Personnel Information

写真a

MATSUDA Noriyuki


Job title

Professor

Homepage URL

https://www.tmd.ac.jp/mri/biom/

Research Areas, Keywords

Protein and organelle degradation, ubiquitylation (ubiqutination), autophagy, mitochondria, hereditary Parkinson's disease

Field Introduction URL

https://www.tmd.ac.jp/mri/biom/

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Graduating School 【 display / non-display 】

  • The University of Tokyo, Faculty of Science, 1995.03, Graduated

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Graduate School 【 display / non-display 】

  • The University of Tokyo, Graduate School, Division of Science, Doctor's Course, 2001.03, Completed

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Campus Career 【 display / non-display 】

  • 2022.01
    -
    2022.04
    Tokyo Medical and Dental University， Medical Research Institute， Pathophysiology， Department of Biomolecular Pathogenesis， Professor
  • 2022.05
    -
    Now
    Tokyo Medical and Dental University， Medical Research Institute， Division of Advanced Pathophysiological Science， Department of Biomolecular Pathogenesis， Professor
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External Career 【 display / non-display 】

  • 2022.01
    -
    Now
    Tokyo Medical and Dental University, Medical Research Institute, Professor
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Research Areas 【 display / non-display 】

  • Cell biology

  • Functional biochemistry

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Research Theme 【 display / non-display 】

  • Detoxification of aldehyde-conjugation as a new mechanism for preventing onset of Parkinson's disease, 2018.04 - 2021.03

  • Detoxification of aldehyde-conjugation as a new mechanism for preventing onset of Parkinson's disease, 2018.04 - 2021.03

  • Detoxification of aldehyde-conjugation as a new mechanism for preventing onset of Parkinson's disease, 2018.04 - 2021.03

  • Detoxification of aldehyde-conjugation as a new mechanism for preventing onset of Parkinson's disease, 2018.04 - 2021.03

  • Detoxification of aldehyde-conjugation as a new mechanism for preventing onset of Parkinson's disease, 2018.04 - 2021.03

  • Detoxification of aldehyde-conjugation as a new mechanism for preventing onset of Parkinson's disease, 2018.04 - 2021.03

  • Identification and functional analysis of substrates of disease-associated protein kinases using multiple phosphoproteomic technologies, 2014.04 - 2017.03

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Published Papers & Misc 【 display / non-display 】

  1. Koyano F, Yamano K, Hoshina T, Kosako H, Fujiki Y, Tanaka K, Matsuda N. AAA+ ATPase chaperone p97/VCP(FAF2) governs basal pexophagy. Nature communications. 2024.10; 15 (1): 9347. ( PubMed, DOI )

  2. Endo R, Kinefuchi H, Sawada M, Kikuchi R, Kojima W, Matsuda N, Yamano K. TBK1 adaptor AZI2/NAP1 regulates NDP52-driven mitochondrial autophagy. The Journal of biological chemistry. 2024.09; 300 (10): 107775. ( PubMed, DOI )

  3. Aiko Watanabe, Fumika Koyano, Kenichiro Imai, Yohei Hizukuri, Shizuka Ogiwara, Tomoya Ito, Jun Miyamoto, Chihiro Shibuya, Mayumi Kimura, Kazuya Toriumi, Chie Motono, Makoto Arai, Keiji Tanaka, Yoshinori Akiyama, Koji Yamano, Noriyuki Matsuda. The origin of esterase activity of Parkinson's disease causative factor DJ-1 implied by evolutionary trace analysis of its prokaryotic homolog HchA. J Biol Chem. 2024.06; 300 (7): 107476. ( PubMed, DOI )

  4. Cui M, Yamano K, Yamamoto K, Yamamoto-Imoto H, Minami S, Yamamoto T, Matsui S, Kaminishi T, Shima T, Ogura M, Tsuchiya M, Nishino K, Layden BT, Kato H, Ogawa H, Oki S, Okada Y, Isaka Y, Kosako H, Matsuda N, Yoshimori T, Nakamura S. HKDC1, a target of TFEB, is essential to maintain both mitochondrial and lysosomal homeostasis, preventing cellular senescence. Proceedings of the National Academy of Sciences of the United States of America. 2024.01; 121 (2): e2306454120. ( PubMed, DOI )

  5. Yamano K, Sawada M, Kikuchi R, Nagataki K, Kojima W, Endo R, Kinefuchi H, Sugihara A, Fujino T, Watanabe A, Tanaka K, Hayashi G, Murakami H, Matsuda N. Optineurin provides a mitophagy contact site for TBK1 activation. The EMBO journal. 2024.01; 43 (5): 754-779. ( PubMed, DOI )

  6. Kawasaki I, Sugiura K, Sasaki T, Matsuda N, Sato M, Sato K. MARC-3, a membrane-associated ubiquitin ligase, is required for fast polyspermy block in Caenorhabditis elegans. Nature communications. 2024.01; 15 (1): 792. ( PubMed, DOI )

  7. Akabane S, Watanabe K, Kosako H, Yamashita SI, Nishino K, Kato M, Sekine S, Kanki T, Matsuda N, Endo T, Oka T. TIM23 facilitates PINK1 activation by safeguarding against OMA1-mediated degradation in damaged mitochondria. Cell reports. 2023.05; 42 (5): 112454. ( PubMed, DOI )

  8. Hayashida R, Kikuchi R, Imai K, Kojima W, Yamada T, Iijima M, Sesaki H, Tanaka K, Matsuda N, Yamano K. Elucidation of ubiquitin-conjugating enzymes that interact with RBR-type ubiquitin ligases using a liquid-liquid phase separation-based method. The Journal of biological chemistry. 2023.02; 299 (2): 102822. ( PubMed, DOI )

  9. Bruno Barros Queliconi, Waka Kojima, Mayumi Kimura, Kenichiro Imai, Chisato Udagawa, Chie Motono, Takatsugu Hirokawa, Shinya Tashiro, Jose M M Caaveiro, Kouhei Tsumoto, Koji Yamano, Keiji Tanaka, Noriyuki Matsuda. Unfolding is the driving force for mitochondrial import and degradation of the Parkinson's disease-related protein DJ-1. J Cell Sci. 2021.11; 134 (22): jcs258653. ( PubMed, DOI )

  10. Waka Kojima, Koji Yamano, Hidetaka Kosako, Kenichiro Imai, Reika Kikuchi, Keiji Tanaka, Noriyuki Matsuda. Mammalian BCAS3 and C16orf70 associate with the phagophore assembly site in response to selective and non-selective autophagy. Autophagy. 2021.08; 17 (8): 2011-2036. ( PubMed, DOI )

  11. Taiki Baba, Susumu Tanimura, Ayane Yamaguchi, Koichiro Horikawa, Masashi Yokozeki, Saki Hachiya, Shun-Ichiro Iemura, Tohru Natsume, Noriyuki Matsuda, Kohsuke Takeda. Cleaved PGAM5 dephosphorylates nuclear serine/arginine-rich proteins during mitophagy. Biochim Biophys Acta Mol Cell Res. 2021.07; 1868 (7): 119045. ( PubMed, DOI )

  12. Yukiko Yoshida, Makoto Asahina, Arisa Murakami, Junko Kawawaki, Meari Yoshida, Reiko Fujinawa, Kazuhiro Iwai, Ryuichi Tozawa, Noriyuki Matsuda, Keiji Tanaka, Tadashi Suzuki. Loss of peptide N-glycanase causes proteasome dysfunction mediated by a sugar-recognizing ubiquitin ligase. Proc Natl Acad Sci U S A. 2021.07; 118 (27): e2102902118. ( PubMed, DOI )

  13. Mashun Onishi, Koji Yamano, Miyuki Sato, Noriyuki Matsuda, Koji Okamoto. Molecular mechanisms and physiological functions of mitophagy. EMBO J. 2021.02; 40 (3): e104705. ( PubMed, DOI )

  14. Matsuda N, Yamano K. Two sides of a coin: Physiological significance and molecular mechanisms for damage-induced mitochondrial localization of PINK1 and Parkin. Neuroscience research. 2020.10; 159 16-24. ( PubMed, DOI )

  15. Koji Yamano, Reika Kikuchi, Waka Kojima, Ryota Hayashida, Fumika Koyano, Junko Kawawaki, Takuji Shoda, Yosuke Demizu, Mikihiko Naito, Keiji Tanaka, Noriyuki Matsuda. Critical role of mitochondrial ubiquitination and the OPTN ATG9A axis in mitophagy Journal of Cell Biology. 2020.09; 219 (9): ( PubMed, DOI )

  16. Yamano K, Kikuchi R, Kojima W, Hayashida R, Koyano F, Kawawaki J, Shoda T, Demizu Y, Naito M, Tanaka K, Matsuda N. Critical role of mitochondrial ubiquitination and the OPTN-ATG9A axis in mitophagy. The Journal of cell biology. 2020.09; 219 (9): ( PubMed, DOI )

  17. Koyano F, Yamano K, Kosako H, Kimura Y, Kimura M, Fujiki Y, Tanaka K, Matsuda N. Parkin-mediated ubiquitylation redistributes MITOL/March5 from mitochondria to peroxisomes. EMBO reports. 2019.12; 20 (12): e47728. ( PubMed, DOI )

  18. Koyano F, Yamano K, Kosako H, Tanaka K, Matsuda N. Parkin recruitment to impaired mitochondria for nonselective ubiquitylation is facilitated by MITOL. The Journal of biological chemistry. 2019.06; 294 (26): 10300-10314. ( PubMed, DOI )

  19. Yamaguchi A, Ishikawa H, Furuoka M, Yokozeki M, Matsuda N, Tanimura S, Takeda K. Cleaved PGAM5 is released from mitochondria depending on proteasome-mediated rupture of the outer mitochondrial membrane during mitophagy. Journal of biochemistry. 2019.01; 165 (1): 19-25. ( PubMed, DOI )

  20. Yamaguchi Ayane, Ishikawa Hayate, Furuoka Mana, Yokozeki Masashi, Matsuda Noriyuki, Tanimura Susumu, Takeda Kohsuke. 切断型PGAM5はマイトファジー中のミトコンドリア外膜のプロテオソーム介在性断裂に応じてミトコンドリアから放出される(Cleaved PGAM5 is released from mitochondria depending on proteasome-mediated rupture of the outer mitochondrial membrane during mitophagy) The Journal of Biochemistry. 2019.01; 165 (1): 19-25. ( ichushi )

  21. Tashiro S, Caaveiro JMM, Nakakido M, Tanabe A, Nagatoishi S, Tamura Y, Matsuda N, Liu D, Hoang QQ, Tsumoto K. Discovery and Optimization of Inhibitors of the Parkinson's Disease Associated Protein DJ-1. ACS chemical biology. 2018.09; 13 (9): 2783-2793. ( PubMed, DOI )

  22. Okatsu K, Sato Y, Yamano K, Matsuda N, Negishi L, Takahashi A, Yamagata A, Goto-Ito S, Mishima M, Ito Y, Oka T, Tanaka K, Fukai S. Structural insights into ubiquitin phosphorylation by PINK1. Scientific reports. 2018.07; 8 (1): 10382. ( PubMed, DOI )

  23. Yamano K, Wang C, Sarraf SA, Münch C, Kikuchi R, Noda NN, Hizukuri Y, Kanemaki MT, Harper W, Tanaka K, Matsuda N, Youle RJ. Endosomal Rab cycles regulate Parkin-mediated mitophagy. eLife. 2018.01; 7 ( PubMed, DOI )

  24. Sato Y, Okatsu K, Saeki Y, Yamano K, Matsuda N, Kaiho A, Yamagata A, Goto-Ito S, Ishikawa M, Hashimoto Y, Tanaka K, Fukai S. Structural basis for specific cleavage of Lys6-linked polyubiquitin chains by USP30. Nature structural & molecular biology. 2017.11; 24 (11): 911-919. ( PubMed, DOI )

  25. Matsuda N, Kimura M, Queliconi BB, Kojima W, Mishima M, Takagi K, Koyano F, Yamano K, Mizushima T, Ito Y, Tanaka K. Parkinson's disease-related DJ-1 functions in thiol quality control against aldehyde attack in vitro. Scientific reports. 2017.10; 7 (1): 12816. ( PubMed, DOI )

  26. Yoshida Y, Yasuda S, Fujita T, Hamasaki M, Murakami A, Kawawaki J, Iwai K, Saeki Y, Yoshimori T, Matsuda N, Tanaka K. Ubiquitination of exposed glycoproteins by SCF(FBXO27) directs damaged lysosomes for autophagy. Proceedings of the National Academy of Sciences of the United States of America. 2017.08; 114 (32): 8574-8579. ( PubMed, DOI )

  27. Unexpected mitochondrial matrix localization of Parkinson's disease-related DJ-1 mutants but not wild-type DJ-1 (vol 21, pg 772, 2016) 2017.01; 22 (1): 124. ( DOI )

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Conference Activities & Talks 【 display / non-display 】

  1. Noriyuki Matsuda. Molecular mechanisms of mitophagy underlying Parkinson's disease pathogenesis. The 19th international symposium of the institute network for biomedical science in Sendai 2024.10.11 Institute of Development, Aging and Cancer, Tohoku University

  2. Noriyuki Matsuda. Molecular mechanisms of mitochondrial quality control and mitophagy underlying PD pathogenesis. 65th Annual Meeting of the Japanese Society of Neurology and 19th Asian Oceanian Congress of Neurology （AOCN2024） 2024.05.30 Tokyo International Forum

  3. Noriyuki Matsuda. Novel autophagy-relevant hereditary disease HEMARS (BCAS3-associated disease) and pexophagy suppression by FAF2-p97/VCP complex. The 10th international symposium on autophagy 2022.10.25 Chateraise Gateaux Kingdom Sapporo, Hokkaido

  4. Noriyuki Matsuda. Mitophagy dysfunction relevant to the hereditary Parkinson’s disease and muerodevelopmental disorder HEMARS. NEURO2022 2022.06.30 Okinawa Convention Center

  5. Noriyuki Matsuda. New role for PINK1/Parkin-mediated ubiquitylation. Singapore Mitochondrial Symposium 2019 2019.11.12 Auditorium, Centre for Life Sciences (CeLS), NUS, Singapore

  6. 小谷野 史香, 山野 晃史, 小迫 英尊, 田中 啓二, 松田 憲之. ミトコンドリア動態とその破綻から読み解く生物の普遍性と多様性　Parkinは損傷ミトコンドリアの選択的除去を仲介しMITOL/March5をペルオキシソームに移行させる. 日本生化学会大会プログラム・講演要旨集 2019.09.01

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Others 【 display / non-display 】

  • Even cells know the importance of recycling，2024.03

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