Personnel Information

写真a

USHIO AYA


Job title

Junior Associate Professor

Field Introduction URL

Department of Oral Pathology, Institute of Science Tokyo

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Graduate School 【 display / non-display 】

  • The University of Tokushima, Doctor's Course, 2018.03, Completed

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Campus Career 【 display / non-display 】

  • 2024.07
    -
    2024.09
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Oral Health Sciences， Oral Pathology， Junior Associate Professor
  • 2024.10
    -
    Now
    Institute of Science Tokyo， -， Graduate Schools， Oral Health Sciences， Oral Pathology， Junior Associate Professor
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External Career 【 display / non-display 】

  • 2018.04
    -
    2019.03
    The University of Tokushima, Assistant Professor
  • 2019.04
    -
    2019.12
    The University of Tokushima, Visiting Lecturer
  • 2019.04
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    2019.12
    Japan Society for the Promotion of Science,
  • 2020.01
    -
    2022.08
    National Institutes of Health, National Cancer Institute, Post-doctoral fellow
  • 2022.09
    -
    2023.12
    The University of Tokushima, Assistant Professor
  • 2024.01
    -
    2024.06
    The University of Tokushima, Junior Associate Professor

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Research Areas 【 display / non-display 】

  • Experimental pathology

  • Immunology

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Qualification Acquired 【 display / non-display 】

  • Dentist

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Research Theme 【 display / non-display 】

  • Clinical application based on the molecular mechanism of autoantibody production in autoimmunity, 2023.06 - 2025.03

  • Novel pathogenesis and therapeutic strategy of autoimmunity based on immune-tuning molecules, 2023.04 - 2027.03

  • Analysis of Pathogenesis of Autoimmunity through Communication between Organs, 2019.04 - 2024.03

  • Analysis of autoimmunity caused by environmental factors~New pathogenesis of autoimmune disease~, 2016.04 - 2019.03

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Published Papers & Misc 【 display / non-display 】

  1. Otsuka, K; Ushio, A; Nagao, R; Matsuzawa, S; Arakaki, R; Fukuta, K; Mouri, Y; Tsunematsu, T; Ishimaru, N. Regulatory Role of FGL-1 in Interorgan Communication by Controlling T Cell Homeostasis During the Onset of Sjögren Disease ARTHRITIS & RHEUMATOLOGY. 2025.07; ( PubMed, DOI )

  2. Functionally diverse thymic medullary epithelial cells interplay to direct central tolerance. 2024.04; 43 (4): 114072. ( PubMed, DOI )

  3. The noncanonical function of borealin, a component of chromosome passenger complex, promotes glycolysis via stabilization of survivin in squamous cell carcinoma cells. 2024.03; 706 149741. ( PubMed, DOI )

  4. Disturbed natural killer cell homeostasis in the salivary gland enhances autoimmune pathology via IFN-γ in a mouse model of primary Sjögren's syndrome. 2022.11; 9 1036787. ( PubMed, DOI )

  5. The thymoproteasome hardwires the TCR repertoire of CD8+ T cells in the cortex independent of negative selection 2021.04; 218 (4): ( PubMed, DOI )

  6. Arakaki Rieko, Ushio Aya, Otsuka Kunihiro, Kudo Yasusei, Ishimaru Naozumi. マウスにおける少量の唾液を計測する新規方法(A novel method for measuring small amounts of saliva in mice) Oral Science International. 2019.12; 16 (3): 178-180. ( ichushi )

  7. Contributions of CXCL12 and its receptor to the T cell autoimmune response in a Sjogren's syndrome murine model 2018; 36 (3): S299-S300.

  8. Kujiraoka, S; Tsunematsu, T; Sato, Y; Yoshida, M; Ishikawa, A; Tohyama, R; Tanaka, M; Kobayashi, Y; Kondo, T; Ushio, A; Otsuka, K; Kurosawa, M; Saito, M; Yamada, A; Arakaki, R; Nagai, H; Nikai, H; Takeuchi, K; Nagao, T; Miyamoto, Y; Ishimaru, N; Kudo, Y. Establishment and characterization of a clear cell odontogenic carcinoma cell line with <i>EWSR1-ATF1</i> fusion gene ORAL ONCOLOGY. 2017.06; 69 46-55. ( PubMed, DOI )

  9. Ushio A, Arakaki R, Eguchi H, Hotta F, Yamada A, Kudo Y, Ishimaru N. Pathological Analysis of Ocular Lesions in a Murine Model of Sjögren's Syndrome. International journal of molecular sciences. 2017.06; 18 (6): ( PubMed, DOI )

  10. Crucial roles of macrophages in the pathogenesis of autoimmune disease. 2017.05; 7 (1):

  11. Tomoyuki Kondo Takaaki Tsunematsu Akiko Yamada Rieko Arakaki Masako Saito Kunihiro Otsuka Satoko Kujiraoka Aya Ushio Mie Kurosawa Yasusei Kudo Naozumi Ishimaru. Acceleration of tumor growth due to dysfunction in M1 macrophages and enhanced angiogenesis in an animal model of autoimmune disease LABORATORY INVESTIGATION. 2016.04; ( DOI )

  12. Akiko Yamada , Aya Ushio , Rieko Arakaki , Takaaki Tsunematsu , Yasusei Kudo , Yoshio Hayashi , Naozumi Ishimaru. Impaired Expansion of Regulatory T Cells in a Neonatal Thymectomy-Induced Autoimmune Mouse Model AMERICAN JOURNAL OF PATHOLOGY. 2015.11; ( PubMed, DOI )

  13. Iwasa A Arakaki R Honma N Ushio A Yamada A Kondo T Kurosawa E Kujiraoka S Tsunematsu T Kudo Y Tanaka E Yoshimura N Harada N Hayashi Y Ishimaru N. Aromatase controls Sjögren syndrome-like lesions through monocyte chemotactic protein-1 in target organ and adipose tissue-associated macrophages. The American journal of pathology. 2015.01;

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Conference Activities & Talks 【 display / non-display 】

  1. 常松 貴明, 俵 宏彰, 永尾 瑠佳, 松澤 鎮史, 大塚 邦紘, 牛尾 綾, 石丸 直澄. HPV陽性癌における新規脱ユビキチン化酵素複合体の機能解析(Functional analysis of novel deubiquitinase complex in HPV-positive cancers). 日本病理学会会誌 2025.03.01

  2. 永尾 瑠佳, 山本 安希子, 牛尾 綾, 大塚 邦紘, 松澤 鎮史, 常松 貴明, 石丸 直澄. シェーグレン症候群モデルマウスにおけるTrat1を介したT細胞活性化抑制機構の解析(Analysis of suppressive mechanism for T cell activation via Trat1 in Sjogren's syndrome model mouse). 日本病理学会会誌 2025.03.01

  3. 俵 宏彰, 常松 貴明, 永尾 瑠佳, 松澤 鎮史, 大塚 邦紘, 牛尾 綾, 石丸 直澄. 頭頸部扁平上皮癌の分化を決定づける転写因子ネットワークの解明(Identification of the transcrition factor networks determining differentiation in HNSCC). 日本病理学会会誌 2025.03.01

  4. 松澤 鎮史, 牛尾 綾, 永尾 瑠佳, 大塚 邦紘, 常松 貴明, 石丸 直澄. 新生仔胸腺におけるオートファジーを介した自己免疫疾患に関わるT細胞分化(T cell differentiation related with autoimmunity via autophagy in neonatal thymus). 日本病理学会会誌 2025.03.01

  5. 牛尾 綾, 布川 裕規, 大塚 邦紘, 常松 貴明, 高橋 祐次, 石丸 直澄. 二酸化ケイ素曝露が肺胞マクロファージを介して免疫毒性へ与える影響(Effect of silicon dioxide exposure on immunotoxicity via alveolar macrophages in mice). 日本病理学会会誌 2025.03.01

  6. Matsuzawa Shigefumi, Ushio Aya, Nagao Ruka, Otsuka Kunihiro, Tsunematsu Takaaki, Ishimaru Naozumi. Hematopoiesis and immune environment　A crucial role of autophagy in neonatal thymus in autoimmunity(タイトル和訳中). 日本免疫学会総会・学術集会記録 2024.11.01

  7. Nagao Ruka, Yamamoto Akiko, Ushio Aya, Otsuka Kunihiro, Matsuzawa Shigefumi, Tsunematsu Takaaki, Ishimaru Naozumi. Systemic Immune Diseases　Analysis of regulatory mechanism for T cell activation via Trat1 in Sjoegren's syndrome(タイトル和訳中). 日本免疫学会総会・学術集会記録 2024.11.01

  8. 牛尾 綾, 松田 真実, 石丸 直澄, 高濱 洋介. 機能的に異なる胸腺髄質上皮細胞欠損マウスにおける自己免疫病変の病理組織学的検討(Pathological analysis of autoimmune phenotype in mice lacking functionally distinct thymic medullary epithelial cells). 日本病理学会会誌 2024.10.01

  9. 俵 宏彰, 常松 貴明, 永尾 瑠佳, 松澤 鎮史, 大塚 邦紘, 牛尾 綾, 石丸 直澄. Borealin-Survivin複合体は頭頸部扁平上皮癌の分化を直接的に制御する(Borealin-Survivin complex directly regulates keratinocyte differentiation in HNSCC). 日本病理学会会誌 2024.02.01

  10. 常松 貴明, 吉川 治孝, 永尾 瑠佳, 松澤 鎮史, 大塚 邦紘, 牛尾 綾, 石丸 直澄. がん特殊化リボソームの同定と機能解析(Identification and characterization of cancer-specialized ribosomes). 日本病理学会会誌 2024.02.01

  11. 永尾 瑠佳, 山本 安希子, 牛尾 綾, 大塚 邦紘, 松澤 鎮史, 常松 貴明, 石丸 直澄. シェーグレン症候群の病態形成に対するT細胞の共抑制性受容体の役割の解析(Analysis of the role of co-inhibitory receptors on T cells to the pathogenesis of Sjogren's syndrome). 日本病理学会会誌 2024.02.01

  12. 松澤 鎮史, 牛尾 綾, 永尾 瑠佳, 大塚 邦紘, 俵 宏彰, 常松 貴明, 石丸 直澄. 新生児期の胸腺におけるオートファジーとシェーグレン症候群の関係性(The relationship between autophagy in the neonatal thymus and Sjogren syndrome). 日本病理学会会誌 2024.02.01

  13. 牛尾 綾, 大塚 邦紘, 常松 貴明, 高橋 祐次, 菅野 純, 石丸 直澄. 多層カーボンナノチューブが免疫システムに及ぼす影響(The influence of multi-walled carbon nanotube for immune systems). 日本病理学会会誌 2024.02.01

  14. Tsunematsu Takaaki, Nagao Ruka, Matsuzawa Shigefumi, Otsuka Kunihiro, Ushio Aya, Ishimaru Naozumi. "Cancer cell cannibalism"の分子機序とがん進展における意義(The molecular mechanism of "Cancer cell cannibalism" and its significance in cancer progression). 日本免疫学会総会・学術集会記録 2023.12.01

  15. Nagao Ruka, Yamamoto Akiko, Ushio Aya, Otsuka Kunihiro, Tawara Hiroaki, Matsuzawa Shigefumi, Tamura Kai, Kawahito Yuhki, Tsunematsu Takaaki, Ishimaru Naozumi. シェーグレン症候群における共抑制性受容体を介した活性化T細胞の抑制機構の解析(Analysis of the suppression mechanism for activated T cells via co-inhibitory receptors in Sjoegren's syndrome). 日本免疫学会総会・学術集会記録 2023.12.01

  16. Otsuka Kunihiro, Kondo Hiroyuki, Tsukumo Shi-ichi, Ushio Aya, Ishimaru Naozumi, Yasutomo Koji. CD153+CD4+T細胞とCD30+細胞がシェーグレン症候群の唾液腺における自己免疫病態を増悪させる(CD153+ CD4+ T cells and CD30+ cells exacerbate the autoimmune pathology in salivary glands of Sjoegren's syndrome). 日本免疫学会総会・学術集会記録 2023.12.01

  17. Tamura Kai, Kawahito Yuki, Sato Mami, Otsuka Kunihiro, Ushio Aya, Tsunematsu Takaaki, Ishimaru Naozumi. シェーグレン症候群モデルマウスにおける加齢に伴う鼻病変の病理学的解析(Pathological analysis of nasal lesions with aging in murine models of Sjoegren's syndrome). 日本免疫学会総会・学術集会記録 2023.12.01

  18. Matsuzawa Shigefumi, Ushio Aya, Nagao Ruka, Otsuka Kunihiro, Tawara Hiroaki, Tsunematsu Takaaki, Ishimaru Naozumi. 胸腺におけるT細胞の分化・成熟とオートファジーの関係に関する研究(Investigation of the relationship between T cell differentiation and maturation and autophagy in the thymus). 日本免疫学会総会・学術集会記録 2023.12.01

  19. Kawahito Yuki, Tamura Kai, Sato Mami, Otsuka Kunihiro, Ushio Aya, Tsunematsu Takaaki, Ishimaru Naozumi. マウスにおけるムチン19の減少とシェーグレン症候群発症との関係(The Relation between the Reduction of Mucin 19 and the Onset of Sjoegren's Syndrome in a Mouse Model). 日本免疫学会総会・学術集会記録 2023.12.01

  20. Aya Ushio. Developing the Career Path.. 2023.08.19

  21. 川人 祐樹, 田村 海, 佐藤 真美, 大塚 邦紘, 牛尾 綾, 常松 貴明, 石丸 直澄. シェーグレン症候群疾患モデルマウスにおけるMucin19の異常と病態との関連性の解析(Relation between Disfunction of Mucin 19 and Pathogenesis in a Mouse Model of Sjogren's Syndrome). 日本病理学会会誌 2023.03.01

  22. Sato Mami, Ushio Aya, Otsuka Kunihiro, Tsunematsu Takaaki, Ishimaru Naozumi. 自己免疫　シェーグレン症候群モデルマウスにおいてTh2応答は濾胞性B細胞への分化を促進し肺の自己免疫病変を進行させる(Autoimmunity　Th2 response enhances the differentiation into follicular B cells to progress the pulmonary autoimmune lesions in a mouse model of Sjoegren's syndrome). 日本免疫学会総会・学術集会記録 2022.11.01

  23. Do heterogeneous thymic medullary epithelial subpopulations cooperate to provide self-tolerance in T cells?. 2022.02.18

  24. mTEC heterogeneity and autoimmune disease.. 2021.02.12

  25. Ushio Aya, Arakaki Rieko, Yamada Akiko, Kudo Yasusei, Ishimaru Naozumi. 樹状細胞、マクロファージ、顆粒球　個体発生と疾患の観点から　シェーグレン症候群のモデルマウスにおける肺病変の分析(Dendritic cells, macrophages, granulocytes: Ontogeny and disease perspectives　Analysis of pulmonary lesions in a murine model of Sjogren's syndrome). 日本免疫学会総会・学術集会記録 2019.11.01

  26. Arakaki Rieko, Sato Mami, Nakayama Shinichiro, Ushio Aya, Kudo Yasusei, Ishimaru Naozumi. 関節リウマチ、シェーグレン症候群、その他の自己免疫疾患　シェーグレン症候群の病状形成におけるIL-33とその受容体の役割(Rheumatoid arthritis, Sjogren's syndrome and other autoimmune diseases　Role of IL-33 and its receptor in pathogenesis of Sjogren's syndrome). 日本免疫学会総会・学術集会記録 2019.11.01

  27. Sato Mami, Arakaki Rieko, Ushio Aya, Kudo Yasusei, Ishimaru Naozumi. 樹状細胞、マクロファージ、顆粒球　免疫調節　多壁炭素ナノチューブへの曝露が肺免疫細胞に対して早期に及ぼす影響(Dendritic cells, macrophages, granulocytes: Immune regulation　Effect of multi-wall carbon nanotube exposure on pulmonary immune cells at the early stage). 日本免疫学会総会・学術集会記録 2019.11.01

  28. Ushio Aya, Arakaki Rieko, Otsuka Kunihiro, Yamada Akiko, Kudo Yasusei, Ishimaru Naozumi. 組織特異的免疫疾患　CCL22産生マクロファージはシェーグレン症候群の標的器官においてT細胞自己免疫を促進する(Tissue-specific immune diseases-2　CCL22-producing macrophages promote T cell autoimmunity in the target organ of Sjoegren's syndrome). 日本免疫学会総会・学術集会記録 2018.12.01

  29. Otsuka Kunihiro, Yamada Akiko, Saito Masako, Ushio Aya, Tsunematsu Takaaki, Kisoda Satoru, Kudo Yasusei, Arakaki Rieko, Ishimaru Naozumi. 組織特異的免疫疾患　シェーグレン症候群マウスモデルの自己免疫における濾胞性ヘルパーT細胞の重要な役割(Tissue-specific immune diseases-2　A crucial role of follicular helper T cells in autoimmunity of a mouse model for Sjoegren's syndrome). 日本免疫学会総会・学術集会記録 2018.12.01

  30. Arakaki Rieko, Nakayama Shinichiro, Ushio Aya, Otsuka Kunihiro, Kisoda Satoshi, Tsunematsu Takaaki, Yamada Akiko, Kudo Yasusei, Ishimaru Naozumi. 組織特異的免疫疾患　シェーグレン症候群(SS)の病因における切断型IL-33の役割(Tissue-specific immune diseases-2　The role of the cleaved form IL-33 in pathogenesis of Sjoegren's syndrome(SS)). 日本免疫学会総会・学術集会記録 2018.12.01

  31. Ushio Aya, Arakaki Rieko, Yamada Akiko, Otsuka Kunihiro, Kudo Yasusei, Ishimaru Naozumi. 樹状細胞とマクロファージ(3)　炎症反応　シェーグレン症候群のマウスモデルにおいてCCL22産生常在マクロファージは自己免疫病変を亢進させる(Dendritic cells and Macrophages: Inflammatory Responses　CCL22-producing resident macrophages enhances autoimmune lesions in a mouse model of Sjoegren's syndrome). 日本免疫学会総会・学術集会記録 2017.12.01

  32. Otsuka Kunihiro, Yamada Akiko, Kurosawa Mie, Ushio Aya, Arakaki Rieko, Kudo Yasusei, Ishimaru Naozumi. 組織特異的免疫疾患(II)　シェーグレン症候群のマウスモデルにおける濾胞性ヘルパーT細胞の解析(Tissue-specific immune diseases(II)　Analysis of follicular helper T cells in a mouse model for Sjoegren's syndrome). 日本免疫学会総会・学術集会記録 2017.12.01

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