Campus Career 【 display / non-display 】

  • 2023.01
    -
    Now
    Tokyo Medical and Dental University， Medical Research Institute， Division of Biological Data Science， Department of Advanced Nanomedical Engineering， Professor
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External Career 【 display / non-display 】

  • 2015.04
    -
    2020.08
    Kawasaki Institute of Industrial Promotion, Innovation Center of NanoMedicine (iCONM), Visiting Scientist
  • 2016.04
    -
    2020.08
    The University of Tokyo, Graduate School of Engineering, Assistant Professor
  • 2020.09
    -
    2022.03
    Kawasaki Institute of Industrial Promotion, Innovation Center of NanoMedicine (iCONM), Deputy Principal Research Scientist
  • 2020.09
    -
    2022.12
    Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Associate Professor
  • 2022.04
    -
    Now
    Kawasaki Institute of Industrial Promotion, Innovation Center of NanoMedicine (iCONM),
  • 2023.01
    -
    Now
    Tokyo Medical and Dental University, Medical Research Institute, Professor

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Academic Society Affiliations 【 display / non-display 】

  • THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM

  • THE JAPANESE SOCIETY FOR BIOMATERIALS

  • THE NUCLEIC ACIDS THERAPEUTICS SOCIETY OF JAPAN

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Research Areas 【 display / non-display 】

  • Biomedical engineering

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Published Papers & Misc 【 display / non-display 】

  1. Joachim F R Van Guyse, Saed Abbasi, Kazuko Toh, Zlata Nagorna, Junjie Li, Anjaneyulu Dirisala, Sabina Quader, Satoshi Uchida, Kazunori Kataoka. Facile Generation of Heterotelechelic Poly(2-Oxazoline)s Towards Accelerated Exploration of Poly(2-Oxazoline)-Based Nanomedicine. Angewandte Chemie International Edition . 2024.07; 63 (27): e202404972. ( PubMed, DOI )

  2. Fangqiao Zheng, Ruizhi Tian, Hongxu Lu, Xiao Liang, Muhammad Shafiq, Satoshi Uchida, Hangrong Chen, Ming Ma. Droplet Microfluidics Powered Hydrogel Microparticles for Stem Cell-Mediated Biomedical Applications. Small. 2024.06; e2401400. ( PubMed, DOI )

  3. Saed Abbasi, Miki Matsui-Masai, Fumihiko Yasui, Akimasa Hayashi, Theofilus A Tockary, Yuki Mochida, Shiro Akinaga, Michinori Kohara, Kazunori Kataoka, Satoshi Uchida. Carrier-free mRNA vaccine induces robust immunity against SARS-CoV-2 in mice and non-human primates without systemic reactogenicity. Molecular Therapy. 2024.05; 32 (5): 1266-1283. ( PubMed, DOI )

  4. Miki Suzuki, Yuki Mochida, Mao Hori, Akimasa Hayashi, Kazuko Toh, Theofilus A. Tockary, Xueying Liu, Victor Marx, Hidetomo Yokoo, Kanjiro Miyata, Makoto Oba, Satoshi Uchida. Poly(ethylene Glycol) (PEG)–OligoRNA Hybridization to mRNA Enables Fine‐Tuned Polyplex PEGylation for Spleen‐Targeted mRNA Delivery Small Science. 2024.02; ( DOI )

  5. Hidetomo Yokoo, Anjaneyulu Dirisala, Satoshi Uchida, Makoto Oba. Oligosarcosine Conjugation of Arginine-Rich Peptides Improves the Intracellular Delivery of Peptide/pDNA Complexes. ACS Biomaterials Science & Engineering. 2024.02; 10 (2): 890-896. ( PubMed, DOI )

  6. Lucas Mixich, Eger Boonstra, Keita Masuda, Shang-Wei Li, Yuki Nakashima, Fanlu Meng, Momoko Sakata, Tatsuro Goda, Satoshi Uchida, Horacio Cabral. Ionizable Polymeric Micelles with Phenylalanine Moieties Enhance Intracellular Delivery of Self-Replicating RNA for Long-Lasting Protein Expression In Vivo. Biomacromolecules. 2024.02; 25 (2): 1058-1067. ( PubMed, DOI )

  7. Jongmin Yum, Fadlina Aulia, Keisuke Kamiya, Mao Hori, Nan Qiao, Beob Soo Kim, Mitsuru Naito, Satomi Ogura, Tetsuya Nagata, Takanori Yokota, Satoshi Uchida, Satoshi Obika, Hyun Jin Kim, Kanjiro Miyata. Hydrophobicity Tuning of Cationic Polyaspartamide Derivatives for Enhanced Antisense Oligonucleotide Delivery. Bioconjugate Chemistry. 2024.02; 35 (2): 125-131. ( PubMed, DOI )

  8. Yuki Mochida, Satoshi Uchida. mRNA vaccine designs for optimal adjuvanticity and delivery. RNA Biology. 2024.01; 21 (1): 1-27. ( PubMed, DOI )

  9. Satoshi Uchida, Chun Yin Jerry Lau, Makoto Oba, Kanjiro Miyata. Polyplex designs for improving the stability and safety of RNA therapeutics. Advanced Drug Delivery Reviews . 2023.08; 199 114972. ( PubMed, DOI )

  10. Theofilus A Tockary, Saed Abbasi, Miki Matsui-Masai, Akimasa Hayashi, Naoto Yoshinaga, Eger Boonstra, Zheng Wang, Shigeto Fukushima, Kazunori Kataoka, Satoshi Uchida. Comb-structured mRNA vaccine tethered with short double-stranded RNA adjuvants maximizes cellular immunity for cancer treatment. Proc Natl Acad Sci U S A. 2023.07; 120 (29): e2214320120. ( PubMed, DOI )

  11. Masahito Inagaki, Naoko Abe, Zhenmin Li, Yuko Nakashima, Susit Acharyya, Kazuya Ogawa, Daisuke Kawaguchi, Haruka Hiraoka, Ayaka Banno, Zheyu Meng, Mizuki Tada, Tatsuma Ishida, Pingxue Lyu, Kengo Kokubo, Hirotaka Murase, Fumitaka Hashiya, Yasuaki Kimura, Satoshi Uchida, Hiroshi Abe. Cap analogs with a hydrophobic photocleavable tag enable facile purification of fully capped mRNA with various cap structures. Nature Communications. 2023.05; 14 (1): 2657. ( PubMed, DOI )

  12. Makoto Oba, Mika Shibuya, Yuto Yamaberi, Hidetomo Yokoo, Satoshi Uchida, Atsushi Ueda, Masakazu Tanaka. An Amphipathic Structure of a Dipropylglycine-Containing Helical Peptide with Sufficient Length Enables Safe and Effective Intracellular siRNA Delivery. Chemical and Pharmaceutical Bulletin. 2023.03; 71 (3): 250-256. ( PubMed, DOI )

  13. Wenqian Yang, Takuya Miyazaki, Yasuhiro Nakagawa, Eger Boonstra, Keita Masuda, Yuki Nakashima, Pengwen Chen, Lucas Mixich, Kevin Barthelmes, Akira Matsumoto, Peng Mi, Satoshi Uchida, Horacio Cabral. Block catiomers with flanking hydrolyzable tyrosinate groups enhance in vivo mRNA delivery via pi-pi stacking-assisted micellar assembly. Science and technology of advanced materials. 2023.01; 24 (1): 2170164. ( PubMed, DOI )

  14. Naoko Abe, Akihiro Imaeda, Masahito Inagaki, Zhenmin Li, Daisuke Kawaguchi, Kaoru Onda, Yuko Nakashima, Satoshi Uchida, Fumitaka Hashiya, Yasuaki Kimura, Hiroshi Abe. Complete Chemical Synthesis of Minimal Messenger RNA by Efficient Chemical Capping Reaction ACS Chemical Biology. 2022.05; 17 (6): 1308-1314. ( DOI )

  15. Satoshi Uchida. Delivery Systems of Plasmid DNA and Messenger RNA for Advanced Therapies Pharmaceutics. 2022.04; 14 (4): 810. ( DOI )

  16. Anjaneyulu Dirisala, Satoshi Uchida, Junjie Li, Joachim F. R. Van Guyse, Kotaro Hayashi, Sai V. C. Vummaleti, Sarandeep Kaur, Yuki Mochida, Shigeto Fukushima, Kazunori Kataoka. Effective mRNA Protection by Poly(l-ornithine) Synergizes with Endosomal Escape Functionality of a Charge-Conversion Polymer toward Maximizing mRNA Introduction Efficiency Macromolecular Rapid Communications. 2022.03; 43 (12): 2100754. ( DOI )

  17. Yasuhiro Nakagawa, Jeonggyu Lee, Yihua Liu, Saed Abbasi, Taehun Hong, Horacio Cabral, Satoshi Uchida, Mitsuhiro Ebara. Microglial Immunoregulation by Apoptotic Cellular Membrane Mimetic Polymeric Particles ACS Macro Letters. 2022.01; 11 (2): 270-275. ( DOI )

  18. Naoto Yoshinaga, Satoshi Uchida, Anjaneyulu Dirisala, Mitsuru Naito, Kyoko Koji, Kensuke Osada, Horacio Cabral, Kazunori Kataoka. Bridging mRNA and Polycation Using RNA Oligonucleotide Derivatives Improves the Robustness of Polyplex Micelles for Efficient mRNA Delivery Advanced Healthcare Materials. 2021.12; 11 (9): 2102016. ( DOI )

  19. Hidetomo Yokoo, Makoto Oba, Satoshi Uchida. Cell-Penetrating Peptides: Emerging Tools for mRNA Delivery Pharmaceutics. 2021.12; 14 (1): 78. ( DOI )

  20. Rimpei Kamegawa, Mitsuru Naito, Satoshi Uchida, Hyun Jin Kim, Beob Soo Kim, Kanjiro Miyata. Bioinspired Silicification of mRNA-Loaded Polyion Complexes for Macrophage-Targeted mRNA Delivery ACS Applied Bio Materials. 2021.10; 4 (11): 7790-779. ( DOI )

  21. Junjie Li, Zhishen Ge, Kazuko Toh, Xueying Liu, Anjaneyulu Dirisala, Wendong Ke, Panyue Wen, Hang Zhou, Zheng Wang, Shiyan Xiao, Joachim F. R. Van Guyse, Theofilus A. Tockary, Jinbing Xie, Daniel Gonzalez-Carter, Hiroaki Kinoh, Satoshi Uchida, Yasutaka Anraku, Kazunori Kataoka. Enzymatically Transformable Polymersome-Based Nanotherapeutics to Eliminate Minimal Relapsable Cancer Advanced Materials . 2021.10; 33 (49): 2105254. ( DOI )

  22. Satoshi Uchida, Yuto Yamaberi, Masakazu Tanaka, Makoto Oba. A helix foldamer oligopeptide improves intracellular stability and prolongs protein expression of the delivered mRNA Nanoscale. 2021.09; 13 (45): 18941-18946. ( DOI )

  23. Naoto Yoshinaga, Mitsuru Naito, Yoshihiro Tachihara, Eger Boonstra, Kensuke Osada, Horacio Cabral, Satoshi Uchida. PEGylation of mRNA by Hybridization of Complementary PEG-RNA Oligonucleotides Stabilizes mRNA without Using Cationic Materials Pharmaceutics. 2021.05; 13 (6): 800. ( DOI )

  24. Saed Abbasi, Satoshi Uchida. Multifunctional Immunoadjuvants for Use in Minimalist Nucleic Acid Vaccines Pharmaceutics. 2021.05; 13 (5): 644. ( DOI )

  25. Eger Boonstra, Hiroaki Hatano, Yuji Miyahara, Satoshi Uchida, Tatsuro Goda, Horacio Cabral. A proton/macromolecule-sensing approach distinguishes changes in biological membrane permeability during polymer/lipid-based nucleic acid delivery Journal of Materials Chemistry B. 2021.05; 9 (21): 4298-4302. ( DOI )

  26. Saed Abbasi, Satoshi Uchida, Kazuko Toh, Theofilus A. Tockary, Anjaneyulu Dirisala, Kotaro Hayashi, Shigeto Fukushima, Kazunori Kataoka. Co-encapsulation of Cas9 mRNA and guide RNA in polyplex micelles enables genome editing in mouse brain Journal of Controlled Release. 2021.02; 332 260-268. ( DOI )

  27. Yuta Fukushima, Satoshi Uchida, Hideaki Imai, Hirofumi Nakatomi, Kazunori Kataoka, Nobuhito Saito, Keiji Itaka. Treatment of ischemic neuronal death by introducing brain-derived neurotrophic factor mRNA using polyplex nanomicelle Biomaterials. 2021.01; 270 120681. ( DOI )

  28. Naoto Yoshinaga, Satoshi Uchida, Anjaneyulu Dirisala, Mitsuru Naito, Kensuke Osada, Horacio Cabral, Kazunori Kataoka. mRNA loading into ATP-responsive polyplex micelles with optimal density of phenylboronate ester crosslinking to balance robustness in the biological milieu and intracellular translational efficiency 2020.12; 330 317-328. ( DOI )

  29. Takuya Miyazaki, Satoshi Uchida, Hiroaki Hatano, Yuji Miyahara, Akira Matsumoto, Horacio Cabral. Guanidine-phosphate interactions stabilize polyion complex micelles based on flexible catiomers to improve mRNA delivery European Polymer Journal. 2020.09; 140 110028. ( DOI )

  30. Satoshi Uchida, Federico Perche, Chantal Pichon, Horacio Cabral. Nanomedicine-Based Approaches for mRNA Delivery Molecular Pharmaceutics. 2020.08; 17 (10): 3654-3684. ( DOI )

  31. Kyoko Koji, Naoto Yoshinaga, Yuki Mochida, Taehun Hong, Takuya Miyazaki, Kazunori Kataoka, Kensuke Osada, Horacio Cabral, Satoshi Uchida. Bundling of mRNA strands inside polyion complexes improves mRNA delivery efficiency in vitro and in vivo Biomaterials. 2020.08; 261 120332. ( DOI )

  32. Anjaneyulu Dirisala, Satoshi Uchida, Kazuko Toh, Junjie Li, Shigehito Osawa, Theofilus A. Tockary, Xueying Liu, Saed Abbasi, Kotaro Hayashi, Yuki Mochida, Shigeto Fukushima, Hiroaki Kinoh, Kensuke Osada, Kazunori Kataoka. Transient stealth coating of liver sinusoidal wall by anchoring two-armed PEG for retargeting nanomedicines Science Advances. 2020.06; 6 (26): eabb8133. ( DOI )

  33. Takuya Miyazaki, Satoshi Uchida, Satoru Nagatoishi, Kyoko Koji, Taehun Hong, Shigeto Fukushima, Kouhei Tsumoto, Kazuhiko Ishihara, Kazunori Kataoka, Horacio Cabral. Polymeric nanocarriers with controlled chain flexibility boost mRNA delivery in vivo through enhanced structural fastening Advanced Healthcare Materials. 2020.06; 9 (16): 2000538. ( DOI )

  34. Satoshi Uchida, Kayoko Yanagihara, Akitsugu Matsui, Kazunori Kataoka, Keiji Itaka. mRNA as a Tool for Gene Transfection in 3D Cell Culture for Future Regenerative Therapy Micromachines. 2020.04; 11 (4): 426. ( DOI )

  35. Ryosuke Ueki, Satoshi Uchida, Naoto Kanda, Naoki Yamada, Ayaka Ueki, Momoko Akiyama, Kazuko Toh, Horacio Cabral, Shinsuke Sando. A chemically unmodified agonistic DNA with growth factor functionality for in vivo therapeutic application Science Advances. 2020.04; 6 (14): eaay2801. ( DOI )

  36. Beob Soo Kim, Shigehito Osawa, Mitsuru Naito, Satomi Ogura, Rimpei Kamegawa, Hiroki Ishida, Hyun Jin Kim, Satoshi Uchida, Kanjiro Miyata. A 50-nm-Sized Micellar Assembly of Thermoresponsive Polymer-Antisense Oligonucleotide Conjugates for Enhanced Gene Knockdown in Lung Cancer by Intratracheal Administration Advanced Therapeutics. 2019.11; 3 (2): 1900123. ( DOI )

  37. Theofilus A. Tockary, Wanling Foo, Anjaneyulu Dirisala, Qixian Chen, Satoshi Uchida, Shigehito Osawa, Yuki Mochida, Xueying Liu, Hiroaki Kinoh, Horacio Cabral, Kensuke Osada, Kazunori Kataoka. Single-Stranded DNA-Packaged Polyplex Micelle as Adeno-Associated-Virus-Inspired Compact Vector to Systemically Target Stroma-Rich Pancreatic Cancer ACS Nano. 2019.10; 13 (11): 12732-12742. ( DOI )

  38. Samuel T Crowley, Yuta Fukushima, Satoshi Uchida, Kazunori Kataoka, Keiji Itaka. Enhancement of motor function recovery after spinal cord injury in mice by delivery of brain-derived neurotrophic factor mRNA Molecular Therapy-Nucleic Acids. 2019.06; 17 (6): 465-476. ( DOI )

  39. Naoto Yoshinaga, Eol Cho, Kyoko Koji, Yuki Mochida, Mitsuru Naito, Kensuke Osada, Kazunori Kataoka, Horacio Cabral, Satoshi Uchida. Bundling mRNA Strands to Prepare Nano-Assemblies with Enhanced Stability Towards RNase for In Vivo Delivery Angewandte Chemie International Edition. 2019.06; 58 (33): 11360-11363. ( DOI )

  40. Sumiyo Watanabe, Kotaro Hayashi, Kazuko Toh, Hyun Jin Kim, Xueying Liu, Hiroyuki Chaya, Shigeto Fukushima, Keisuke Katsushima, Yutaka Kondo, Satoshi Uchida, Satomi Ogura, Takahiro Nomoto, Hiroyasu Takemoto, Horacio Cabral, Hiroaki Kinoh, Hiroyoshi Y. Tanaka, Mitsunobu R. Kano, Yu Matsumoto, Hiroshi Fukuhara, Shunya Uchida, Masaomi Nangaku, Kensuke Osada, Nobuhiro Nishiyama, Kanjiro Miyata, Kazunori Kataoka. In vivo rendezvous of small nucleic acid drugs with charge-matched block catiomers to target cancers Nature communications. 2019.04; 10 (1): 1894. ( DOI )

  41. Shota Kurimoto, Naoto Yoshinaga, Kazunori Igarashi, Yu Matsumoto, Horacio Cabral, Satoshi Uchida. PEG-OligoRNA Hybridization of mRNA for Developing Sterically Stable Lipid Nanoparticles toward In Vivo Administration Molecules. 2019.04; 24 (7): 1303. ( DOI )

  42. Anjaneyulu Dirisala, Satoshi Uchida, Theofilus A Tockary, Naoto Yoshinaga, Junjie Li, Shigehito Osawa, Lahari Gorantla, Shigeto Fukushima, Kensuke Osada, Kazunori Kataoka. Precise tuning of disulphide crosslinking in mRNA polyplex micelles for optimising extracellular and intracellular nuclease tolerability Journal of Drug Targeting . 2019.04; 27 (5-6): 670-680. ( DOI )

  43. Chin-Yu Lin, Samuel Thomas Crowley, Satoshi Uchida, Yuji Komaki, Kazunori Kataoka, Keiji Itaka. Treatment of intervertebral disk disease by the administration of mRNA encoding a cartilage-anabolic transcription factor Molecular Therapy-Nucleic Acids. 2019.02; 16 (7): 162-171. ( DOI )

  44. Mitsuru Naito, Yuta Otsu, Rimpei Kamegawa, Kotaro Hayashi, Satoshi Uchida, Hyun Jin Kim, Kanjiro Miyata. Tunable nonenzymatic degradability of N-substituted polyaspartamide main chain by amine protonation and alkyl spacer length in side chains for enhanced messenger RNA transfection efficiency Science and technology of advanced materials. 2019.02; 20 (1): 105-115. ( DOI )

  45. Satoshi Uchida, Kazunori Kataoka. Design concepts of polyplex micelles for in vivo therapeutic delivery of plasmid DNA and messenger RNA Journal of Biomedical Materials Research Part A. 2019.01; 107 978-990. ( DOI )

  46. Naoto Yoshinaga, Satoshi Uchida, Mitsuru Naito, Kensuke Osada, Horacio Cabral, Kazunori Kataoka. Induced packaging of mRNA into polyplex micelles by regulated hybridization with a small number of cholesteryl RNA oligonucleotides directed enhanced in vivo transfection Biomaterials. 2019.01; 197 255-267. ( DOI )

  47. Akitsugu Matsui, Satoshi Uchida, Akimasa Hayashi, Kazunori Kataoka, Keiji Itaka. Prolonged engraftment of transplanted hepatocytes in the liver by transient pro-survival factor supplementation using ex vivo mRNA transfection Journal of Controlled Release. 2018.06; 285 1-11. ( DOI )

  48. Kayoko Yanagihara, Satoshi Uchida, Shinsuke Ohba, Kazunori Kataoka, Keiji Itaka. Treatment of Bone Defects by Transplantation of Genetically Modified Mesenchymal Stem Cell Spheroids Molecular Therapy - Methods & Clinical Development. 2018.04; 9 358-366. ( DOI )

  49. Naoto Yoshinaga, Takehiko Ishii, Mitsuru Naito, Taisuke Endo, Satoshi Uchida, Horacio Cabral, Kensuke Osada, Kazunori Kataoka. Polyplex micelles with phenylboronate/gluconamide cross-linking in the core exerting promoted gene transfection through spatiotemporal responsivity to intracellular pH and ATP concentration Journal of the American Chemical Society. 2017.11; 139 (51): 18567-18575. ( DOI )

  50. Yasutaka Anraku, Hiroya Kuwahara, Yu Fukusato, Akihiro Mizoguchi, Takehiko Ishii, Keiko Nitta, Yu Matsumoto, Kazuko Toh, Kanjiro Miyata, Satoshi Uchida, Kazutaka Nishina, Kensuke Osada, Keiji Itaka, Nobuhiro Nishiyama, Hidehiro Mizusawa, Tatsuya Yamasoba, Takanori Yokota, Kazunori Kataoka. Glycaemic control boosts glucosylated nanocarrier crossing the BBB into the brain Nature communications . 2017.10; 8 (1): 1001. ( DOI )

  51. Satoshi Uchida, Naoto Yoshinaga, Kayoko Yanagihara, Eiji Yuba, Kazunori Kataoka, Keiji Itaka. Designing immunostimulatory double stranded messenger RNA with maintained translational activity through hybridization with poly A sequences for effective vaccination Biomaterials. 2017.09; 150 162-170. ( DOI )

  52. Dian-Jang Lee, Eva Kessel, Taavi Lehto, Xueying Liu, Naoto Yoshinaga, Kärt Padari, Ying-Chen Chen, Susanne Kempter, Satoshi Uchida, Joachim O. Rädler, Margus Pooga, Ming-Thau Sheu, Kazunori Kataoka, Ernst Wagner. Systemic Delivery of Folate-PEG siRNA Lipopolyplexes with Enhanced Intracellular Stability for In Vivo Gene Silencing in Leukemia Bioconjugate Chemistry. 2017.08; 28 (9): 2393-2409. ( DOI )

  53. Federico Perche, Satoshi Uchida, Hiroki Akiba, Chin-Yu Lin, Masaru Ikegami, Anjaneyulu Dirisala, Toshihiro Nakashima, Keiji Itaka, Kohei Tsumoto, Kazunori Kataoka. Improved brain expression of anti-amyloid β scfv by complexation of mRNA including a secretion sequence with PEG-based block catiomer Current Alzheimer Research. 2017.03; 14 (3): 295-302. ( DOI )

  54. Qixian Chen, Kensuke Osada, Zhishen Ge, Satoshi Uchida, Theofilus A. Tockary, Anjaneyulu Dirisala, Akitsugu Matsui, Kazuko Toh, Kaori M. Takeda, Xueying Liu, Takahiro Nomoto, Tekihiko Ishii, Makoto Oba, Yu Matsumoto, Kazunori Kataoka. Polyplex micelle installing intracellular self-processing functionalities without free catiomers for safe and efficient systemic gene therapy through tumor vasculature targeting Biomaterials. 2016.10; 113 253-265. ( DOI )

  55. Satoshi Uchida, Kentaro Hayakawa, Toru Ogata, Sakae Tanaka, Kazunori Kataoka, Keiji Itaka. Treatment of spinal cord injury by an advanced cell transplantation technology using brain-derived neurotrophic factor-transfected mesenchymal stem cell spheroids Biomaterials. 2016.09; 109 1-11. ( DOI )

  56. Chin-Yu Lin, Federico Perche, Masaru Ikegami, Satoshi Uchida, Kazunori Kataoka, Keiji Itaka. Messenger RNA-based therapeutics for brain diseases: An animal study for augmenting clearance of beta-amyloid by intracerebral administration of neprilysin mRNA loaded in polyplex nanomicelles Journal of Controlled Release. 2016.06; 235 268-275. ( DOI )

  57. Hirokuni Uchida, Keiji Itaka, Satoshi Uchida, Takehiko Ishii, Tomoya Suma, Kanjiro Miyata, Makoto Oba, Nobuhiro Nishiyama, Kazunori Kataoka. Synthetic polyamines to regulate mRNA translation through the preservative binding of eukaryotic initiation factor 4E to the cap structure Journal of the American Chemical Society . 2016.01; 138 (5): 1478-1481. ( DOI )

  58. Hailati Aini, Keiji Itaka, Ayano Fujisawa, Hirokuni Uchida, Satoshi Uchida, Shigeto Fukushima, Kazunori Kataoka, Taku Saito, Ung-il Chung, Shinsuke Ohba. Messenger RNA delivery of a cartilage-anabolic transcription factor as a disease-modifying strategy for osteoarthritis treatment Scientific Reports . 2016.01; 6 18743. ( DOI )

  59. Satoshi Uchida, Hiroaki Kinoh, Takehiko Ishii, Akitsugu Matsui, Theofilus Agrios Tockary, Kaori Machitani Takeda, Hirokuni Uchida, Kensuke Osada, Keiji Itaka, Kazunori Kataoka. Systemic delivery of messenger RNA for the treatment of pancreatic cancer using polyplex nanomicelles with a cholesterol moiety Biomaterials. 2015.12; 82 221-228. ( DOI )

  60. Akitsugu Matsui, Satoshi Uchida, Takehiko Ishii, Keiji Itaka, Kazunori Kataoka. Messenger RNA-based therapeutics for the treatment of apoptosis-associated diseases Scientific Reports . 2015.10; 5 1-10. ( DOI )

  61. Tomoyuki Okuda, Yumiko Suzuki, Yuko Kobayashi, Takehiko Ishii, Satoshi Uchida, Keiji Itaka, Kazunori Kataoka, Hirokazu Okamoto. Development of biodegradable polycation-based inhalable dry gene powders by spray freeze drying Pharmaceutics. 2015.08; 7 (3): 233-254. ( DOI )

  62. Yanmin Li, Kensuke Osada, Qixian Chen, Theofilus A Tockary, Anjaneyulu Dirisala, Kaori M Takeda, Satoshi Uchida, Kazuya Nagata, Keiji Itaka, Kazunori Kataoka. Toroidal packaging of pDNA into block ionomer micelles exerting promoted in vivo gene expression Biomacromolecules. 2015.07; 16 (9): 2664-2671. ( DOI )

  63. Satoshi Uchida, Kazunori Kataoka, Keiji Itaka. Screening of mRNA chemical modification to maximize protein expression with reduced immunogenicity Pharmaceutics. 2015.07; 7 (3): 137-151. ( DOI )

  64. Qixian Chen, Kensuke Osada, Matthew Pennisi, Satoshi Uchida, Theofilus A. Tockary, Anjaneyulu Dirisala, Yanmin Li, Kaori M. Takeda, Satoshi Oniyanagi, Keiji Itaka, Kazunori Kataoka. A tadpole-shaped gene carrier with distinct phase segregation in a ternary polymeric micelle Soft matter. 2015.02; 11 (14): 2718-2722. ( DOI )

  65. Kentaro Hayakawa, Satoshi Uchida, Toru Ogata, Sakae Tanaka, Kazunori Kataoka, Keiji Itaka. Intrathecal injection of a therapeutic gene-containing polyplex to treat spinal cord injury Journal of Controlled Release. 2014.11; 197 1-9. ( DOI )

  66. Anjaneyulu Dirisala, Kensuke Osada, Qixian Chen, Theofilus A. Tockary, Kaori Machitani, Shigehito Osawa, Xueying Liu, Takehiko Ishii, Kanjiro Miyata, Makoto Oba, Satoshi Uchida, Keiji Itaka, Kazunori Kataoka. Optimized rod length of polyplex micelles for maximizing transfection efficiency and their performance in systemic gene therapy against stroma-rich pancreatic tumors Biomaterials. 2014.04; 35 (20): 5359-5368. ( DOI )

  67. Kazuya Nagata, Keiji Itaka, Miyuki Baba, Satoshi Uchida, Takehiko Ishii, Kazunori Kataoka. Muscle-targeted hydrodynamic gene introduction of insulin-like growth factor-1 using polyplex nanomicelle to treat peripheral nerve injury Journal of Controlled Release. 2014.03; 183 27-34. ( DOI )

  68. Zhishen Ge, Qixian Chen, Kensuke Osada, Xueying Liu, Theofilus A. Tockary, Satoshi Uchida, Anjaneyulu Dirisala, Takehiko Ishii, Takahiro Nomoto, Kazuko Toh, Yu Matsumoto, Makoto Oba, Mitsunobu R. Kano, Keiji Itaka, Kazunori Kataoka. Targeted gene delivery by polyplex micelles with crowded PEG palisade and cRGD moiety for systemic treatment of pancreatic tumors Biomaterials. 2014.01; 35 (10): 3416-3426. ( DOI )

  69. Satoshi Uchida, Keiji Itaka, Takahiro Nomoto, Taisuke Endo, Yu Matsumoto, Takehiko Ishii, Kazunori Kataoka. An injectable spheroid system with genetic modification for cell transplantation therapy Biomaterials. 2013.12; 35 (8): 2499-2506. ( DOI )

  70. Theofilus A. Tockary, Kensuke Osada, Qixian Chen, Kaori Machitani, Anjaneyulu Dirisala, Satoshi Uchida, Takahiro Nomoto, Kazuko Toh, Yu Matsumoto, Keiji Itaka, Koji Nitta, Kuniaki Nagayama, Kazunori Kataoka. Tethered PEG Crowdedness Determining Shape and Blood Circulation Profile of Polyplex Micelle Gene Carriers Macromolecules. 2013.08; 46 (16): 6585-6592. ( DOI )

  71. Hiroyasu Takemoto, Kanjiro Miyata, Shota Hattori, Takehiko Ishii, Tomoya Suma, Satoshi Uchida, Nobuhiro Nishiyama, Kazunori Kataoka. Acidic pH‐Responsive siRNA Conjugate for Reversible Carrier Stability and Accelerated Endosomal Escape with Reduced IFNα‐Associated Immune Response Angewandte Chemie International Edition. 2013.04; 125 (24): 6338-6341. ( DOI )

  72. Satoshi Uchida, Keiji Itaka, Hirokuni Uchida, Kentaro Hayakawa, Toru Ogata, Takehiko Ishii, Shigeto Fukushima, Kensuke Osada, Kazunori Kataoka. In vivo messenger RNA introduction into the central nervous system using polyplex nanomicelle PLOS ONE. 2013.02; 8 (2): e56220. ( DOI )

  73. Taisuke Endo, Keiji Itaka, Momoko Shioyama, Satoshi Uchida, Kazunori Kataoka. Gene transfection to spheroid culture system on micropatterned culture plate by polyplex nanomicelle: a novel platform of genetically-modified cell transplantation Drug delivery and translational research . 2012.09; 2 (5): 398-405. ( DOI )

  74. Qixian Chen, Kensuke Osada, Takehiko Ishii, Makoto Oba, Satoshi Uchida, Theofilus A. Tockary, Taisuke Endo, Zhishen Ge, Hiroaki Kinoh, Mitsunobu R. Kano, Keiji Itaka, Kazunori Kataoka. Homo-catiomer integration into PEGylated polyplex micelle from block-catiomer for systemic anti-angiogenic gene therapy for fibrotic pancreatic tumors Biomaterials. 2012.03; 33 (18): 4722-4730. ( DOI )

  75. Satoshi Uchida, Keiji Itaka, Qixian Chen, Kensuke Osada, Takehiko Ishii, Masa-Aki Shibata, Mariko Harada-Shiba, Kazunori Kataoka. PEGylated polyplex with optimized PEG shielding enhances gene introduction in lungs by minimizing inflammatory responses Molecular Therapy . 2012.02; 20 (6): 1196-1203. ( DOI )

  76. Tomoya Suma, Kanjiro Miyata, Takehiko Ishii, Satoshi Uchida, Hirokuni Uchida, Keiji Itaka, Nobuhiro Nishiyama, Kazunori Kataoka. Enhanced stability and gene silencing ability of siRNA-loaded polyion complexes formulated from polyaspartamide derivatives with a repetitive array of amino groups in the side chain Biomaterials. 2011.12; 33 (9): 2770-2779. ( DOI )

  77. Satoshi Uchida, Keiji Itaka, Qixian Chen, Kensuke Osada, Kanjiro Miyata, Takehiko Ishii, Mariko Harada-Shiba, Kazunori Kataoka. Combination of chondroitin sulfate and polyplex micelles from Poly (ethylene glycol)-poly {N’-[N-(2-aminoethyl)-2-aminoethyl] aspartamide} block copolymer for prolonged in vivo gene transfection with reduced toxicity Journal of Controlled Release. 2011.05; 155 (2): 296-302. ( DOI )

  78. Tomoyuki Yoshida, Satoshi Uchida, Masayoshi Mishina. Regulation of synaptic vesicle accumulation and axon terminal remodeling during synapse formation by distinct Ca2+ signaling Journal of Neurochemistry. 2009.09; 111 (1): 160-170. ( DOI )

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Books etc 【 display / non-display 】

  1. Ze Song, Muhammad Shafiq, Ruizhi Tian, Satoshi Uchida, Hangrong Chen, Ming Ma, Microfluidic Production of Inorganic Nanoparticles. Microfluidics in Pharmaceutical Sciences: Formulation, Drug Delivery, Screening, and Diagnostics. Springer Nature， 2024.06 Microfluidic Production of Inorganic Nanoparticles

  2. Satoshi Uchida, Keiji Itaka, Kazunori Kataoka. Nanoparticles in the Lung. 2015 Drug and Gene Delivery in the Lungs

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Conference Activities & Talks 【 display / non-display 】

  1. 内田智士. mRNA 単体からなる感染症予防ワクチンの開発. 第19回ナノ・バイオメディカル学会 2024.09.06

  2. Satoshi Uchida. Cutaneous jet injection of naked mRNA for safe and effective vaccination against infectious diseases. World Vaccine Congress Washington 2024 2024.04.04

  3. Satoshi Uchida. Next-generation mRNA vaccines against infectious diseases and cancer. "Integrated Science for a Sustainable Society" 14th Indian Scientists Association in Japan (ISAJ) Annual Symposium 2023.11.10

  4. Satoshi Uchida, Saed Abbasi, Miki Matsui-Masai, Fumihiko Yasui, Akimasa Hayashi, Theofilus A. Tockary, Shiro Akinaga, Michinori Kohara, Kazunori Kataoka. Naked mRNA Jet Injection into the Skin Enables the Robust Vaccination against SARS-CoV-2 in Mice and Cynomolgus Monkeys. 11th International mRNA Health Conference 2023.10.31

  5. Satoshi Uchida. mRNA vaccine development for infectious disease prevention and cancer treatment. The 18th international Symposium of the institute Network for Biomedical Science 2023.10.05

  6. Satoshi Uchida, Saed Abbasi, Miki Masai, Akimasa Hayashi, Theofilus Tockary, Shiro Akinaga, Kazunori Kataoka. Small and large animal studies of COVID-19 vaccines based on naked mRNA jet-injection. 日本核酸医薬学会第8回年会 2023.07.14

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Awards & Honors 【 display / non-display 】

  • Young Investigator Award, the Nucleic Acids Therapeutics Society of Japan，2020.11

  • 8th International mRNA Health Conference 1st Abstract Prize，8th International mRNA Health Conference，2020.11

  • 10th Young Scientist Award，2018.06

  • American Society of Gene and Cell Therapy (ASGCT) 17th Annual Meeting, Outstanding Poster Presentation Award ，American Society of Gene and Cell Therapy (ASGCT)，2014.05

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Others 【 display / non-display 】

  • A new coating method in mRNA engineering points the way to advanced therapies，2024.04

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