Personnel Information

写真a

TAKAYAMA Kazuo


Job title

Professor

Birth date

1986

Laboratory Address

M&D tower 23th floor

Laboratory Phone number

+81-3-5803-5820

Mail Address

takayama.kazuo@tmd.ac.jp

Homepage URL

https://www.ktakayama.com/

Research Areas, Keywords

iPS cells, organoids, organ-on-a-chip, viral infections, drug discovery

Field Introduction URL

https://www.ktakayama.com/

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Graduating School 【 display / non-display 】

  • Osaka University, Faculty of Pharmaceutical Science, 2010.03, Graduated

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Graduate School 【 display / non-display 】

  • Osaka University, Graduate School, Division of Pharmaceutical Sciences, Doctor's Course, 2015.03, Completed

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Campus Career 【 display / non-display 】

  • 2025.02
    -
    Now
    Institute of Science Tokyo， -， Institute of Integrated Research， -， -， Professor
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External Career 【 display / non-display 】

  • 2015.04
    -
    2018.01
    , Project Assistant Professor
  • 2018.02
    -
    2020.02
    , Assistant Professor
  • 2020.03
    -
    2025.03
    , Junior Associate Professor
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Research Areas 【 display / non-display 】

  • Biomedical engineering

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Published Papers & Misc 【 display / non-display 】

  1. Hiroko Toyoda, Ayaka Nozue, Yuki Nishida, Yasuko Yakabe, Yasuhiko Aiki, Yukiko Ueyama-Toba, Kazuo Takayama, Hiroyuki Mizuguchi, Chihiro Mori, Yu-Suke Torisawa, Yoko Sakai, Takahiro Iwao, Tamihide Matsunaga, Shinichiro Horiuchi, Daiju Yamazaki, Seiichi Ishida, Nobuhiko Kojima, Kosuke Inamura, Yasuyuki Sakai, Masaki Nishikawa, Ikue Mihara, Takafumi Akabane, Yuzuru Ito. Considerations for developing CYP induction assays in hepatocytes: Insights from a multilaboratory study. Eur J Cell Biol. 2025.09; 104 (3): 151497. ( PubMed, DOI )

  2. Shuhei Tsujino, Masumi Tsuda, Naganori Nao, Kaho Okumura, Lei Wang, Yoshitaka Oda, Yume Mimura, Jingshu Li, Rina Hashimoto, Yasufumi Matsumura, Rigel Suzuki, Saori Suzuki, Kumiko Yoshimatsu, Miki Nagao, Jumpei Ito, Kazuo Takayama, Kei Sato, Keita Matsuno, Tomokazu Tamura, Shinya Tanaka, Takasuke Fukuhara, . Evolution of BA.2.86 to JN.1 reveals that functional changes in non-structural viral proteins are required for fitness of SARS-CoV-2. J Virol. 2025.09; e0090825. ( PubMed, DOI )

  3. Miguel Martí, Alba Cano-Vicent, Mercedes Cervera-Alamar, Rina Hashimoto, Kazuo Takayama, Ángel Serrano-Aroca. Multifunctional materials with potential antiviral applications in face masks, face shields, and hydrogels against mpox virus. Sci Rep. 2025.09; 15 (1): 32075. ( PubMed, DOI )

  4. Soichiro Hashimoto, Toshiro Hirai, Koki Ueda, Mako Kakihara, Nagisa Tokunoh, Chikako Ono, Yoshiharu Matsuura, Kazuo Takayama, Yasuo Yoshioka. Hypertonic intranasal vaccines gain nasal epithelia access to exert strong immunogenicity. Mucosal Immunol. 2025.08; 18 (4): 793-809. ( PubMed, DOI )

  5. Shuhei Higuchi, Yafei Liu, Jun Shimizu, Chikako Ono, Yumi Itoh, Wataru Nakai, Hui Jin, Kazuki Kishida, Kazuo Takayama, Toru Okamoto, Yoshiko Murakami, Taroh Kinoshita, Yoshiharu Matsuura, Tatsuo Shioda, Hisashi Arase. Evolutionary dynamics of heparan sulfate utilization by SARS-CoV-2. mBio. 2025.08; 16 (8): e0130325. ( PubMed, DOI )

  6. Jumana Khalil, Kosuke Miyauchi, Yosie Suzuki, Sewon Ki, Yasuyo Harada, Takanori Sasaki, Yuichiro Yamamoto, Rina Hashimoto, Takako Yamamoto, Masashi Matsuda, Haruhiko Koseki, Manabu Nakayama, Masayoshi Fukasawa, Takaji Wakita, Hideki Ueno, Kohji Noguchi, Kazuo Takayama, Masato Kubo. The Role of IL-4+ Memory T Cells in SARS-CoV-2 Booster Vaccination. Int Immunol. 2025.08; ( PubMed, DOI )

  7. Chunhui Tian, Zheng Ao, Jonas Cerneckis, Hongwei Cai, Lei Chen, Hengyao Niu, Kazuo Takayama, Jungsu Kim, Yanhong Shi, Mingxia Gu, Takahisa Kanekiyo, Feng Guo. Understanding monocyte-driven neuroinflammation in Alzheimer's disease using human cortical organoid microphysiological systems. Sci Adv. 2025.08; 11 (34): eadu2708. ( PubMed, DOI )

  8. Rina Hashimoto, Yukio Watanabe, Abeer Keshta, Masaya Sugiyama, Yuki Kitai, Ai Hirabayashi, Naoko Yasuhara, Shiho Morimoto, Ayaka Sakamoto, Yasufumi Matsumura, Hidekazu Nishimura, Takeshi Noda, Takuya Yamamoto, Miki Nagao, Makoto Takeda, Kazuo Takayama. Human iPS cell-derived respiratory organoids as a model for respiratory syncytial virus infection. Life Sci Alliance. 2025.07; 8 (7): ( PubMed, DOI )

  9. Yuki Kitai, Shohei Kojima, Aikeda Aishajiang, Miyuki Kawase, Oshi Watanabe, Haruka Yabukami, Rina Hashimoto, Yukiko Akahori, Hiroshi Katoh, Kazuo Takayama, Hidekazu Nishimura, Kazuya Shirato, Makoto Takeda. Changes in ORF4 of HCoV-229E under different culture conditions. J Gen Virol. 2025.07; 106 (7): ( PubMed, DOI )

  10. Malvin Leonardo Pardi, Kazuo Takayama, Hirohide Saito. SARS-CoV-2 Nsp1-Resistant Modified RNA for the Creation of Nsp1-Responsive Systems. ACS Synth Biol. 2025.06; 14 (6): 2386-2392. ( PubMed, DOI )

  11. Fuki Yokoi, Sayaka Deguchi, Kazuo Takayama. Advancing intestinal disease research using gut-on-a-chip. Regen Ther. 2025.06; 29 541-550. ( PubMed, DOI )

  12. Hiroshi Arakawa, Kazuo Takayama. Future direction of animal alternative/microphysiological systems in drug discovery and development. Drug Metab Pharmacokinet. 2025.04; 61 101479. ( PubMed, DOI )

  13. Sayaka Deguchi, Fuki Yokoi, Kazuo Takayama. Organoids and microphysiological systems for pharmaceutical research of viral respiratory infections. Drug Metab Pharmacokinet. 2025.02; 60 101041. ( PubMed, DOI )

  14. Masatoshi Kakizaki, Rina Hashimoto, Noriyo Nagata, Takuya Yamamoto, Takashi Okura, Hiroshi Katoh, Yuki Kitai, Yukiko Akahori, Kazuya Shirato, Akihide Ryo, Kazuo Takayama, Makoto Takeda. The respective roles of TMPRSS2 and cathepsins for SARS-CoV-2 infection in human respiratory organoids. J Virol. 2025.01; 99 (1): e0185324. ( PubMed, DOI )

  15. Yasufumi Matsumura, Masaki Yamamoto, Yusuke Tsuda, Koh Shinohara, Yasuhiro Tsuchido, Satomi Yukawa, Taro Noguchi, Kazuo Takayama, Miki Nagao. Epidemiology of respiratory viruses according to age group, 2023-24 winter season, Kyoto, Japan. Sci Rep. 2025.01; 15 (1): 924. ( PubMed, DOI )

  16. Junya Michibata, Yoshimasa Kawaguchi, Hisaaki Hirose, Akiko Eguchi, Sayaka Deguchi, Kazuo Takayama, Wei Xu, Takuro Niidome, Yoshihiro Sasaki, Kazunari Akiyoshi, Shiroh Futaki. Polysaccharide-Based Coacervate Microgel Bearing Cationic Peptides That Achieve Dynamic Cell-Membrane Structure Alteration and Facile Cytosolic Infusion of IgGs. Bioconjug Chem. 2024.12; 35 (12): 1888-1899. ( PubMed, DOI )

  17. Minoru Inoue, Kazuo Takayama, Rina Hashimoto, Masahiro Enomoto, Naoki Date, Akihiro Ohsumi, Takashi Mizowaki. Hyponatremia unleashes neutrophil extracellular traps elevating life-threatening pulmonary embolism risk. Proc Natl Acad Sci U S A. 2024.11; 121 (45): e2404947121. ( PubMed, DOI )

  18. Masako Yamasaki, Wakana Saso, Takuya Yamamoto, Masayoshi Sato, Hiroko Takagi, Tetsuya Hasegawa, Yuji Kozakura, Hiroyuki Yokoi, Hirofumi Ohashi, Kana Tsuchimoto, Rina Hashimoto, Shuetsu Fukushi, Akihiko Uda, Masamichi Muramatsu, Kazuo Takayama, Ken Maeda, Yoshimasa Takahashi, Tsuyoshi Nagase, Koichi Watashi. Anti-SARS-CoV-2 gapmer antisense oligonucleotides targeting the main protease region of viral RNA. Antiviral Res. 2024.10; 230 105992. ( PubMed, DOI )

  19. Fuki Yokoi, Sayaka Deguchi, Yukio Watanabe, Kazuo Takayama. Establishment of an ulcerative colitis model using colon organoids derived from human induced pluripotent stem cells. iScience. 2024.10; 27 (10): 111049. ( PubMed, DOI )

  20. Shuhei Tsujino, Sayaka Deguchi, Tomo Nomai, Miguel Padilla-Blanco, Arnon Plianchaisuk, Lei Wang, Mst Monira Begum, Keiya Uriu, Keita Mizuma, Naganori Nao, Isshu Kojima, Tomoya Tsubo, Jingshu Li, Yasufumi Matsumura, Miki Nagao, Yoshitaka Oda, Masumi Tsuda, Yuki Anraku, Shunsuke Kita, Hisano Yajima, Kaori Sasaki-Tabata, Ziyi Guo, Alfredo A Hinay, Kumiko Yoshimatsu, Yuki Yamamoto, Tetsuharu Nagamoto, Hiroyuki Asakura, Mami Nagashima, Kenji Sadamasu, Kazuhisa Yoshimura, Hesham Nasser, Michael Jonathan, Olivia Putri, Yoonjin Kim, Luo Chen, Rigel Suzuki, Tomokazu Tamura, Katsumi Maenaka, Takashi Irie, Keita Matsuno, Shinya Tanaka, Jumpei Ito, Terumasa Ikeda, Kazuo Takayama, Jiri Zahradnik, Takao Hashiguchi, Takasuke Fukuhara, Kei Sato, . Virological characteristics of the SARS-CoV-2 Omicron EG.5.1 variant. Microbiol Immunol. 2024.09; 68 (9): 305-330. ( PubMed, DOI )

  21. Sayaka Deguchi, Kaori Kosugi, Naoki Takeishi, Yukio Watanabe, Shiho Morimoto, Ryosuke Negoro, Fuki Yokoi, Hiroki Futatsusako, May Nakajima-Koyama, Mio Iwasaki, Takuya Yamamoto, Yoshiya Kawaguchi, Yu-Suke Torisawa, Kazuo Takayama. Construction of multilayered small intestine-like tissue by reproducing interstitial flow. Cell Stem Cell. 2024.09; 31 (9): 1315-1326.e8. ( PubMed, DOI )

  22. Mengyang Wang, Yuko Sasaki, Rena Sakagami, Tomotaka Minamikawa, Masahiro Tsuda, Ryohei Ueno, Sayaka Deguchi, Ryosuke Negoro, Kanako So, Yuriko Higuchi, Ryuji Yokokawa, Kazuo Takayama, Fumiyoshi Yamashita. Perfluoropolyether-Based Gut-Liver-on-a-Chip for the Evaluation of First-Pass Metabolism and Oral Bioavailability of Drugs. ACS Biomater Sci Eng. 2024.07; 10 (7): 4635-4644. ( PubMed, DOI )

  23. Shigeru Fujita, Arnon Plianchaisuk, Sayaka Deguchi, Hayato Ito, Naganori Nao, Lei Wang, Hesham Nasser, Tomokazu Tamura, Izumi Kimura, Yukie Kashima, Rigel Suzuki, Saori Suzuki, Izumi Kida, Masumi Tsuda, Yoshitaka Oda, Rina Hashimoto, Yukio Watanabe, Keiya Uriu, Daichi Yamasoba, Ziyi Guo, Alfredo A Hinay, Yusuke Kosugi, Luo Chen, Lin Pan, Yu Kaku, Hin Chu, Flora Donati, Sarah Temmam, Marc Eloit, Yuki Yamamoto, Tetsuharu Nagamoto, Hiroyuki Asakura, Mami Nagashima, Kenji Sadamasu, Kazuhisa Yoshimura, Yutaka Suzuki, , Jumpei Ito, Terumasa Ikeda, Shinya Tanaka, Keita Matsuno, Takasuke Fukuhara, Kazuo Takayama, Kei Sato. Virological characteristics of a SARS-CoV-2-related bat coronavirus, BANAL-20-236. EBioMedicine. 2024.06; 104 105181. ( PubMed, DOI )

  24. Hiroki Futatsusako, Rina Hashimoto, Masaki Yamamoto, Jumpei Ito, Yasufumi Matsumura, Hajime Yoshifuji, Kotaro Shirakawa, Akifumi Takaori-Kondo, , Kei Sato, Miki Nagao, Kazuo Takayama. Longitudinal analysis of genomic mutations in SARS-CoV-2 isolates from persistent COVID-19 patient. iScience. 2024.05; 27 (5): 109597. ( PubMed, DOI )

  25. Masato Tanaka, Keisuke Shirakura, Yui Takayama, Miki Μatsui, Yukio Watanabe, Takuya Yamamoto, Junya Takahashi, Shota Tanaka, Nobumasa Hino, Takefumi Doi, Masanori Obana, Yasushi Fujio, Kazuo Takayama, Yoshiaki Okada. Endothelial ROBO4 suppresses PTGS2/COX-2 expression and inflammatory diseases. Commun Biol. 2024.05; 7 (1): 599. ( PubMed, DOI )

  26. Atsushi Masui, Rina Hashimoto, Yasufumi Matsumura, Takuya Yamamoto, Miki Nagao, Takeshi Noda, Kazuo Takayama, Shimpei Gotoh. Micro-patterned culture of iPSC-derived alveolar and airway cells distinguishes SARS-CoV-2 variants. Stem Cell Reports. 2024.04; 19 (4): 545-561. ( PubMed, DOI )

  27. Ryosuke Negoro, Ayu Ouchi, Sayaka Deguchi, Kazuo Takayama, Takuya Fujita. Refining Hepatocyte Models to Capture the Impact of CYP2D6*10 Utilizing a PITCh System. Biol Pharm Bull. 2024; 47 (8): 1422-1428. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display 】

  1. Kazuo Takayama. Infectious disease research using organoids and organ-on-a-chip. 第5回ロート再生医療フォーラム 2025.09.19

  2. Kazuo Takayama. RESEARCH FOR VIRAL RESPIRATORY INFECTIONS USING ORGANOIDS AND ORGAN-ON-A-CHIP. ISSCR 2025 Annual Meeting 2025.06.13

  3. Kazuo Takayama. Human ES/iPS cell-derived respiratory models for virus research. 31st FAOBMB Conference & 2025 KSBMB International Conference 2025.05.21

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