Personnel Information

写真a

KUSUYAMA JOJI


Job title

Associate Professor

Field Introduction URL

https://bsin.jp/

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Campus Career 【 display / non-display 】

  • 2022.10
    -
    2023.01
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Associate Professor
  • 2023.02
    -
    Now
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Division of Bio-Matrix， Department of Biosignals and Inheritance， Associate Professor
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External Career 【 display / non-display 】

  • 2015.12
    -
    2017.08
    Kagoshima University, Graduate School of Medical and Dental Sciences, Assistant Professor
  • 2020.04
    -
    2022.09
    Tohoku University, Frontier Research Institute for Interdisciplinary Sciences, Creative Interdisciplinary Research Division, Assistant Professor
  • 2021.04
    -
    2022.09
    Tohoku University,
  • 2021.07
    -
    2022.09
    Tohoku University,
  • 2022.10
    -
    Now
    Tokyo Medical and Dental University (TMDU), Graduate School of Medicine and Dentistry, Department of Biosignal and Inheritance, Associate Professor
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Academic Society Affiliations 【 display / non-display 】

  • JAPANESE ASSOCIATION FOR ORAL BIOLOGY

  • THE MOLECULAR BIOLOGY SOCIETY OF JAPAN

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Research Areas 【 display / non-display 】

  • Oral biological science

  • Metabolism and endocrinology

  • Sports sciences

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Research Theme 【 display / non-display 】

  • Analysis of common mechanisms of craniofacial and digital congenital anomalies, 2023.04 - 2026.03

  • Beneficial effects of exercise in the middle ages on overall health outcomes in aging, 2022.07 - 2023.03

  • The Effects of Exercise in the Middle Ages on Metabolic Health in Elderly, 2020.11 - 2021.03

  • Regulatory T-cell signaling in periodontitis, 2017.04 - 2020.03

  • Investigation of Novel isoform-specific signal transcution mechanisms of JNKs, 2017.04 - 2020.03

  • Molecular basis of regenerative therapy for musculoskeletal system using mechanical stress, 2015 - 2017

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Published Papers & Misc 【 display / non-display 】

  1. Zhang, JH; Tam, WWS; Hounsri, K; Kusuyama, J; Wu, VX. Effectiveness of Combined Aerobic and Resistance Exercise on Cognition, Metabolic Health, Physical Function, and Health-related Quality of Life in Middle-aged and Older Adults With Type 2 Diabetes Mellitus: A Systematic Review and Meta-analysis ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION. 2024.08; 105 (8): 1585-1599. ( PubMed, DOI )

  2. Choisez A, Ishihara S, Ishii T, Xu Y, Firouzjah SD, Haga H, Nagatomi R, Kusuyama J. Matrix stiffness regulates the triad communication of adipocytes/macrophages/endothelial cells through CXCL13. Journal of lipid research. 2024.08; 100620. ( PubMed, DOI )

  3. Zhang J, Tam WWS, Hounsri K, Kusuyama J, Wu VX. Response to Letter to the Editor on "Effectiveness of Combined Aerobic and Resistance Exercise on Cognition, Metabolic Health, Physical Function, and Health-Related Quality of Life in Middle-Aged and Older Adults With Type 2 Diabetes Mellitus: A Systematic Review and Meta-analysis". Archives of physical medicine and rehabilitation. 2024.05; 105 (5): 1023-1024. ( PubMed, DOI )

  4. Xu Y, Kusuyama J, Osana S, Matsuhashi S, Li L, Takada H, Inada H, Nagatomi R. Lactate promotes neuronal differentiation of SH-SY5Y cells by lactate-responsive gene sets through NDRG3-dependent and -independent manners. The Journal of biological chemistry. 2023.05; 299 (6): 104802. ( PubMed, DOI )

  5. Handedness did not affect motor skill acquisition by the dominant hand or interlimb transfer to the non-dominant hand regardless of task complexity level. 2022.10; 12 (1): 18181. ( PubMed, DOI )

  6. Joji Kusuyama, Nathan S Makarewicz, Brent G Albertson, Ana Barbara Alves-Wagner, Royce H Conlin, Noah B Prince, Christiano R R Alves, Krithika Ramachandran, Chisayo Kozuka, Yang Xiudong, Yang Xia, Michael F Hirshman, Toshihisa Hatta, Ryoichi Nagatomi, Eva S Nozik, Laurie J Goodyear. Maternal Exercise-Induced SOD3 Reverses the Deleterious Effects of Maternal High-Fat Diet on Offspring Metabolism Through Stabilization of H3K4me3 and Protection Against WDR82 Carbonylation. Diabetes. 2022.06; 71 (6): 1170-1181. ( PubMed, DOI )

  7. Grandmaternal exercise improves metabolic health of second-generation offspring. 2022.06; 60 101490. ( PubMed, DOI )

  8. Brown adipose tissue-derived MaR2 contributes to cold-induced resolution of inflammation. 2022.06; 4 (6): 775-790. ( PubMed, DOI )

  9. Bromodomain Inhibition Reveals FGF15/19 As a Target of Epigenetic Regulation and Metabolic Control. 2022.05; 71 (5): 1023-1033. ( PubMed, DOI )

  10. Effect of Aerobic and Resistant Exercise Intervention on Inflammaging of Type 2 Diabetes Mellitus in Middle-Aged and Older Adults: A Systematic Review and Meta-Analysis. 2022.05; 23 (5): 823-830. ( PubMed, DOI )

  11. HIF-1α plays an essential role in BMP9-mediated osteoblast differentiation through the induction of a glycolytic enzyme, PDK1. 2022.04; 237 (4): 2183-2197. ( PubMed, DOI )

  12. Joji Kusuyama, Ana Barbara Alves-Wagner, Royce H Conlin, Nathan S Makarewicz, Brent G Albertson, Noah B Prince, Shio Kobayashi, Chisayo Kozuka, Magnus Møller, Mette Bjerre, Jens Fuglsang, Emily Miele, Roeland J W Middelbeek, Yang Xiudong, Yang Xia, Léa Garneau, Jayonta Bhattacharjee, Céline Aguer, Mary Elizabeth Patti, Michael F Hirshman, Niels Jessen, Toshihisa Hatta, Per Glud Ovesen, Kristi B Adamo, Eva Nozik-Grayck, Laurie J Goodyear. Placental superoxide dismutase 3 mediates benefits of maternal exercise on offspring health. Cell metabolism. 2021.05; 33 (5): 939-956. ( PubMed, DOI )

  13. Tomokazu Ohnishi, Mitsuhiro Hisadome, Kusuyama Joji, Norika Chiba, Muhammad Subhan Amir, Takuro Kanekura, Tetsuya Matsuguchi. Ultraviolet B irradiation decreases CXCL10 expression in keratinocytes through endoplasmic reticulum stress. Journal of cellular biochemistry. 2021.04; ( PubMed, DOI )

  14. Chang-Hwan Seong, Norika Chiba, Joji Kusuyama, Muhammad Subhan Amir, Nahoko Eiraku, Sachiko Yamashita, Tomokazu Ohnishi, Norifumi Nakamura, Tetsuya Matsuguchi. Bone morphogenetic protein 9 (BMP9) directly induces Notch effector molecule Hes1 through the SMAD signaling pathway in osteoblasts. FEBS letters. 2021.02; 595 (3): 389-403. ( PubMed, DOI )

  15. Effects of maternal and paternal exercise on offspring metabolism. 2020.09; 2 (9): 858-872. ( PubMed, DOI )

  16. Glut1 expression is increased by p53 reduction to switch metabolism to glycolysis during osteoblast differentiation. 2020.05; 477 (10): 1795-1811. ( PubMed, DOI )

  17. Nahoko Eiraku, Norika Chiba, Toshiaki Nakamura, Muhammad Subhan Amir, Chang-Hwan Seong, Tomokazu Ohnishi, Joji Kusuyama, Kazuyuki Noguchi, Tetsuya Matsuguchi. BMP9 directly induces rapid GSK3-β phosphorylation in a Wnt-independent manner through class I PI3K-Akt axis in osteoblasts. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2019.11; 33 (11): 12124-12134. ( PubMed, DOI )

  18. CXCL13 is a differentiation- and hypoxia-induced adipocytokine that exacerbates the inflammatory phenotype of adipocytes through PHLPP1 induction. 2019.11; 476 (22): 3533-3548. ( PubMed, DOI )

  19. BMP9 prevents induction of osteopontin in JNK-inactivated osteoblasts via Hey1-Id4 interaction. 2019.11; 116 105614. ( PubMed, DOI )

  20. Low intensity pulsed ultrasound (LIPUS) maintains osteogenic potency by the increased expression and stability of Nanog through spleen tyrosine kinase (Syk) activation. 2019.10; 62 109345. ( PubMed, DOI )

  21. Low-intensity pulsed ultrasound promotes bone morphogenic protein 9-induced osteogenesis and suppresses inhibitory effects of inflammatory cytokines on cellular responses via Rho-associated kinase 1 in human periodontal ligament fibroblasts. 2019.09; 120 (9): 14657-14669. ( PubMed, DOI )

  22. JNK inactivation suppresses osteogenic differentiation, but robustly induces osteopontin expression in osteoblasts through the induction of inhibitor of DNA binding 4 (Id4). 2019.06; 33 (6): 7331-7347. ( PubMed, DOI )

  23. Spleen tyrosine kinase influences the early stages of multilineage differentiation of bone marrow stromal cell lines by regulating phospholipase C gamma activities. 2018.03; 233 (3): 2549-2559. ( PubMed, DOI )

  24. Joji Kusuyama, Tomokazu Ohnishi, Kenjiro Bandow, Muhammad Subhan Amir, Kaori Shima, Ichiro Semba, Tetsuya Matsuguchi. Constitutive activation of p46JNK2 is indispensable for C/EBPδ induction in the initial stage of adipogenic differentiation. The Biochemical journal. 2017.10; 474 (20): 3421-3437. ( PubMed, DOI )

  25. Higashi Yuko, Yoshioka Takako, Kawai Kazuhiro, Fujii Kazuyasu, Yoshimitsu Makoto, Kusuyama Joji, Shima Kaori, Tanimoto Akihide, Kanekura Takuro. 肺病変を伴わず潰瘍形成性皮下病変および筋病変を初期病変としたリンパ腫様肉芽腫症(Lymphomatoid granulomatosis initially presenting as ulcerated subcutaneous and muscle lesions without pulmonary involvement) The Journal of Dermatology. 2017.05; 44 (5): e107-e108. ( ichushi )

  26. Osteopontin inhibits osteoblast responsiveness through the down-regulation of focal adhesion kinase mediated by the induction of low-molecular weight protein tyrosine phosphatase. 2017.05; 28 (10): 1326-1336. ( PubMed, DOI )

  27. Lymphomatoid granulomatosis initially presenting as ulcerated subcutaneous and muscle lesions without pulmonary involvement. 2017.05; 44 (5): e107-e108-e108. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display 】

  1. Kusuyama Joji. 胎盤のSOD3が介在する子供の健康に及ぼす母体運動の影響(Placental SOD3 mediates benefits of maternal exercise on offspring health). The Journal of Physical Fitness and Sports Medicine 2021.11.01

  2. Joji Kusuyama, Ana Wagner, Michael Hirshman, Laurie J Goodyear. 母体運動による糖尿病予防効果の次世代伝播機構. 第42回日本分子生物学会 2019.12.03

  3. Joji Kusuyama, Ana Wagner, Michael Hirshman, Laurie J Goodyear. Identification of a Novel Placenta-Derived Protein that Mediates the Beneficial Effects of Maternal Exercise on Offspring Liver. The Japan-US Science forum in Boston 2019 2019.11.02

  4. Joji Kusuyama, Ana Wagner, Michael Hirshman, Laurie J Goodyear. Novel Epigenetic Mechanism for Maternal Exercise Effects on Offspring Metabolic Health. American Association Diabetes 79th Scientific Sessions 2019.06.10

  5. Joji Kusuyama, Ana Wagner, Michael Hirshman, Laurie J Goodyear. Maternal Exercise Improves Offspring Metabolic Health Through Epigenetics Changes Mediated by a Novel Placenta-Derived Protein. Cell Symposia, Exercise Metabolism 2019.05.05

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Awards & Honors 【 display / non-display 】

  • The Japan-US Science forum in Boston 2019 JSPS Washington Office Award，2019.11

  • American Diabetes Association Young Investigator Travel Grant Award，2019.03

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