Personnel Information

写真a

HORI Takeshi


Job title

Assistant Professor
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Campus Career 【 display / non-display 】

  • 2021.10
    -
    2022.08
    Tokyo Medical and Dental University， Institute of Biomaterials and Bioengineering， Biofunctional Restoration， Biomechanics， Assistant Professor
  • 2022.09
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    2023.03
    Tokyo Medical and Dental University， Institute of Biomaterials and Bioengineering， Biofunctional Restoration， Biomechanics， Assistant Professor
  • 2023.04
    -
    Now
    Tokyo Medical and Dental University， Institute of Biomaterials and Bioengineering， -， -， Assistant Professor
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External Career 【 display / non-display 】

  • 2013.04
    -
    2017.04
    National Institutes of Health (NIH)/National Institute of Environmental Health Sciences (NIEHS), Reproductive and Developmental Biology Laboratory, Pharmacogenetics Section,
  • 2017.05
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    2020.02
    RIKEN,
  • 2020.03
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    2021.09
    Tohoku University, Graduate School of Engineering Department of Finemechanics, Project Assistant Professor
  • 2021.10
    -
    2022.08
    Tokyo Medical and Dental University, Institute of Biomaterials and Bioengineering Division of Biofunctional Restoration,
  • 2022.08
    -
    Now
    Tokyo Medical and Dental University, Institute of Biomaterials and Bioengineering Division of Biofunctional Restoration, Assistant Professor
  • 2022.09
    -
    2023.03
    Tokyo Medical and Dental University, Institute of Biomaterials and Bioengineering, Division of Biomechanics, Assistant Professor
  • 2023.04
    -
    Now
    Tokyo Medical and Dental University, Institute of Biomaterials and Bioengineering, Division of Diagnostic & Therapeutic Systems Engineering, Assistant Professor
  • 2024.06
    -
    Now
    Tokyo Medical and Dental University, Institute of Biomaterials and Bioengineering, Division of Diagnostic & Therapeutic Systems Engineering,

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Academic Activity 【 display / non-display 】

  • 2024.01
    -
    Now
    Editorial Board Member of Scientific Reports (Nature Publishing Group)
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Research Theme 【 display / non-display 】

  • Creation of in vitro evaluation systems for integrated understanding of oral dysbiosis and systemic diseases, 2023.04 - 2026.03

  • 食資源のサステナビリティを拓く高開口率足場シートを用いた3次元組織構築技術の開発, 2023.04 - 2024.03

  • Preparation of organoids with human placental structure and construction of placental barrier ability evaluation system, 2022.06 - 2024.03

  • Preparation of organoids with human placental structure and construction of placental barrier ability evaluation system, 2022.06 - 2024.03

  • Preparation of organoids with human placental structure and construction of placental barrier ability evaluation system, 2022.06 - 2024.03

  • 灌流可能な三次元血管網を有する多検体評価システムの開発, 2022.05 - 2023.03

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Published Papers & Misc 【 display / non-display 】

  1. Shibata S, Endo S, Nagai LAE, H Kobayashi E, Oike A, Kobayashi N, Kitamura A, Hori T, Nashimoto Y, Nakato R, Hamada H, Kaji H, Kikutake C, Suyama M, Saito M, Yaegashi N, Okae H, Arima T. Modeling embryo-endometrial interface recapitulating human embryo implantation. Science advances. 2024.02; 10 (8): eadi4819. ( PubMed, DOI )

  2. Hori T, Okae H, Shibata S, Kobayashi N, Kobayashi EH, Oike A, Sekiya A, Arima T, Kaji H. Trophoblast stem cell-based organoid models of the human placental barrier. Nature communications. 2024.02; 15 (1): 962. ( PubMed, DOI )

  3. Nashimoto Y, Konno A, Imaizumi T, Nishikawa K, Ino K, Hori T, Kaji H, Shintaku H, Goto M, Shiku H. Microfluidic vascular formation model for assessing angiogenic capacities of single islets. Biotechnology and bioengineering. 2023.12; 121 (3): 1050-1059. ( PubMed, DOI )

  4. Yamashita Kazuya, Ostrovidov Serge, Raut Bibek, Hori Takeshi, Nashimoto Yuji, Nagai Nobuhiro, Abe Toshiaki, Kaji Hirokazu. Minimally Invasive Sub-Retinal Transplantation of RPE-J Cells on a Biodegradable Composite PCL/Collagen Nanosheet CELL TRANSPLANTATION. 2023; 32 9636897231165117. ( PubMed, DOI )

  5. Hori T, Yokobori K, Moore R, Negishi M, Sueyoshi T. CAR requires Gadd45β to promote phenobarbital-induced mouse liver tumors in early stage. Frontiers in oncology. 2023; 13 1217847. ( PubMed, DOI )

  6. Carvalho V, Gonçalves I, Lage T, Rodrigues RO, Minas G, Teixeira SFCF, Moita AS, Hori T, Kaji H, Lima RA. 3D Printing Techniques and Their Applications to Organ-on-a-Chip Platforms: A Systematic Review. Sensors (Basel, Switzerland). 2021.05; 21 (9): 3304. ( PubMed, DOI )

  7. Raut B, Chen LJ, Hori T, Kaji H. An Open-Source Add-On EVOM<sup>®</sup> Device for Real-Time Transepithelial/Endothelial Electrical Resistance Measurements in Multiple Transwell Samples. Micromachines. 2021.03; 12 (3): 1-13. ( PubMed, DOI )

  8. Hori T, Kurosawa O, Ishihara K, Mizuta T, Iwata H. Three-Dimensional Cell Sheet Construction Method with a Polyester Micromesh Sheet. Tissue engineering. Part C, Methods. 2020.03; 26 (3): 170-179. ( PubMed, DOI )

  9. A microfluidic model of the human placenta 2020; 921-922.

  10. Hori T, Yamane K, Anazawa T, Kurosawa O, Iwata H. Compact fluidic system for functional assessment of pancreatic islets. Biomedical microdevices. 2019.11; 21 (4): 91. ( PubMed, DOI )

  11. Hori Takeshi, Sugahara Kazuma, Tsuda Junko, Hirose Yoshinobu, Hashimoto Makoto, Takemoto Yousuke, Tarumoto Shunsuke, Yamashita Hiroshi. 糖尿病モデルマウスの進行性難聴の予防を目的とした生薬の経口投与(Oral administration of an herbal medicine to prevent progressive hearing loss in a mouse model of diabetes) Auris・Nasus・Larynx. 2019.10; 46 (5): 703-708. ( ichushi )

  12. Hori T, Kurosawa O. A Three-dimensional Cell Culture Method with a Micromesh Sheet and Its Application to Hepatic Cells. Tissue engineering. Part C, Methods. 2018.11; ( PubMed, DOI )

  13. Hori T, Saito K, Moore R, Flake GP, Negishi M. Nuclear Receptor CAR Suppresses GADD45B-p38 MAPK Signaling to Promote Phenobarbital-induced Proliferation in Mouse Liver. Molecular cancer research : MCR. 2018.08; 16 (8): 1309-1318. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display 】

  1. Hori Takeshi, Ando Moe, Yamamoto Akane, Kitano Isamu, Ishihara Kohei, Mizuta Taro, Yoshida Shotaro, Nashimoto Yuji, Kaji Hirokazu. インサートカラム型血管網MPSの開発(Development of insert column type vascular network MPS). AATEX: Alternatives to Animal Testing and EXperimentation 2023.12.01

  2. Sato Yuki, Nashimoto Yuji, Ohsugi Yujin, Hori Takeshi, Yoshida Shotaro, Katagiri Sayaka, Kaji Hirokazu. 歯肉組織への細菌の浸潤観察を目的とした歯肉上皮および歯肉血管網の構築(Construction of gingival epithelium and gingival vascular network for observation of bacterial invasion into to gingival tissue). AATEX: Alternatives to Animal Testing and EXperimentation 2023.12.01

  3. Hori Takeshi. Development of alternatives to animal testing for predicting the health effects of chemicals on the human fetus(タイトル和訳中). AATEX: Alternatives to Animal Testing and EXperimentation 2022.12.01

  4. Hori Takeshi. 化学物質のヒト胎児への健康影響を予測する動物実験代替法の開発(Development of alternatives to animal testing for predicting the health effects of chemicals on the human fetus). AATEX: Alternatives to Animal Testing and EXperimentation 2022.12.01

  5. Hori Takeshi. 化学物質のヒト胎児への健康影響を予測する動物実験代替法の開発(Development of alternatives to animal testing for predicting the health effects of chemicals on the human fetus). AATEX: Alternatives to Animal Testing and EXperimentation 2022.12.01

  6. Takeshi Hori. Microphysiological systems and 3D cell cultures for accelerating human placenta research. 第7回生体医歯工学共同研究拠点国際シンポジウム(ISBE2022) 2022.11.25

  7. Takeshi Hori, Sayaka Katagiri, Hiroaki Okae, Takahiro Arima, Yuji Nashimoto, Hirokazu Kaji. Generation of human placental organoids to study the effects of oral dysbiosis on the placental development. The 17th International Workshop on Biomaterials in Interface Science 2022.08.24

  8. Hori Takeshi, Ohmori Kazuo, Ono Koichiro. 内視鏡下腰椎椎間板ヘルニア摘出術後の腰椎椎間板ヘルニアの再発(Recurrence of lumbar disc herniation after full-endoscopic lumbar discectomy, interlaminar approach). 日本内視鏡外科学会雑誌 2021.03.01

  9. Hori Takeshi, Kurosawa Osamu, Tani Nobutaka, Mizuta Taro, Iwata Hiroo. 動物実験代替法および再生医療に向けた新しい3D細胞シート培養法(Novel 3D cell sheet culture method for alternatives to animal testing and regenerative medicine). AATEX: Alternatives to Animal Testing and EXperimentation 2019.12.01

  10. Ono Koichiro, Ohmori Kazuo, Hori Takeshi. 低侵襲手術手技を用いたfloating fusion術後に生じた遠位隣接椎間障害に対する経皮的内視鏡下除圧術(Full-endoscopic lumbar decompression for adjacent segmental disease after minimally invasive lumbar floating fusion). JOSKAS 2018.05.01

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Others 【 display / non-display 】

  • Breaking through barriers，2024.02

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Campus class subject 【 display / non-display 】

  • バイオメディカルシステム理工学ⅠⅠ(英語)，2022 - Now

  • Biomedical system science and engineering，2022 - Now

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Social Contribution 【 display / non-display 】

  • Novel In Vitro Model For Human Placental Barrier，2024.02.09

  • Revolutionary Organoid Model of Human Placental Barrier Developed by Tokyo Medical and Dental University，2024.02.09

  • Breaking through barriers，EurekAlert! AAAS，2024.02.08

  • Researchers develop model to assess biology of human placental barrier，MDLinx，2024.02.08

  • The Trophoblast Organoids Reinventing Fetal Safety，2024.02.08

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