Personnel Information

写真a

HIGA Tsunaki


Job title

Junior Associate Professor
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Campus Career 【 display / non-display 】

  • 2024.04
    -
    2024.09
    Tokyo Medical and Dental University， TMDU Advanced Research Institute (TMDU-ARIS)， ， -， Assistant Professor
  • 2024.10
    -
    2026.03
    Institute of Science Tokyo， -， Institute of Integrated Research， -， Anticancer Strategies Laboratory， Assistant Professor
  • 2026.04
    -
    Now
    Institute of Science Tokyo， -， Institute of Integrated Research， Division of Health Intelligence Research， -， Junior Associate Professor
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Research Areas 【 display / non-display 】

  • Developmental biology

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Research Theme 【 display / non-display 】

  • Exploration of cancer stem cells using a marker gene p57 and establishment of an eradicative anti-cancer therapy, 2019.04 - 2021.03

  • Deciphering positive and negative selection in thymocyte from information theoretic approach, 2018.04 - 2021.03

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Published Papers & Misc 【 display / non-display 】

  1. Identification of endometrial CD169+ macrophages essential for Treg cell accumulation and implantation. 2026.02; 45 (3): 117040. ( PubMed, DOI )

  2. Antitumor Activity of Tumor-Infiltrating Neutrophils Revealed by a Syngeneic Mouse Model of Cholangiocarcinoma. 2025.09; 116 (9): 2457-2470. ( PubMed, DOI )

  3. Sugahara Osamu, Koga Daisuke, Oka Takeru, Sugiyama Shigeaki, Wada Reona, Higa Tsunaki, Nakayama Keiichi I.. 胆管癌のシンジェニックマウスモデルにより解明された腫瘍浸潤好中球の抗腫瘍作用(Antitumor Activity of Tumor-Infiltrating Neutrophils Revealed by a Syngeneic Mouse Model of Cholangiocarcinoma) Cancer Science. 2025.09; 116 (9): 2457-2470. ( ichushi )

  4. Mizoo Taisuke, Oka Takeru, Sugahara Osamu, Minato Takafumi, Higa Tsunaki, Nakayama Keiichi I.. GPLD1陽性癌幹細胞は、腸癌における化学療法耐性および腫瘍の再発に寄与する(GPLD1+ cancer stem cells contribute to chemotherapy resistance and tumour relapse in intestinal cancer) The Journal of Biochemistry. 2025.02; 177 (2): 105-119. ( ichushi )

  5. GPLD1+ cancer stem cells contribute to chemotherapy resistance and tumor relapse in intestinal cancer. 2025.01; ( PubMed, DOI )

  6. Identification and characterization of an enhancer element regulating expression of Cdkn1c (p57 gene). 2024.10; 29 (12): 1264-1274. ( PubMed, DOI )

  7. Tsunaki Higa, Keiichi I Nakayama. Cell cycle heterogeneity and plasticity of colorectal cancer stem cells. Cancer Sci. 2024.05; 115 (5): 1370-1377. ( PubMed, DOI )

  8. Higa Tsunaki, Nakayama Keiichi I.. 大腸癌幹細胞の細胞周期の不均質性と可塑性(Cell cycle heterogeneity and plasticity of colorectal cancer stem cells) Cancer Science. 2024.05; 115 (5): 1370-1377. ( ichushi )

  9. Takeru Oka, Tsunaki Higa, Osamu Sugahara, Daisuke Koga, Shogo Nakayama, Keiichi I Nakayama. Ablation of p57+ Quiescent Cancer Stem Cells Suppresses Recurrence after Chemotherapy of Intestinal Tumors. Cancer Res. 2023.05; 83 (9): 1393-1409. ( PubMed, DOI )

  10. Tsunaki Higa, Yasutaka Okita, Akinobu Matsumoto, Shogo Nakayama, Takeru Oka, Osamu Sugahara, Daisuke Koga, Shoichiro Takeishi, Hirokazu Nakatsumi, Naoki Hosen, Sylvie Robine, Makoto M Taketo, Toshiro Sato, Keiichi I Nakayama. Spatiotemporal reprogramming of differentiated cells underlies regeneration and neoplasia in the intestinal epithelium. Nat Commun. 2022.03; 13 (1): 1500. ( PubMed, DOI )

  11. Nuclear-cytoplasmic shuttling protein PP2AB56 contributes to mTORC1-dependent dephosphorylation of FOXK1. 2018.07; 23 (7): 599-605. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display 】

  1. 須賀原 修, 比嘉 綱己, 中山 敬一. 膵がん幹細胞の同定と特異的焼灼法による治療法開発(Identification of pancreatic cancer stem cells and development of specific ablation therapy). 日本癌学会総会記事 2025.09.01

  2. Tsunaki Higa, Keiichi I. Nakayama. Elucidation of normal and cancer stem cell systems in the intestinal epithelium by a quiescence-maintaining factor p57. Joint Meeting of JSCB 77th & JSDB 58th 2025.07.18

  3. Higa Tsunaki, Oka Takeru, Nakayama Keiichi I.. 最新技術を用いた細胞周期研究の新局面　静止期維持因子p57による腸上皮の正常・がん幹細胞システムの解明(Pioneering new frontiers in cell cycle research through cutting-edge technologies　Elucidation of normal and cancer stem cell systems in the intestinal epithelium by a quiescence-maintaining factor p57). 日本発生生物学会・日本細胞生物学会合同大会要旨集 2025.07.01

  4. 比嘉 綱己, 沖田 康孝, 松本 有樹修, 武石 昭一郎, 中津海 洋一, 中山 敬一. p57陽性細胞の追跡により明らかとなった、消化管+4ポジション細胞の幹細胞性の差異. 生命科学系学会合同年次大会 2017.12.01

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