基本情報

写真a

内田　智士(ウチダ　サトシ)

UCHIDA SATOSHI


職名

教授

分野紹介URL

東京医科歯科大学 難治疾患研究所 先端ナノ医工学分野

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経歴(学内) 【 表示 ／ 非表示 】

  • 2023年01月
    -
    現在
    東京医科歯科大学 難治疾患研究所 バイオデータ科学研究部門 先端ナノ医工学分野 教授
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経歴(学外) 【 表示 ／ 非表示 】

  • 2015年04月
    -
    2020年08月
    公益財団法人川崎市産業振興財団 ナノ医療イノベーションセンター (iCONM) 客員研究員
  • 2016年04月
    -
    2020年08月
    東京大学 大学院工学系研究科 特任助教
  • 2020年09月
    -
    2022年03月
    公益財団法人川崎市産業振興財団 ナノ医療イノベーションセンター(iCONM) 副主幹研究員
  • 2020年09月
    -
    2022年12月
    京都府立医科大学 大学院医学研究科 准教授
  • 2022年04月
    -
    現在
    川崎市産業振興財団 ナノ医療イノベーションセンター (iCONM) 主幹研究員
  • 2023年01月
    -
    現在
    東京医科歯科大学 難治疾患研究所 教授

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所属学協会 【 表示 ／ 非表示 】

  • 日本DDS学会

  • 日本バイオマテリアル学会

  • 日本核酸医薬学会

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研究分野 【 表示 ／ 非表示 】

  • 生体医工学

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競争的資金等の研究課題 【 表示 ／ 非表示 】

  • 単鎖抗体mRNAネブライジングによる多剤耐性菌治療法の開拓

    文部科学省/日本学術振興会 : 2023年 - 2025年

  • mRNA工学を基盤とした中分子mRNA医薬の創製とその治療応用

    文部科学省/日本学術振興会 : 2021年 - 2024年

  • 精密設計ペプチドを用いた細胞外DNAのin situ PEG被覆による抗炎症治療

    文部科学省/日本学術振興会 : 2021年 - 2022年

  • LNPとスマートポリマーが創るコアシェル構造を有する活性型mRNA送達システム

    文部科学省/日本学術振興会

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論文・総説 【 表示 ／ 非表示 】

  1. Joachim F R Van Guyse, Saed Abbasi, Kazuko Toh, Zlata Nagorna, Junjie Li, Anjaneyulu Dirisala, Sabina Quader, Satoshi Uchida, Kazunori Kataoka. Facile Generation of Heterotelechelic Poly(2-Oxazoline)s Towards Accelerated Exploration of Poly(2-Oxazoline)-Based Nanomedicine. Angewandte Chemie International Edition . 2024.07; 63 (27): e202404972. ( PubMed, DOI )

  2. Fangqiao Zheng, Ruizhi Tian, Hongxu Lu, Xiao Liang, Muhammad Shafiq, Satoshi Uchida, Hangrong Chen, Ming Ma. Droplet Microfluidics Powered Hydrogel Microparticles for Stem Cell-Mediated Biomedical Applications. Small. 2024.06; e2401400. ( PubMed, DOI )

  3. Saed Abbasi, Miki Matsui-Masai, Fumihiko Yasui, Akimasa Hayashi, Theofilus A Tockary, Yuki Mochida, Shiro Akinaga, Michinori Kohara, Kazunori Kataoka, Satoshi Uchida. Carrier-free mRNA vaccine induces robust immunity against SARS-CoV-2 in mice and non-human primates without systemic reactogenicity. Molecular Therapy. 2024.05; 32 (5): 1266-1283. ( PubMed, DOI )

  4. Miki Suzuki, Yuki Mochida, Mao Hori, Akimasa Hayashi, Kazuko Toh, Theofilus A. Tockary, Xueying Liu, Victor Marx, Hidetomo Yokoo, Kanjiro Miyata, Makoto Oba, Satoshi Uchida. Poly(ethylene Glycol) (PEG)–OligoRNA Hybridization to mRNA Enables Fine‐Tuned Polyplex PEGylation for Spleen‐Targeted mRNA Delivery Small Science. 2024.02; ( DOI )

  5. Hidetomo Yokoo, Anjaneyulu Dirisala, Satoshi Uchida, Makoto Oba. Oligosarcosine Conjugation of Arginine-Rich Peptides Improves the Intracellular Delivery of Peptide/pDNA Complexes. ACS Biomaterials Science & Engineering. 2024.02; 10 (2): 890-896. ( PubMed, DOI )

  6. Lucas Mixich, Eger Boonstra, Keita Masuda, Shang-Wei Li, Yuki Nakashima, Fanlu Meng, Momoko Sakata, Tatsuro Goda, Satoshi Uchida, Horacio Cabral. Ionizable Polymeric Micelles with Phenylalanine Moieties Enhance Intracellular Delivery of Self-Replicating RNA for Long-Lasting Protein Expression In Vivo. Biomacromolecules. 2024.02; 25 (2): 1058-1067. ( PubMed, DOI )

  7. Jongmin Yum, Fadlina Aulia, Keisuke Kamiya, Mao Hori, Nan Qiao, Beob Soo Kim, Mitsuru Naito, Satomi Ogura, Tetsuya Nagata, Takanori Yokota, Satoshi Uchida, Satoshi Obika, Hyun Jin Kim, Kanjiro Miyata. Hydrophobicity Tuning of Cationic Polyaspartamide Derivatives for Enhanced Antisense Oligonucleotide Delivery. Bioconjugate Chemistry. 2024.02; 35 (2): 125-131. ( PubMed, DOI )

  8. Yuki Mochida, Satoshi Uchida. mRNA vaccine designs for optimal adjuvanticity and delivery. RNA Biology. 2024.01; 21 (1): 1-27. ( PubMed, DOI )

  9. Satoshi Uchida, Chun Yin Jerry Lau, Makoto Oba, Kanjiro Miyata. Polyplex designs for improving the stability and safety of RNA therapeutics. Advanced Drug Delivery Reviews . 2023.08; 199 114972. ( PubMed, DOI )

  10. Theofilus A Tockary, Saed Abbasi, Miki Matsui-Masai, Akimasa Hayashi, Naoto Yoshinaga, Eger Boonstra, Zheng Wang, Shigeto Fukushima, Kazunori Kataoka, Satoshi Uchida. Comb-structured mRNA vaccine tethered with short double-stranded RNA adjuvants maximizes cellular immunity for cancer treatment. Proc Natl Acad Sci U S A. 2023.07; 120 (29): e2214320120. ( PubMed, DOI )

  11. Masahito Inagaki, Naoko Abe, Zhenmin Li, Yuko Nakashima, Susit Acharyya, Kazuya Ogawa, Daisuke Kawaguchi, Haruka Hiraoka, Ayaka Banno, Zheyu Meng, Mizuki Tada, Tatsuma Ishida, Pingxue Lyu, Kengo Kokubo, Hirotaka Murase, Fumitaka Hashiya, Yasuaki Kimura, Satoshi Uchida, Hiroshi Abe. Cap analogs with a hydrophobic photocleavable tag enable facile purification of fully capped mRNA with various cap structures. Nature Communications. 2023.05; 14 (1): 2657. ( PubMed, DOI )

  12. Makoto Oba, Mika Shibuya, Yuto Yamaberi, Hidetomo Yokoo, Satoshi Uchida, Atsushi Ueda, Masakazu Tanaka. An Amphipathic Structure of a Dipropylglycine-Containing Helical Peptide with Sufficient Length Enables Safe and Effective Intracellular siRNA Delivery. Chemical and Pharmaceutical Bulletin. 2023.03; 71 (3): 250-256. ( PubMed, DOI )

  13. Wenqian Yang, Takuya Miyazaki, Yasuhiro Nakagawa, Eger Boonstra, Keita Masuda, Yuki Nakashima, Pengwen Chen, Lucas Mixich, Kevin Barthelmes, Akira Matsumoto, Peng Mi, Satoshi Uchida, Horacio Cabral. Block catiomers with flanking hydrolyzable tyrosinate groups enhance in vivo mRNA delivery via pi-pi stacking-assisted micellar assembly. Science and technology of advanced materials. 2023.01; 24 (1): 2170164. ( PubMed, DOI )

  14. Naoko Abe, Akihiro Imaeda, Masahito Inagaki, Zhenmin Li, Daisuke Kawaguchi, Kaoru Onda, Yuko Nakashima, Satoshi Uchida, Fumitaka Hashiya, Yasuaki Kimura, Hiroshi Abe. Complete Chemical Synthesis of Minimal Messenger RNA by Efficient Chemical Capping Reaction ACS Chemical Biology. 2022.05; 17 (6): 1308-1314. ( DOI )

  15. Satoshi Uchida. Delivery Systems of Plasmid DNA and Messenger RNA for Advanced Therapies Pharmaceutics. 2022.04; 14 (4): 810. ( DOI )

  16. Anjaneyulu Dirisala, Satoshi Uchida, Junjie Li, Joachim F. R. Van Guyse, Kotaro Hayashi, Sai V. C. Vummaleti, Sarandeep Kaur, Yuki Mochida, Shigeto Fukushima, Kazunori Kataoka. Effective mRNA Protection by Poly(l-ornithine) Synergizes with Endosomal Escape Functionality of a Charge-Conversion Polymer toward Maximizing mRNA Introduction Efficiency Macromolecular Rapid Communications. 2022.03; 43 (12): 2100754. ( DOI )

  17. Yasuhiro Nakagawa, Jeonggyu Lee, Yihua Liu, Saed Abbasi, Taehun Hong, Horacio Cabral, Satoshi Uchida, Mitsuhiro Ebara. Microglial Immunoregulation by Apoptotic Cellular Membrane Mimetic Polymeric Particles ACS Macro Letters. 2022.01; 11 (2): 270-275. ( DOI )

  18. Hidetomo Yokoo, Makoto Oba, Satoshi Uchida. Cell-Penetrating Peptides: Emerging Tools for mRNA Delivery Pharmaceutics. 2021.12; 14 (1): 78. ( DOI )

  19. Naoto Yoshinaga, Satoshi Uchida, Anjaneyulu Dirisala, Mitsuru Naito, Kyoko Koji, Kensuke Osada, Horacio Cabral, Kazunori Kataoka. Bridging mRNA and Polycation Using RNA Oligonucleotide Derivatives Improves the Robustness of Polyplex Micelles for Efficient mRNA Delivery Advanced Healthcare Materials. 2021.12; 11 (9): 2102016. ( DOI )

  20. Rimpei Kamegawa, Mitsuru Naito, Satoshi Uchida, Hyun Jin Kim, Beob Soo Kim, Kanjiro Miyata. Bioinspired Silicification of mRNA-Loaded Polyion Complexes for Macrophage-Targeted mRNA Delivery ACS Applied Bio Materials. 2021.10; 4 (11): 7790-779. ( DOI )

  21. Junjie Li, Zhishen Ge, Kazuko Toh, Xueying Liu, Anjaneyulu Dirisala, Wendong Ke, Panyue Wen, Hang Zhou, Zheng Wang, Shiyan Xiao, Joachim F. R. Van Guyse, Theofilus A. Tockary, Jinbing Xie, Daniel Gonzalez-Carter, Hiroaki Kinoh, Satoshi Uchida, Yasutaka Anraku, Kazunori Kataoka. Enzymatically Transformable Polymersome-Based Nanotherapeutics to Eliminate Minimal Relapsable Cancer Advanced Materials . 2021.10; 33 (49): 2105254. ( DOI )

  22. Satoshi Uchida, Yuto Yamaberi, Masakazu Tanaka, Makoto Oba. A helix foldamer oligopeptide improves intracellular stability and prolongs protein expression of the delivered mRNA Nanoscale. 2021.09; 13 (45): 18941-18946. ( DOI )

  23. Naoto Yoshinaga, Mitsuru Naito, Yoshihiro Tachihara, Eger Boonstra, Kensuke Osada, Horacio Cabral, Satoshi Uchida. PEGylation of mRNA by Hybridization of Complementary PEG-RNA Oligonucleotides Stabilizes mRNA without Using Cationic Materials Pharmaceutics. 2021.05; 13 (6): 800. ( DOI )

  24. Saed Abbasi, Satoshi Uchida. Multifunctional Immunoadjuvants for Use in Minimalist Nucleic Acid Vaccines Pharmaceutics. 2021.05; 13 (5): 644. ( DOI )

  25. Eger Boonstra, Hiroaki Hatano, Yuji Miyahara, Satoshi Uchida, Tatsuro Goda, Horacio Cabral. A proton/macromolecule-sensing approach distinguishes changes in biological membrane permeability during polymer/lipid-based nucleic acid delivery Journal of Materials Chemistry B. 2021.05; 9 (21): 4298-4302. ( DOI )

  26. Saed Abbasi, Satoshi Uchida, Kazuko Toh, Theofilus A. Tockary, Anjaneyulu Dirisala, Kotaro Hayashi, Shigeto Fukushima, Kazunori Kataoka. Co-encapsulation of Cas9 mRNA and guide RNA in polyplex micelles enables genome editing in mouse brain Journal of Controlled Release. 2021.02; 332 260-268. ( DOI )

  27. Yuta Fukushima, Satoshi Uchida, Hideaki Imai, Hirofumi Nakatomi, Kazunori Kataoka, Nobuhito Saito, Keiji Itaka. Treatment of ischemic neuronal death by introducing brain-derived neurotrophic factor mRNA using polyplex nanomicelle Biomaterials. 2021.01; 270 120681. ( DOI )

  28. Naoto Yoshinaga, Satoshi Uchida, Anjaneyulu Dirisala, Mitsuru Naito, Kensuke Osada, Horacio Cabral, Kazunori Kataoka. mRNA loading into ATP-responsive polyplex micelles with optimal density of phenylboronate ester crosslinking to balance robustness in the biological milieu and intracellular translational efficiency 2020.12; 330 317-328. ( DOI )

  29. Takuya Miyazaki, Satoshi Uchida, Hiroaki Hatano, Yuji Miyahara, Akira Matsumoto, Horacio Cabral. Guanidine-phosphate interactions stabilize polyion complex micelles based on flexible catiomers to improve mRNA delivery European Polymer Journal. 2020.09; 140 110028. ( DOI )

  30. Satoshi Uchida, Federico Perche, Chantal Pichon, Horacio Cabral. Nanomedicine-Based Approaches for mRNA Delivery Molecular Pharmaceutics. 2020.08; 17 (10): 3654-3684. ( DOI )

  31. Kyoko Koji, Naoto Yoshinaga, Yuki Mochida, Taehun Hong, Takuya Miyazaki, Kazunori Kataoka, Kensuke Osada, Horacio Cabral, Satoshi Uchida. Bundling of mRNA strands inside polyion complexes improves mRNA delivery efficiency in vitro and in vivo Biomaterials. 2020.08; 261 120332. ( DOI )

  32. Anjaneyulu Dirisala, Satoshi Uchida, Kazuko Toh, Junjie Li, Shigehito Osawa, Theofilus A. Tockary, Xueying Liu, Saed Abbasi, Kotaro Hayashi, Yuki Mochida, Shigeto Fukushima, Hiroaki Kinoh, Kensuke Osada, Kazunori Kataoka. Transient stealth coating of liver sinusoidal wall by anchoring two-armed PEG for retargeting nanomedicines Science Advances. 2020.06; 6 (26): eabb8133. ( DOI )

  33. Takuya Miyazaki, Satoshi Uchida, Satoru Nagatoishi, Kyoko Koji, Taehun Hong, Shigeto Fukushima, Kouhei Tsumoto, Kazuhiko Ishihara, Kazunori Kataoka, Horacio Cabral. Polymeric nanocarriers with controlled chain flexibility boost mRNA delivery in vivo through enhanced structural fastening Advanced Healthcare Materials. 2020.06; 9 (16): 2000538. ( DOI )

  34. Satoshi Uchida, Kayoko Yanagihara, Akitsugu Matsui, Kazunori Kataoka, Keiji Itaka. mRNA as a Tool for Gene Transfection in 3D Cell Culture for Future Regenerative Therapy Micromachines. 2020.04; 11 (4): 426. ( DOI )

  35. Ryosuke Ueki, Satoshi Uchida, Naoto Kanda, Naoki Yamada, Ayaka Ueki, Momoko Akiyama, Kazuko Toh, Horacio Cabral, Shinsuke Sando. A chemically unmodified agonistic DNA with growth factor functionality for in vivo therapeutic application Science Advances. 2020.04; 6 (14): eaay2801. ( DOI )

  36. Beob Soo Kim, Shigehito Osawa, Mitsuru Naito, Satomi Ogura, Rimpei Kamegawa, Hiroki Ishida, Hyun Jin Kim, Satoshi Uchida, Kanjiro Miyata. A 50-nm-Sized Micellar Assembly of Thermoresponsive Polymer-Antisense Oligonucleotide Conjugates for Enhanced Gene Knockdown in Lung Cancer by Intratracheal Administration Advanced Therapeutics. 2019.11; 3 (2): 1900123. ( DOI )

  37. Theofilus A. Tockary, Wanling Foo, Anjaneyulu Dirisala, Qixian Chen, Satoshi Uchida, Shigehito Osawa, Yuki Mochida, Xueying Liu, Hiroaki Kinoh, Horacio Cabral, Kensuke Osada, Kazunori Kataoka. Single-Stranded DNA-Packaged Polyplex Micelle as Adeno-Associated-Virus-Inspired Compact Vector to Systemically Target Stroma-Rich Pancreatic Cancer ACS Nano. 2019.10; 13 (11): 12732-12742. ( DOI )

  38. Samuel T Crowley, Yuta Fukushima, Satoshi Uchida, Kazunori Kataoka, Keiji Itaka. Enhancement of motor function recovery after spinal cord injury in mice by delivery of brain-derived neurotrophic factor mRNA Molecular Therapy-Nucleic Acids. 2019.06; 17 (6): 465-476. ( DOI )

  39. Naoto Yoshinaga, Eol Cho, Kyoko Koji, Yuki Mochida, Mitsuru Naito, Kensuke Osada, Kazunori Kataoka, Horacio Cabral, Satoshi Uchida. Bundling mRNA Strands to Prepare Nano-Assemblies with Enhanced Stability Towards RNase for In Vivo Delivery Angewandte Chemie International Edition. 2019.06; 58 (33): 11360-11363. ( DOI )

  40. Sumiyo Watanabe, Kotaro Hayashi, Kazuko Toh, Hyun Jin Kim, Xueying Liu, Hiroyuki Chaya, Shigeto Fukushima, Keisuke Katsushima, Yutaka Kondo, Satoshi Uchida, Satomi Ogura, Takahiro Nomoto, Hiroyasu Takemoto, Horacio Cabral, Hiroaki Kinoh, Hiroyoshi Y. Tanaka, Mitsunobu R. Kano, Yu Matsumoto, Hiroshi Fukuhara, Shunya Uchida, Masaomi Nangaku, Kensuke Osada, Nobuhiro Nishiyama, Kanjiro Miyata, Kazunori Kataoka. In vivo rendezvous of small nucleic acid drugs with charge-matched block catiomers to target cancers Nature communications. 2019.04; 10 (1): 1894. ( DOI )

  41. Shota Kurimoto, Naoto Yoshinaga, Kazunori Igarashi, Yu Matsumoto, Horacio Cabral, Satoshi Uchida. PEG-OligoRNA Hybridization of mRNA for Developing Sterically Stable Lipid Nanoparticles toward In Vivo Administration Molecules. 2019.04; 24 (7): 1303. ( DOI )

  42. Anjaneyulu Dirisala, Satoshi Uchida, Theofilus A Tockary, Naoto Yoshinaga, Junjie Li, Shigehito Osawa, Lahari Gorantla, Shigeto Fukushima, Kensuke Osada, Kazunori Kataoka. Precise tuning of disulphide crosslinking in mRNA polyplex micelles for optimising extracellular and intracellular nuclease tolerability Journal of Drug Targeting . 2019.04; 27 (5-6): 670-680. ( DOI )

  43. Chin-Yu Lin, Samuel Thomas Crowley, Satoshi Uchida, Yuji Komaki, Kazunori Kataoka, Keiji Itaka. Treatment of intervertebral disk disease by the administration of mRNA encoding a cartilage-anabolic transcription factor Molecular Therapy-Nucleic Acids. 2019.02; 16 (7): 162-171. ( DOI )

  44. Mitsuru Naito, Yuta Otsu, Rimpei Kamegawa, Kotaro Hayashi, Satoshi Uchida, Hyun Jin Kim, Kanjiro Miyata. Tunable nonenzymatic degradability of N-substituted polyaspartamide main chain by amine protonation and alkyl spacer length in side chains for enhanced messenger RNA transfection efficiency Science and technology of advanced materials. 2019.02; 20 (1): 105-115. ( DOI )

  45. Satoshi Uchida, Kazunori Kataoka. Design concepts of polyplex micelles for in vivo therapeutic delivery of plasmid DNA and messenger RNA Journal of Biomedical Materials Research Part A. 2019.01; 107 978-990. ( DOI )

  46. Naoto Yoshinaga, Satoshi Uchida, Mitsuru Naito, Kensuke Osada, Horacio Cabral, Kazunori Kataoka. Induced packaging of mRNA into polyplex micelles by regulated hybridization with a small number of cholesteryl RNA oligonucleotides directed enhanced in vivo transfection Biomaterials. 2019.01; 197 255-267. ( DOI )

  47. Akitsugu Matsui, Satoshi Uchida, Akimasa Hayashi, Kazunori Kataoka, Keiji Itaka. Prolonged engraftment of transplanted hepatocytes in the liver by transient pro-survival factor supplementation using ex vivo mRNA transfection Journal of Controlled Release. 2018.06; 285 1-11. ( DOI )

  48. Kayoko Yanagihara, Satoshi Uchida, Shinsuke Ohba, Kazunori Kataoka, Keiji Itaka. Treatment of Bone Defects by Transplantation of Genetically Modified Mesenchymal Stem Cell Spheroids Molecular Therapy - Methods & Clinical Development. 2018.04; 9 358-366. ( DOI )

  49. Naoto Yoshinaga, Takehiko Ishii, Mitsuru Naito, Taisuke Endo, Satoshi Uchida, Horacio Cabral, Kensuke Osada, Kazunori Kataoka. Polyplex micelles with phenylboronate/gluconamide cross-linking in the core exerting promoted gene transfection through spatiotemporal responsivity to intracellular pH and ATP concentration Journal of the American Chemical Society. 2017.11; 139 (51): 18567-18575. ( DOI )

  50. Yasutaka Anraku, Hiroya Kuwahara, Yu Fukusato, Akihiro Mizoguchi, Takehiko Ishii, Keiko Nitta, Yu Matsumoto, Kazuko Toh, Kanjiro Miyata, Satoshi Uchida, Kazutaka Nishina, Kensuke Osada, Keiji Itaka, Nobuhiro Nishiyama, Hidehiro Mizusawa, Tatsuya Yamasoba, Takanori Yokota, Kazunori Kataoka. Glycaemic control boosts glucosylated nanocarrier crossing the BBB into the brain Nature communications . 2017.10; 8 (1): 1001. ( DOI )

  51. Satoshi Uchida, Naoto Yoshinaga, Kayoko Yanagihara, Eiji Yuba, Kazunori Kataoka, Keiji Itaka. Designing immunostimulatory double stranded messenger RNA with maintained translational activity through hybridization with poly A sequences for effective vaccination Biomaterials. 2017.09; 150 162-170. ( DOI )

  52. Dian-Jang Lee, Eva Kessel, Taavi Lehto, Xueying Liu, Naoto Yoshinaga, Kärt Padari, Ying-Chen Chen, Susanne Kempter, Satoshi Uchida, Joachim O. Rädler, Margus Pooga, Ming-Thau Sheu, Kazunori Kataoka, Ernst Wagner. Systemic Delivery of Folate-PEG siRNA Lipopolyplexes with Enhanced Intracellular Stability for In Vivo Gene Silencing in Leukemia Bioconjugate Chemistry. 2017.08; 28 (9): 2393-2409. ( DOI )

  53. Federico Perche, Satoshi Uchida, Hiroki Akiba, Chin-Yu Lin, Masaru Ikegami, Anjaneyulu Dirisala, Toshihiro Nakashima, Keiji Itaka, Kohei Tsumoto, Kazunori Kataoka. Improved brain expression of anti-amyloid β scfv by complexation of mRNA including a secretion sequence with PEG-based block catiomer Current Alzheimer Research. 2017.03; 14 (3): 295-302. ( DOI )

  54. Qixian Chen, Kensuke Osada, Zhishen Ge, Satoshi Uchida, Theofilus A. Tockary, Anjaneyulu Dirisala, Akitsugu Matsui, Kazuko Toh, Kaori M. Takeda, Xueying Liu, Takahiro Nomoto, Tekihiko Ishii, Makoto Oba, Yu Matsumoto, Kazunori Kataoka. Polyplex micelle installing intracellular self-processing functionalities without free catiomers for safe and efficient systemic gene therapy through tumor vasculature targeting Biomaterials. 2016.10; 113 253-265. ( DOI )

  55. Satoshi Uchida, Kentaro Hayakawa, Toru Ogata, Sakae Tanaka, Kazunori Kataoka, Keiji Itaka. Treatment of spinal cord injury by an advanced cell transplantation technology using brain-derived neurotrophic factor-transfected mesenchymal stem cell spheroids Biomaterials. 2016.09; 109 1-11. ( DOI )

  56. Chin-Yu Lin, Federico Perche, Masaru Ikegami, Satoshi Uchida, Kazunori Kataoka, Keiji Itaka. Messenger RNA-based therapeutics for brain diseases: An animal study for augmenting clearance of beta-amyloid by intracerebral administration of neprilysin mRNA loaded in polyplex nanomicelles Journal of Controlled Release. 2016.06; 235 268-275. ( DOI )

  57. Hirokuni Uchida, Keiji Itaka, Satoshi Uchida, Takehiko Ishii, Tomoya Suma, Kanjiro Miyata, Makoto Oba, Nobuhiro Nishiyama, Kazunori Kataoka. Synthetic polyamines to regulate mRNA translation through the preservative binding of eukaryotic initiation factor 4E to the cap structure Journal of the American Chemical Society . 2016.01; 138 (5): 1478-1481. ( DOI )

  58. Hailati Aini, Keiji Itaka, Ayano Fujisawa, Hirokuni Uchida, Satoshi Uchida, Shigeto Fukushima, Kazunori Kataoka, Taku Saito, Ung-il Chung, Shinsuke Ohba. Messenger RNA delivery of a cartilage-anabolic transcription factor as a disease-modifying strategy for osteoarthritis treatment Scientific Reports . 2016.01; 6 18743. ( DOI )

  59. Satoshi Uchida, Hiroaki Kinoh, Takehiko Ishii, Akitsugu Matsui, Theofilus Agrios Tockary, Kaori Machitani Takeda, Hirokuni Uchida, Kensuke Osada, Keiji Itaka, Kazunori Kataoka. Systemic delivery of messenger RNA for the treatment of pancreatic cancer using polyplex nanomicelles with a cholesterol moiety Biomaterials. 2015.12; 82 221-228. ( DOI )

  60. Akitsugu Matsui, Satoshi Uchida, Takehiko Ishii, Keiji Itaka, Kazunori Kataoka. Messenger RNA-based therapeutics for the treatment of apoptosis-associated diseases Scientific Reports . 2015.10; 5 1-10. ( DOI )

  61. Tomoyuki Okuda, Yumiko Suzuki, Yuko Kobayashi, Takehiko Ishii, Satoshi Uchida, Keiji Itaka, Kazunori Kataoka, Hirokazu Okamoto. Development of biodegradable polycation-based inhalable dry gene powders by spray freeze drying Pharmaceutics. 2015.08; 7 (3): 233-254. ( DOI )

  62. Yanmin Li, Kensuke Osada, Qixian Chen, Theofilus A Tockary, Anjaneyulu Dirisala, Kaori M Takeda, Satoshi Uchida, Kazuya Nagata, Keiji Itaka, Kazunori Kataoka. Toroidal packaging of pDNA into block ionomer micelles exerting promoted in vivo gene expression Biomacromolecules. 2015.07; 16 (9): 2664-2671. ( DOI )

  63. Satoshi Uchida, Kazunori Kataoka, Keiji Itaka. Screening of mRNA chemical modification to maximize protein expression with reduced immunogenicity Pharmaceutics. 2015.07; 7 (3): 137-151. ( DOI )

  64. Qixian Chen, Kensuke Osada, Matthew Pennisi, Satoshi Uchida, Theofilus A. Tockary, Anjaneyulu Dirisala, Yanmin Li, Kaori M. Takeda, Satoshi Oniyanagi, Keiji Itaka, Kazunori Kataoka. A tadpole-shaped gene carrier with distinct phase segregation in a ternary polymeric micelle Soft matter. 2015.02; 11 (14): 2718-2722. ( DOI )

  65. Kentaro Hayakawa, Satoshi Uchida, Toru Ogata, Sakae Tanaka, Kazunori Kataoka, Keiji Itaka. Intrathecal injection of a therapeutic gene-containing polyplex to treat spinal cord injury Journal of Controlled Release. 2014.11; 197 1-9. ( DOI )

  66. Anjaneyulu Dirisala, Kensuke Osada, Qixian Chen, Theofilus A. Tockary, Kaori Machitani, Shigehito Osawa, Xueying Liu, Takehiko Ishii, Kanjiro Miyata, Makoto Oba, Satoshi Uchida, Keiji Itaka, Kazunori Kataoka. Optimized rod length of polyplex micelles for maximizing transfection efficiency and their performance in systemic gene therapy against stroma-rich pancreatic tumors Biomaterials. 2014.04; 35 (20): 5359-5368. ( DOI )

  67. Kazuya Nagata, Keiji Itaka, Miyuki Baba, Satoshi Uchida, Takehiko Ishii, Kazunori Kataoka. Muscle-targeted hydrodynamic gene introduction of insulin-like growth factor-1 using polyplex nanomicelle to treat peripheral nerve injury Journal of Controlled Release. 2014.03; 183 27-34. ( DOI )

  68. Zhishen Ge, Qixian Chen, Kensuke Osada, Xueying Liu, Theofilus A. Tockary, Satoshi Uchida, Anjaneyulu Dirisala, Takehiko Ishii, Takahiro Nomoto, Kazuko Toh, Yu Matsumoto, Makoto Oba, Mitsunobu R. Kano, Keiji Itaka, Kazunori Kataoka. Targeted gene delivery by polyplex micelles with crowded PEG palisade and cRGD moiety for systemic treatment of pancreatic tumors Biomaterials. 2014.01; 35 (10): 3416-3426. ( DOI )

  69. Satoshi Uchida, Keiji Itaka, Takahiro Nomoto, Taisuke Endo, Yu Matsumoto, Takehiko Ishii, Kazunori Kataoka. An injectable spheroid system with genetic modification for cell transplantation therapy Biomaterials. 2013.12; 35 (8): 2499-2506. ( DOI )

  70. Theofilus A. Tockary, Kensuke Osada, Qixian Chen, Kaori Machitani, Anjaneyulu Dirisala, Satoshi Uchida, Takahiro Nomoto, Kazuko Toh, Yu Matsumoto, Keiji Itaka, Koji Nitta, Kuniaki Nagayama, Kazunori Kataoka. Tethered PEG Crowdedness Determining Shape and Blood Circulation Profile of Polyplex Micelle Gene Carriers Macromolecules. 2013.08; 46 (16): 6585-6592. ( DOI )

  71. Hiroyasu Takemoto, Kanjiro Miyata, Shota Hattori, Takehiko Ishii, Tomoya Suma, Satoshi Uchida, Nobuhiro Nishiyama, Kazunori Kataoka. Acidic pH‐Responsive siRNA Conjugate for Reversible Carrier Stability and Accelerated Endosomal Escape with Reduced IFNα‐Associated Immune Response Angewandte Chemie International Edition. 2013.04; 125 (24): 6338-6341. ( DOI )

  72. Satoshi Uchida, Keiji Itaka, Hirokuni Uchida, Kentaro Hayakawa, Toru Ogata, Takehiko Ishii, Shigeto Fukushima, Kensuke Osada, Kazunori Kataoka. In vivo messenger RNA introduction into the central nervous system using polyplex nanomicelle PLOS ONE. 2013.02; 8 (2): e56220. ( DOI )

  73. Taisuke Endo, Keiji Itaka, Momoko Shioyama, Satoshi Uchida, Kazunori Kataoka. Gene transfection to spheroid culture system on micropatterned culture plate by polyplex nanomicelle: a novel platform of genetically-modified cell transplantation Drug delivery and translational research . 2012.09; 2 (5): 398-405. ( DOI )

  74. Qixian Chen, Kensuke Osada, Takehiko Ishii, Makoto Oba, Satoshi Uchida, Theofilus A. Tockary, Taisuke Endo, Zhishen Ge, Hiroaki Kinoh, Mitsunobu R. Kano, Keiji Itaka, Kazunori Kataoka. Homo-catiomer integration into PEGylated polyplex micelle from block-catiomer for systemic anti-angiogenic gene therapy for fibrotic pancreatic tumors Biomaterials. 2012.03; 33 (18): 4722-4730. ( DOI )

  75. Satoshi Uchida, Keiji Itaka, Qixian Chen, Kensuke Osada, Takehiko Ishii, Masa-Aki Shibata, Mariko Harada-Shiba, Kazunori Kataoka. PEGylated polyplex with optimized PEG shielding enhances gene introduction in lungs by minimizing inflammatory responses Molecular Therapy . 2012.02; 20 (6): 1196-1203. ( DOI )

  76. Tomoya Suma, Kanjiro Miyata, Takehiko Ishii, Satoshi Uchida, Hirokuni Uchida, Keiji Itaka, Nobuhiro Nishiyama, Kazunori Kataoka. Enhanced stability and gene silencing ability of siRNA-loaded polyion complexes formulated from polyaspartamide derivatives with a repetitive array of amino groups in the side chain Biomaterials. 2011.12; 33 (9): 2770-2779. ( DOI )

  77. Satoshi Uchida, Keiji Itaka, Qixian Chen, Kensuke Osada, Kanjiro Miyata, Takehiko Ishii, Mariko Harada-Shiba, Kazunori Kataoka. Combination of chondroitin sulfate and polyplex micelles from Poly (ethylene glycol)-poly {N’-[N-(2-aminoethyl)-2-aminoethyl] aspartamide} block copolymer for prolonged in vivo gene transfection with reduced toxicity Journal of Controlled Release. 2011.05; 155 (2): 296-302. ( DOI )

  78. Tomoyuki Yoshida, Satoshi Uchida, Masayoshi Mishina. Regulation of synaptic vesicle accumulation and axon terminal remodeling during synapse formation by distinct Ca2+ signaling Journal of Neurochemistry. 2009.09; 111 (1): 160-170. ( DOI )

  79. 内田智士. 中枢神経系を標的としたmRNA医薬のDDSと治療応用 Drug Delivery System. 2023.03; 38 125-133. ( DOI )

  80. 内田智士. mRNAワクチン，医薬を支える基盤技術と今後の展望 化学と教育. 2023.01; 71 (1): 12-15. ( DOI )

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書籍等出版物 【 表示 ／ 非表示 】

  1. Ze Song, Muhammad Shafiq, Ruizhi Tian, Satoshi Uchida, Hangrong Chen, Ming Ma, Microfluidic Production of Inorganic Nanoparticles. Microfluidics in Pharmaceutical Sciences: Formulation, Drug Delivery, Screening, and Diagnostics. Springer Nature, 2024.06 Microfluidic Production of Inorganic Nanoparticles

  2. Satoshi Uchida, Keiji Itaka, Kazunori Kataoka. Nanoparticles in the Lung. 2015 Drug and Gene Delivery in the Lungs

  3. Eger Boonstra, Satoshi Uchida, Horacio Cabral. Messenger RNA Therapeutics. Springer International Publishing, 2022.09 RNA/Polymer-Based Supramolecular Approaches for mRNA Deliver

このページの先頭へ▲

講演・口頭発表等 【 表示 ／ 非表示 】

  1. 内田智士. mRNA 単体からなる感染症予防ワクチンの開発. 第19回ナノ・バイオメディカル学会 2024.09.06

  2. Satoshi Uchida. Cutaneous jet injection of naked mRNA for safe and effective vaccination against infectious diseases. World Vaccine Congress Washington 2024 2024.04.04

  3. Satoshi Uchida. Next-generation mRNA vaccines against infectious diseases and cancer. "Integrated Science for a Sustainable Society" 14th Indian Scientists Association in Japan (ISAJ) Annual Symposium 2023.11.10

  4. Satoshi Uchida, Saed Abbasi, Miki Matsui-Masai, Fumihiko Yasui, Akimasa Hayashi, Theofilus A. Tockary, Shiro Akinaga, Michinori Kohara, Kazunori Kataoka. Naked mRNA Jet Injection into the Skin Enables the Robust Vaccination against SARS-CoV-2 in Mice and Cynomolgus Monkeys. 11th International mRNA Health Conference 2023.10.31

  5. Satoshi Uchida. mRNA vaccine development for infectious disease prevention and cancer treatment. The 18th international Symposium of the institute Network for Biomedical Science 2023.10.05

  6. Satoshi Uchida, Saed Abbasi, Miki Masai, Akimasa Hayashi, Theofilus Tockary, Shiro Akinaga, Kazunori Kataoka. Small and large animal studies of COVID-19 vaccines based on naked mRNA jet-injection. 日本核酸医薬学会第8回年会 2023.07.14

  7. 内田智士. 新型コロナウイルスワクチンの先にあるmRNAワクチン、医薬品の未来. ジェンスクリプトジャパンセミナー 2024.06.27

  8. 内田智士. mRNA工学を基盤としたmRNA送達システムの開発とワクチンへの展開. 徳島大学大学院医歯薬学研究部DDSセンター 2024年第1回シンポジウム 2024.06.04

  9. 内田智士. 新型コロナウイルスワクチンの先にあるmRNAワクチン、医薬品の未来. 第5期バイオインベストメントギルド第７回セミナー 2024.03.08

  10. 内田智士. mRNAのワクチン、医薬品としての応用. 東京工業大学生命理工学院　東京医科歯科大学難治疾患研究所　教員交流シンポジウム 2023.12.14

  11. 内田智士. 新型コロナウイルスワクチンの先にあるmRNAワクチン、医薬品の未来. 第10回みずほ医薬・バイオカンファレンス 2023.12.13

  12. 内田智士. 感染症、がんを標的とした次世代mRNAワクチンのための技術開発. 第55回 日本小児感染症学会総会・学術集会 2023.11.25

  13. 感染症、がんを標的とした次世代mRNAワクチンのための技術開発. 第 45 回日本バイオマテリアル学会大会 2023.11.07

  14. mRNA医薬品のワクチンを超えた中枢神経系疾患治療への展開. 第41回日本神経治療学会学術集会 2023.11.05

  15. 内田智士. 感染症やがんを標的とした次世代 mRNA ワクチンの開発. 第 12 回 iCONM 学術セミナー 2023.10.13

  16. 内田智士. 感染症、がんを標的とした次世代mRNAワクチンの開発. 第14回日本RNAi研究会 2023.09.01

  17. 内田智士. 感染症及びがんを標的としたmRNAワクチンの開発. 2023年度遺伝子・デリバリー研究会　夏期セミナー　 2023.08.27

  18. 内田 智士, Saed Abbasi, 正井 三貴, 林 玲匡, Theofilus Tockary, 秋永 士朗, 片岡 一則. mRNA単体のジェットインジェクションによるCOVID-19ワクチン. 第39回日本DDS学会学術集会 2023.07.28

  19. 内田智士. mRNAワクチン、医薬品の基盤技術開発と医療応用. 第72回高分子学会年次大会 2023.05.24

  20. 内田智士. mRNAワクチン、医薬品のためのナノDDS開発. iSeminar 2023.05.17

  21. 内田智士. 今さら聞けないmRNAワクチンの基礎. 第97回日本感染症学会学術集会 2023.04.29

  22. 内田智士. mRNA分子設計に着目したDDSとワクチン. 日本薬学会第143年会 2023.03.28

  23. 内田智士. mRNA医薬の再生医療分野への展開とバイオマテリアル. 第22回再生医療学会 2023.03.25

  24. 内田智士. mRNAワクチン、医薬における免疫と医用高分子. 第73回医用高分子研究会　～免疫とバイオアダプティブポリマー～ 2023.03.06

  25. 内田智士. mRNAワクチン、医薬品の基盤技術、応用、今後の展望. JSSX-APDD合同ワークショップ – 今後の医薬品開発促進への薬物動態学の貢献(第7回) 2023.03.03

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受賞学術賞 【 表示 ／ 非表示 】

  • 第19回ナノ・バイオメディカル学会大会　学会賞，ナノ・バイオメディカル学会，2024年09月

  • 日本核酸医薬学会 奨励賞 (DDS)，2020年11月

  • 8th International mRNA Health Conference 1st Abstract Prize，2020年11月

  • 第10回日本DDS学会奨励賞 (臨床)，日本DDS学会，2018年06月

  • 若手研究者交流AWARD，日韓バイオマテリアル学会，2016年11月

  • アンチセンス・遺伝子・デリバリーシンポジウム 2014　奨励賞，アンチセンス・遺伝子・デリバリーシンポジウム，2014年09月

  • American Society of Gene and Cell Therapy (ASGCT) 17th Annual Meeting, Outstanding Poster Presentation Award ，2014年05月

  • 日本バイオマテリアル学会　2012年優秀ポスター発表賞，日本バイオマテリアル学会，2012年11月

  • 第28回日本DDS学会学術集会　優秀発表賞，日本DDS学会，2012年06月

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その他業績 【 表示 ／ 非表示 】

  • A new coating method in mRNA engineering points the way to advanced therapies，2024年04月

    AAAS EurekAlert! The Global Source for Science News

  • 「　脾臓にmRNAを送り届け、ワクチンへ応用　」 ―　核酸工学を応用したmRNA送達システムの開発　―，2024年03月

    Small Science

  • 「裸のmRNA」からなる安全な新型コロナウイルスワクチンの開発に成功 ～ナノ粒子製剤化していない「裸のmRNA」が全身性の副作用を伴わず強力な免疫を誘導できることを世界で初めて実証～，2024年03月

    -

  • 「くし型 mRNA」の創成と、がんmRNAワクチンとして 新たながん治療に繋がるその細胞性免疫力について ～　米国科学アカデミー紀要 PNAS に掲載　～，2023年07月

    －

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担当授業科目(学内) 【 表示 ／ 非表示 】

  • Introduction to Biomedical Sciences and Engineering ，2023年 - 現在

  • 薬理学，2023年 - 現在

  • 主題別選択I・Ⅱ 「生命科学と医学」，2023年 - 現在

  • 生化学，2023年 - 現在

このページの先頭へ▲

担当授業科目(学外) 【 表示 ／ 非表示 】

  • マテリアル設計学，東京大学工学部

  • ライフエンジニアリング特別講義第三，東京工業大学

  • 基礎統合講義、基礎臨床社会医学統合講義，東京大学医学部

このページの先頭へ▲

社会貢献活動 【 表示 ／ 非表示 】

  • ｍRNAワクチン，NHK，あさイチ，2024年04月12日 - 2024年07月01日

  • ワクチン開発について，NHK，NHK各ニュース，2024年04月10日 - 現在

  • プレスリリース“「裸のｍＲＮＡ」からなる安全な新型コロナウイルスワクチンの開発に成功”について，日本経済新聞社，日本経済新聞，2024年04月01日 - 2024年04月03日

  • インフルエンザのワクチン等について，朝日放送テレビ，正義のミカタ，2023年10月14日

  • mRNAワクチンについて，京都新聞社，京都新聞，2023年10月02日 - 2023年10月03日

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