Personnel Information

写真a

OHNO SATOSHI


Job title

Junior Associate Professor

Research Areas, Keywords

Systems biology, Systems medicine, Metabolic engineering

Field Introduction URL

https://shimizuhideyuki-lab.org/s_ohno/

To the head of this page.▲

Graduating School 【 display / non-display 】

  • Osaka University, Faculty of Engineering, Division of Applied Science, 2010.03, Graduated

To the head of this page.▲

Graduate School 【 display / non-display 】

  • Osaka University, Graduate School of Information Science and Technology, Department of Bioinformatic Engineering, Master's Course, 2012.03, Completed

  • Osaka University, Graduate School of Information Science and Technology, Department of Bioinformatic Engineering, Doctor's Course, 2015.03, Completed

To the head of this page.▲

Degree 【 display / non-display 】

  • Ph.D. (Information Science), Osaka University

To the head of this page.▲

Campus Career 【 display / non-display 】

  • 2023.01
    -
    Now
    Tokyo Medical and Dental University， M&D Data Science Center， Division of Health Intelligence， Department of AI Systems Medicine， Junior Associate Professor
To the head of this page.▲

External Career 【 display / non-display 】

  • 2015.04
    -
    2016.03
    The University of Tokyo, Graduate School of Science, Project Research Associate
  • 2016.04
    -
    2019.03
    The University of Tokyo, Graduate School of Science, Project Assistant Professor
  • 2019.04
    -
    2022.12
    The University of Tokyo, Graduate School of Science, Assistant Professor
  • 2023.01
    -
    Now
    Tokyo Medical and Dental University, M&D Data Science Center, Junior Associate Professor
To the head of this page.▲

Research Areas 【 display / non-display 】

  • Life, health and medical informatics

  • Metabolism and endocrinology

  • Biofunction and bioprocess engineering

  • System genome science

To the head of this page.▲
 

Research Theme 【 display / non-display 】

  • Inter-organ metabolic flux analysis for glucose-administrated mice, 2021.04 - 2025.03

  • Metabolic flux analysis for the liver of mice administered with glucose, 2017.04 - 2020.03

To the head of this page.▲

Published Papers & Misc 【 display / non-display 】

  1. DNA hypomethylation characterizes genes encoding tissue-dominant functional proteins in liver and skeletal muscle 2023.11; 13 (1): ( DOI )

  2. Toshiya Kokaji, Miki Eto, Atsushi Hatano, Katsuyuki Yugi, Keigo Morita, Satoshi Ohno, Masashi Fujii, Ken-Ichi Hironaka, Yuki Ito, Riku Egami, Saori Uematsu, Akira Terakawa, Yifei Pan, Hideki Maehara, Dongzi Li, Yunfan Bai, Takaho Tsuchiya, Haruka Ozaki, Hiroshi Inoue, Hiroyuki Kubota, Yutaka Suzuki, Akiyoshi Hirayama, Tomoyoshi Soga, Shinya Kuroda. In vivo transomic analyses of glucose-responsive metabolism in skeletal muscle reveal core differences between the healthy and obese states. Sci Rep. 2022.08; 12 (1): 13719. ( PubMed, DOI )

  3. Akira Terakawa, Yanhui Hu, Toshiya Kokaji, Katsuyuki Yugi, Keigo Morita, Satoshi Ohno, Yifei Pan, Yunfan Bai, Andrey A Parkhitko, Xiaochun Ni, John M Asara, Martha L Bulyk, Norbert Perrimon, Shinya Kuroda. Trans-omics analysis of insulin action reveals a cell growth subnetwork which co-regulates anabolic processes. iScience. 2022.05; 25 (5): 104231. ( PubMed, DOI )

  4. Satoshi Ohno, Saori Uematsu, Shinya Kuroda. Quantitative metabolic fluxes regulated by trans-omic networks. Biochem J. 2022.03; 479 (6): 787-804. ( PubMed, DOI )

  5. Saori Uematsu, Satoshi Ohno, Kaori Y Tanaka, Atsushi Hatano, Toshiya Kokaji, Yuki Ito, Hiroyuki Kubota, Ken-Ichi Hironaka, Yutaka Suzuki, Masaki Matsumoto, Keiichi I Nakayama, Akiyoshi Hirayama, Tomoyoshi Soga, Shinya Kuroda. Multi-omics-based label-free metabolic flux inference reveals obesity-associated dysregulatory mechanisms in liver glucose metabolism. iScience. 2022.02; 25 (2): 103787. ( PubMed, DOI )

  6. Riku Egami, Toshiya Kokaji, Atsushi Hatano, Katsuyuki Yugi, Miki Eto, Keigo Morita, Satoshi Ohno, Masashi Fujii, Ken-Ichi Hironaka, Saori Uematsu, Akira Terakawa, Yunfan Bai, Yifei Pan, Takaho Tsuchiya, Haruka Ozaki, Hiroshi Inoue, Shinsuke Uda, Hiroyuki Kubota, Yutaka Suzuki, Masaki Matsumoto, Keiichi I Nakayama, Akiyoshi Hirayama, Tomoyoshi Soga, Shinya Kuroda. Trans-omic analysis reveals obesity-associated dysregulation of inter-organ metabolic cycles between the liver and skeletal muscle. iScience. 2021.03; 24 (3): 102217. ( PubMed, DOI )

  7. Toshiya Kokaji, Atsushi Hatano, Yuki Ito, Katsuyuki Yugi, Miki Eto, Keigo Morita, Satoshi Ohno, Masashi Fujii, Ken-Ichi Hironaka, Riku Egami, Akira Terakawa, Takaho Tsuchiya, Haruka Ozaki, Hiroshi Inoue, Shinsuke Uda, Hiroyuki Kubota, Yutaka Suzuki, Kazutaka Ikeda, Makoto Arita, Masaki Matsumoto, Keiichi I Nakayama, Akiyoshi Hirayama, Tomoyoshi Soga, Shinya Kuroda. Transomics analysis reveals allosteric and gene regulation axes for altered hepatic glucose-responsive metabolism in obesity. Sci Signal. 2020.12; 13 (660): ( PubMed, DOI )

  8. Satoshi Ohno, Lake-Ee Quek, James R Krycer, Katsuyuki Yugi, Akiyoshi Hirayama, Satsuki Ikeda, Futaba Shoji, Kumi Suzuki, Tomoyoshi Soga, David E James, Shinya Kuroda. Kinetic Trans-omic Analysis Reveals Key Regulatory Mechanisms for Insulin-Regulated Glucose Metabolism in Adipocytes. iScience. 2020.09; 23 (9): 101479. ( PubMed, DOI )

  9. Lake-Ee Quek, James R Krycer, Satoshi Ohno, Katsuyuki Yugi, Daniel J Fazakerley, Richard Scalzo, Sarah D Elkington, Ziwei Dai, Akiyoshi Hirayama, Satsuki Ikeda, Futaba Shoji, Kumi Suzuki, Jason W Locasale, Tomoyoshi Soga, David E James, Shinya Kuroda. Dynamic 13C Flux Analysis Captures the Reorganization of Adipocyte Glucose Metabolism in Response to Insulin. iScience. 2020.02; 23 (2): 100855. ( PubMed, DOI )

  10. Rate-oriented trans-omics: integration of multiple omic data on the basis of reaction kinetics 2019.06; 15 109-120.

  11. James R Krycer, Katsuyuki Yugi, Akiyoshi Hirayama, Daniel J Fazakerley, Lake-Ee Quek, Richard Scalzo, Satoshi Ohno, Mark P Hodson, Satsuki Ikeda, Futaba Shoji, Kumi Suzuki, Westa Domanova, Benjamin L Parker, Marin E Nelson, Sean J Humphrey, Nigel Turner, Kyle L Hoehn, Gregory J Cooney, Tomoyoshi Soga, Shinya Kuroda, David E James. Dynamic Metabolomics Reveals that Insulin Primes the Adipocyte for Glucose Metabolism. Cell Rep. 2017.12; 21 (12): 3536-3547. ( PubMed, DOI )

  12. Takanori Sano, Kentaro Kawata, Satoshi Ohno, Katsuyuki Yugi, Hiroaki Kakuda, Hiroyuki Kubota, Shinsuke Uda, Masashi Fujii, Katsuyuki Kunida, Daisuke Hoshino, Atsushi Hatano, Yuki Ito, Miharu Sato, Yutaka Suzuki, Shinya Kuroda. Selective control of up-regulated and down-regulated genes by temporal patterns and doses of insulin. Sci Signal. 2016.11; 9 (455): ra112. ( PubMed, DOI )

  13. Kento Tokuyama, Satoshi Ohno, Katsunori Yoshikawa, Takashi Hirasawa, Shotaro Tanaka, Chikara Furusawa, Hiroshi Shimizu. Increased 3-hydroxypropionic acid production from glycerol, by modification of central metabolism in Escherichia coli. Microbial Cell Factories. 2014.05; 13 64. ( PubMed, DOI )

  14. Satoshi Ohno, Hiroshi Shimizu, Chikara Furusawa. FastPros: screening of reaction knockout strategies for metabolic engineering. Bioinformatics. 2014.04; 30 (7): 981-987. ( PubMed, DOI )

  15. Nobutaka Nakashima, Satoshi Ohno, Katsunori Yoshikawa, Hiroshi Shimizu, Tomohiro Tamura. A vector library for silencing central carbon metabolism genes with antisense RNAs in Escherichia coli. Applied and Environmental Microbiology. 2014.01; 80 (2): 564-573. ( PubMed, DOI )

  16. Satoshi Ohno, Chikara Furusawa, Hiroshi Shimizu. In silico screening of triple reaction knockout Escherichia coli strains for overproduction of useful metabolites. J Biosci Bioeng. 2013.02; 115 (2): 221-228. ( PubMed, DOI )

▼display all

To the head of this page.▲

Conference Activities & Talks 【 display / non-display 】

  1. Takumi Abekawa, Satoshi Ohno, Shinya Kuroda. Metabolome analysis in mice liver using thermodynamics. IUPAB2024 2024.06.24

  2. 大野聡, 黒田真也. 少数の酵素に対するインスリン依存性リン酸化とアロステリック制御による脂肪細胞の糖代謝制御. 第45回日本分子生物学会 2022.12.02

To the head of this page.▲

Awards & Honors 【 display / non-display 】

  • Student/Young Investigator Poster Award, Topical Area: System biology and Metabolic engineering.，Metabolic Engineering IX，2012

To the head of this page.▲
 

External class subject 【 display / non-display 】

  • システム生物学，The University of Tokyo

  • システム生物学，The University of Tokyo

  • システム生物学，The University of Tokyo

  • システム生物学，The University of Tokyo

  • Systems biology，The University of Tokyo

  • 生物化学実験I，The University of Tokyo

  • 生物化学実験I，The University of Tokyo

  • 生物化学実験I，The University of Tokyo

  • 生物化学実験I，The University of Tokyo

  • 生物化学実験I，The University of Tokyo

  • 生物化学実験I，The University of Tokyo

  • 生物化学実験I，The University of Tokyo

▼display all

To the head of this page.▲