Personnel Information

写真a

SHIROGANE YUTA


Job title

Professor

Field Introduction URL

https://molv.org/

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Graduating School 【 display / non-display 】

  • Kyushu University, Faculty of Medicine, MD-PhD program, 2013.03, Graduated

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Graduate School 【 display / non-display 】

  • Kyushu University, Graduate School, Division of Medical Sciences, Doctor's Course, 2011.03, Completed

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Degree 【 display / non-display 】

  • MD-PhD, Kyushu University

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Campus Career 【 display / non-display 】

  • 2024.05
    -
    Now
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Bio-Environmental Response， Molecular Virology， Professor
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External Career 【 display / non-display 】

  • 2016.05
    -
    2018.03
    University of California, San Francisco,
  • 2018.04
    -
    2023.11
    , Assistant Professor
  • 2023.12
    -
    2024.04
    , Junior Associate Professor
  • 2024.04
    -
    2024.09
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Professor
  • 2024.10
    -
    Now
    Institute of Science Tokyo, Graduate School of Medical and Dental Sciences, Professor
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Academic Society Affiliations 【 display / non-display 】

  • THE JAPANESE SOCIETY FOR VIROLOGY

  • THE MOLECULAR BIOLOGY SOCIETY OF JAPAN

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Research Areas 【 display / non-display 】

  • Virology

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Qualification Acquired 【 display / non-display 】

  • Doctor

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Research Theme 【 display / non-display 】

  • The mechanism of measles virus neuropathogenesis through `cis-acting fusion triggering`, 2022.01 - 2023.03

  • The mechanism of measles virus neuropathogenesis through `cis-acting fusion triggering`, 2022.01 - 2023.03

  • Wakaba Challenge, 2019.04 - 2020.03

  • Wakaba Challenge, 2019.04 - 2020.03

  • Mechanisms of interference between different viruses, 2018.08 - 2020.03

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Published Papers & Misc 【 display / non-display 】

  1. Takemoto Ryuichi, Hirai Yuichi, Watanabe Shumpei, Harada Hidetaka, Suzuki Tateki, Hashiguchi Takao, Yanagi Yusuke, Shirogane Yuta. Interaction of the Hemagglutinin Stalk Region with Cell Adhesion Molecule (CADM) 1 and CADM2 Mediates the Spread between Neurons and Neuropathogenicity of Measles Virus with a Hyperfusogenic Fusion Protein. J Virol. 2023.05; 97 (5): e0034023. ( PubMed, DOI )

  2. Shirogane Yuta, Harada Hidetaka, Hirai Yuichi, Takemoto Ryuichi, Suzuki Tateki, Hashiguchi Takao, Yanagi Yusuke. Collective fusion activity determines neurotropism of an en bloc transmitted enveloped virus. Sci Adv. 2023.01; 9 (4): eadf3731. ( PubMed, DOI )

  3. Takemoto Ryuichi, Suzuki Tateki, Hashiguchi Takao, Yanagi Yusuke, Shirogane Yuta. Short-Stalk Isoforms of CADM1 and CADM2 Trigger Neuropathogenic Measles Virus-Mediated Membrane Fusion by Interacting with the Viral Hemagglutinin. J Virol. 2022.02; 96 (3): e0194921. ( PubMed, DOI )

  4. Xiao Yinghong, Lidsky Peter V, Shirogane Yuta, Aviner Ranen, Wu Chien-Ting, Li Weiyi, Zheng Weihao, Talbot Dale, Catching Adam, Doitsh Gilad, Su Weiheng, Gekko Colby E, Nayak Arabinda, Ernst Joel D, Brodsky Leonid, Brodsky Elia, Rousseau Elsa, Capponi Sara, Bianco Simone, Nakamura Robert, Jackson Peter K, Frydman Judith, Andino Raul. A defective viral genome strategy elicits broad protective immunity against respiratory viruses. Cell. 2021.12; 184 (25): 6037-6051.e14. ( PubMed, DOI )

  5. Shirogane Yuta, Rousseau Elsa, Voznica Jakub, Xiao Yinghong, Su Weiheng, Catching Adam, Whitfield Zachary J, Rouzine Igor M, Bianco Simone, Andino Raul. Experimental and mathematical insights on the interactions between poliovirus and a defective interfering genome. PLoS Pathog. 2021.09; 17 (9): e1009277. ( PubMed, DOI )

  6. Shirogane Yuta, Takemoto Ryuichi, Suzuki Tateki, Kameda Tomonori, Nakashima Kinichi, Hashiguchi Takao, Yanagi Yusuke. CADM1 and CADM2 Trigger Neuropathogenic Measles Virus-Mediated Membrane Fusion by Acting in cis. J Virol. 2021.06; 95 (14): e0052821. ( PubMed, DOI )

  7. Ueo Ayako, Kubota Marie, Shirogane Yuta, Ohno Shinji, Hashiguchi Takao, Yanagi Yusuke. Lysosome-Associated Membrane Proteins Support the Furin-Mediated Processing of the Mumps Virus Fusion Protein. J Virol. 2020.06; 94 (12): e00050-20. ( PubMed, DOI )

  8. Kubota Marie, Okabe Iori, Nakakita Shin-Ichi, Ueo Ayako, Shirogane Yuta, Yanagi Yusuke, Hashiguchi Takao. Disruption of the Dimer-Dimer Interaction of the Mumps Virus Attachment Protein Head Domain, Aided by an Anion Located at the Interface, Compromises Membrane Fusion Triggering. J Virol. 2020.01; 94 (2): e01732-19. ( PubMed, DOI )

  9. Shirogane Yuta, Hashiguchi Takao, Yanagi Yusuke. Weak cis and trans Interactions of the Hemagglutinin with Receptors Trigger Fusion Proteins of Neuropathogenic Measles Virus Isolates. J Virol. 2020.01; 94 (2): e01727-19. ( PubMed, DOI )

  10. Shirogane Yuta, Watanabe Shumpei, Yanagi Yusuke. Cooperation between different variants: A unique potential for virus evolution. Virus Res. 2019.04; 264 68-73. ( PubMed, DOI )

  11. Watanabe Shumpei, Shirogane Yuta, Sato Yuma, Hashiguchi Takao, Yanagi Yusuke. New Insights into Measles Virus Brain Infections. Trends Microbiol. 2019.02; 27 (2): 164-175. ( PubMed, DOI )

  12. Nao Naganori, Sato Ko, Yamagishi Junya, Tahara Maino, Nakatsu Yuichiro, Seki Fumio, Katoh Hiroshi, Ohnuma Aiko, Shirogane Yuta, Hayashi Masahiro, Suzuki Tamio, Kikuta Hideaki, Nishimura Hidekazu, Takeda Makoto. Consensus and variations in cell line specificity among human metapneumovirus strains. PLoS One. 2019; 14 (4): e0215822. ( PubMed, DOI )

  13. Hashiguchi Takao, Fukuda Yoshinari, Matsuoka Rei, Kuroda Daisuke, Kubota Marie, Shirogane Yuta, Watanabe Shumpei, Tsumoto Kouhei, Kohda Daisuke, Plemper Richard Karl, Yanagi Yusuke. Structures of the prefusion form of measles virus fusion protein in complex with inhibitors. Proc Natl Acad Sci U S A. 2018.03; 115 (10): 2496-2501. ( PubMed, DOI )

  14. Shirogane Yuta, Watanabe Shumpei, Yanagi Yusuke. Cooperative Interaction Within RNA Virus Mutant Spectra. Curr Top Microbiol Immunol. 2016; 392 219-229. ( PubMed, DOI )

  15. Watanabe Shumpei, Ohno Shinji, Shirogane Yuta, Suzuki Satoshi O, Koga Ritsuko, Yanagi Yusuke. Measles virus mutants possessing the fusion protein with enhanced fusion activity spread effectively in neuronal cells, but not in other cells, without causing strong cytopathology. J Virol. 2015.03; 89 (5): 2710-2717. ( PubMed, DOI )

  16. Shirogane Yuta, Watanabe Shumpei, Yanagi Yusuke. Cooperation: another mechanism of viral evolution. Trends Microbiol. 2013.07; 21 (7): 320-324. ( PubMed, DOI )

  17. Nakashima Mai, Shirogane Yuta, Hashiguchi Takao, Yanagi Yusuke. Mutations in the putative dimer-dimer interfaces of the measles virus hemagglutinin head domain affect membrane fusion triggering. J Biol Chem. 2013.03; 288 (12): 8085-8091. ( PubMed, DOI )

  18. Watanabe Shumpei, Shirogane Yuta, Suzuki Satoshi O, Ikegame Satoshi, Koga Ritsuko, Yanagi Yusuke. Mutant fusion proteins with enhanced fusion activity promote measles virus spread in human neuronal cells and brains of suckling hamsters. J Virol. 2013.03; 87 (5): 2648-2659. ( PubMed, DOI )

  19. Shirogane Yuta, Watanabe Shumpei, Yanagi Yusuke. Cooperation between different RNA virus genomes produces a new phenotype. Nat Commun. 2012; 3 1235. ( PubMed, DOI )

  20. Shirogane Yuta, Takeda Makoto, Tahara Maino, Ikegame Satoshi, Nakamura Takanori, Yanagi Yusuke. Epithelial-mesenchymal transition abolishes the susceptibility of polarized epithelial cell lines to measles virus. J Biol Chem. 2010.07; 285 (27): 20882-20890. ( PubMed, DOI )

  21. Iwasaki Masaharu, Takeda Makoto, Shirogane Yuta, Nakatsu Yuichiro, Nakamura Takanori, Yanagi Yusuke. The matrix protein of measles virus regulates viral RNA synthesis and assembly by interacting with the nucleocapsid protein. J Virol. 2009.10; 83 (20): 10374-10383. ( PubMed, DOI )

  22. Takeda Makoto, Ohno Shinji, Tahara Maino, Takeuchi Hiroki, Shirogane Yuta, Ohmura Hirofumi, Nakamura Takafumi, Yanagi Yusuke. Measles viruses possessing the polymerase protein genes of the Edmonston vaccine strain exhibit attenuated gene expression and growth in cultured cells and SLAM knock-in mice. J Virol. 2008.12; 82 (23): 11979-11984. ( PubMed, DOI )

  23. Nakatsu Yuichiro, Takeda Makoto, Ohno Shinji, Shirogane Yuta, Iwasaki Masaharu, Yanagi Yusuke. Measles virus circumvents the host interferon response by different actions of the C and V proteins. J Virol. 2008.09; 82 (17): 8296-8306. ( PubMed, DOI )

  24. Shirogane Yuta, Takeda Makoto, Iwasaki Masaharu, Ishiguro Nobuhisa, Takeuchi Hiroki, Nakatsu Yuichiro, Tahara Maino, Kikuta Hideaki, Yanagi Yusuke. Efficient multiplication of human metapneumovirus in Vero cells expressing the transmembrane serine protease TMPRSS2. J Virol. 2008.09; 82 (17): 8942-8946. ( PubMed, DOI )

  25. Tahara Maino, Takeda Makoto, Shirogane Yuta, Hashiguchi Takao, Ohno Shinji, Yanagi Yusuke. Measles virus infects both polarized epithelial and immune cells by using distinctive receptor-binding sites on its hemagglutinin. J Virol. 2008.05; 82 (9): 4630-4637. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display 】

  1. Yuta Shirogane. Intrahost Evolution of Measles Virus: A Pathway to Fatal Brain Disease . The 22nd Awaji International Forum on Infection and Immunity 2024.09.17 Kyoto, Japan

  2. Yuta Shirogane. Intrahost Evolution of Measles Virus: A Pathway to Fatal Brain Disease. 第22回あわじ感染と免疫国際フォーラム 2024.09.17

  3. 平居優一, 竹本竜一, 鈴木干城, 橋口隆生, 柳雄介, 白銀勇太. SSPE分離株に見られる麻疹ウイルス膜融合タンパク質の多重変異は特定の培養細胞でのみ膜融合を上昇させる. 第70回日本ウイルス学会・学術集会 2023.09.28

  4. 白銀勇太, 竹本竜一, 平居優一, 柳雄介. 麻疹ウイルス糖タンパク質の変異が重篤な神経疾患を引き起こすメカニズム. 第70回日本ウイルス学会・学術集会（ワークショップ） 2023.09.26

  5. 白銀勇太. Cooperation and interference among different measles virus fusion proteins drive the viral evolution to neurovirulence. THE SOCIAL LIVES OF VIRUSES 2022.03.22

  6. Cell adhesion molecule (CADM) 1 and CADM2 enable measles virus spread in subacute sclerosing panencephalitis by cis-acting fusion triggering. 第68回日本ウイルス学会学術集会 2021.11.16

  7. Short-stalk isoforms of CADM1 and CADM2 induce membrane fusion mediated by hyperfusogenic fusion proteins of neuropathogenic measles viruses. 第68回日本ウイルス学会学術集会 2021.11.16

  8. A hyperfusogenic mutation in the measles virus fusion gene rescues the defect of receptor-blind mutations in the hemagglutinin gene. 第67回日本ウイルス学会学術集会 2019.10.29

  9. Nao Naganori, Sato Ko, Seki Fumio, Yamagishi Junya, Tahara Maino, Shirogane Yuta, Nishimura Hidekazu, Takeda Makoto. ヒトメタニューモウイルスの臨床株および研究室株の特性解析(Characterization of clinical and laboratory strains of human metapneumovirus). 日本小児感染症学会総会・学術集会プログラム・抄録集 2018.11.01

  10. 白銀 勇太. Combinatorial minigenome assays reveal cooperative effects of RNA-dependent RNA polymerases between different mononegavirus families. 日本ウイルス学会学術集会 2018.10.28

  11. 白銀 勇太. Defective Interfering RNAs of Poliovirus Inhibit Wild-type Virus Production in Two Steps. 日本ウイルス学会学術集会 2017.10.26

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Awards & Honors 【 display / non-display 】

  • Young Researchers Excellent Presentation，2023.09

  • Sugiura award，The Japanese Society of Virology，2022.11

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Campus class subject 【 display / non-display 】

  • Infection/Basic，2024 - Now

  • Basic Medical Experiment，2024 - Now

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