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ＣＨＥＮＧ ＬＩＨＯＮＧ(チェン リーホン) CHENG LIHONG
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出身学校 【 表示 ／ 非表示 】
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河南大学(Henan University) 薬学部(School of Pharmacy) 薬学(Phamacy) 2014年06月 卒業
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浙江大学(Zhengjiang University) 薬学部(College of Pharmaceutical Sciences) 薬物化学(Medicinal chemistry) 2019年06月 卒業
出身大学院 【 表示 ／ 非表示 】
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浙江大学(Zhejiang University) 薬学院(College of Pharmaceutical Sciences) 薬物化学(Medicinal chemistry) 博士課程 2019年06月 修了
経歴(学外) 【 表示 ／ 非表示 】
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2019年07月-2021年07月浙江大学 薬学部(College of Pharmacetical Sciences) 特任研究員
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2021年11月-2023年11月九州大学 農学部 特任研究員
研究テーマ 【 表示 ／ 非表示 】
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光遺伝学ツールとライブイメージングを用いたC-RAFによるミトコンドリア形状と分布の急速な変化のメカニズムに関する研究，2024年04月 - 現在
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認知症予防を実践できる食品因子の解明に関する研究，2021年11月 - 2023年11月
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天然由来の神経成長因子様活性を有する化合物の化学および生物学的研究，2014年06月 - 2021年06月
競争的資金等の研究課題 【 表示 ／ 非表示 】
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Study on the mechanism of rapid change of mitochondrial shape and distribution induced by C-RAF using optogenetics tools and live imaging
文部科学省/日本学術振興会 : 2024年 - 2025年
論文・総説 【 表示 ／ 非表示 】
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Lihong Cheng, Caiyue Shi, Xixi Li, Toshiro Matsui. Impact of Peptide Transport and Memory Function in the Brain Nutrients. 2024.09; ( DOI )
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Cheng L, Shi C, Nakamura S, Esaki N, Ichiba Y, Tanaka M, Sakai K, Matsui T. Adiponectin-Receptor Agonistic Dipeptide Tyr-Pro Stimulates the Acetylcholine Nervous System in NE-4C Cells. Journal of agricultural and food chemistry. 2024.04; 72 (13): 7121-7129. ( PubMed, DOI )
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Cheng L, Tanaka M, Yoshino A, Nagasato Y, Takata F, Dohgu S, Matsui T. A memory-improving dipeptide, Tyr-Pro, can reach the mouse brain after oral administration. Scientific reports. 2023.10; 13 (1): 16908. ( PubMed, DOI )
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Xiang, L; Wu, QB; Cheng, LH; Sun, KY; Li, J; Yoshida, M; Qi, JH. Leptin and Adiponectin Signaling Pathways Are Involved in the Antiobesity Effects of Peanut Skin Extract OXIDATIVE MEDICINE AND CELLULAR LONGEVITY. 2019.10; 2019 1-14. ( PubMed, DOI )
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Bian, LL; Cao, SN; Cheng, LH; Nakazaki, A; Nishikawa, T; Qi, JH. Semi-synthesis and Structure-Activity Relationship of Neuritogenic Oleanene Derivatives CHEMMEDCHEM. 2018.09; 13 (18): 1972-1977. ( PubMed, DOI )
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Qi, JH; Cheng, LH; Sun, YJ; Hirata, Y; Ushida, N; Ma, ZH; Osada, H; Nishikawa, T; Xiang, L. Identification of an Asexual Reproduction Inducer of Phytopathogenic and Toxigenic <i>Fusarium</i> ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 2018.07; 57 (27): 8100-8104. ( PubMed, DOI )
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Zhang, H; Farooq, U; Cheng, LH; Ye, Y; Wang, YC; Kawagishi, H; Ojika, M; Qi, JH. Specific Inhibitors of Sporangium Formation of <i>Phytophthora capsici</i> from <i>Kalimeris indica</i> CHEMISTRY OF NATURAL COMPOUNDS. 2018.05; 54 (3): 567-569. ( DOI )
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Cheng, LH; Wang, YH; Xiang, L; Qi, JH. Heat Shock Cognate 70 kDa Protein Is the Target of Tetradecyl 2,3-Dihydroxybenzoate for Neuritogenic Effect in PC12 Cells BIOMEDICINES. 2021.10; 9 (10): 1483. ( PubMed, DOI )
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Cheng, LH; Osada, H; Xing, TY; Yoshida, M; Xiang, L; Qi, JH. The Insulin Receptor: A Potential Target of Amarogentin Isolated from <i>Gentiana rigescens</i> Franch That Induces Neurogenesis in PC12 Cells BIOMEDICINES. 2021.05; 9 (5): ( PubMed, DOI )
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Pan, YJ; Liu, YN; Fujii, R; Farooq, U; Cheng, LH; Matsuura, A; Qi, JH; Xiang, L. Ehretiquinone from <i>Onosma bracteatum</i> Wall Exhibits Antiaging Effect on Yeasts and Mammals through Antioxidative Stress and Autophagy Induction OXIDATIVE MEDICINE AND CELLULAR LONGEVITY. 2021.01; 2021 1-15. ( PubMed, DOI )
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Disasa, D; Cheng, LH; Manzoor, M; Liu, Q; Wang, Y; Xiang, L; Qi, JH. Amarogentin from <i>Gentiana rigescens</i> Franch Exhibits Antiaging and Neuroprotective Effects through Antioxidative Stress OXIDATIVE MEDICINE AND CELLULAR LONGEVITY. 2020.08; 2020 1-15. ( PubMed, DOI )
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Liu, Q; Cheng, LH; Matsuura, A; Xiang, L; Qi, JH. Gentiopicroside, a Secoiridoid Glycoside from <i>Gentiana rigescens</i> Franch, Extends the Lifespan of Yeast via Inducing Mitophagy and Antioxidative Stress OXIDATIVE MEDICINE AND CELLULAR LONGEVITY. 2020.08; 2020 1-12. ( PubMed, DOI )
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Cheng, LH; Muroi, M; Cao, SN; Bian, LL; Osada, H; Xiang, L; Qi, JH. 3β,23,28-Trihydroxy-12-oleanene 3β-Caffeate from <i>Desmodium sambuense</i>-Induced Neurogenesis in PC12 Cells Mediated by ER Stress and BDNF-TrkB Signaling Pathways MOLECULAR PHARMACEUTICS. 2019.04; 16 (4): 1423-1432. ( PubMed, DOI )
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Cheng, LH; Ye, Y; Xiang, L; Osada, H; Qi, JH. Lindersin B from <i>Lindernia crustacea</i> induces neuritogenesis by activation of tyrosine kinase A/phosphatidylinositol 3 kinase/extracellular signal-regulated kinase signaling pathway PHYTOMEDICINE. 2017.01; 24 31-38. ( PubMed, DOI )
講演・口頭発表等 【 表示 ／ 非表示 】
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Lihong Cheng. Bioavailability and mechanism of action of blood brain barrier transportable dipeptide Tyr-Pro for its therapeutic potential on cognitive impairment. 日本食品科学工学会第71回大会 2024.08.30 名古屋
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Lihong Cheng, Atsuko Yoshino, Yuki Nagasato, Fuyuko Takata, Shinya Dohgu, Mitsuru Tanaka, Toshiro Matsui. Tyr-Pro, a dipeptide with anti-cognitive impairment effect, can enter into mouse brain after oral intake. 日本食品科学工学会第70回記念大会 2023.08.25
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Lihong Cheng, Atsuko Yoshino, Yuki Nagasato, Fuyuko Takata, Shinya Dohgu, Mitsuru Tanaka, Toshiro Matsui. Oral intake of anti-cognitive impairment dipeptide, Tyr-Pro, leads to its intact accumulation in mouse brain. 第77回日本栄養・食糧学会大会 2023.05.13
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Cheng Lihong, 芳野 温子, 永里 侑貴, 高田 芙友子, 道具 伸也, 田中 充, 松井 利郎. 抗認知障害ジペプチドTyr-Proの経口摂取によるマウス脳への蓄積(Oral intake of anti-cognitive impairment dipeptide, Tyr-Pro, leads to its intact accumulation in mouse brain). 日本栄養・食糧学会大会講演要旨集 2023.03.01
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Lihong Cheng, Atsuko Yoshino, Yuki Nagasato, Fuyuko Takata, Shinya Dohgu, Mitsuru Tanaka, Toshiro Matsui. Evidence on a brain transport of anti-cognitive dipeptide, Tyr-Pro, after oral administration to mice. 22nd IUNS-ICN International Congress of Nutrition 2022.12.08
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Lihong Cheng, Ying Ye, Lan Xiang, Hiroyuki Osada, Jianhua Qi. A neuritogenic triterpenoid from Lindernia crustacea and its mechanism of action. Joint Symposium on Integrated Biosciences between Zhejiang University and The University of Tokyo 2017.12.01
受賞学術賞 【 表示 ／ 非表示 】
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優秀ポスター賞（国際ポスタープレゼンテーショングループ），日本食品科学工学会，2023年08月
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JSPS外国人特別研究員（スタンダード），日本学術振興会，2021年11月