Personnel Information

写真a

ISHIKAWA FUMIHIKO


Job title

Professor

Field Introduction URL

包括病理学分野

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Campus Career 【 display / non-display 】

  • 2023.08
    　
    　
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Advanced Therapeutic Sciences， Comprehensive Pathology， Professor
  • 2023.09
    -
    2023.11
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Advanced Therapeutic Sciences， Comprehensive Pathology， Professor
  • 2023.12
    -
    2024.09
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Advanced Therapeutic Sciences， Comprehensive Pathology， Professor
  • 2024.10
    -
    Now
    Institute of Science Tokyo， -， Graduate Schools， Advanced Therapeutic Sciences， Department of Comprehensive Pathology， Professor
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Published Papers & Misc 【 display / non-display 】

  1. Akira Nishimura, Kazuaki Yokoyama, Takuya Naruto, Chika Yamagishi, Toshihiko Imamura, Hiroto Nakazono, Shunsuke Kimura, Mieko Ito, Maiko Sagisaka, Yukie Tanaka, Jinhua Piao, Yui Namikawa, Masakatsu Yanagimachi, Takeshi Isoda, Akinori Kanai, Hirotaka Matsui, Tomoya Isobe, Aiko Sato-Otsubo, Naoko Higuchi, Akiko Takada, Haruna Okuno, Shoji Saito, Shuhei Karakawa, Shogo Kobayashi, Daisuke Hasegawa, Hiroyuki Fujisaki, Daiichiro Hasegawa, Kazutoshi Koike, Takashi Koike, Shinya Rai, Katsutsugu Umeda, Hideki Sano, Yujin Sekinaka, Atsushi Ogawa, Akitoshi Kinoshita, Norio Shiba, Mizuka Miki, Fumihiko Kimura, Hideki Nakayama, Yozo Nakazawa, Takashi Taga, Tomohiko Taki, Souichi Adachi, Atsushi Manabe, Katsuyoshi Koh, Yasushi Ishida, Junko Takita, Fumihiko Ishikawa, Hiroaki Goto, Tomohiro Morio, Shuki Mizutani, Arinobu Tojo, Masatoshi Takagi. Myeloid/natural killer (NK) cell precursor acute leukemia as a distinct leukemia type. Sci Adv. 2023.12; 9 (50): eadj4407. ( PubMed, DOI )

  2. Jane Chuprin, Hannah Buettner, Mina O Seedhom, Dale L Greiner, James G Keck, Fumihiko Ishikawa, Leonard D Shultz, Michael A Brehm. Humanized mouse models for immuno-oncology research. Nat Rev Clin Oncol. 2023.03; 20 (3): 192-206. ( PubMed, DOI )

  3. Tomoya Isobe, Masatoshi Takagi, Aiko Sato-Otsubo, Akira Nishimura, Genta Nagae, Chika Yamagishi, Moe Tamura, Yosuke Tanaka, Shuhei Asada, Reina Takeda, Akiho Tsuchiya, Xiaonan Wang, Kenichi Yoshida, Yasuhito Nannya, Hiroo Ueno, Ryo Akazawa, Itaru Kato, Takashi Mikami, Kentaro Watanabe, Masahiro Sekiguchi, Masafumi Seki, Shunsuke Kimura, Mitsuteru Hiwatari, Motohiro Kato, Shiro Fukuda, Kenji Tatsuno, Shuichi Tsutsumi, Akinori Kanai, Toshiya Inaba, Yusuke Shiozawa, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Rishi S Kotecha, Mark N Cruickshank, Fumihiko Ishikawa, Tomohiro Morio, Mariko Eguchi, Takao Deguchi, Nobutaka Kiyokawa, Yuki Arakawa, Katsuyoshi Koh, Yuki Aoki, Takashi Ishihara, Daisuke Tomizawa, Takako Miyamura, Eiichi Ishii, Shuki Mizutani, Nicola K Wilson, Berthold Göttgens, Satoru Miyano, Toshio Kitamura, Susumu Goyama, Akihiko Yokoyama, Hiroyuki Aburatani, Seishi Ogawa, Junko Takita. Multi-omics analysis defines highly refractory RAS burdened immature subgroup of infant acute lymphoblastic leukemia. Nat Commun. 2022.08; 13 (1): 4501. ( PubMed, DOI )

  4. Noriyuki Saito, Takuji Yamauchi, Noriaki Kawano, Rintaro Ono, Shuro Yoshida, Toshihiro Miyamoto, Tomohiko Kamimura, Leonard D Shultz, Yoriko Saito, Katsuto Takenaka, Kazuya Shimoda, Mine Harada, Koichi Akashi, Fumihiko Ishikawa. Circulating CD34+ cells of primary myelofibrosis patients contribute to myeloid-dominant hematopoiesis and bone marrow fibrosis in immunodeficient mice. Int J Hematol. 2022.02; 115 (2): 198-207. ( PubMed, DOI )

  5. Mari Hashimoto, Yoriko Saito, Ryo Nakagawa, Ikuko Ogahara, Shinsuke Takagi, Sadaaki Takata, Hanae Amitani, Mikiko Endo, Hitomi Yuki, Jordan A Ramilowski, Jessica Severin, Ri-Ichiroh Manabe, Takashi Watanabe, Kokoro Ozaki, Akiko Kaneko, Hiroshi Kajita, Saera Fujiki, Kaori Sato, Teruki Honma, Naoyuki Uchida, Takehiro Fukami, Yasushi Okazaki, Osamu Ohara, Leonard D Shultz, Makoto Yamada, Shuichi Taniguchi, Paresh Vyas, Michiel de Hoon, Yukihide Momozawa, Fumihiko Ishikawa. Combined inhibition of XIAP and BCL2 drives maximal therapeutic efficacy in genetically diverse aggressive acute myeloid leukemia. Nat Cancer. 2021.03; 2 (3): 340-356. ( PubMed, DOI )

  6. Anne P de Groot, Yoriko Saito, Eiryo Kawakami, Mari Hashimoto, Yuki Aoki, Rintaro Ono, Ikuko Ogahara, Saera Fujiki, Akiko Kaneko, Kaori Sato, Hiroshi Kajita, Takashi Watanabe, Masatoshi Takagi, Daisuke Tomizawa, Katsuyoshi Koh, Mariko Eguchi, Eiichi Ishii, Osamu Ohara, Leonard D Shultz, Shuki Mizutani, Fumihiko Ishikawa. Targeting critical kinases and anti-apoptotic molecules overcomes steroid resistance in MLL-rearranged leukaemia. EBioMedicine. 2021.02; 64 103235. ( PubMed, DOI )

  7. Yoriko Saito, Leonard D Shultz, Fumihiko Ishikawa. Understanding Normal and Malignant Human Hematopoiesis Using Next-Generation Humanized Mice. Trends Immunol. 2020.08; 41 (8): 706-720. ( PubMed, DOI )

  8. Inez Johanna, Patricia Hernández-López, Sabine Heijhuurs, Laura Bongiovanni, Alain de Bruin, Dennis Beringer, Sanne van Dooremalen, Leonard D Shultz, Fumihiko Ishikawa, Zsolt Sebestyen, Trudy Straetemans, Jürgen Kuball. TEG011 persistence averts extramedullary tumor growth without exerting off-target toxicity against healthy tissues in a humanized HLA-A*24:02 transgenic mice. J Leukoc Biol. 2020.06; 107 (6): 1069-1079. ( PubMed, DOI )

  9. Eri Kumaki, Keisuke Tanaka, Kohsuke Imai, Yuki Aoki-Nogami, Akira Ishiguro, Satoshi Okada, Hirokazu Kanegane, Fumihiko Ishikawa, Tomohiro Morio. Atypical SIFD with novel TRNT1 mutations: a case study on the pathogenesis of B-cell deficiency. Int J Hematol. 2019.04; 109 (4): 382-389. ( PubMed, DOI )

  10. Masashi Matsuda, Rintaro Ono, Tomonori Iyoda, Takaho Endo, Makoto Iwasaki, Mariko Tomizawa-Murasawa, Yoriko Saito, Akiko Kaneko, Kanako Shimizu, Daisuke Yamada, Narumi Ogonuki, Takashi Watanabe, Manabu Nakayama, Yoko Koseki, Fuyuko Kezuka-Shiotani, Takanori Hasegawa, Hiromasa Yabe, Shunichi Kato, Atsuo Ogura, Leonard D Shultz, Osamu Ohara, Masaru Taniguchi, Haruhiko Koseki, Shin-Ichiro Fujii, Fumihiko Ishikawa. Human NK cell development in hIL-7 and hIL-15 knockin NOD/SCID/IL2rgKO mice. Life Sci Alliance. 2019.04; 2 (2): ( PubMed, DOI )

  11. Rintaro Ono, Takashi Watanabe, Eiryo Kawakami, Makoto Iwasaki, Mariko Tomizawa-Murasawa, Masashi Matsuda, Yuho Najima, Shinsuke Takagi, Saera Fujiki, Rumi Sato, Yoshiki Mochizuki, Hisahiro Yoshida, Kaoru Sato, Hiromasa Yabe, Shunichi Kato, Yoriko Saito, Shuichi Taniguchi, Leonard D Shultz, Osamu Ohara, Masayuki Amagai, Haruhiko Koseki, Fumihiko Ishikawa. Co-activation of macrophages and T cells contribute to chronic GVHD in human IL-6 transgenic humanised mouse model. EBioMedicine. 2019.03; 41 584-596. ( PubMed, DOI )

  12. Miho Tanaka, Akiko Ishige, Masami Yaguchi, Takehisa Matsumoto, Mikako Shirouzu, Shigeyuki Yokoyama, Fumihiko Ishikawa, Issay Kitabayashi, Toshitada Takemori, Michishige Harada. Development of a simple new flow cytometric antibody-dependent cellular cytotoxicity (ADCC) assay with excellent sensitivity. J Immunol Methods. 2019.01; 464 74-86. ( PubMed, DOI )

  13. Hanae Fujimoto, Yoriko Saito, Kenoki Ohuchida, Eiryo Kawakami, Saera Fujiki, Takashi Watanabe, Rintaro Ono, Akiko Kaneko, Shinsuke Takagi, Yuho Najima, Atsushi Hijikata, Lin Cui, Takashi Ueki, Yoshinao Oda, Shohei Hori, Osamu Ohara, Masafumi Nakamura, Takashi Saito, Fumihiko Ishikawa. T Cells in Human Colorectal Cancer. J Immunol. 2018.05; 200 (9): 3291-3303. ( PubMed, DOI )

  14. Yoriko Saito, Yoshiki Mochizuki, Ikuko Ogahara, Takashi Watanabe, Leah Hogdal, Shinsuke Takagi, Kaori Sato, Akiko Kaneko, Hiroshi Kajita, Naoyuki Uchida, Takehiro Fukami, Leonard D Shultz, Shuichi Taniguchi, Osamu Ohara, Anthony G Letai, Fumihiko Ishikawa. Overcoming mutational complexity in acute myeloid leukemia by inhibition of critical pathways. Sci Transl Med. 2017.10; 9 (413): ( PubMed, DOI )

  15. Fumihiko Ishikawa. Guest editorial: Connecting multiple aspects of hematologic malignancies toward creation of new therapeutics. Int J Hematol. 2017.05; 105 (5): 547-548. ( PubMed, DOI )

  16. Noriaki Kawano, Takuro Kuriyama, Shuro Yoshida, Sayaka Kawano, Yoshihisa Yamano, Kousuke Marutsuka, Seiichirou Minato, Kiyoshi Yamashita, Hidenobu Ochiai, Kazuya Shimoda, Fumihiko Ishikawa, Ikuo Kikuchi. The Impact of a Humanized CCR4 Antibody (Mogamulizumab) on Patients with Aggressive-Type Adult T-Cell Leukemia-Lymphoma Treated with Allogeneic Hematopoietic Stem Cell Transplantation. J Clin Exp Hematop. 2017; 56 (3): 135-144. ( PubMed, DOI )

  17. Yuho Najima, Mariko Tomizawa-Murasawa, Yoriko Saito, Takashi Watanabe, Rintaro Ono, Toshiki Ochi, Nahoko Suzuki, Hiroshi Fujiwara, Osamu Ohara, Leonard D Shultz, Masaki Yasukawa, Fumihiko Ishikawa. Induction of WT1-specific human CD8+ T cells from human HSCs in HLA class I Tg NOD/SCID/IL2rgKO mice. Blood. 2016.02; 127 (6): 722-734. ( PubMed, DOI )

  18. Noriaki Kawano, Shuro Yoshida, Sayaka Kawano, Takuro Kuriyama, Kiyoshi Yamashita, Hidenobu Ochiai, Kazuya Shimoda, Fumihiko Ishikawa, Akira Ueda, Ikuo Kikuchi. Clinical Features and Treatment Outcomes of 51 Patients with Chronic Myeloid Leukemia Treated with a Tyrosine Kinase Inhibitor at a Single Institution from 2002 to 2014. J Clin Exp Hematop. 2016; 56 (1): 34-42. ( PubMed, DOI )

  19. Noriaki Kawano, Takuro Kuriyama, Koh-Hei Sonoda, Shuro Yoshida, Kiyoshi Yamashita, Hidenobu Ochiai, Kazuya Shimoda, Fumihiko Ishikawa, Akira Ueda, Ikuo Kikuchi. Clinical Impact of a Humanized CCR4 Antibody (Mogamulizumab) in 14 Patients with Aggressive Adult T-cell Leukemia-lymphoma Treated at a Single Institution During a Three-year Period (2012-2014). Intern Med. 2016; 55 (11): 1439-1445. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display 】

  1. 石川文彦. 難治性白血病の再現と理解、そして克服へ . 第70回日本病理学会秋期特別総会 2024.11.07 東京・一ツ橋ホール

  2. 伊藤亜里・石川文彦. Targeting poor prognosis acute myeloid leukemia with CD25- targeted chemokine receptor expressing CAR T cell therapy. 第83回日本癌学会学術総会 2024.09.19 福岡マリンメッセ

  3. 石川文彦. Understanding normal and malignant human hematopoiesis. 第21回幹細胞シンポジウム 2024.05.24 淡路島・淡路夢舞台国際会議場

  4. 石川文彦. 急性骨髄性白血病の複雑性理解と克服に向けた取り組み. 菊池昌弘先生記念講演会 2024.04.07 福岡大学医学部附属病院メディカルホール

  5. 石川文彦. 造血幹細胞分化・移植免疫のsingle cell biology. 第46回日本造血・免疫細胞療法学会総会 2024.03.23 東京国際フォーラム

  6. 國枝 純子, 高松 学, 山下 享子, 阿江 啓介, 松本 誠一, 石川 文彦, 竹内 賢吾. 粘液型脂肪肉腫における人工知能を活用した組織画像分類モデルの構築(Histologic artificial intelligence(AI) model for predicting prognosis of myxoid liposarcoma). 日本病理学会会誌 2024.02.01

  7. 大西 威一郎, 韓 知佑, 倉田 盛人, 田口 登和子, 石川 文彦. CRISPR screeningデータベースを用いた、遺伝性乳癌の新規治療標的因子の探索(Identification of synthetic lethal genes of hereditary breast cancer using CRISPR screening database). 日本病理学会会誌 2024.02.01

  8. 田口 登和子, 林 琉美加, 大西 威一郎, 石橋 佐知子, 池田 真住, 井上 美織, 倉田 盛人, 石川 文彦. 卵巣子宮内膜症におけるCRISPR libraryを用いたフェロトーシス誘導因子の同定(Identification of factors inducing ferroptosis in ovarian endometriosis by using the CRISPR library). 日本病理学会会誌 2024.02.01

  9. 岩﨑惇, 石川文彦. Single cell genomics revealed critical molecules affecting cell fate of human stem/progenitor cells. The 52th Annual Meeting of The Japanese Society for Immunology 2024.01.15 千葉・幕張メッセ

  10. 中川諒, 石川文彦. Combined targeting of patient-specific anti-apoptotic molecules and cell surface proteins in high-risk lymphocytic and myeloid leukemia. 第52回日本免疫学会学術集会 2024.01.15 千葉・幕張メッセ

  11. Saumya Agrawal, Fumihiko Ishikawa他. Comparative analysis of cellular response to onset of infection due to SARS-CoV-2 strains . The 46th Annual Meeting of the Molecular Biology Society of Japan 2023.12.06 兵庫・神戸ポートアイランド

  12. 中川諒, 石川文彦. Targeting patient-specific anti-apoptotic molecules and cell surface proteins in high-risk leukemia. 第85回日本血液学会学術集会 2023.10.13 東京・東京国際フォーラム

  13. Saumya Agrawal, Fumihiko Ishikawa他. Comparative analysis of transcriptome landscape and chromatin conformation in response to onset of infection due to different SARS-CoV-2 strains . The 14th International Workshop on Advanced Genomics (14AGW) 2023.10.04 東京・一橋講堂

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