; Jayne, D; Suzuki, K; Arimura, Y; Makino, H; Fujimoto, S. TWO INTERNATIONAL MULTIREGIONAL INVESTIGATOR INITIATED CLINICAL TRIALS ON VASCULITIS: COLLABORATION WITH EUVAS, VCRC AND NATIONWIDE VASCULITIS STUDY GROUPS OF JAPAN RHEUMATOLOGY. 2017.03; 56 149.
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Liu, L; Okazaki, K; Yoshida, T; Suzuki, H; Horio, M; Ambolode, LCC; Xu, J; Ideta, S; Hashimoto, M; Lu, DH; Shen, ZX; Ota, Y; Shin, S; Nakajima, M; Ishida, S; Kihou, K; Lee, CH; Iyo, A; Eisaki, H; Mikami, T; Kakeshita, T; Yamakawa, Y; Kontani, H; Uchida, S; Fujimori, A. Unusual nodal behaviors of the superconducting gap in the iron-based superconductor Ba(Fe<sub>0.65</sub>Ru<sub>0.35</sub>)<sub>2</sub>As<sub>2</sub>: Effects of spin-orbit coupling PHYSICAL REVIEW B. 2017.03; 95 (10): ( DOI )
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Uchida, S; Teubner, BJW; Hevi, C; Hara, K; Kobayashi, A; Dave, RM; Shintaku, T; Jaikhan, P; Yamagata, H; Suzuki, T; Watanabe, Y; Zakharenko, SS; Shumyatsky, GP. CRTC1 Nuclear Translocation Following Learning Modulates Memory Strength via Exchange of Chromatin Remodeling Complexes on the <i>Fgf1</i> Gene CELL REPORTS. 2017.01; 18 (2): 352-366. ( PubMed, DOI )
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Li, HY; Ogata, H; Tsuchiya, T; Suzuki, Y; Uchida, S; Ohashi, H; Konomi, S. Using Learning Analytics to Support Computer-Assisted Language Learning 25TH INTERNATIONAL CONFERENCE ON COMPUTERS IN EDUCATION (ICCE 2017). 2017; 908-913.
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Abe-Higuchi N, Uchida S, Yamagata H, Higuchi F, Hobara T, Hara K, Kobayashi A, Watanabe Y. Hippocampal Sirtuin 1 Signaling Mediates Depression-like Behavior. Biological psychiatry. 2016.12; 80 (11): 815-826. ( PubMed, DOI )
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Martel G, Uchida S, Hevi C, Chévere-Torres I, Fuentes I, Park YJ, Hafeez H, Yamagata H, Watanabe Y, Shumyatsky GP. Genetic Demonstration of a Role for Stathmin in Adult Hippocampal Neurogenesis, Spinogenesis, and NMDA Receptor-Dependent Memory. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2016.01; 36 (4): 1185-1202. ( PubMed, DOI )
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Uchida S, Shumyatsky GP. Deceivingly dynamic: Learning-dependent changes in stathmin and microtubules. Neurobiology of learning and memory. 2015.10; 124 52-61. ( PubMed, DOI )
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Understanding Fear Memory Encoding Is Critical for Improving Memory Strength 2015.05; 77 (9): 33S-34S.
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Uchida S, Martel G, Pavlowsky A, Takizawa S, Hevi C, Watanabe Y, Kandel ER, Alarcon JM, Shumyatsky GP. Learning-induced and stathmin-dependent changes in microtubule stability are critical for memory and disrupted in ageing. Nature communications. 2014.07; 5 4389. ( PubMed, DOI )
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Shibata T, Yamagata H, Uchida S, Otsuki K, Hobara T, Higuchi F, Abe N, Watanabe Y. The alteration of hypoxia inducible factor-1 (HIF-1) and its target genes in mood disorder patients. Progress in neuro-psychopharmacology & biological psychiatry. 2013.06; 43 222-229. ( PubMed, DOI )
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Dysfunction of the RAR/RXR signaling pathway in the forebrain impairs hippocampal memory and synaptic plasticity 2012.02; 5 8. ( PubMed, DOI )
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Murine GRPR and Stathmin Control in Opposite Directions both Cued Fear Extinction and Neural Activities of the Amygdala and Prefrontal Cortex 2012.02; 7 (2): e30942. ( PubMed, DOI )
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Higuchi F, Uchida S, Yamagata H, Otsuki K, Hobara T, Abe N, Shibata T, Watanabe Y. State-dependent changes in the expression of DNA methyltransferases in mood disorder patients. Journal of psychiatric research. 2011.10; 45 (10): 1295-1300. ( PubMed, DOI )
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ストレスによる脳機能障害の分子基盤 気分障害におけるエピジェネティクス(Molecular mechanism of brain dysfunction induced by stress Epigenetic regulation in depression) 2011.10; 21回・41回 105. ( ichushi )
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Molecular Basis of Depression エピジェネティクスとストレス脆弱性、うつ病(Molecular Basis of Depression Epigenetic regulation of stress vulnerability and depression) 2011.09; 50 (2-3): 136. ( ichushi )
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Abe N, Uchida S, Otsuki K, Hobara T, Yamagata H, Higuchi F, Shibata T, Watanabe Y. Altered sirtuin deacetylase gene expression in patients with a mood disorder. Journal of psychiatric research. 2011.08; 45 (8): 1106-1112. ( PubMed, DOI )
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Development of a tightly-regulated tetracycline-dependent transcriptional activator and repressor co-expression system for the strong induction of transgene expression 2011.05; 63 (3): 211-216. ( PubMed, DOI )
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Uchida S, Hara K, Kobayashi A, Otsuki K, Yamagata H, Hobara T, Suzuki T, Miyata N, Watanabe Y. Epigenetic status of Gdnf in the ventral striatum determines susceptibility and adaptation to daily stressful events. Neuron. 2011.01; 69 (2): 359-372. ( PubMed, DOI )
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Uchida S, Hara K, Kobayashi A, Fujimoto M, Otsuki K, Yamagata H, Hobara T, Abe N, Higuchi F, Shibata T, Hasegawa S, Kida S, Nakai A, Watanabe Y. Impaired hippocampal spinogenesis and neurogenesis and altered affective behavior in mice lacking heat shock factor 1. Proceedings of the National Academy of Sciences of the United States of America. 2011.01; 108 (4): 1681-1686. ( PubMed, DOI )
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BubR1 regulates neurite outgrowth of neuroblastoma cells 2011; 71 E334-E335. ( DOI )
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MicroRNA-124 might be involved in the mechanism of depression-like behavior and neuronal plasticity 2011; 71 E303. ( DOI )
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Roles of retinoic acid signaling pathway in emotional behavior 2011; 71 E270. ( DOI )
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Possible involvement of SIRT1, a histone deacetylase, in neural plasticity and depression-like behavior 2011; 71 E302-E303. ( DOI )
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Molecular mechanisms of rapid antidepressant action induced by histone deacetylase inhibitor 2011; 71 E301. ( DOI )
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Uchida S, Hara K, Kobayashi A, Funato H, Hobara T, Otsuki K, Yamagata H, McEwen BS, Watanabe Y. Early life stress enhances behavioral vulnerability to stress through the activation of REST4-mediated gene transcription in the medial prefrontal cortex of rodents. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2010.11; 30 (45): 15007-15018. ( PubMed, DOI )
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REST4を介した遺伝子発現調節異常はストレス脆弱性を高める(Involvement of REST4-mediated gene regulations in stress vulnerability) 2010.08; 49 (2-3): 676. ( ichushi )
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ヒストン脱アセチル化酵素阻害剤による抗うつ効果の分子機構の解析(Molecular mechanisms of the antidepressant actions by histone deacetylase inhibitors) 2010.08; 49 (2-3): 676. ( ichushi )
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前脳領域レチノイン酸受容体情報伝達経路による記憶形成の制御(Regulation of memory formation by Retinoic acid receptors) 2010.08; 49 (2-3): 655. ( ichushi )
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気分障害患者におけるヒストン脱アセチル化酵素SIRT遺伝子群の発現変化(Altered gene expression of sirtuins in mood disorder patients) 2010.08; 49 (2-3): 677. ( ichushi )
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気分障害患者におけるDNAメチル基転移酵素群遺伝子の発現解析(Altered gene expression of DNA methyltransferases in mood disorder patients) 2010.08; 49 (2-3): 677. ( ichushi )
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抗うつ薬はHDAC4によるヒストン修飾を介してGDNF遺伝子の転写活性を増加させる(Antidepressants increase GDNF gene transcription through the histone modifications by HDAC4) 2010.08; 49 (2-3): 677. ( ichushi )
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Otsuki K, Uchida S, Wakabayashi Y, Matsubara T, Hobara T, Funato H, Watanabe Y. Aberrant REST-mediated transcriptional regulation in major depressive disorder. Journal of psychiatric research. 2010.04; 44 (6): 378-384. ( PubMed, DOI )
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Hobara T, Uchida S, Otsuki K, Matsubara T, Funato H, Matsuo K, Suetsugi M, Watanabe Y. Altered gene expression of histone deacetylases in mood disorder patients. Journal of psychiatric research. 2010.04; 44 (5): 263-270. ( PubMed, DOI )
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Uchida S, Hara K, Kobayashi A, Otsuki K, Hobara T, Yamagata H, Watanabe Y. Maternal and genetic factors in stress-resilient and -vulnerable rats: a cross-fostering study. Brain research. 2010.02; 1316 43-50. ( PubMed, DOI )
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Higuchi, F; Uchida, S; Otsuki, K; Teruyuki, H; Abe, N; Watanabe, Y. Altered gene expression of DNA methyltransferases in mood disorder patients NEUROSCIENCE RESEARCH. 2010; 68 E318. ( DOI )
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Otsuki, K; Uchida, S; Yamagata, H; Watanabe, Y. Antidepressants increase GDNF gene transcription through the histone modifications by HDAC4 NEUROSCIENCE RESEARCH. 2010; 68 E317. ( DOI )
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Abe, N; Uchida, S; Otsuki, K; Hobara, T; Higuchi, F; Watanabe, Y. Altered gene expression of sirtuins in mood disorder patients NEUROSCIENCE RESEARCH. 2010; 68 E318. ( DOI )
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Uchida, S; Hara, K; Kobayashi, A; Watanabe, Y. Involvement of REST4-mediated gene regulations in stress vulnerability NEUROSCIENCE RESEARCH. 2010; 68 E316. ( DOI )
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Hobara, T; Uchida, S; Otsuki, K; Yamagata, H; Watanabe, Y. Molecular mechanisms of the antidepressant actions by histone deacetylase inhibitors NEUROSCIENCE RESEARCH. 2010; 68 E316. ( DOI )
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Hobara, T; Uchida, S; Otsuki, K; Matsubara, T; Funato, H; Matsuo, K; Suetsugi, M; Watanabe, Y. Altered gene expression of histone deacetylases in mood disorder patients NEUROSCIENCE RESEARCH. 2009; 65 S90. ( DOI )
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Uchida, S; Otsuki, K; Hara, K; Kobayashi, A; Hobara, T; Watanabe, Y. HDAC2-mediated epigenetic repression of the GDNF gene in the striatum modulates behavioral vulnerability to stress NEUROSCIENCE RESEARCH. 2009; 65 S184. ( DOI )
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Otsuki, K; Uchida, S; Watanabe, Y. Antidepressant drugs upregurate glial astrocyte GDNF gene transcription throgh the histone modifications NEUROSCIENCE RESEARCH. 2009; 65 S254. ( DOI )
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Positive and negative regulation of memory formation by Retinoic acid receptors 2009; 65 S234. ( DOI )
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Otsuki, K; Uchida, S; Watanuki, T; Wakabayashi, Y; Fujimoto, M; Matsubara, T; Funato, H; Watanabe, Y. Altered expression of neurotrophic factors in patients with major depression JOURNAL OF PSYCHIATRIC RESEARCH. 2008.10; 42 (14): 1145-1153. ( PubMed, DOI )
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Watanuki, T; Funato, H; Uchida, S; Matsubara, T; Kobayashi, A; Wakabayashi, Y; Otsuki, K; Nishida, A; Watanabe, Y. Increased expression of splicing factor SRp20 mRNA in bipolar disorder patients JOURNAL OF AFFECTIVE DISORDERS. 2008.09; 110 (1-2): 62-69. ( PubMed, DOI )
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発達期うつ様行動のリスク下における転写抑制因子REST/NRSFを介した遺伝子発現調節の役割(Role of REST/NRSF repressor-mediated gene regulations in the risk of developing depression-like behavior) 2008.08; 47 (2-3): 249. ( ichushi )
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Wakabayashi, Y; Uchida, S; Funato, H; Matsubara, T; Watanuki, T; Otsuki, K; Fujimoto, M; Nishida, A; Watanabe, Y. State-dependent changes in the expression levels of NCAM-140 and L1 in the peripheral blood cells of bipolar disorders, but not in the major depressive disorders PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY. 2008.07; 32 (5): 1199-1205. ( PubMed, DOI )
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Fujimoto, J; Bando, T; Minoshima, M; Uchida, S; Iwasaki, M; Shinohara, K; Sugiyama, H. Detection of triplet repeat sequences in the double-stranded DNA using pyrene-functionalized pyrrole-imidazole polyamides with rigid linkers BIOORGANIC & MEDICINAL CHEMISTRY. 2008.06; 16 (11): 5899-5907. ( PubMed, DOI )
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Fujimoto, M; Uchida, S; Watanuki, T; Wakabayashi, Y; Otsuki, K; Matsubara, T; Suetsugi, M; Funato, H; Watanabe, Y. Reduced expression of glyoxalase-1 mRNA in mood disorder patients NEUROSCIENCE LETTERS. 2008.06; 438 (2): 196-199. ( PubMed, DOI )
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Uchida, S; Nishida, A; Hara, K; Kamemoto, T; Suetsugi, M; Fujimoto, M; Watanuki, T; Wakabayashi, Y; Otsuki, K; McEwen, BS; Watanabe, Y. Characterization of the vulnerability to repeated stress in Fischer 344 rats: possible involvement of microRNA-mediated down-regulation of the glucocorticoid receptor EUROPEAN JOURNAL OF NEUROSCIENCE. 2008.05; 27 (9): 2250-2261. ( PubMed, DOI )
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Otsuki, K; Uchida, S; Watanuki, T; Wakabayashi, Y; Matsubara, T; Watanabe, Y. Expression analysis of neurotrophic factors in patients with mood disorders PSYCHIATRY AND CLINICAL NEUROSCIENCES. 2008.02; 62 (1): S14.
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Morphological alterations of hippocampal pyramidal neurons induced by chronic stress in F344 rats 2008.02; 62 (1): S8.
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Fujimoto, M; Uchida, S; Hara, K; Watanabe, Y. Morphological alterations of hippocampal pyramidal neurons induced by chronic stress in F344 rats PSYCHIATRY AND CLINICAL NEUROSCIENCES. 2008.02; 62 (1): S8.
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Otsuki, K; Uchida, S; Hara, K; Kobayashi, A; Watanabe, Y. Involvement of glucocorticoids-mediated downregulation of GDNF expression in the susceptibility to chronic ultra mild stress NEUROSCIENCE RESEARCH. 2008; 61 S206.
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Retinoic acid receptors function as positive regulators for memory formation 2008; 61 S193.
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Involvement of REST/NRSF repressor-mediated gene regulations in the risk of developing depression-like behavior in the maternally separated rats 2008; 61 S207.
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Involvement of glucocorticoids-mediated downregulation of GDNF expression in the susceptibility to chronic ultra mild stress 2008; 61 S206.
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Chronic reduction in dietary tryptophan leads to a selective impairment of contextual fear memory in mice 2007.05; 1149 149-156. ( PubMed, DOI )
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Suetsugi, M; Mizuki, Y; Yamamoto, K; Uchida, S; Watanabe, Y. The effect of placebo administration on the first-night effect in healthy young volunteers PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY. 2007.05; 31 (4): 839-847. ( PubMed, DOI )
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Wakabayashi, Y; Uchida, S; Matsubara, T; Funato, H; Kobayashi, A; Nishida, A; Watanabe, Y. Expression analysis of cell adhesion molecules in mood disorders PSYCHIATRY AND CLINICAL NEUROSCIENCES. 2007.04; 61 (2): S6.
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Expression analysis of cell adhesion molecules in mood disorders 2007.04; 61 (2): S6.
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Expression analysis of neurotrophic factors in patients with mood disorders 2007; 58 S123.
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Involvement of microRNA-mediated downregulation of glucocorticoid receptor in vulnerability to stress 2007; 58 S166.
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Otsuki, K; Uchida, S; Matsubara, T; Watanuki, T; Wakabayashi, Y; Watanabe, Y. Expression analysis of neurotrophic factors in patients with mood disorders NEUROSCIENCE RESEARCH. 2007; 58 S123. ( DOI )
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Watanuki, T; Uchida, S; Funato, H; Otsuki, K; Wakabayashi, Y; Watanabe, Y. Expression analysis of adhesion molecule CD44 isoform mRNA in the patients with mood disorders NEUROSCIENCE RESEARCH. 2007; 58 S124. ( DOI )
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Expression analysis of adhesion molecule CD44 isoform mRNA in the patients with mood disorders 2007; 58 S124.
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Roles of retinoic acid receptors in learning and memory 2007; 58 S111.
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Uchida, S; Nishida, A; Hara, K; Suetsugi, M; Fujimoto, M; Watanabe, Y. Involvement of microRNA-mediated downregulation of glucocorticoid receptor in vulnerability to stress NEUROSCIENCE RESEARCH. 2007; 58 S166. ( DOI )
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Tight regulation of transgene expression by tetracycline-dependent activator and repressor in brain 2006.02; 5 (1): 96-106. ( PubMed, DOI )
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Watanuki, T; Funato, H; Matsubara, T; Uchida, S; Watanabe, Y. Expression analysis of alternative splicing-related SR protein family in patients with mood disorders NEUROSCIENCE RESEARCH. 2006; 55 S233.
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Expression analysis of alternative splicing-related SR protein family in patients with mood disorders 2006; 55 S233.
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Chronic reduction in dietary tryptophan leads to changes in the emotional response to stress in mice 2005.06; 51 (3): 175-181. ( PubMed, DOI )
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Uchida Shusaku, Kitamoto Aya, Umeeda Hisahiro, Nakagawa Nobutoshi, Masushige Shoichi, Kida Satoshi. マウスにおいて食餌中慢性的トリプトファン減少はストレスに対する情動反応に変化を来たす(Chronic Reduction in Dietary Tryptophan Leads to Changes in the Emotional Response to Stress in Mice) Journal of Nutritional Science and Vitaminology. 2005.06; 51 (3): 175-181. ( ichushi )
Conference Activities & Talks 【 display / non-display 】
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内田周作. Epigenetic mechanisms driving synaptic plasticity and affective states under stressful situation. 第44回日本神経科学会 2021.07.28
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内田周作. Molecular and neural mechanisms of stress susceptibility and resilience. 第42回日本神経科学会 2019.07.01
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樋口 文宏, 内田 周作, 山形 弘隆, 關 友恵, 渡辺 義文. ストレス適応機構におけるヒストン脱アセチル化酵素の役割の解析(The role of histone deacetylase in stress-induced depression-like behavior in mice). 日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集 2017.09.01
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關 友恵, 山形 弘隆, 内田 周作, 原田 健一郎, 松尾 幸治, 渡邉 義文. 大うつ病性障害患者における長鎖非コードRNAの発現解析(Expression profiling of long, noncoding RNAs in patients with major depression). 日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集 2017.09.01
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大朏 孝治, 内田 周作, 芳原 輝之, 山形 弘隆, 渡邉 義文. ストレスによる脳機能障害の分子基盤 気分障害におけるエピジェネティクス(Molecular mechanism of brain dysfunction induced by stress Epigenetic regulation in depression). 日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集 2011.10.01
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山形 弘隆, 内田 周作, 大朏 孝治, 芳原 輝之, 渡邉 義文. Molecular Basis of Depression エピジェネティクスとストレス脆弱性、うつ病(Molecular Basis of Depression Epigenetic regulation of stress vulnerability and depression). 神経化学 2011.09.01
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内田 周作, 原 久美子, 古林 亜由美, 渡辺 義文. REST4を介した遺伝子発現調節異常はストレス脆弱性を高める(Involvement of REST4-mediated gene regulations in stress vulnerability). 神経化学 2010.08.01
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芳原 輝之, 内田 周作, 大朏 孝治, 山形 弘隆, 渡邊 義文. ヒストン脱アセチル化酵素阻害剤による抗うつ効果の分子機構の解析(Molecular mechanisms of the antidepressant actions by histone deacetylase inhibitors). 神経化学 2010.08.01
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阿部 尚子, 内田 周作, 大朏 孝治, 芳原 輝之, 樋口 文宏, 渡邉 義文. 気分障害患者におけるヒストン脱アセチル化酵素SIRT遺伝子群の発現変化(Altered gene expression of sirtuins in mood disorder patients). 神経化学 2010.08.01
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樋口 文宏, 内田 周作, 大朏 孝治, 芳原 輝之, 阿部 尚子, 渡邉 義文. 気分障害患者におけるDNAメチル基転移酵素群遺伝子の発現解析(Altered gene expression of DNA methyltransferases in mood disorder patients). 神経化学 2010.08.01
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大朏 孝治, 内田 周作, 山形 弘隆, 渡邉 義文. 抗うつ薬はHDAC4によるヒストン修飾を介してGDNF遺伝子の転写活性を増加させる(Antidepressants increase GDNF gene transcription through the histone modifications by HDAC4). 神経化学 2010.08.01
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武田 陽平, 野本 真順, 榎本 初音, 崔 泰樹, 内田 周作, 宮尾 貴久, 喜田 聡. 前脳領域レチノイン酸受容体情報伝達経路による記憶形成の制御(Regulation of memory formation by Retinoic acid receptors). 神経化学 2010.08.01
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Nomoto Masanori, Enomoto Hatsune, Takeda Yohei, Choi Tesu, Uchida Shusaku, Kida Satoshi. レチノイン酸受容体による記憶形成の陽性および陰性制御(Positive and negative regulation of memory formation by Retinoic acid receptors). Neuroscience Research 2009.09.01
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Uchida Shusaku, Otsuki Koji, Hara Kumiko, Kobayashi Ayumi, Hobara Teruyuki, Watanabe Yoshifumi. 線条体におけるHDAC2を介するGDNF遺伝子のエピジェネティックな抑制はストレスに対する行動感受性を調節する(HDAC2-mediated epigenetic repression of the GDNF gene in the striatum modulates behavioral vulnerability to stress). Neuroscience Research 2009.09.01
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Hobara Teruyuki, Uchida Shusaku, Otsuki Koji, Matsubara Toshio, Funato Hiromasa, Matsuo Koji, Suetsugi Masatomo, Watanabe Yoshifumi. 気分障害患者におけるヒストン脱アセチル化酵素の遺伝子発現変化(Altered gene expression of histone deacetylases in mood disorder patients). Neuroscience Research 2009.09.01
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Otsuki Koji, Uchida Shusaku, Watanabe Yoshifumi. 抗鬱薬はヒストン修飾を介してアストロサイトのGDNF遺伝子転写をアップレギュレートする(Antidepressant drugs upregurate glial astrocyte GDNF gene transcription through the histone modifications). Neuroscience Research 2009.09.01
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内田 周作, 原 久美子, 古林 亜由美, 大朏 孝治, 渡辺 義文. 発達期うつ様行動のリスク下における転写抑制因子REST/NRSFを介した遺伝子発現調節の役割(Role of REST/NRSF repressor-mediated gene regulations in the risk of developing depression-like behavior). 神経化学 2008.08.01
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Otsuki Koji, Uchida Shusaku, Hara Kumiko, Kobayashi Ayumi, Watanabe Yoshifumi. 慢性超軽微ストレスに対する感受性におけるGDNF発現のグルココルチコイド介在性下方制御の関与(Involvement of glucocorticoids-mediated downregulation of GDNF expression in the susceptibility to chronic ultra mild stress). Neuroscience Research 2008.07.01
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Nomoto Masanori, Enomoto Hatsune, Choi Tesu, Uchida Shusaku, Miyao Takahisa, Kida Satoshi. 記憶形成の正方向制御因子としてのレチノイン酸受容体機能(Retinoic acid receptors function as positive regulators for memory formation). Neuroscience Research 2008.07.01
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Uchida Shusaku, Hara Kumiko, Kobayashi Ayumi, Watanabe Yoshifumi. 母仔分離ラットの鬱病様行動の発症リスクにおけるREST/NRSFリプレッサー介在性遺伝子制御の関与(Involvement of REST/NRSF repressor-mediated gene regulations in the risk of developing depression-like behavior in the maternally separated rats). Neuroscience Research 2008.07.01
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Uchida Shusaku, Nishida Akira, Hara Kumiko, Suetsugi Masatomo, Fujimoto Michiko, Watanabe Yoshifumi. ストレス脆弱性モデルラットにおけるマイクロRNAを介したグルココルチコイド受容体の発現調節異常(Involvement of microRNA-mediated downregulation of glucocorticoid receptor in vulnerability to stress). 神経化学 2007.08.01
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Watanuki Toshio, Uchida Shusaku, Funato Hiromasa, Otsuki Koji, Wakabayashi Yusuke, Watanabe Yoshifumi. 気分障害患者末梢白血球における付着分子CD44 isoform mRNAの表現分析 選択的スプライシング調節機構異常の検討(Expression analysis of adhesion molecule CD44 isoform mRNA in the patients with mood disorders). 神経化学 2007.08.01
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Otsuki Koji, Uchida Shusaku, Matsubara Toshio, Watanuki Toshio, Wakabayashi Yusuke, Watanabe Yoshifumi. 気分障害患者における神経栄養因子群発現異常の検討(Expression analysis of neurotrophic factors in patients with mood disorders). 神経化学 2007.08.01
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Enomoto Hatune, Choi Tesu, Uchida Shusaku, Miyao Takahisa, Kida Satoshi. レチノイン酸受容体の記憶・学習に対する役割の解析(Roles of retinoic acid receptors in learning and memory). 神経化学 2007.08.01
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Watanuki Toshio, Funato Hiromasa, Matsubara Toshio, Uchida Shusaku, Watanabe Yoshifumi. 情動障害患者における選択的スプライシング-関連SR蛋白ファミリーの発現解析(Expression analysis of alternative splicing-related SR protein family in patients with mood disorders). Neuroscience Research 2006.07.01
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Uchida Shusaku, Umeeda Hisahiro, Hatakeyama Satoshi, Kida Satoshi. レチノイン酸受容体はセロトニン転送因子発現の調節を介して不安行動を調節する(Retinoic acid receptors regulate anxiety behavior through the control of serotonin transporter expression). Neuroscience Research 2005.07.01
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内田 周作, 舛重 正一, 喜田 聡. 前脳特異的エストロゲン受容体過剰発現マウスを用いた情動行動解析(Analysis of transgenic mice overexpressing estrogen receptor in forebrain). 神経化学 2004.08.01
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Fukumura Reiko, Kato Haruno, Shirode Yuko, Uchida Shusaku, Masushige Shoichi, Kida Satoshi. セロトニントランスポータプロモーターの転写調節におけるレチノイン酸受容体及びエストロゲン受容体の役割(Roles of retinoic acid receptor and estrogen receptor in transcriptional regulation of serotonin transporter promoter). Neuroscience Research 2003.07.01
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Uchida Shusaku, Sakai Shinsuke, Toyota Kozue, Yoshida Aya, Masushige Shoichi, Kida Satoshi. テトラサイクリン依存的な活性化因子及びリプレッサーによって調節される前脳特異的な導入遺伝子発現(Forebrain-specific transgene expression regulated by tetracycline-dependent activator and repressor). Neuroscience Research 2003.07.01