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Graduating School 【 display / non-display 】
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The University of Tokyo, Faculty of Engineering, 2009.03, Graduated
Graduate School 【 display / non-display 】
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The University of Tokyo, Doctor's Course, 2014.03, Completed
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The University of Tokyo, Master's Course, 2011.03, Completed
Campus Career 【 display / non-display 】
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2024.04-2024.09Tokyo Medical and Dental University, Medical Research Institute, Division of Biological Data Science, -, Associate Professor
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2024.10-NowInstitute of Science Tokyo, -, Institute of Integrated Research, Biological Data Science, Computational Drug Discovery and Design, Associate Professor
External Career 【 display / non-display 】
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2016.11-2024.03The University of Tokyo, Graduate School of Agricultural and Life Sciences, Assistant Professor
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2024.04-2024.09Tokyo Medical and Dental University, Medical Research Institute, Associate Professor
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2024.10-NowInstitute of Science Tokyo, Laboratory of Medical Research, Institute of Integrated Research, Associate Professor
Academic Society Affiliations 【 display / non-display 】
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PROTEIN SCIENCE SOCIETY OF JAPAN
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THE BIOPHYSICAL SOCIETY OF JAPAN
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Japan Society for Bioscience, Biotechnology, and Agrochemistry
Academic Activity 【 display / non-display 】
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2025.06-2027.06The Biophysical Society of Japan Delegates
Research Theme 【 display / non-display 】
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Development of a method to predict substrate and reaction specificities using predicted structures, 2022.06 - 2027.03
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Computational design and experimental validation of a novel heme-binding protein with desired structure and function, 2018.04 - 2021.03
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Integrated implementation of human computation and computational drug discovery, 2018.04 - 2021.03
Published Papers & Misc 【 display / non-display 】
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Mori, T; Moriwaki, Y; Sakurada, K; Lyu, S; Kadlcik, S; Janata, J; Mazumdar, A; Koberska, M; Terada, T; Kamenik, Z; Abe, I. Molecular basis for the diversification of lincosamide biosynthesis by pyridoxal phosphate-dependent enzymes NATURE CHEMISTRY. 2025.02; 17 (2): 256-264. ( PubMed, DOI )
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Kim, G; Lee, S; Karin, EL; Kim, H; Moriwaki, Y; Ovchinnikov, S; Steinegger, M; Mirdita, M. Easy and accurate protein structure prediction using ColabFold NATURE PROTOCOLS. 2024.10; ( PubMed, DOI )
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Homma, M; Wakabayashi, T; Moriwaki, Y; Shiotani, N; Shigeta, T; Isobe, K; Okazawa, A; Ohta, D; Terada, T; Shimizu, K; Mizutani, M; Takikawa, H; Sugimoto, Y. Insights into stereoselective ring formation in canonical strigolactone: Identification of a dirigent domaincontaining enzyme catalyzing orobanchol synthesis PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2024.06; 121 (26): e2313683121. ( PubMed, DOI )
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Fan Zhao, Yoshitaka Moriwaki, Tomohiro Noguchi, Kentaro Shimizu, Tomohisa Kuzuyama, Tohru Terada. QM/MM Study of the Catalytic Mechanism and Substrate Specificity of the Aromatic Substrate <i>C</i>-Methyltransferase Fur6 Biochemistry. 2024.02; 63 (6): 806-814. ( DOI )
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Tomoki Sawa, Yoshitaka Moriwaki, Hanting Jiang, Kohji Murase, Seiji Takayama, Kentaro Shimizu, Tohru Terada. Comprehensive computational analysis of the SRK–SP11 molecular interaction underlying self-incompatibility in Brassicaceae using improved structure prediction for cysteine-rich proteins Computational and Structural Biotechnology Journal. 2023.10; 21 5228-5239. ( DOI )
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Kano Hasegawa, Yoshitaka Moriwaki, Tohru Terada, Cao Wei, Kentaro Shimizu. Feedback-AVPGAN: Feedback-guided generative adversarial network for generating antiviral peptides Journal of Bioinformatics and Computational Biology. 2022.12; 20 (06): ( DOI )
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Li Liu, Wen Song, Shijia Huang, Kai Jiang, Yoshitaka Moriwaki, Yichuan Wang, Yongfan Men, Dan Zhang, Xing Wen, Zhifu Han, Jijie Chai, Hongwei Guo. Extracellular pH sensing by plant cell-surface peptide-receptor complexes Cell. 2022.09; 185 (18): 3341-3355.e13. ( DOI )
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Shohei Yamaguchi, Haruka Nakashima, Yoshitaka Moriwaki, Tohru Terada, Kentaro Shimizu. Prediction of protein mononucleotide binding sites using AlphaFold2 and machine learning Computational Biology and Chemistry. 2022.07; 107744. ( DOI )
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Xiaoyu Yang, Natsuko I Kobayashi, Yoshiki Hayashi, Koichi Ito, Yoshitaka Moriwaki, Tohru Terada, Kentaro Shimizu, Motoyuki Hattori, Ren Iwata, Hisashi Suzuki, Tomoko M Nakanishi, Keitaro Tanoi. Mutagenesis Analysis of GMN Motif in <i>Arabidopsis thaliana</i> Mg2+ Transporter MRS2-1 Bioscience, Biotechnology, and Biochemistry. 2022.05; 86 (7): 870-874. ( PubMed, DOI )
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Milot Mirdita, Konstantin Schütze, Yoshitaka Moriwaki, Lim Heo, Sergey Ovchinnikov, Martin Steinegger. ColabFold: making protein folding accessible to all Nature Methods. 2022.05; 19 (6): 679-682. ( DOI )
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Hayama Tsutsumi, Yoshitaka Moriwaki, Tohru Terada, Kentaro Shimizu, Kazuo Shin‐ya, Yohei Katsuyama, Yasuo Ohnishi. Structural and Molecular Basis of the Catalytic Mechanism of Geranyl Pyrophosphate C6‐Methyltransferase: Creation of an Unprecedented Farnesyl Pyrophosphate C6‐Methyltransferase Angewandte Chemie International Edition. 2022.01; 61 (1): e202111217. ( DOI )
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Yanagisawa, K; Moriwaki, Y; Terada, T; Shimizu, K. EXPRORER: Rational Cosolvent Set Construction Method for Cosolvent Molecular Dynamics Using Large-Scale Computation JOURNAL OF CHEMICAL INFORMATION AND MODELING. 2021.06; 61 (6): 2744-2753. ( PubMed, DOI )
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Kohji Murase, Yoshitaka Moriwaki, Tomoyuki Mori, Xiao Liu, Chiho Masaka, Yoshinobu Takada, Ryoko Maesaki, Masaki Mishima, Sota Fujii, Yoshinori Hirano, Zen Kawabe, Koji Nagata, Tohru Terada, Go Suzuki, Masao Watanabe, Kentaro Shimizu, Toshio Hakoshima, Seiji Takayama. Mechanism of self/nonself-discrimination in <i>Brassica</i> self-incompatibility Nature Communications. 2020.10; 11 (4916): ( DOI )
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Miho Chikazawa, Yoshitaka Moriwaki, Mari Uramoto, Yoshio Yamauchi, Makoto Shimizu, Kentaro Shimizu, Ryuichiro Sato. Functional effect of nobiletin as a food-derived allosteric modulator of mouse CRFR2β in skeletal muscle Biochemical and biophysical research communications. 2020.08; 529 (2): 328-334. ( PubMed, DOI )
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Dissecting the stereocontrolled conversion of short-lived sulfenic acid by lachrymatory factor synthase 2020.01; 10 (1): 9-19. ( DOI )
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Chiba, S; Ohue, M; Gryniukova, A; Borysko, P; Zozulya, S; Yasuo, N; Yoshino, R; Ikeda, K; Shin, WH; Kihara, D; Iwadate, M; Umeyama, H; Ichikawa, T; Teramoto, R; Hsin, KY; Gupta, V; Kitano, H; Sakamoto, M; Higuchi, A; Miura, N; Yura, K; Mochizuki, M; Ramakrishnan, C; Thangakani, AM; Velmurugan, D; Gromiha, MM; Nakane, I; Uchida, N; Hakariya, H; Tan, MD; Nakamura, HK; Suzuki, SD; Ito, T; Kawatani, M; Kudoh, K; Takashina, S; Yamamoto, KZ; Moriwaki, Y; Oda, K; Kobayashi, D; Okuno, T; Minami, S; Chikenji, G; Prathipati, P; Nagao, C; Mohsen, A; Ito, M; Mizuguchi, K; Honma, T; Ishida, T; Hirokawa, T; Akiyama, Y; Sekijima, M. A prospective compound screening contest identified broader inhibitors for Sirtuin 1 SCIENTIFIC REPORTS. 2019.12; 9 (1): ( PubMed, DOI )
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Yoshitaka Moriwaki, Mirai Yato, Tohru Terada, Seiji Saito, Noriyuki Nukui, Takumi Iwasaki, Tatsunari Nishi, Yuko Kawaguchi, Ken Okamoto, Takatoshi Arakawa, Chihaya Yamada, Shinya Fushinobu, Kentaro Shimizu. Understanding the molecular mechanism underlying the high catalytic activity of <i>p</i>-hydroxybenzoate hydroxylase mutants for producing gallic acid Biochemistry. 2019.10; 58 (45): 4543-4558. ( PubMed, DOI )
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Peng Lu, Yoshitaka Moriwaki, Mimin Zhang, Yukie Katayama, Yi Lu, Ken Okamoto, Tohru Terada, Kentaro Shimizu, Mengyao Wang, Takehiro Kamiya, Toru Fujiwara, Tomiko Asakura, Michio Suzuki, Etsuro Yoshimura, Koji Nagata. Functional characterisation of two ferric-ion coordination modes of TtFbpA, the periplasmic subunit of an ABC-type iron transporter from Thermus thermophilus HB8 Metallomics. 2019.10; 11 (12): 2078-2088. ( DOI )
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Chun Fang, Yoshitaka Moriwaki, Aikui Tian, Caihong Li, Kentaro Shimizu. Identifying Short Disorder-to-Order Binding Regions in Disordered Proteins with a Deep Convolutional Neural Network Method Journal of Bioinformatics and Computational Biology. 2018.11; 17 (1): 1950004. ( DOI )
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Identifying MoRFs in disordered proteins using enlarged conserved features 2018.03; 50-54. ( DOI )
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Saeko Yanaka, Yoshitaka Moriwaki, Kouhei Tsumoto, Kenji Sugase. Elucidation of potential sites for antibody engineering by fluctuation editing Scientific Reports. 2017.12; 7 (9597): ( DOI )
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Chiba, S; Ishida, T; Ikeda, K; Mochizuki, M; Teramoto, R; Taguchi, Y; Iwadate, M; Umeyama, H; Ramakrishnan, C; Thangakani, AM; Velmurugan, D; Gromiha, MM; Okuno, T; Kato, K; Minami, S; Chikenji, G; Suzuki, SD; Yanagisawa, K; Shin, WH; Kihara, D; Yamamoto, KZ; Moriwaki, Y; Yasuo, N; Yoshino, R; Zozulya, S; Borysko, P; Stavniichuk, R; Honma, T; Hirokawa, T; Akiyama, Y; Sekijima, M. An iterative compound screening contest method for identifying target protein inhibitors using the tyrosine-protein kinase Yes SCIENTIFIC REPORTS. 2017.09; 7 12038. ( PubMed, DOI )
Works 【 display / non-display 】
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localcolabfold,Software,GitHub,2021.09 - Now
Awards & Honors 【 display / non-display 】
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The 21st Annual Meeting of the Protein Science Society of Japan, Young Scientist Award,Protein Science Society of Japan,2021.06
External class subject 【 display / non-display 】
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Biochemistry with protein structure and molecular simulation.,Tokyo University of Agriculture
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Synthetic organic chemistry,The University of Tokyo
Social Contribution 【 display / non-display 】
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What's next for AlphaFold and the AI protein-folding revolution,Nature,Nature,2022.04.13