Personnel Information

写真a

KANAYAMA Keiko


Job title

Assistant Professor
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Graduating School 【 display / non-display 】

  • Hokkaido University, Faculty of Fisheries, 2007.03, Graduated

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Graduate School 【 display / non-display 】

  • Hokkaido University, Graduate School, Division of Medical Science, Master's Course, 2009.03, Completed

  • Hokkaido University, Graduate School, Division of Medicine, Doctor's Course, 2013.03, Completed

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Campus Career 【 display / non-display 】

  • 2021.12
    -
    2022.03
    Tokyo Medical and Dental University， Medical Research Institute， Pathophysiology， Developmental and Regenerative Biology， Project Assistant Professor
  • 2022.04
    　
    　
    Tokyo Medical and Dental University， Medical Research Institute， Pathophysiology， Developmental and Regenerative Biology， Assistant Professor
  • 2022.05
    -
    Now
    Tokyo Medical and Dental University， Medical Research Institute， Division of Visionary Life Science， Department of Developmental and Regenerative Biology， Assistant Professor
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External Career 【 display / non-display 】

  • 2013.04
    -
    2015.10
    Duke University Medical Center, Department of Immunology, Mari L Shinohara Lab, postdoctoral fellow
  • 2015.11
    -
    2017.05
    Duke University Medical Center, Department of Pediatrics, Pediatrics-Endocrinology, Nancie J. MacIver Lab, postdoctoral fellow
  • 2018.10
    -
    2021.06
    , Research Assistant
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Published Papers & Misc 【 display / non-display 】

  1. Jing Pu, Satoshi Kofuji, Yoshimi Okamoto-Uchida, Keiko Danzaki, Ruoxing Yu, Akira Suzuki, Satoshi Kitajima, Hiroshi Nishina. Lethal Phenotype-Based Database Screening Identifies Ceramide as a Negative Regulator of Primitive Streak Formation Stem Cells. 2023;

  2. Yazan Alwarawrah, Keiko Danzaki, Amanda G Nichols, Brian E Fee, Cheryl Bock, Gary Kucera, Laura P Hale, Gregory A Taylor, Nancie J MacIver. Irgm1 regulates metabolism and function in T cell subsets. Scientific Reports. 2022.01; 12 (1): 850. ( PubMed, DOI )

  3. Ichiro Fukunaga, Yoko Oe, Keiko Danzaki, Sayaka Ohta, Cheng Chen, Kyoko Shirai, Atsushi Kawano, Katsuhisa Ikeda, Kazusaku Kamiya. Modeling gap junction beta 2 gene-related deafness with human iPSC. Human Molecular Genetics. 2021.07; 30 (15): 1429-1442. ( PubMed, DOI )

  4. Ichiro Fukunaga, Yoko Oe, Keiko Danzaki, Sayaka Ohta, Cheng Chen, Madoka Iizumi, Takahiro Shiga, Rina Matsuoka, Takashi Anzai, Remi Hibiya-Motegi, Shori Tajima, Katsuhisa Ikeda, Wado Akamatsu, Kazusaku Kamiya. Generation of two iPSC lines from siblings of a homozygous patient with hearing loss and a heterozygous carrier with normal hearing carrying p.G45E/Y136X mutation in GJB2. Stem Cell Research. 2021.05; 53 102290. ( PubMed, DOI )

  5. Ichiro Fukunaga, Yoko Oe, Cheng Chen, Keiko Danzaki, Sayaka Ohta, Akito Koike, Katsuhisa Ikeda, Kazusaku Kamiya. Differentiation of Embryonic Stem Cells. Frontiers in Cell and Developmental Biology. 2021.04; 9 602197. ( PubMed, DOI )

  6. M Elizabeth Deerhake, Keiko Danzaki, Makoto Inoue, Emre D Cardakli, Toshiaki Nonaka, Nupur Aggarwal, William E Barclay, Ru-Rong Ji, Mari L Shinohara. Dectin-1 limits autoimmune neuroinflammation and promotes myeloid cell-astrocyte crosstalk via Card9-independent expression of Oncostatin M. Immunity. 2021.03; 54 (3): 484-498.e8. ( PubMed, DOI )

  7. Ichiro Fukunaga, Kyoko Shirai, Yoko Oe, Keiko Danzaki, Sayaka Ohta, Takahiro Shiga, Cheng Chen, Katsuhisa Ikeda, Wado Akamatsu, Atsushi Kawano, Kazusaku Kamiya. Generation of two induced pluripotent stem cell lines from PBMCs of siblings carrying c.235delC mutation in the GJB2 gene associated with sensorineural hearing loss. Stem Cell Research. 2020.07; 47 101910. ( PubMed, DOI )

  8. Shori Tajima, Keiko Danzaki, Katsuhisa Ikeda, Kazusaku Kamiya. Degradation and modification of cochlear gap junction proteins in the early development of age-related hearing loss. Experimental & Molecular Medicine. 2020.01; 52 (1): 166-175. ( PubMed, DOI )

  9. Ichiro Fukunaga, Takahiro Shiga, Cheng Chen, Yoko Oe, Keiko Danzaki, Sayaka Ohta, Rina Matsuoka, Takashi Anzai, Remi Hibiya-Motegi, Shori Tajima, Katsuhisa Ikeda, Wado Akamatsu, Kazusaku Kamiya. Generation of the induced pluripotent stem cell (hiPSC) line (JUFMDOi004-A) from a patient with hearing loss carrying GJB2 (p.V37I) mutation. Stem Cell Research. 2019.12; 43 101674. ( PubMed, DOI )

  10. Jennifer Rebeles, William D Green, Yazan Alwarawrah, Amanda G Nichols, William Eisner, Keiko Danzaki, Nancie J MacIver, Melinda A Beck. Obesity-Induced Changes in T-Cell Metabolism Are Associated With Impaired Memory T-Cell Response to Influenza and Are Not Reversed With Weight Loss. The Journal of Infectious Diseases. 2019.04; 219 (10): 1652-1661. ( PubMed, DOI )

  11. Masashi Kanayama, Shengjie Xu, Keiko Danzaki, Jason R Gibson, Makoto Inoue, Simon G Gregory, Mari L Shinohara. Skewing of the population balance of lymphoid and myeloid cells by secreted and intracellular osteopontin. Nature Immunology. 2017.09; 18 (9): 973-984. ( PubMed, DOI )

  12. Sivan Cohen, Keiko Danzaki, Nancie J MacIver. Nutritional effects on T-cell immunometabolism. European Journal of Immunology. 2017.02; 47 (2): 225-235. ( PubMed, DOI )

  13. Keiko Danzaki, Masashi Kanayama, Oscar Alcazar, Mari L Shinohara. Osteopontin has a protective role in prostate tumor development in mice. European Journal of Immunology. 2016.11; 46 (11): 2669-2678. ( PubMed, DOI )

  14. Masashi Kanayama, Keiko Danzaki, You-Wen He, Mari L Shinohara. Lung inflammation stalls Th17-cell migration en route to the central nervous system during the development of experimental autoimmune encephalomyelitis. International Immunology. 2016.09; 28 (9): 463-469. ( PubMed, DOI )

  15. Valerie A Gerriets, Keiko Danzaki, Rigel J Kishton, William Eisner, Amanda G Nichols, Donte C Saucillo, Mari L Shinohara, Nancie J MacIver. Leptin directly promotes T-cell glycolytic metabolism to drive effector T-cell differentiation in a mouse model of autoimmunity. European Journal of Immunology. 2016.05; 46 (8): 1970-1983. ( PubMed, DOI )

  16. Masashi Kanayama, Makoto Inoue, Keiko Danzaki, Gianna Hammer, You-Wen He, Mari L Shinohara. Autophagy enhances NFκB activity in specific tissue macrophages by sequestering A20 to boost antifungal immunity. Nature Communications. 2015.01; 6 5779. ( PubMed, DOI )

  17. Keiko Danzaki, Yutaka Matsui, Masahiro Ikesue, Daichi Ohta, Koyu Ito, Masashi Kanayama, Daisuke Kurotaki, Junko Morimoto, Yoichiro Iwakura, Hideo Yagita, Hiroyuki Tsutsui, Toshimitsu Uede. Interleukin-17A deficiency accelerates unstable atherosclerotic plaque formation in apolipoprotein E-deficient mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 2012.02; 32 (2): 273-280. ( PubMed, DOI )

  18. Masashi Kanayama, Junko Morimoto, Yutaka Matsui, Masahiro Ikesue, Keiko Danzaki, Daisuke Kurotaki, Koyu Ito, Toshimichi Yoshida, Toshimitsu Uede. α9β1 integrin-mediated signaling serves as an intrinsic regulator of pathogenic Th17 cell generation. The Journal of Immunology. 2011.12; 187 (11): 5851-5864. ( PubMed, DOI )

  19. Masahiro Ikesue, Yutaka Matsui, Daichi Ohta, Keiko Danzaki, Koyu Ito, Masashi Kanayama, Daisuke Kurotaki, Junko Morimoto, Tetsuhito Kojima, Hiroyuki Tsutsui, Toshimitsu Uede. Syndecan-4 deficiency limits neointimal formation after vascular injury by regulating vascular smooth muscle cell proliferation and vascular progenitor cell mobilization. Arteriosclerosis, Thrombosis, and Vascular Biology. 2011.05; 31 (5): 1066-1074. ( PubMed, DOI )

  20. Yutaka Matsui, Masahiro Ikesue, Keiko Danzaki, Junko Morimoto, Mami Sato, Shinya Tanaka, Tetsuhito Kojima, Hiroyuki Tsutsui, Toshimitsu Uede. Syndecan-4 prevents cardiac rupture and dysfunction after myocardial infarction. Circulation Research. 2011.05; 108 (11): 1328-1339. ( PubMed, DOI )

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