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高山 和雄(タカヤマ カズオ) TAKAYAMA Kazuo
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経歴(学外) 【 表示 ／ 非表示 】
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2015年04月-2018年01月大阪大学大学院薬学研究科 特任助教
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2018年02月-2020年02月大阪大学大学院薬学研究科 助教
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2020年03月-2025年03月京都大学iPS細胞研究所 講師
所属学協会 【 表示 ／ 非表示 】
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International Society for Stem Cell Research (ISSCR)
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バイオインダストリー協会
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肝細胞研究会
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日本ウイルス学会
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日本再生医療学会
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日本組織培養学会
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日本動物実験代替法学会
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日本毒性学会
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日本分子生物学会
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日本薬学会
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日本薬物動態学会
競争的資金等の研究課題 【 表示 ／ 非表示 】
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次世代の医療を開拓するヒト小腸組織チップの開発と応用
文部科学省/日本学術振興会 : 2025年 - 2026年
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生体模倣デバイスを用いた腸運動異常を起点とする炎症スバイラルの解析
文部科学省/日本学術振興会
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血管バリアに着目する新しい視点での重症感染症の病態・後遺症発症機構の解明と制御
文部科学省/日本学術振興会
論文・総説 【 表示 ／ 非表示 】
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Sayaka Deguchi, Fuki Yokoi, Kazuo Takayama. Organoids and microphysiological systems for pharmaceutical research of viral respiratory infections. Drug Metab Pharmacokinet. 2025.02; 60 101041. ( PubMed, DOI )
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Masatoshi Kakizaki, Rina Hashimoto, Noriyo Nagata, Takuya Yamamoto, Takashi Okura, Hiroshi Katoh, Yuki Kitai, Yukiko Akahori, Kazuya Shirato, Akihide Ryo, Kazuo Takayama, Makoto Takeda. The respective roles of TMPRSS2 and cathepsins for SARS-CoV-2 infection in human respiratory organoids. J Virol. 2025.01; 99 (1): e0185324. ( PubMed, DOI )
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Yasufumi Matsumura, Masaki Yamamoto, Yusuke Tsuda, Koh Shinohara, Yasuhiro Tsuchido, Satomi Yukawa, Taro Noguchi, Kazuo Takayama, Miki Nagao. Epidemiology of respiratory viruses according to age group, 2023-24 winter season, Kyoto, Japan. Sci Rep. 2025.01; 15 (1): 924. ( PubMed, DOI )
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Junya Michibata, Yoshimasa Kawaguchi, Hisaaki Hirose, Akiko Eguchi, Sayaka Deguchi, Kazuo Takayama, Wei Xu, Takuro Niidome, Yoshihiro Sasaki, Kazunari Akiyoshi, Shiroh Futaki. Polysaccharide-Based Coacervate Microgel Bearing Cationic Peptides That Achieve Dynamic Cell-Membrane Structure Alteration and Facile Cytosolic Infusion of IgGs. Bioconjug Chem. 2024.12; 35 (12): 1888-1899. ( PubMed, DOI )
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Minoru Inoue, Kazuo Takayama, Rina Hashimoto, Masahiro Enomoto, Naoki Date, Akihiro Ohsumi, Takashi Mizowaki. Hyponatremia unleashes neutrophil extracellular traps elevating life-threatening pulmonary embolism risk. Proc Natl Acad Sci U S A. 2024.11; 121 (45): e2404947121. ( PubMed, DOI )
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Masako Yamasaki, Wakana Saso, Takuya Yamamoto, Masayoshi Sato, Hiroko Takagi, Tetsuya Hasegawa, Yuji Kozakura, Hiroyuki Yokoi, Hirofumi Ohashi, Kana Tsuchimoto, Rina Hashimoto, Shuetsu Fukushi, Akihiko Uda, Masamichi Muramatsu, Kazuo Takayama, Ken Maeda, Yoshimasa Takahashi, Tsuyoshi Nagase, Koichi Watashi. Anti-SARS-CoV-2 gapmer antisense oligonucleotides targeting the main protease region of viral RNA. Antiviral Res. 2024.10; 230 105992. ( PubMed, DOI )
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Fuki Yokoi, Sayaka Deguchi, Yukio Watanabe, Kazuo Takayama. Establishment of an ulcerative colitis model using colon organoids derived from human induced pluripotent stem cells. iScience. 2024.10; 27 (10): 111049. ( PubMed, DOI )
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Shuhei Tsujino, Sayaka Deguchi, Tomo Nomai, Miguel Padilla-Blanco, Arnon Plianchaisuk, Lei Wang, Mst Monira Begum, Keiya Uriu, Keita Mizuma, Naganori Nao, Isshu Kojima, Tomoya Tsubo, Jingshu Li, Yasufumi Matsumura, Miki Nagao, Yoshitaka Oda, Masumi Tsuda, Yuki Anraku, Shunsuke Kita, Hisano Yajima, Kaori Sasaki-Tabata, Ziyi Guo, Alfredo A Hinay, Kumiko Yoshimatsu, Yuki Yamamoto, Tetsuharu Nagamoto, Hiroyuki Asakura, Mami Nagashima, Kenji Sadamasu, Kazuhisa Yoshimura, Hesham Nasser, Michael Jonathan, Olivia Putri, Yoonjin Kim, Luo Chen, Rigel Suzuki, Tomokazu Tamura, Katsumi Maenaka, Takashi Irie, Keita Matsuno, Shinya Tanaka, Jumpei Ito, Terumasa Ikeda, Kazuo Takayama, Jiri Zahradnik, Takao Hashiguchi, Takasuke Fukuhara, Kei Sato, . Virological characteristics of the SARS-CoV-2 Omicron EG.5.1 variant. Microbiol Immunol. 2024.09; 68 (9): 305-330. ( PubMed, DOI )
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Sayaka Deguchi, Kaori Kosugi, Naoki Takeishi, Yukio Watanabe, Shiho Morimoto, Ryosuke Negoro, Fuki Yokoi, Hiroki Futatsusako, May Nakajima-Koyama, Mio Iwasaki, Takuya Yamamoto, Yoshiya Kawaguchi, Yu-Suke Torisawa, Kazuo Takayama. Construction of multilayered small intestine-like tissue by reproducing interstitial flow. Cell Stem Cell. 2024.09; 31 (9): 1315-1326.e8. ( PubMed, DOI )
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Mengyang Wang, Yuko Sasaki, Rena Sakagami, Tomotaka Minamikawa, Masahiro Tsuda, Ryohei Ueno, Sayaka Deguchi, Ryosuke Negoro, Kanako So, Yuriko Higuchi, Ryuji Yokokawa, Kazuo Takayama, Fumiyoshi Yamashita. Perfluoropolyether-Based Gut-Liver-on-a-Chip for the Evaluation of First-Pass Metabolism and Oral Bioavailability of Drugs. ACS Biomater Sci Eng. 2024.07; 10 (7): 4635-4644. ( PubMed, DOI )
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Shigeru Fujita, Arnon Plianchaisuk, Sayaka Deguchi, Hayato Ito, Naganori Nao, Lei Wang, Hesham Nasser, Tomokazu Tamura, Izumi Kimura, Yukie Kashima, Rigel Suzuki, Saori Suzuki, Izumi Kida, Masumi Tsuda, Yoshitaka Oda, Rina Hashimoto, Yukio Watanabe, Keiya Uriu, Daichi Yamasoba, Ziyi Guo, Alfredo A Hinay, Yusuke Kosugi, Luo Chen, Lin Pan, Yu Kaku, Hin Chu, Flora Donati, Sarah Temmam, Marc Eloit, Yuki Yamamoto, Tetsuharu Nagamoto, Hiroyuki Asakura, Mami Nagashima, Kenji Sadamasu, Kazuhisa Yoshimura, Yutaka Suzuki, , Jumpei Ito, Terumasa Ikeda, Shinya Tanaka, Keita Matsuno, Takasuke Fukuhara, Kazuo Takayama, Kei Sato. Virological characteristics of a SARS-CoV-2-related bat coronavirus, BANAL-20-236. EBioMedicine. 2024.06; 104 105181. ( PubMed, DOI )
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Hiroki Futatsusako, Rina Hashimoto, Masaki Yamamoto, Jumpei Ito, Yasufumi Matsumura, Hajime Yoshifuji, Kotaro Shirakawa, Akifumi Takaori-Kondo, , Kei Sato, Miki Nagao, Kazuo Takayama. Longitudinal analysis of genomic mutations in SARS-CoV-2 isolates from persistent COVID-19 patient. iScience. 2024.05; 27 (5): 109597. ( PubMed, DOI )
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Masato Tanaka, Keisuke Shirakura, Yui Takayama, Miki Μatsui, Yukio Watanabe, Takuya Yamamoto, Junya Takahashi, Shota Tanaka, Nobumasa Hino, Takefumi Doi, Masanori Obana, Yasushi Fujio, Kazuo Takayama, Yoshiaki Okada. Endothelial ROBO4 suppresses PTGS2/COX-2 expression and inflammatory diseases. Commun Biol. 2024.05; 7 (1): 599. ( PubMed, DOI )
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Atsushi Masui, Rina Hashimoto, Yasufumi Matsumura, Takuya Yamamoto, Miki Nagao, Takeshi Noda, Kazuo Takayama, Shimpei Gotoh. Micro-patterned culture of iPSC-derived alveolar and airway cells distinguishes SARS-CoV-2 variants. Stem Cell Reports. 2024.04; 19 (4): 545-561. ( PubMed, DOI )
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Ryosuke Negoro, Ayu Ouchi, Sayaka Deguchi, Kazuo Takayama, Takuya Fujita. Refining Hepatocyte Models to Capture the Impact of CYP2D6*10 Utilizing a PITCh System. Biol Pharm Bull. 2024; 47 (8): 1422-1428. ( PubMed, DOI )
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Kazuo Takayama, Daiju Yamazaki. [Preface]. Nihon Yakurigaku Zasshi. 2025; 160 (2): 86. ( PubMed, DOI )
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Rina Hashimoto, Atsushi Masui, Shimpei Gotoh, Kazuo Takayama. [Development of human iPS cell-derived alveolar and airway models using micropatterning plate for SARS-CoV-2 research]. Uirusu. 2024; 74 (1): 35-44. ( PubMed, DOI )