Personnel Information

写真a

ASO Hirofumi


Job title

Assistant Professor

Research Areas, Keywords

Infectious diseases, Bioinformatics

Field Introduction URL

国立・東京医科歯科大学AIシステム医科学分野【清水研】

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Graduating School 【 display / non-display 】

  • Kyoto University, Faculty of Pharmaceutical Science, 2018.03, Graduated

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Graduate School 【 display / non-display 】

  • Kyoto University, Graduate School, Division of Pharmaceutical Sciences, Doctor's Course, 2023.03, Completed

  • Kyoto University, Graduate School, Division of Pharmaceutical Sciences, Master's Course, 2020.03, Completed

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Campus Career 【 display / non-display 】

  • 2023.04
    -
    2024.03
    Tokyo Medical and Dental University， M&D Data Science Center， Division of Health Intelligence， Department of AI Systems Medicine， Project Assistant Professor
  • 2024.04
    -
    Now
    Tokyo Medical and Dental University， M&D Data Science Center， Division of Health Intelligence， Department of AI Systems Medicine， Assistant Professor
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Academic Society Affiliations 【 display / non-display 】

  • The Japanese Society for Virology

  • The Molecular Biology Society of Japan

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Research Areas 【 display / non-display 】

  • Bacteriology

  • Life, health and medical informatics

  • Virology

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Research Theme 【 display / non-display 】

  • Single-cell transcriptome analysis illuminating the characteristics of species-specific innate immune responses against viral infections, 2020.04 - 2023.10

  • Reconstitution of prospermatogonial specification in vitro from human induced pluripotent stem cells, 2020.01 - 2020.10

  • Comparative description of the expression profile ofiInterferon-stimulated genes in multiple cell lineages targeted by HIV-1 infection, 2018.05 - 2019.03

  • Comprehensive Investigation on the Interplay between Feline APOBEC3Z3 Proteins and Feline Immunodeficiency Virus Vif Proteins, 2017.04 - 2021.07

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Published Papers & Misc 【 display / non-display 】

  1. Hirofumi Aso, Jumpei Ito, Haruka Ozaki, Yukie Kashima, Yutaka Suzuki, Yoshio Koyanagi, Kei Sato. Single-cell transcriptome analysis illuminating the characteristics of species-specific innate immune responses against viral infections. GigaScience. 2023.10; 12 giad086. ( PubMed, DOI )

  2. Hirofumi Aso, Shumpei Nagaoka, Eiryo Kawakami, Jumpei Ito, Saiful Islam, Benjy Jek Yang Tan, Shinji Nakaoka, Koichi Ashizaki, Katsuyuki Shiroguchi, Yutaka Suzuki, Yorifumi Satou, Yoshio Koyanagi, Kei Sato. Multiomics investigation revealing the characteristics of HIV-1-infected cells in vivo Cell Reports. 2020.07; 32 (2): 107887. ( PubMed, DOI )

  3. Hirofumi Aso, Jumpei Ito, Yoshio Koyanagi, Kei Sato. Comparative description of the expression profile of interferon-stimulated genes in multiple cell lineages targeted by HIV-1 infection Frontiers in Microbiology. 2019.03; 10 429. ( PubMed, DOI )

  4. Yusuke Kosugi, Keiya Uriu, Narumi Suzuki, Keisuke Yamamoto, Shumpei Nagaoka, Izumi Kimura, Yoriyuki Konno, Hirofumi Aso, Brian J Willett, Tomoko Kobayashi, Yoshio Koyanagi, Mahoko Takahashi Ueda, Jumpei Ito, Kei Sato. Comprehensive investigation on the interplay between feline APOBEC3Z3 proteins and feline immunodeficiency virus Vif proteins Journal of Virology. 2021.07; 95 (13): e0017821-e00178-21. ( PubMed, DOI )

  5. Yoriyuki Konno, Keiya Uriu, Takayuki Chikata, Toru Takada, Jun-Ichi Kurita, Mahoko Takahashi Ueda, Saiful Islam, Benjy Jek Yang Tan, Jumpei Ito, Hirofumi Aso, Ryuichi Kumata, Carolyn Williamson, Shingo Iwami, Masafumi Takiguchi, Yoshifumi Nishimura, Eiji Morita, Yorifumi Satou, So Nakagawa, Yoshio Koyanagi, Kei Sato. Two-step evolution of HIV-1 budding system leading to pandemic in the human population. Cell Reports. 2024.02; 43 (2): 113697. ( PubMed, DOI )

  6. Young Sun Hwang, Shinnosuke Suzuki, Yasunari Seita, Jumpei Ito, Yuka Sakata, Hirofumi Aso, Kei Sato, Brian P Hermann, Kotaro Sasaki. Reconstitution of prospermatogonial specification in vitro from human induced pluripotent stem cells Nature Communications. 2020.11; 11 (1): 5656. ( PubMed, DOI )

  7. Yusuke Nakano, Keisuke Yamamoto, Mahoko Takahashi Ueda, Andrew Soper, Yoriyuki Konno, Izumi Kimura, Keiya Uriu, Ryuichi Kumata, Hirofumi Aso, Naoko Misawa, Shumpei Nagaoka, Soma Shimizu, Keito Mitsumune, Yusuke Kosugi, Guillermo Juarez-Fernandez, Jumpei Ito, So Nakagawa, Terumasa Ikeda, Yoshio Koyanagi, Reuben S Harris, Kei Sato. A role for gorilla APOBEC3G in shaping lentivirus evolution including transmission to humans PLoS Pathogens. 2020.09; 16 (9): e1008812. ( PubMed, DOI )

  8. Yoriyuki Konno, Shumpei Nagaoka, Izumi Kimura, Keisuke Yamamoto, Yumiko Kagawa, Ryuichi Kumata, Hirofumi Aso, Mahoko Takahashi Ueda, So Nakagawa, Tomoko Kobayashi, Yoshio Koyanagi, Kei Sato. New World feline APOBEC3 potently controls inter-genus lentiviral transmission Retrovirology. 2018.04; 15 (1): 31. ( PubMed, DOI )

  9. Kei Sato, Naoko Misawa, Junko S Takeuchi, Tomoko Kobayashi, Taisuke Izumi, Hirofumi Aso, Shumpei Nagaoka, Keisuke Yamamoto, Izumi Kimura, Yoriyuki Konno, Yusuke Nakano, Yoshio Koyanagi. Experimental adaptive evolution of simian immunodeficiency virus SIVcpz to pandemic human immunodeficiency virus type 1 by using a humanized mouse model Journal of Virology. 2018.02; 92 (4): e01905-17. ( PubMed, DOI )

  10. Yusuke Nakano, Hirofumi Aso, Andrew Soper, Eri Yamada, Miyu Moriwaki, Guillermo Juarez-Fernandez, Yoshio Koyanagi, Kei Sato. A conflict of interest: the evolutionary arms race between mammalian APOBEC3 and lentiviral Vif Retrovirology. 2017.05; 14 (1): 31. ( PubMed, DOI )

  11. Andrew Soper, Guillermo Juarez-Fernandez, Hirofumi Aso, Miyu Moriwaki, Eri Yamada, Yusuke Nakano, Yoshio Koyanagi, Kei Sato. Various plus unique: Viral protein U as a plurifunctional protein for HIV-1 replication Experimental Biology and Medicine. 2017.04; 242 (8): 850-858. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display 】

  1. 麻生啓文, 大野聡, 清水秀幸. プラスミドDNAの宿主細菌を予測するツールの開発. 第46回日本分子生物学会年会 2023.12 神戸

  2. Kohei Ota, Daisuke Koga, Hirofumi Aso, Hideyuki Shimizu. Developing a model that predicts the effectiveness of anti-cancer drug combination therapy. 第46回日本分子生物学会年会 2023.12 神戸

  3. 大谷 悠喜, 脇阪 康成, 麻生 啓文, 古賀 大介, 清水 秀幸. 微生物学を学んだ AI による次世代の感染症創薬に向けて. 第46回日本分子生物学会年会 2023.12 神戸

  4. 古賀 大介, 麻生 啓文, 大野 聡, 清水 秀幸. 機械学習を用いたゲノミクスによる2型糖尿病の病態解析. 第46回日本分子生物学会年会 2023.12 神戸

  5. Aso H, Ito J, Ozaki H, Kashima Y, Suzuki Y, Sato K. Comparative analysis of innate immune response to viral infection among animal species. EMBO Workshop Pathogen immunity and signaling 2022.04 Saint-Malo, France

  6. Kei Sato, Hirofumi Aso, Shumpei Nagaoka, Naoko Misawa, Jumpei Ito, Saiful Islam, Yutaka Suzuki, Katsuyuki Shiroguchi, Eiryo Kawakami, Yorifumi Satou, Yoshio Koyanagi. HIV持続潜伏感染に関する最先端研究　ヒト化マウスモデルにおけるHIV-1感染細胞のマルチオミクス解析. 日本エイズ学会誌 2019.11.01 熊本

  7. Sato K, Nakano Y, Yamamoto K, Ueda MT, Soper A, Kumata R, Aso H, Misawa N, Konno Y, Kimura I, Nagaoka S, Juarez-Fernandez G, Ito J, Nakagawa S, Koyanagi Y. Gorilla APOBEC3G restricts SIVcpz and influences lentiviral evolution in great ape cross-species transmissions. The 18th Awaji International Forum on Infection and Immunity 2019.09 淡路島

  8. Aso H, Ito J, Koyanagi Y, Sato K. Transcriptomic meta-analysis of interferon-stimulated genes in multiple cell lineages targeted by HIV-1 infection. The 17th International Student Seminar 2019.03 京都

  9. Konno Y, Nagaoka S, Kimura I, Yamamoto K, Kagawa Y, Kumata R, Aso H, Ueda MT, Nakagawa S, Kobayashi T, Koyanagi Y, Sato K. New World feline APOBEC3 potently controls inter-genus lentiviral transmission. 第66回日本ウイルス学会学術集会 2018.10 京都

  10. Nakano Y, Yamamoto K, Kumata R, Aso H, Soper A, Misawa N, Konno Y, Kimura I, Nagaoka S, Ikeda T, Juarez-Fernandez G, Ito J, Harris RS, Sato K, Koyanagi Y. Evolutionary journey of primate lentivirus transmission from chimpanzee to gorilla focusing on relationship between Vif and APOBEC3. Cold Spring Harbor meeting Retroviruses 2018.05 New York, USA

  11. Nakano Y, Misawa N, Kimura I, Konno Y, Nagaoka S, Yamamoto K, Aso H, Sato K, Koyanagi Y. Influence of human APOBEC3H on primate lentivirus evolution. 第65回日本ウイルス学会学術集会 2017.10 大阪

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Performance of duties 【 display / non-display 】

  • ，2023.04 - Now

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