Personnel Information

写真a

MOCHIDA Yuki


Job title

Junior Associate Professor

Field Introduction URL

https://www.tmd.ac.jp/mri/anme/en/index.html

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Graduating School 【 display / non-display 】

  • The University of Tokyo, Faculty of Liberal Arts, 2007.03

  • The University of Tokyo, Faculty of Engineering, Department of Chemistry and Biotechnology, 2009.03, Graduated

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Graduate School 【 display / non-display 】

  • The University of Tokyo, Graduate School, Division of Engineering, Department of Bioengineering, Master's Course, 2011.03, Completed

  • The University of Tokyo, Graduate School, Division of Engineering, Department of Bioengineering, Doctor's Course, 2014.03, Completed

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Campus Career 【 display / non-display 】

  • 2023.04
    -
    Now
    Tokyo Medical and Dental University， Medical Research Institute， Division of Biological Data Science， Department of Advanced Nanomedical Engineering， Junior Associate Professor
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External Career 【 display / non-display 】

  • 2014.04
    -
    2015.03
    The University of Tokyo, Graduate School of Medicine Center for Disease Biology and Integrative Medicine, Project Researcher
  • 2015.04
    -
    2016.03
    The University of Tokyo, Graduate School of Medicine Center for Disease Biology and Integrative Medicine,
  • 2015.06
    -
    2023.03
    Kawasaki Institute of Industrial Promotion, Innovation Center of NanoMedicine, Senior Research Scientist
  • 2016.04
    -
    2017.03
    The University of Tokyo, The Graduate School of Engineering, Department of Bioengineering,
  • 2022.04
    -
    Now
    Meisei University, Visiting Lecturer
  • 2023.04
    -
    Now
    Kawasaki Institute of Industrial Promotion, Innovation Center of NanoMedicine, Dupty Principal Research Scientist
  • 2023.04
    -
    Now
    Tokyo Medical and Dental University, Medical Research Institute, Department of Advanced Nanomedical Engineering, Junior Associate Professor

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Academic Society Affiliations 【 display / non-display 】

  • THE SOCIETY OF POLYMER SCIENCE, JAPAN

  • THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM

  • THE JAPANESE SOCIETY FOR BIOMATERIALS

  • The Pharmaceutical Society of Japan

  • Japanese Association of Cancer Immunology

  • The Antibody Society of Japan

  • Japanese Cancer Association

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Research Areas 【 display / non-display 】

  • Polymer materials

  • Polymer chemistry

  • Pharmaceutical analytical chemistry and physicochemistry

  • Biomedical engineering

  • Bio chemistry

  • Clinical pharmacy

  • Analytical chemistry

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Qualification Acquired 【 display / non-display 】

  • X-ray Work Chief Person

  • Chief Person of Radiation Handling （first and second kind）

  • Organic Solvent Work Chief Person

  • Specified Chemical Substances Work Chief

  • Hazardous Material Handler (first kind)

  • Person in Charge of Poison and Deleterious Substance Handling

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Research Theme 【 display / non-display 】

  • Development of technology to control avidity of antibody therapeutics, 2024.09 - 2029.03

  • Size-tunable drug delivery systems for their application to X-ray therapy for brain tumors, 2024.04 - 2028.03

  • Development of multidisciplinary immunotherapy utilizing NK cells in combination with PEG-conjugated immune checkpoint antibodies, 2023.04 - 2026.03

  • Development of intracellular antibody delivery systems for intracellular immune checkpoint blockade therapy, 2022.04 - 2026.03

  • Development of nanotherapeutic agents that boost immunotherapy by precision targeting of cancer-related fibroblasts, 2021.10 - 2025.03

  • Cancer immunotherapy with mRNA-loaded polymeric micelles for in situ creation of tumor-infiltrating killer cells, 2021.04 - 2024.03

  • Development of novel prodrug-type polymeric micelles for targeting systemic cancers by oral administration, 2019.04 - 2022.03

  • Development of siRNA carriers by utilizing the specificity of supramolecular metal comlexes for treating intractable cancers, 2017.04 - 2019.03

  • Development of a nano-pharmaceutical strategy for safely and effectively treating pregnant cancer patients, 2016.04 - 2020.03

  • Development of super-selective cancer therapy by utilizing vitamin C-activatable oxidized polymeric micelles, 2015.04 - 2017.03

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Published Papers & Misc 【 display / non-display 】

  1. Yukine Ishibashi, Mitsuru Naito, Yusuke Watanuki, Mao Hori, Satomi Ogura, Kaori Taniwaki, Masaru Cho, Ryosuke Komiya, Yuki Mochida, Kanjiro Miyata. Size-Dependent Glioblastoma Targeting by Polymeric Nanoruler with Prolonged Blood Circulation. Bioconjugate chemistry. 2024.07; 35 (8): 1154-1159. ( PubMed, DOI )

  2. Saed Abbasi, Miki Matsui-Masai, Fumihiko Yasui, Akimasa Hayashi, Theofilus A. Tockary, Yuki Mochida, Shiro Akinaga, Michinori Kohara, Kazunori Kataoka, Satoshi Uchida. Carrier-free mRNA vaccine induces robust immunity against SARS-CoV-2 in mice and non-human primates without systemic reactogenicity. Molecular therapy. 2024.04; 32 (5): 1266-1283. ( PubMed, DOI )

  3. Pengwen Chen, Wenqian Yang, Yuki Mochida, Shangwei Li, Taehun Hong, Hiroaki Kinoh, Kazunori Kataoka, Horacio Cabral. Selective Intracellular Delivery of Antibodies in Cancer Cells with Nanocarriers Sensing Endo/Lysosomal Enzymatic Activity. Angewandte Chemie International Edition. 2024.04; 63 (14): e202317817. ( PubMed, DOI )

  4. Yuki Mochida, Satoshi Uchida. mRNA vaccine designs for optimal adjuvanticity and delivery. RNA biology. 2024.03; 21 (1): 1-27. ( PubMed, DOI )

  5. Miki Suzuki, Yuki Mochida, Mao Hori, Akimasa Hayashi, Kazuko Toh, Theofilus A. Tockary, Xueying Liu, Victor Marx, Hidetomo Yokoo, Kanjiro Miyata, Makoto Oba, Satoshi Uchida. Poly(ethylene Glycol) (PEG)–OligoRNA Hybridization to mRNA Enables Fine‐Tuned Polyplex PEGylation for Spleen‐Targeted mRNA Delivery. Small Science. 2024.02; 4 (4): 2300258. ( DOI )

  6. Debabrata Maiti, Hao Yu, Yuki Mochida, Seongyeon Won, Shinichi Yamashita, Mitsuru Naito, Kanjiro Miyata, Hyun Jin Kim. Terbium-Rose Bengal Coordination Nanocrystals-Induced ROS Production under Low-Dose X-rays in Cultured Cancer Cells for Photodynamic Therapy. ACS Applied Bio Materials. 2023.06; 6 (6): 2505-2513. ( DOI )

  7. Aziz Awaad, Hiroyasu Takemoto, Muneaki Iizuka, Koichi Ogi, Yuki Mochida, Abdul-Hackam Ranneh, Masahiro Toyoda, Makoto Matsui, Takahiro Nomoto, Yuto Honda, Kotaro Hayashi, Keishiro Tomoda, Tomoyuki Ohtake, Yutaka Miura, Nobuhiro Nishiyama. Changeable net charge on nanoparticles facilitates intratumor accumulation and penetration. Journal of Controlled Release. 2022.06; 346 392-404. ( PubMed, DOI )

  8. Anjaneyulu Dirisala, Satoshi Uchida, Junjie Li, Joachim F. R. Van Guyse, Kotaro Hayashi, Sai V. C. Vummaleti, Sarandeep Kaur, Yuki Mochida, Shigeto Fukushima, Kazunori Kataoka. Effective mRNA Protection by Poly(L‐Ornithine) Synergizes with Endosomal Escape Functionality of a Charge‐Conversion Polymer Toward Maximizing mRNA Introduction Efficiency. Macromolecular Rapid Communications. 2022.03; 43 (12): 2100754. ( DOI )

  9. Tao Yang, Yuki Mochida, Xueying Liu, Hang Zhou, Jinbing Xie, Yasutaka Anraku, Hiroaki Kinoh, Horacio Cabral, Kazunori Kataoka. Conjugation of glucosylated polymer chains to checkpoint blockade antibodies augments their efficacy and specificity for glioblastoma. Nature Biomedical Engineering. 2021.10; 5 (11): 1274-1287. ( DOI )

  10. West Kristian D. Paraiso, Jesús Garcia-Chica, Xavier Ariza, Sebastián Zagmutt, Shigeto Fukushima, Jordi Garcia, Yuki Mochida, Dolors Serra, Laura Herrero, Hiroaki Kinoh, Núria Casals, Kazunori Kataoka, Rosalía Rodríguez-Rodríguez, Sabina Quader. Poly-ion complex micelles effectively deliver CoA-conjugated CPT1A inhibitors to modulate lipid metabolism in brain cells. Biomaterials Science. 2021.07; 9 (21): 7076-7091. ( DOI )

  11. Hitoshi Shibasaki, Hiroaki Kinoh, Horacio Cabral, Sabina Quader, Yuki Mochida, Xueying Liu, Kazuko Toh, Kazuki Miyano, Yu Matsumoto, Tatsuya Yamasoba, Kazunori Kataoka. Efficacy of pH-Sensitive Nanomedicines in Tumors with Different c-MYC Expression Depends on the Intratumoral Activation Profile. ACS Nano. 2021.03; 15 (3): 5545-5559. ( PubMed, DOI )

  12. Sabina Quader, Xueying Liu, Kazuko Toh, Yu-Lin Su, Amit Ranjan Maity, Anqi Tao, West Kristian D. Paraiso, Yuki Mochida, Hiroaki Kinoh, Horacio Cabral, Kazunori Kataoka. Supramolecularly enabled pH- triggered drug action at tumor microenvironment potentiates nanomedicine efficacy against glioblastoma. Biomaterials. 2021.01; 267 120463. ( PubMed, DOI )

  13. Noriko Nakamura, Yuki Mochida, Kazuko Toh, Shigeto Fukushima, Horacio Cabral, Yasutaka Anraku. Effect of Mixing Ratio of Oppositely Charged Block Copolymers on Polyion Complex Micelles for In Vivo Application. Polymers. 2020.12; 13 (1): 5. ( PubMed, DOI )

  14. Kyoko Koji, Naoto Yoshinaga, Yuki Mochida, Taehun Hong, Takuya Miyazaki, Kazunori Kataoka, Kensuke Osada, Horacio Cabral, Satoshi Uchida. Bundling of mRNA strands inside polyion complexes improves mRNA delivery efficiency in vitro and in vivo. Biomaterials. 2020.08; 261 120332. ( DOI )

  15. Anjaneyulu Dirisala, Satoshi Uchida, Kazuko Toh, Junjie Li, Shigehito Osawa, Theofilus A. Tockary, Xueying Liu, Saed Abbasi, Kotaro Hayashi, Yuki Mochida, Shigeto Fukushima, Hiroaki Kinoh, Kensuke Osada, Kazunori Kataoka. Transient stealth coating of liver sinusoidal wall by anchoring two-armed PEG for retargeting nanomedicines. Science Advances. 2020.06; 6 (26): eabb8133. ( DOI )

  16. Theofilus A Tockary, Wanling Foo, Anjaneyulu Dirisala, Qixian Chen, Satoshi Uchida, Shigehito Osawa, Yuki Mochida, Xueying Liu, Hiroaki Kinoh, Horacio Cabral, Kensuke Osada, Kazunori Kataoka. Single-Stranded DNA-Packaged Polyplex Micelle as Adeno-Associated-Virus-Inspired Compact Vector to Systemically Target Stroma-Rich Pancreatic Cancer. ACS Nano. 2019.10; 13 (11): 12732-12742. ( DOI )

  17. Naoto Yoshinaga, Eol Cho, Kyoko Koji, Yuki Mochida, Mitsuru Naito, Kensuke Osada, Kazunori Kataoka, Horacio Cabral, Uchida Satoshi. Bundling mRNA Strands to Prepare Nanoassemblies with Enhanced RNase Stability for In Vivo Delivery. Angewandte Chemie International Edition. 2019.06; 58 (33): 11360-11363. ( PubMed, DOI )

  18. Kazumi Suzuki, Yutaka Miura, Yuki Mochida, Takuya Miyazaki, Kazuko Toh, Yasutaka Anraku, Vinicio Melo, Xueying Liu, Takehiko Ishii, Osamu Nagano, Hideyuki Saya, Horacio Cabral, Kazunori Kataoka. Glucose transporter 1-mediated vascular translocation of nanomedicines enhances accumulation and efficacy in solid tumors. Journal of Controlled Release. 2019.05; 301 28-41. ( PubMed, DOI )

  19. Yu Yi, Hyun Jin Kim, Meng Zheng, Peng Mi, Mitsuru Naito, Beob Soo Kim, Hyun Su Min, Kotaro Hayashi, Federico Perche, Kazuko Toh, Xueying Liu, Yuki Mochida, Hiroaki Kinoh, Horacio Cabral, Kanjiro Miyata, Kazunori Kataoka. Glucose-linked sub-50-nm unimer polyion complex-assembled gold nanoparticles for targeted siRNA delivery to glucose transporter 1-overexpressing breast cancer stem-like cells. Journal of Controlled Release. 2019.02; 295 268-277. ( PubMed, DOI )

  20. Abdul-Hackam Ranneh, Hiroyasu Takemoto, Shunya Sakuma, Aziz Awaad, Takahiro Nomoto, Yuki Mochida, Makoto Matsui, Keishiro Tomoda, Mitsuru Naito, Nobuhiro Nishiyama. An Ethylenediamine-based Switch to Render the Polyzwitterion Cationic at Tumorous pH for Effective Tumor Accumulation of Coated Nanomaterials. Angewandte Chemie International Edition. 2018.04; 57 (18): 5057-5061. ( PubMed, DOI )

  21. Kazuki Miyano, Horacio Cabral, Yutaka Miura, Yu Matsumoto, Yuki Mochida, Hiroaki Kinoh, Caname Iwata, Osamu Nagano, Hideyuki Saya, Nobuhiro Nishiyama, Kazunori Kataoka, Tatsuya Yamasoba. cRGD peptide installation on cisplatin-loaded nanomedicines enhances efficacy against locally advanced head and neck squamous cell carcinoma bearing cancer stem-like cells. Journal of Controlled Release. 2017.09; 261 275-286. ( DOI )

  22. Yuki Mochida, Horacio Cabral, Kazunori Kataoka. Polymeric micelles for targeted tumor therapy of platinum anticancer drugs. Expert Opinion on Drug Delivery. 2017.03; 14 (12): 1423-1438. ( DOI )

  23. Ming Wang, Yutaka Miura, Kenji Tsuchihashi, Kazuki Miyano, Osamu Nagano, Momoko Yoshikawa, Ami Tanabe, Jun Makino, Yuki Mochida, Nobuhiro Nishiyama, Hideyuki Saya, Horacio Cabral, Kazunori Kataoka. Eradication of CD44-variant positive population in head and neck tumors through controlled intracellular navigation of cisplatin-loaded nanomedicines. Journal of Controlled Release. 2016.05; 230 26-33. ( DOI )

  24. Jun Makino, Horacio Cabral, Yutaka Miura, Yu Matsumoto, Ming Wang, Hiroaki Kinoh, Yuki Mochida, Nobuhiro Nishiyama, Kazunori Kataoka. cRGD-installed polymeric micelles loading platinum anticancer drugs enable cooperative treatment against lymph node metastasis. Journal of Controlled Release. 2015.12; 220 783-791. ( DOI )

  25. Omer Faruk Mutaf, Akihiro Kishimura, Yuki Mochida, Ahram Kim, Kazunori Kataoka. Induction of Secondary Structure through Micellization of an Oppositely Charged Pair of Homochiral Block‐and Homopolypeptides in an Aqueous Medium. Macromolar Rapid Communications. 2015.11; 36 (22): 1958-1964. ( DOI )

  26. S. Quader, H. Cabral, Y. Mochida, T. Ishii, X. Liu, K. Toh, H. Kinoh, Y. Miura, N. Nishiyama, K. Kataoka. Selective intracellular delivery of proteasome inhibitors through pH-sensitive polymeric micelles directed to efficient antitumor therapy. Journal of Controlled Release. 2014.08; 188 67-77. ( DOI )

  27. Yuki Mochida, Horacio Cabral, Yutaka Miura, Francesco Albertini, Shigeto Fukushima, Kensuke Osada, Nobuhiro Nishiyama, Kazunori Kataoka. Bundled Assembly of Helical Nanostructures in Polymeric Micelles Loaded with Platinum Drugs Enhancing Therapeutic Efficiency against Pancreatic Tumor. ACS Nano. 2014.06; 8 (7): 6724-6738. ( DOI )

  28. Kensuke Osada, Horacio Cabral, Yuki Mochida, Sangeun Lee, Kazuya Nagata, Tetsuya Matsuura, Megumi Yamamoto, Yasutaka Anraku, Akihiro Kishimura, Nobuhiro Nishiyama, Kazunori Kataoka. Bioactive Polymeric Metallosomes Self-Assembled through Block Copolymer–Metal Complexation. Journal of the American Chemical Society. 2012.08; 134 (32): 13172-13175. ( DOI )

  29. Masahiro Kawahara, Yusuke Shimo, Azusa Hitomi, Yuki Mochida, Takahiro Sogo, Hiroshi Ueda, Teruyuki Nagamune. Fluorescein-responsive migration of mammalian cells equipped with an antibody/receptor chimera. Journal of Bioscience and Bioengineering. 2009.11; 108 S33. ( DOI )

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Conference Activities & Talks 【 display / non-display 】

  1. Yuki Mochida. PEGylation of Therapeutic Antibodies and Nucleic Acids for Improving their In Vivo Performance. Translational Cancer Research and Precision Oncology 2024.02.28 University of Cyprus

  2. 持田祐希. ナノテクノロジーを基盤とする次世代型がん治療薬の開発. 第81回日本癌学会学術総会 2022.09.29 パシフィコ横浜

  3. Yuki Mochida. Elaborate Assembly of Platinum-Complexed Polymeric Micelles for Targeted Chemotherapy. The 39th International Conference of Photopolymer Science and Technology 2022.06.29 Online

  4. Yuki Mochida. Design Strategy of Polymeric Micelles Invading Intractable Tumors with Low Permeability. The 37th International Conference of Photopolymer Science and Technology 2020.05.19 幕張メッセ国際会議場

  5. Yuki Mochida, Horacio Cabral, Yutaka Miura, Kensuke Osada, Nobuhiro Nishiyama, Kazunori Kataoka. Helix-navigated Uniform Polymeric Micelles Incorporating Platinum Anticancer Drugs for Pancreatic Cancer Therapy. The 16th Pacific Polymer Conference 2019.12.11 Suntec Singapore Convention & Exhibition Centre

  6. Yuki Mochida. Uniform Assembly and Improved Tumor-targeting Ability of Polymeric Micelles Loading Hydrophobic Platform Anticancer Drugs by Helix Formation. 12th International Symposium on Nanobiotechnology 2019.02.27 Nanyang Technological University, Singapore

  7. Yuki Mochida. Overcoming biological barriers by the rational design of polymeric micelles incorporating anticancer drugs. 11th International Symposium on Nanobiotechnology 2017.02.26 川崎市産業振興会館

  8. Yuki Mochida, Horacio Cabral, Yutaka Miura, Albertini Francesco, Kensuke Osada, Nobuhiro Nishiyama, Kazunori Kataoka. Secondary structures in the core of platinum-loaded polymeric micelles improve tumor-targeted drug delivery. 10th International Symposium on Nanobiotechnology 2016.02.04 University of California, Los Angeles

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Awards & Honors 【 display / non-display 】

  • IPC2023 Young Scientist Poster Award，The Society of Polymer Science, Japan，2023.07

  • Nano Biomedical Society Award，Nano Biomedical Society，2022.11

  • Best Presentation Award - 15th COINS General meeting，2021.01

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Others 【 display / non-display 】

  • A new coating method in mRNA engineering points the way to advanced therapies，2024.04

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External class subject 【 display / non-display 】

  • Environment and Human Engineering，The University of Tokyo

  • Advanced Pharmacokinetics，Gifu Pharmaceutical University

  • Coordination Chemistry，Meisei University

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Social Contribution 【 display / non-display 】

  • Challenge to the nano-world，Innovation Center of NanoMedicine，2021.02

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