Genome-wide screening for revealing molecular mechanisms of anhydrobiosis in Polypedilum vanderplanki, 2018.04 - 2021.03

Summary： Pv11 is a cultured cell line derived from embryos of the sleeping chironomid Polypedilum vanderplanki. Like the midge, Pv11 cells also display extreme desiccation tolerance; consequently, the cells can be stored in a dry state at room temperature. To apply the amazing ability to store biological things under dry conditions at room temperature, many researchers have tried to reveal the molecular mechanisms of the desiccation tolerance. However, only a few mechanisms were cleared, and most of them were still uncleared. So, I tried the genome-wide screening for understanding the molecular mechanisms of Pv11 cells.
At first, I constituted the experimental system for the screening. Through the construction, I identified several genes necessary for the anhydrobiotic ability of Pv11 cells.

Specific differentiation mechanisms of visceral adipogenic cells, 2015.04 - 2018.03

Summary： A large number of papers have shown that fat accumulation and the dysfunction of visceral adipose tissue cause abnormalities in whole body metabolic homeostasis. Recently, we developed a practical in vitro culture system for mesenteric adipocytes. Using the system, specific differentiation mechanisms of in vitro mesenteric adipogenic cells was shown.

Practice of Pharmacology.，2024