基本情報

写真a

石川 文彦(イシカワ フミヒコ)

ISHIKAWA FUMIHIKO


職名

教授

ホームページ

https://tmdu-comppath.jp/

分野紹介URL

包括病理学分野

経歴(学内) 【 表示 / 非表示

  • 2023年08月
     
     
    東京医科歯科大学 大学院医歯学総合研究科 医歯学系専攻 先端医療開発学講座 包括病理学 教授
  • 2023年09月
    -
    2023年11月
    東京医科歯科大学 大学院医歯学総合研究科 医歯学系専攻 先端医療開発学講座 包括病理学 教授
  • 2023年12月
    -
    2024年09月
    東京医科歯科大学 大学院医歯学総合研究科 医歯学系専攻 先端医療開発学講座 包括病理学 教授
  • 2024年10月
    -
    現在
    東京科学大学 教育研究組織 大学院 医歯学専攻・先端医療開発学講座 包括病理学分野 教授
 

論文・総説 【 表示 / 非表示

  1. Saumya Agrawal, Emi Kanamaru, Yoriko Saito, Fumihiko Ishikawa, Michiel de Hoon. Cell type-dependent directional transcription at enhancers. NAR Genom Bioinform. 2025.03; 7 (1): lqaf007. ( PubMed, DOI )

  2. Akira Nishimura, Kazuaki Yokoyama, Takuya Naruto, Chika Yamagishi, Toshihiko Imamura, Hiroto Nakazono, Shunsuke Kimura, Mieko Ito, Maiko Sagisaka, Yukie Tanaka, Jinhua Piao, Yui Namikawa, Masakatsu Yanagimachi, Takeshi Isoda, Akinori Kanai, Hirotaka Matsui, Tomoya Isobe, Aiko Sato-Otsubo, Naoko Higuchi, Akiko Takada, Haruna Okuno, Shoji Saito, Shuhei Karakawa, Shogo Kobayashi, Daisuke Hasegawa, Hiroyuki Fujisaki, Daiichiro Hasegawa, Kazutoshi Koike, Takashi Koike, Shinya Rai, Katsutsugu Umeda, Hideki Sano, Yujin Sekinaka, Atsushi Ogawa, Akitoshi Kinoshita, Norio Shiba, Mizuka Miki, Fumihiko Kimura, Hideki Nakayama, Yozo Nakazawa, Takashi Taga, Tomohiko Taki, Souichi Adachi, Atsushi Manabe, Katsuyoshi Koh, Yasushi Ishida, Junko Takita, Fumihiko Ishikawa, Hiroaki Goto, Tomohiro Morio, Shuki Mizutani, Arinobu Tojo, Masatoshi Takagi. Myeloid/natural killer (NK) cell precursor acute leukemia as a distinct leukemia type. Sci Adv. 2023.12; 9 (50): eadj4407. ( PubMed, DOI )

  3. Jane Chuprin, Hannah Buettner, Mina O Seedhom, Dale L Greiner, James G Keck, Fumihiko Ishikawa, Leonard D Shultz, Michael A Brehm. Humanized mouse models for immuno-oncology research. Nat Rev Clin Oncol. 2023.03; 20 (3): 192-206. ( PubMed, DOI )

  4. Tomoya Isobe, Masatoshi Takagi, Aiko Sato-Otsubo, Akira Nishimura, Genta Nagae, Chika Yamagishi, Moe Tamura, Yosuke Tanaka, Shuhei Asada, Reina Takeda, Akiho Tsuchiya, Xiaonan Wang, Kenichi Yoshida, Yasuhito Nannya, Hiroo Ueno, Ryo Akazawa, Itaru Kato, Takashi Mikami, Kentaro Watanabe, Masahiro Sekiguchi, Masafumi Seki, Shunsuke Kimura, Mitsuteru Hiwatari, Motohiro Kato, Shiro Fukuda, Kenji Tatsuno, Shuichi Tsutsumi, Akinori Kanai, Toshiya Inaba, Yusuke Shiozawa, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Rishi S Kotecha, Mark N Cruickshank, Fumihiko Ishikawa, Tomohiro Morio, Mariko Eguchi, Takao Deguchi, Nobutaka Kiyokawa, Yuki Arakawa, Katsuyoshi Koh, Yuki Aoki, Takashi Ishihara, Daisuke Tomizawa, Takako Miyamura, Eiichi Ishii, Shuki Mizutani, Nicola K Wilson, Berthold Göttgens, Satoru Miyano, Toshio Kitamura, Susumu Goyama, Akihiko Yokoyama, Hiroyuki Aburatani, Seishi Ogawa, Junko Takita. Multi-omics analysis defines highly refractory RAS burdened immature subgroup of infant acute lymphoblastic leukemia. Nat Commun. 2022.08; 13 (1): 4501. ( PubMed, DOI )

  5. Noriyuki Saito, Takuji Yamauchi, Noriaki Kawano, Rintaro Ono, Shuro Yoshida, Toshihiro Miyamoto, Tomohiko Kamimura, Leonard D Shultz, Yoriko Saito, Katsuto Takenaka, Kazuya Shimoda, Mine Harada, Koichi Akashi, Fumihiko Ishikawa. Circulating CD34+ cells of primary myelofibrosis patients contribute to myeloid-dominant hematopoiesis and bone marrow fibrosis in immunodeficient mice. Int J Hematol. 2022.02; 115 (2): 198-207. ( PubMed, DOI )

  6. Mari Hashimoto, Yoriko Saito, Ryo Nakagawa, Ikuko Ogahara, Shinsuke Takagi, Sadaaki Takata, Hanae Amitani, Mikiko Endo, Hitomi Yuki, Jordan A Ramilowski, Jessica Severin, Ri-Ichiroh Manabe, Takashi Watanabe, Kokoro Ozaki, Akiko Kaneko, Hiroshi Kajita, Saera Fujiki, Kaori Sato, Teruki Honma, Naoyuki Uchida, Takehiro Fukami, Yasushi Okazaki, Osamu Ohara, Leonard D Shultz, Makoto Yamada, Shuichi Taniguchi, Paresh Vyas, Michiel de Hoon, Yukihide Momozawa, Fumihiko Ishikawa. Combined inhibition of XIAP and BCL2 drives maximal therapeutic efficacy in genetically diverse aggressive acute myeloid leukemia. Nat Cancer. 2021.03; 2 (3): 340-356. ( PubMed, DOI )

  7. Anne P de Groot, Yoriko Saito, Eiryo Kawakami, Mari Hashimoto, Yuki Aoki, Rintaro Ono, Ikuko Ogahara, Saera Fujiki, Akiko Kaneko, Kaori Sato, Hiroshi Kajita, Takashi Watanabe, Masatoshi Takagi, Daisuke Tomizawa, Katsuyoshi Koh, Mariko Eguchi, Eiichi Ishii, Osamu Ohara, Leonard D Shultz, Shuki Mizutani, Fumihiko Ishikawa. Targeting critical kinases and anti-apoptotic molecules overcomes steroid resistance in MLL-rearranged leukaemia. EBioMedicine. 2021.02; 64 103235. ( PubMed, DOI )

  8. Yoriko Saito, Leonard D Shultz, Fumihiko Ishikawa. Understanding Normal and Malignant Human Hematopoiesis Using Next-Generation Humanized Mice. Trends Immunol. 2020.08; 41 (8): 706-720. ( PubMed, DOI )

  9. Inez Johanna, Patricia Hernández-López, Sabine Heijhuurs, Laura Bongiovanni, Alain de Bruin, Dennis Beringer, Sanne van Dooremalen, Leonard D Shultz, Fumihiko Ishikawa, Zsolt Sebestyen, Trudy Straetemans, Jürgen Kuball. TEG011 persistence averts extramedullary tumor growth without exerting off-target toxicity against healthy tissues in a humanized HLA-A*24:02 transgenic mice. J Leukoc Biol. 2020.06; 107 (6): 1069-1079. ( PubMed, DOI )

  10. Eri Kumaki, Keisuke Tanaka, Kohsuke Imai, Yuki Aoki-Nogami, Akira Ishiguro, Satoshi Okada, Hirokazu Kanegane, Fumihiko Ishikawa, Tomohiro Morio. Atypical SIFD with novel TRNT1 mutations: a case study on the pathogenesis of B-cell deficiency. Int J Hematol. 2019.04; 109 (4): 382-389. ( PubMed, DOI )

  11. Masashi Matsuda, Rintaro Ono, Tomonori Iyoda, Takaho Endo, Makoto Iwasaki, Mariko Tomizawa-Murasawa, Yoriko Saito, Akiko Kaneko, Kanako Shimizu, Daisuke Yamada, Narumi Ogonuki, Takashi Watanabe, Manabu Nakayama, Yoko Koseki, Fuyuko Kezuka-Shiotani, Takanori Hasegawa, Hiromasa Yabe, Shunichi Kato, Atsuo Ogura, Leonard D Shultz, Osamu Ohara, Masaru Taniguchi, Haruhiko Koseki, Shin-Ichiro Fujii, Fumihiko Ishikawa. Human NK cell development in hIL-7 and hIL-15 knockin NOD/SCID/IL2rgKO mice. Life Sci Alliance. 2019.04; 2 (2): ( PubMed, DOI )

  12. Rintaro Ono, Takashi Watanabe, Eiryo Kawakami, Makoto Iwasaki, Mariko Tomizawa-Murasawa, Masashi Matsuda, Yuho Najima, Shinsuke Takagi, Saera Fujiki, Rumi Sato, Yoshiki Mochizuki, Hisahiro Yoshida, Kaoru Sato, Hiromasa Yabe, Shunichi Kato, Yoriko Saito, Shuichi Taniguchi, Leonard D Shultz, Osamu Ohara, Masayuki Amagai, Haruhiko Koseki, Fumihiko Ishikawa. Co-activation of macrophages and T cells contribute to chronic GVHD in human IL-6 transgenic humanised mouse model. EBioMedicine. 2019.03; 41 584-596. ( PubMed, DOI )

  13. Miho Tanaka, Akiko Ishige, Masami Yaguchi, Takehisa Matsumoto, Mikako Shirouzu, Shigeyuki Yokoyama, Fumihiko Ishikawa, Issay Kitabayashi, Toshitada Takemori, Michishige Harada. Development of a simple new flow cytometric antibody-dependent cellular cytotoxicity (ADCC) assay with excellent sensitivity. J Immunol Methods. 2019.01; 464 74-86. ( PubMed, DOI )

  14. Hanae Fujimoto, Yoriko Saito, Kenoki Ohuchida, Eiryo Kawakami, Saera Fujiki, Takashi Watanabe, Rintaro Ono, Akiko Kaneko, Shinsuke Takagi, Yuho Najima, Atsushi Hijikata, Lin Cui, Takashi Ueki, Yoshinao Oda, Shohei Hori, Osamu Ohara, Masafumi Nakamura, Takashi Saito, Fumihiko Ishikawa. T Cells in Human Colorectal Cancer. J Immunol. 2018.05; 200 (9): 3291-3303. ( PubMed, DOI )

  15. Yoriko Saito, Yoshiki Mochizuki, Ikuko Ogahara, Takashi Watanabe, Leah Hogdal, Shinsuke Takagi, Kaori Sato, Akiko Kaneko, Hiroshi Kajita, Naoyuki Uchida, Takehiro Fukami, Leonard D Shultz, Shuichi Taniguchi, Osamu Ohara, Anthony G Letai, Fumihiko Ishikawa. Overcoming mutational complexity in acute myeloid leukemia by inhibition of critical pathways. Sci Transl Med. 2017.10; 9 (413): ( PubMed, DOI )

  16. Fumihiko Ishikawa. Guest editorial: Connecting multiple aspects of hematologic malignancies toward creation of new therapeutics. Int J Hematol. 2017.05; 105 (5): 547-548. ( PubMed, DOI )

  17. Noriaki Kawano, Takuro Kuriyama, Shuro Yoshida, Sayaka Kawano, Yoshihisa Yamano, Kousuke Marutsuka, Seiichirou Minato, Kiyoshi Yamashita, Hidenobu Ochiai, Kazuya Shimoda, Fumihiko Ishikawa, Ikuo Kikuchi. The Impact of a Humanized CCR4 Antibody (Mogamulizumab) on Patients with Aggressive-Type Adult T-Cell Leukemia-Lymphoma Treated with Allogeneic Hematopoietic Stem Cell Transplantation. J Clin Exp Hematop. 2017; 56 (3): 135-144. ( PubMed, DOI )

  18. Yuho Najima, Mariko Tomizawa-Murasawa, Yoriko Saito, Takashi Watanabe, Rintaro Ono, Toshiki Ochi, Nahoko Suzuki, Hiroshi Fujiwara, Osamu Ohara, Leonard D Shultz, Masaki Yasukawa, Fumihiko Ishikawa. Induction of WT1-specific human CD8+ T cells from human HSCs in HLA class I Tg NOD/SCID/IL2rgKO mice. Blood. 2016.02; 127 (6): 722-734. ( PubMed, DOI )

  19. Noriaki Kawano, Shuro Yoshida, Sayaka Kawano, Takuro Kuriyama, Kiyoshi Yamashita, Hidenobu Ochiai, Kazuya Shimoda, Fumihiko Ishikawa, Akira Ueda, Ikuo Kikuchi. Clinical Features and Treatment Outcomes of 51 Patients with Chronic Myeloid Leukemia Treated with a Tyrosine Kinase Inhibitor at a Single Institution from 2002 to 2014. J Clin Exp Hematop. 2016; 56 (1): 34-42. ( PubMed, DOI )

  20. Noriaki Kawano, Takuro Kuriyama, Koh-Hei Sonoda, Shuro Yoshida, Kiyoshi Yamashita, Hidenobu Ochiai, Kazuya Shimoda, Fumihiko Ishikawa, Akira Ueda, Ikuo Kikuchi. Clinical Impact of a Humanized CCR4 Antibody (Mogamulizumab) in 14 Patients with Aggressive Adult T-cell Leukemia-lymphoma Treated at a Single Institution During a Three-year Period (2012-2014). Intern Med. 2016; 55 (11): 1439-1445. ( PubMed, DOI )

  21. 石川 文彦. Humanized mouseを用いた白血病の理解と克服に向けた研究 臨牀と研究. 2024.12; 101 (12): 1515-1521. ( 医中誌 )

  22. 石川 文彦. 【ヒト化マウス】正常と悪性のヒト造血研究におけるhumanized mouse 臨床免疫・アレルギー科. 2024.09; 82 (3): 254-260.

  23. Mari Hashimoto, Fumihiko Ishikawa. [Performing integrative transcriptomic and chemical screening to identify patient-specific vulnerabilities in poor-prognosis acute myeloid leukemia]. Rinsho Ketsueki. 2021; 62 (7): 774-780. ( PubMed, DOI )

  24. Chizu Yamada, Hiroshi Nitta, Fumihiko Ishikawa, Yoshihisa Fujita, Hideyuki Omoto, Shigeyuki Kamata, Youhei Miyauchi, Takashi Morinaka, Hiroshi Ito. [A Case of Perforative Peritonitis Due to Intestinal Metastasis from Lung Cancer]. Gan To Kagaku Ryoho. 2017.11; 44 (12): 1176-1178. ( PubMed )

  25. Chizu Yamada, Fumihiko Ishikawa, Hiroshi Nitta, Yoshihisa Fujita, Hideyuki Omoto, Shigeyuki Kamata, Hiroshi Ito. [Conversion Therapy of Initially Unresectable Rectal Cancer with Perforation via FOLFOX4 Chemotherapy]. Gan To Kagaku Ryoho. 2015.11; 42 (12): 2328-2329. ( PubMed )

  26. Chizu Yamada, Fumihiko Ishikawa, Hiroshi Nitta, Yoshihisa Fujita, Hideyuki Omoto, Shigeyuki Kamata, Hiroshi Ito. [Repeated Insertion of Self-Expandable Metallic Stents as a Palliative Therapy for Unresectable Colorectal Cancer]. Gan To Kagaku Ryoho. 2015.11; 42 (12): 2271-2272. ( PubMed )

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講演・口頭発表等 【 表示 / 非表示

  1. 伊藤亜里・石川文彦. Targeting poor prognosis acute myeloid leukemia with CD25- targeted chemokine receptor expressing CAR T cell therapy. 第83回日本癌学会学術総会 2024.09.19 福岡マリンメッセ

  2. 石川文彦. Understanding normal and malignant human hematopoiesis. 第21回幹細胞シンポジウム 2024.05.24 淡路島・淡路夢舞台国際会議場

  3. 石川文彦. 造血幹細胞分化・移植免疫のsingle cell biology. 第46回日本造血・免疫細胞療法学会総会 2024.03.23 東京国際フォーラム

  4. 國枝 純子, 高松 学, 山下 享子, 阿江 啓介, 松本 誠一, 石川 文彦, 竹内 賢吾. 粘液型脂肪肉腫における人工知能を活用した組織画像分類モデルの構築(Histologic artificial intelligence(AI) model for predicting prognosis of myxoid liposarcoma). 日本病理学会会誌 2024.02.01

  5. 大西 威一郎, 韓 知佑, 倉田 盛人, 田口 登和子, 石川 文彦. CRISPR screeningデータベースを用いた、遺伝性乳癌の新規治療標的因子の探索(Identification of synthetic lethal genes of hereditary breast cancer using CRISPR screening database). 日本病理学会会誌 2024.02.01

  6. 田口 登和子, 林 琉美加, 大西 威一郎, 石橋 佐知子, 池田 真住, 井上 美織, 倉田 盛人, 石川 文彦. 卵巣子宮内膜症におけるCRISPR libraryを用いたフェロトーシス誘導因子の同定(Identification of factors inducing ferroptosis in ovarian endometriosis by using the CRISPR library). 日本病理学会会誌 2024.02.01

  7. Saumya Agrawal, Fumihiko Ishikawa他. Comparative analysis of cellular response to onset of infection due to SARS-CoV-2 strains . The 46th Annual Meeting of the Molecular Biology Society of Japan 2023.12.06 兵庫・神戸ポートアイランド

  8. 中川諒, 石川文彦. Targeting patient-specific anti-apoptotic molecules and cell surface proteins in high-risk leukemia. 第85回日本血液学会学術集会 2023.10.13 東京・東京国際フォーラム

  9. Saumya Agrawal, Fumihiko Ishikawa他. Comparative analysis of transcriptome landscape and chromatin conformation in response to onset of infection due to different SARS-CoV-2 strains . The 14th International Workshop on Advanced Genomics (14AGW) 2023.10.04 東京・一橋講堂

  10. 石川文彦. 急性骨髄性白血病の複雑性理解と克服に向けた取り組み. 菊池昌弘先生記念講演会 2024.04.07 福岡大学医学部附属病院メディカルホール

  11. 林 琉美加, 田口 登和子, 井上 美織, 大西 威一郎, 倉田 盛人, 石川 文彦. FFPE標本を用いた卵巣子宮内膜症におけるフェロトーシス関連因子の免疫組織学的検討. 日本病理学会会誌 2024.02.01

  12. 川出 玄二, 山本 浩平, 倉田 盛人, 大西 威一郎, 松木 裕子, 北川 昌伸, 大橋 健一, 石川 文彦. DLBCLにおける4-HNEの蓄積とApoptosis, Ferroptosis抵抗性獲得の検討. 日本病理学会会誌 2024.02.01

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