Personnel Information

写真a

YOKOYAMA YUKI


Job title

Junior Associate Professor

Graduating School 【 display / non-display

  • Kagoshima University, Faculty of Agriculture, 2006.03, Graduated

Graduate School 【 display / non-display

  • Kyoto University, Graduate School, Division of Medicine, Doctor's Course, 2010.03, Accomplished credits for doctoral program

Campus Career 【 display / non-display

  • 2022.07
     
     
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Maxillofacial and Neck Reconstruction, Molecular Craniofacial Embryology, Junior Associate Professor
  • 2022.08
    -
    Now
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Division of Maxillofacial and Neck Reconstruction, Department of Molecular Craniofacial Embryology and Oral Histology, Junior Associate Professor

External Career 【 display / non-display

  • 2013.04
    -
    2014.03
    , Technical Assistant
  • 2014.04
    -
    2018.03
    , Project Assistant Professor
 

Research Theme 【 display / non-display

  • Understanding of the musculoskeletal system regulated by the transcription factor Scleraxis, 2021.04 - 2024.03

  • Analysis of the molecular mechanisms involving tooth root formation and maintenance using genetic modified mouse., 2017.04 - 2019.03

  • Establishment of a new mouse model of cledocranial dysplasia by TALEN mediated genome editing, 2016.04 - 2018.03

  • Analyses of a mouse model for claniofacial disease generated by genome editing, 2015.04 - 2017.03

  • Scleraxis-mediated regulation of mechanical responses in the periodontal ligament, 2013.04 - 2015.03

Published Papers & Misc 【 display / non-display

  1. Jin, CX; Adachi, N; Yoshimoto, Y; Sasabuchi, A; Kawashima, N; Ota, MS; Iseki, S. Fibroblast growth factor signalling regulates the development of tooth root JOURNAL OF ANATOMY. 2024.01; ( PubMed, DOI )

  2. Fukuma Y, Tokunaga T, Tanimura S, Yoshimoto Y, Mashimo T, Kaneko T, Tian X, Ideo K, Yonemitsu R, Matsushita K, Sugimoto K, Yugami M, Hisanaga S, Nakamura T, Uehara Y, Masuda T, Shukunami C, Karasugi T, Miyamoto T. Potential function of Scx+/Sox9+ cells as progenitor cells in rotator cuff tear repair in rats. Biochemical and biophysical research communications. 2023.07; 676 84-90. ( PubMed, DOI )

  3. Yuki Yoshimoto, Yumiko Oishi. Mechanisms of skeletal muscle-tendon development and regeneration/healing as potential therapeutic targets. Pharmacol Ther. 2023.03; 243 108357. ( PubMed, DOI )

  4. Fuiten Allison M., Yoshimoto Yuki, Shukunami Chisa, Stadler H. Scott. Digits in a dish: An in vitro system to assess the molecular genetics of hand/foot development at single-cell resolution FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2023.03; 11 1135025. ( PubMed, DOI )

  5. Kawakami J, Hisanaga S, Yoshimoto Y, Mashimo T, Kaneko T, Yoshimura N, Shimada M, Tateyama M, Matsunaga H, Shibata Y, Tanimura S, Takata K, Arima T, Maeda K, Fukuma Y, Uragami M, Ideo K, Sugimoto K, Yonemitsu R, Matsushita K, Yugami M, Uehara Y, Nakamura T, Tokunaga T, Karasugi T, Sueyoshi T, Shukunami C, Okamoto N, Masuda T, Miyamoto T. Remnant tissue enhances early postoperative biomechanical strength and infiltration of Scleraxis-positive cells within the grafted tendon in a rat anterior cruciate ligament reconstruction model. PloS one. 2023; 18 (11): e0293944. ( PubMed, DOI )

  6. Ikemoto-Uezumi M, Zhou H, Kurosawa T, Yoshimoto Y, Toyoda M, Kanazawa N, Nakazawa T, Morita M, Tsuchida K, Uezumi A. Increased MFG-E8 at neuromuscular junctions is an exacerbating factor for sarcopenia-associated denervation. Aging cell. 2022.01; 21 (1): e13536. ( PubMed, DOI )

  7. Keitaro Minato, Yuki Yoshimoto, Tamaki Kurosawa, Kei Watanabe, Hiroyuki Kawashima, Madoka Ikemoto-Uezumi, Akiyoshi Uezumi. Measurement of Lateral Transmission of Force in the Extensor Digitorum Longus Muscle of Young and Old Mice. Int J Mol Sci. 2021.11; 22 (22): ( PubMed, DOI )

  8. Masayoshi Kawatsu, Nobuo Takeshita, Aki Takimoto, Yuki Yoshimoto, Masahiro Seiryu, Arata Ito, Seiji Kimura, Tadafumi Kawamoto, Yuji Hiraki, Chisa Shukunami, Teruko Takano-Yamamoto. Scleraxis upregulated by transforming growth factor-β1 signaling inhibits tension-induced osteoblast differentiation of priodontal ligament cells via ephrin A2. Bone. 2021.08; 149 115969. ( PubMed, DOI )

  9. Akiyoshi Uezumi, Madoka Ikemoto-Uezumi, Heying Zhou, Tamaki Kurosawa, Yuki Yoshimoto, Masashi Nakatani, Keisuke Hitachi, Hisateru Yamaguchi, Shuji Wakatsuki, Toshiyuki Araki, Mitsuhiro Morita, Harumoto Yamada, Masashi Toyoda, Nobuo Kanazawa, Tatsu Nakazawa, Jun Hino, So-Ichiro Fukada, Kunihiro Tsuchida. Mesenchymal Bmp3b expression maintains skeletal muscle integrity and decreases in age-related sarcopenia. J Clin Invest. 2021.01; 131 (1): ( PubMed, DOI )

  10. Mao Kuriki, Fuminori Sato, Hiroyuki N Arai, Maina Sogabe, Mari Kaneko, Hiroshi Kiyonari, Koichi Kawakami, Yuki Yoshimoto, Chisa Shukunami, Atsuko Sehara-Fujisawa. Transient and lineage-restricted requirement of Ebf3 for sternum ossification. Development. 2020.05; 147 (9): ( PubMed, DOI )

  11. Katsumasa Ideo, Takuya Tokunaga, Chisa Shukunami, Aki Takimoto, Yuki Yoshimoto, Ryuji Yonemitsu, Tatsuki Karasugi, Hiroshi Mizuta, Yuji Hiraki, Takeshi Miyamoto. Role of Scx+/Sox9+ cells as potential progenitor cells for postnatal supraspinatus enthesis formation and healing after injury in mice. PLoS One. 2020; 15 (12): e0242286. ( PubMed, DOI )

  12. Yuki Yoshimoto, Madoka Ikemoto-Uezumi, Keisuke Hitachi, So-Ichiro Fukada, Akiyoshi Uezumi. Methods for Accurate Assessment of Myofiber Maturity During Skeletal Muscle Regeneration. Front Cell Dev Biol. 2020; 8 267. ( PubMed, DOI )

  13. Hiroyuki N Arai, Fuminori Sato, Takuya Yamamoto, Knut Woltjen, Hiroshi Kiyonari, Yuki Yoshimoto, Chisa Shukunami, Haruhiko Akiyama, Ralf Kist, Atsuko Sehara-Fujisawa. Metalloprotease-Dependent Attenuation of BMP Signaling Restricts Cardiac Neural Crest Cell Fate. Cell Rep. 2019.10; 29 (3): 603-616.e5. ( PubMed, DOI )

  14. Chisa Shukunami, Aki Takimoto, Yuriko Nishizaki, Yuki Yoshimoto, Seima Tanaka, Shigenori Miura, Hitomi Watanabe, Tetsushi Sakuma, Takashi Yamamoto, Gen Kondoh, Yuji Hiraki. Scleraxis is a transcriptional activator that regulates the expression of Tenomodulin, a marker of mature tenocytes and ligamentocytes. Sci Rep. 2018.02; 8 (1): 3155. ( PubMed, DOI )

  15. Yuki Yoshimoto, Aki Takimoto, Hitomi Watanabe, Yuji Hiraki, Gen Kondoh, Chisa Shukunami. Scleraxis is required for maturation of tissue domains for proper integration of the musculoskeletal system. Sci Rep. 2017.03; 7 45010. ( PubMed, DOI )

  16. Chisa Shukunami, Yuki Yoshimoto, Aki Takimoto, Hiroshi Yamashita, Yuji Hiraki. Molecular characterization and function of tenomodulin, a marker of tendons and ligaments that integrate musculoskeletal components. Jpn Dent Sci Rev. 2016.11; 52 (4): 84-92. ( PubMed, DOI )

  17. Min Cui, Soshi Kanemoto, Xiang Cui, Masayuki Kaneko, Rie Asada, Koji Matsuhisa, Keiji Tanimoto, Yuki Yoshimoto, Chisa Shukunami, Kazunori Imaizumi. OASIS modulates hypoxia pathway activity to regulate bone angiogenesis. Sci Rep. 2015.11; 5 16455. ( PubMed, DOI )

  18. Aki Takimoto, Masayoshi Kawatsu, Yuki Yoshimoto, Tadafumi Kawamoto, Masahiro Seiryu, Teruko Takano-Yamamoto, Yuji Hiraki, Chisa Shukunami. Scleraxis and osterix antagonistically regulate tensile force-responsive remodeling of the periodontal ligament and alveolar bone. Development. 2015.02; 142 (4): 787-796. ( PubMed, DOI )

  19. Yuki Sugimoto, Aki Takimoto, Haruhiko Akiyama, Ralf Kist, Gerd Scherer, Takashi Nakamura, Yuji Hiraki, Chisa Shukunami. Scx+/Sox9+ progenitors contribute to the establishment of the junction between cartilage and tendon/ligament. Development. 2013.06; 140 (11): 2280-2288. ( PubMed, DOI )

  20. Yuki Sugimoto, Aki Takimoto, Yuji Hiraki, Chisa Shukunami. Generation and characterization of ScxCre transgenic mice. Genesis. 2013.04; 51 (4): 275-283. ( PubMed, DOI )

  21. Kazuto Yamanokuchi, Akira Yabuki, Yuki Yoshimoto, Ko Arai, Makoto Fujiki, Kazuhiro Misumi. Gene and protein expression of cartilage oligomeric matrix protein associated with oncogenesis in canine tumors. J Vet Med Sci. 2009.04; 71 (4): 499-503. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display

  1. 吉本 由紀,上住 聡芳,上住 円,田中 かおり,余 昕怡,黒澤 珠希,山家 新勢,前原 一満,大川 恭行,外丸 祐介,宿南 知. 腱・靭帯分化誘導システムにおけるシングルセル解析. 第45回日本分子生物学会年会 2022.11.30

  2. 山家 新勢、余 昕怡、吉本 由紀、樋口 真之輔、秋山 治彦、安達 泰治、宿南 知佐. 線維軟骨性エンテーシスの形成・維持に寄与する細胞群の特性解析. 第40回日本骨代謝学会学術集会 2022.07.22