Personnel Information

写真a

AMEKU Tomotsune


Job title

Assistant Professor
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Graduating School 【 display / non-display 】

  • University of Tsukuba, Graduate School of Life and Environmental Sciences, PhD. in Science, 2018.03, Graduated

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Campus Career 【 display / non-display 】

  • 2025.02
    -
    Now
    Institute of Science Tokyo， -， Institute of Integrated Research， -， Homeostatic Medicine， Assistant Professor
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External Career 【 display / non-display 】

  • 2018.04
    　
    　
    University of Tsukuba, Graduate School of Life and Environmental Sciences,
  • 2018.05
    -
    2020.04
    JSPS,
  • 2018.05
    -
    2024.03
    Imperial College London, Research Associate
  • 2018.05
    -
    2024.03
    MRC Laboratory of Medical Sciences, Research Associate
  • 2020.05
    -
    2021.04
    The Uehara Memorial Foundation,
  • 2024.04
    -
    2025.01
    The Francis Crick Institute, Postdoctoral Fellow
  • 2025.02
    -
    Now
    Institute of Science Tokyo, Medical Research Institute, Project Assistant Professor

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Research Areas 【 display / non-display 】

  • Cell biology

  • Developmental biology

  • Animal physiological chemistry, physiology and behavioral biology

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Published Papers & Misc 【 display / non-display 】

  1. Mineo Alessandro, Blackie Laura, Milona Alexandra, Strachan Emily, Gaspar Pedro, Luis Nuno Miguel, Castano-Medina Alvaro, Ameku Tomotsune, Silva Bryon, Prasad Anadika, Essmann Clara L, Jacobson Jake, Fallesen Todd, Dao Vanessa, Khadayate Sanjay, Young George, Cabreiro Filipe, Schnorrer Frank, Miguel-Aliaga Irene. The sex and reproductive plasticity of intestinal muscles instruct gut size. Cell. 2026.08; ( PubMed, DOI )

  2. Amourda Christopher, Blackie Laura, Gaspar Pedro, Martin-Coll Laura, Prasad Anadika R, House Andrew H, Holopainen Minna, Ruhanen Hanna, Lamichane Nicole, Hadjieconomou Dafni, Ameku Tomotsune, Mineo Alessandro, Coxhead Milly, Soler-Sáez Irene, Galiana-Roselló Cristina, García-Garcia Francisco, Wang Yi-Fang, Alexandre Cyrille, Hietakangas Ville, Käkelä Reijo, Vernia Santiago, Miguel-Aliaga Irene. Myc sustains sex-biased organ zonation in the Drosophila intestine. Dev Cell. 2026.07; 61 (7): 1535-1554.e6. ( PubMed, DOI )

  3. Ameku Tomotsune. Maternal Organ Growth: How the Adult Intestine Remodels During Pregnancy and Lactation. Dev Growth Differ. 2026.01; 68 (1): e70037. ( PubMed, DOI )

  4. Ameku Tomotsune, Laddach Anna, Beckwith Hannah, Milona Alexandra, Rogers Loranzie S, Schwayer Cornelia, Nye Emma, Tough Iain R, Thoumas Jean-Louis, Gautam Umesh Kumar, Wang Yi-Fang, Jha Shreya, Castano-Medina Alvaro, Amourda Christopher, Vaelli Patric M, Gevers Sira, Irvine Elaine E, Meyer Leah, Andrew Ivan, Choi Ka Lok, Patel Bhavik, Francis Alice J, Studd Chris, Game Laurence, Young George, Murphy Kevin G, Owen Bryn, Withers Dominic J, Rodriguez-Colman Maria, Cox Helen M, Liberali Prisca, Schwarzer Martin, Leulier François, Pachnis Vassilis, Bellono Nicholas W, Miguel-Aliaga Irene. Growth of the maternal intestine during reproduction. Cell. 2025.05; 188 (10): 2738-2756.e22. ( PubMed, DOI )

  5. Blackie Laura, Gaspar Pedro, Mosleh Salem, Lushchak Oleh, Kong Lingjin, Jin Yuhong, Zielinska Agata P, Cao Boxuan, Mineo Alessandro, Silva Bryon, Ameku Tomotsune, Lim Shu En, Mao Yanlan, Prieto-Godino Lucía, Schoborg Todd, Varela Marta, Mahadevan L, Miguel-Aliaga Irene. The sex of organ geometry. Nature. 2024.06; 630 (8016): 392-400. ( PubMed, DOI )

  6. Hadjieconomou Dafni, King George, Gaspar Pedro, Mineo Alessandro, Blackie Laura, Ameku Tomotsune, Studd Chris, de Mendoza Alex, Diao Fengqiu, White Benjamin H, Brown André E X, Plaçais Pierre-Yves, Préat Thomas, Miguel-Aliaga Irene. Enteric neurons increase maternal food intake during reproduction. Nature. 2020.11; 587 (7834): 455-459. ( PubMed, DOI )

  7. Yoshinari Yuto, Ameku Tomotsune, Kondo Shu, Tanimoto Hiromu, Kuraishi Takayuki, Shimada-Niwa Yuko, Niwa Ryusuke. Neuronal octopamine signaling regulates mating-induced germline stem cell increase in female Drosophila melanogaster. Elife. 2020.10; 9 ( PubMed, DOI )

  8. Ameku Tomotsune, Beckwith Hannah, Blackie Laura, Miguel-Aliaga Irene. Food, microbes, sex and old age: on the plasticity of gastrointestinal innervation. Curr Opin Neurobiol. 2020.06; 62 83-91. ( PubMed, DOI )

  9. Yoshinari Yuto, Kurogi Yoshitomo, Ameku Tomotsune, Niwa Ryusuke. Endocrine regulation of female germline stem cells in the fruit fly Drosophila melanogaster. Curr Opin Insect Sci. 2019.02; 31 14-19. ( PubMed, DOI )

  10. Ameku Tomotsune, Yoshinari Yuto, Texada Michael J, Kondo Shu, Amezawa Kotaro, Yoshizaki Goro, Shimada-Niwa Yuko, Niwa Ryusuke. Midgut-derived neuropeptide F controls germline stem cell proliferation in a mating-dependent manner. PLoS Biol. 2018.09; 16 (9): e2005004. ( PubMed, DOI )

  11. Ameku Tomotsune, Yoshinari Yuto, Fukuda Ruriko, Niwa Ryusuke. Ovarian ecdysteroid biosynthesis and female germline stem cells. Fly (Austin). 2017.07; 11 (3): 185-193. ( PubMed, DOI )

  12. Ameku Tomotsune, Niwa Ryusuke. Mating-Induced Increase in Germline Stem Cells via the Neuroendocrine System in Female Drosophila. PLoS Genet. 2016.06; 12 (6): e1006123. ( PubMed, DOI )

  13. Uryu Outa, Ameku Tomotsune, Niwa Ryusuke. Recent progress in understanding the role of ecdysteroids in adult insects: Germline development and circadian clock in the fruit fly Drosophila melanogaster. Zoological Lett. 2015; 1 32. ( PubMed, DOI )

  14. Enya Sora, Ameku Tomotsune, Igarashi Fumihiko, Iga Masatoshi, Kataoka Hiroshi, Shinoda Tetsuro, Niwa Ryusuke. A Halloween gene noppera-bo encodes a glutathione S-transferase essential for ecdysteroid biosynthesis via regulating the behaviour of cholesterol in Drosophila. Sci Rep. 2014.10; 4 6586. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display 】

  1. Tomotsune Ameku. Growth of the maternal intestine during reproduction in mice. 第77回日本細胞生物学会・第58回日本発生生物学会 合同大会 2025.07.16

  2. 天久朝恒. 妊娠に伴う母体の臓器リモデリング：腸管に着目して. 筑波大学 World Science Leaders’ Seminar 2025.05.23

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