経歴(学外) 【 表示 ／ 非表示 】
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2018年04月筑波大学 生命環境科学研究科 博士研究員
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2018年05月-2020年04月日本学術振興会 海外特別研究員
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2018年05月-2024年03月Imperial College London Research Associate
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2018年05月-2024年03月MRC Laboratory of Medical Sciences Research Associate
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2020年05月-2021年04月上原記念生命科学財団 ポストドクトラルフェロー
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2024年04月-2025年01月The Francis Crick Institute Postdoctoral Fellow
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2025年02月-現在東京科学大学 総合研究院 難治疾患研究所 プロジェクト助教
研究テーマ 【 表示 ／ 非表示 】
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母体腸管リモデリングを介した母体心理と胎児発達の連関メカニズムの解明，2026年06月 - 2028年03月
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微量栄養素依存的な母体の腸管リモデリング制御メカニズムの解明，2026年04月 - 2029年03月
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妊娠に伴う母体の腸管リモデリング：栄養依存的なメカニズムの追究，2025年07月 - 2027年03月
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交尾刺激による生殖幹細胞の増加を司るステロイドホルモンを介した神経機構の追究，2015年04月 - 2018年03月
論文・総説 【 表示 ／ 非表示 】
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Mineo Alessandro, Blackie Laura, Milona Alexandra, Strachan Emily, Gaspar Pedro, Luis Nuno Miguel, Castano-Medina Alvaro, Ameku Tomotsune, Silva Bryon, Prasad Anadika, Essmann Clara L, Jacobson Jake, Fallesen Todd, Dao Vanessa, Khadayate Sanjay, Young George, Cabreiro Filipe, Schnorrer Frank, Miguel-Aliaga Irene. The sex and reproductive plasticity of intestinal muscles instruct gut size. Cell. 2026.08; ( PubMed, DOI )
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Amourda Christopher, Blackie Laura, Gaspar Pedro, Martin-Coll Laura, Prasad Anadika R, House Andrew H, Holopainen Minna, Ruhanen Hanna, Lamichane Nicole, Hadjieconomou Dafni, Ameku Tomotsune, Mineo Alessandro, Coxhead Milly, Soler-Sáez Irene, Galiana-Roselló Cristina, García-Garcia Francisco, Wang Yi-Fang, Alexandre Cyrille, Hietakangas Ville, Käkelä Reijo, Vernia Santiago, Miguel-Aliaga Irene. Myc sustains sex-biased organ zonation in the Drosophila intestine. Dev Cell. 2026.07; 61 (7): 1535-1554.e6. ( PubMed, DOI )
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Ameku Tomotsune. Maternal Organ Growth: How the Adult Intestine Remodels During Pregnancy and Lactation. Dev Growth Differ. 2026.01; 68 (1): e70037. ( PubMed, DOI )
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Ameku Tomotsune, Laddach Anna, Beckwith Hannah, Milona Alexandra, Rogers Loranzie S, Schwayer Cornelia, Nye Emma, Tough Iain R, Thoumas Jean-Louis, Gautam Umesh Kumar, Wang Yi-Fang, Jha Shreya, Castano-Medina Alvaro, Amourda Christopher, Vaelli Patric M, Gevers Sira, Irvine Elaine E, Meyer Leah, Andrew Ivan, Choi Ka Lok, Patel Bhavik, Francis Alice J, Studd Chris, Game Laurence, Young George, Murphy Kevin G, Owen Bryn, Withers Dominic J, Rodriguez-Colman Maria, Cox Helen M, Liberali Prisca, Schwarzer Martin, Leulier François, Pachnis Vassilis, Bellono Nicholas W, Miguel-Aliaga Irene. Growth of the maternal intestine during reproduction. Cell. 2025.05; 188 (10): 2738-2756.e22. ( PubMed, DOI )
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Blackie Laura, Gaspar Pedro, Mosleh Salem, Lushchak Oleh, Kong Lingjin, Jin Yuhong, Zielinska Agata P, Cao Boxuan, Mineo Alessandro, Silva Bryon, Ameku Tomotsune, Lim Shu En, Mao Yanlan, Prieto-Godino Lucía, Schoborg Todd, Varela Marta, Mahadevan L, Miguel-Aliaga Irene. The sex of organ geometry. Nature. 2024.06; 630 (8016): 392-400. ( PubMed, DOI )
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Hadjieconomou Dafni, King George, Gaspar Pedro, Mineo Alessandro, Blackie Laura, Ameku Tomotsune, Studd Chris, de Mendoza Alex, Diao Fengqiu, White Benjamin H, Brown André E X, Plaçais Pierre-Yves, Préat Thomas, Miguel-Aliaga Irene. Enteric neurons increase maternal food intake during reproduction. Nature. 2020.11; 587 (7834): 455-459. ( PubMed, DOI )
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Yoshinari Yuto, Ameku Tomotsune, Kondo Shu, Tanimoto Hiromu, Kuraishi Takayuki, Shimada-Niwa Yuko, Niwa Ryusuke. Neuronal octopamine signaling regulates mating-induced germline stem cell increase in female Drosophila melanogaster. Elife. 2020.10; 9 ( PubMed, DOI )
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Ameku Tomotsune, Beckwith Hannah, Blackie Laura, Miguel-Aliaga Irene. Food, microbes, sex and old age: on the plasticity of gastrointestinal innervation. Curr Opin Neurobiol. 2020.06; 62 83-91. ( PubMed, DOI )
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Yoshinari Yuto, Kurogi Yoshitomo, Ameku Tomotsune, Niwa Ryusuke. Endocrine regulation of female germline stem cells in the fruit fly Drosophila melanogaster. Curr Opin Insect Sci. 2019.02; 31 14-19. ( PubMed, DOI )
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Ameku Tomotsune, Yoshinari Yuto, Texada Michael J, Kondo Shu, Amezawa Kotaro, Yoshizaki Goro, Shimada-Niwa Yuko, Niwa Ryusuke. Midgut-derived neuropeptide F controls germline stem cell proliferation in a mating-dependent manner. PLoS Biol. 2018.09; 16 (9): e2005004. ( PubMed, DOI )
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Ameku Tomotsune, Yoshinari Yuto, Fukuda Ruriko, Niwa Ryusuke. Ovarian ecdysteroid biosynthesis and female germline stem cells. Fly (Austin). 2017.07; 11 (3): 185-193. ( PubMed, DOI )
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Ameku Tomotsune, Niwa Ryusuke. Mating-Induced Increase in Germline Stem Cells via the Neuroendocrine System in Female Drosophila. PLoS Genet. 2016.06; 12 (6): e1006123. ( PubMed, DOI )
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Uryu Outa, Ameku Tomotsune, Niwa Ryusuke. Recent progress in understanding the role of ecdysteroids in adult insects: Germline development and circadian clock in the fruit fly Drosophila melanogaster. Zoological Lett. 2015; 1 32. ( PubMed, DOI )
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Enya Sora, Ameku Tomotsune, Igarashi Fumihiko, Iga Masatoshi, Kataoka Hiroshi, Shinoda Tetsuro, Niwa Ryusuke. A Halloween gene noppera-bo encodes a glutathione S-transferase essential for ecdysteroid biosynthesis via regulating the behaviour of cholesterol in Drosophila. Sci Rep. 2014.10; 4 6586. ( PubMed, DOI )
講演・口頭発表等 【 表示 ／ 非表示 】
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Tomotsune Ameku. Growth of the maternal intestine during reproduction in mice. 第77回日本細胞生物学会・第58回日本発生生物学会 合同大会 2025.07.16
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天久朝恒. 妊娠に伴う母体の臓器リモデリング：腸管に着目して. 筑波大学 World Science Leaders’ Seminar 2025.05.23
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天久朝恒. 妊娠期における母体の臓器リモデリング. CREST 多細胞領域 第7回領域会議 2025.12.08
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天久朝恒. 妊娠・授乳に伴う母体臓器のリモデリングと母胎連関. 第48回日本分子生物学会年会 2025.12.05
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Tomotsune Ameku. Maternal gut remodelling during reproduction. 14th Crick Physiology & Metabolism Forum (PhysMet) 2024.11.19
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Tomotsune Ameku. Growth of the maternal gut during reproduction in mice. MRC LMS Spatial Genomics Symposium 2024.11.14
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Tomotsune Ameku. Growth of the maternal intestine during reproduction in mice. Crick Development & Stem Cells Symposium 2024.10.25
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天久朝恒. 生殖期における成体の腸管リモデリング. 京都大学 生命科学セミナー 2024.03.08
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Tomotsune Ameku. Growth of the maternal intestine during reproduction. RIKEN BDR Symposium 2024, Time Across Scales 2024.03.05
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Tomotsune Ameku. Transcriptome and proteome analysis to investigate sex differences and the reproductive plasticity of the intestine. The European Drosophila Research Conference (EDRC) 2023 2023.10.22
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天久朝恒. 生殖期における成体の腸管リモデリング. 第45回日本分子生物学会年会 2022.12.02
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Tomotsune Ameku. Organ plasticity in the adult intestine during reproduction. MRC LMS Single-cell Workshop 2021.05.19
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Tomotsune Ameku. Sex difference in adult intestine. MRC LMS Work In Progress Seminar 2019.05.24
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Tomotsune Ameku. Intrinsic sex differences in the murine intestine. BSCB/BSDB Joint Spring Meeting 2019 2019.04.07
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Tomotsune Ameku. Intrinsic sex differences in intestinal cell plasticity. Organoids: Modelling Organ Development and Disease in 3D Culture 2018.09.10
受賞学術賞 【 表示 ／ 非表示 】
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若手優秀発表賞，日本細胞生物学会・日本発生生物学会，2025年07月
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学長表彰，筑波大学，2018年03月
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Excellent Presentation Award，Insect Hormone Workshop，2017年07月