基本情報

写真a

石野 智子(イシノ トモコ)

ISHINO Tomoko


職名

教授

ホームページ

https://sites.google.com/view/tmdu-parasitology

研究分野・キーワード

寄生虫学、マラリア、感染機構、スポロゾイト、有性生殖

出身学校 【 表示 / 非表示

  • 東京大学  薬学部  1996年03月  卒業

出身大学院 【 表示 / 非表示

  • 東京大学  薬学系研究科  修士課程  1998年03月  修了

  • 東京大学  薬学系研究科  博士課程  2001年03月  修了

取得学位 【 表示 / 非表示

  • 薬学修士  

  • 薬学博士  

  • 医学博士  

経歴(学内) 【 表示 / 非表示

  • 2021年08月
    -
    2021年11月
    東京医科歯科大学 大学院医歯学総合研究科 医歯学系専攻 環境社会医歯学講座 国際環境寄生虫病学 教授
  • 2021年12月
    -
    現在
    東京医科歯科大学 大学院医歯学総合研究科 医歯学専攻 環境社会医歯学講座 寄生虫学・熱帯医学分野 教授

経歴(学外) 【 表示 / 非表示

  • 2001年04月
    -
    2005年03月
    三重大学 医学部 医動物学講座 特任研究員
  • 2005年04月
    -
    2006年06月
    三重大学 医学部 医動物学講座 助教
  • 2006年07月
    -
    2009年02月
    パスツール研究所 特任研究員
  • 2009年03月
    -
    2021年07月
    愛媛大学 医学部 寄生病原体学分野 准教授
  • 2011年08月
    -
    2013年07月
    文部科学省 学術調査官
  • 2013年04月
    -
    2021年07月
    愛媛大学 プロテオサイエンスセンター 寄生病原体学部門 准教授

▼全件表示

所属学協会 【 表示 / 非表示

  • 日本生化学会

  • 日本寄生虫学会

研究分野 【 表示 / 非表示

  • 寄生虫学

資格、免許 【 表示 / 非表示

  • 高等学校教諭免許(専修・1種)

  • 薬剤師

 

研究テーマ 【 表示 / 非表示

  • マラリア原虫有性生殖メカニズムの解明

  • マラリア原虫スポロゾイトの感染の分子基盤の解明

競争的資金等の研究課題 【 表示 / 非表示

  • 三日熱マラリア伝搬阻止効果のある患者血漿を用いた新規ワクチン候補抗原の探索

    文部科学省/日本学術振興会 : 2019年 - 2022年

  • スポロゾイトの分泌タンパク質輸送メカニズムにおけるRAMAの作用機序の解明

    文部科学省/日本学術振興会 : 2019年 - 2021年

  • 熱帯熱マラリアのミクロガメート表面抗原を標的とする伝搬阻止ワクチンの開発

    文部科学省/日本学術振興会

  • スポロゾイトと肝細胞の相互作用に着目したマラリア原虫感染成立の分子基盤の解明

    文部科学省/日本学術振興会

論文・総説 【 表示 / 非表示

  1. Cha SJ, Yu X, Gregory BD, Lee YS, Ishino T, Opoka RO, John CC, Jacobs-Lorena M. Identification of Key Determinants of Cerebral Malaria Development and Inhibition Pathways. mBio. 2022.01; e0370821. ( PubMed, DOI )

  2. Miura K, Takashima E, Pham TP, Deng B, Zhou L, Huang WC, Diouf A, Gebremicale YT, Tachibana M, Ishino T, Richter King C, Lovell JF, Long CA, Tsuboi T. Elucidating functional epitopes within the N-terminal region of malaria transmission blocking vaccine antigen Pfs230. NPJ vaccines. 2022.01; 7 (1): 4. ( PubMed, DOI )

  3. Tachibana M, Takashima E, Morita M, Sattabongkot J, Ishino T, Culleton R, Torii M, Tsuboi T. Plasmodium vivax transmission-blocking vaccines: Progress, challenges and innovation. Parasitology international. 2021.12; 87 102525. ( PubMed, DOI )

  4. Tachibana M, Iriko H, Baba M, Torii M, Ishino T. PSOP1, putative secreted ookinete protein 1, is localized to the micronemes of Plasmodium yoelii and P. berghei ookinetes. Parasitology international. 2021.06; 84 102407. ( PubMed, DOI )

  5. Ishizaki Takahiro, Chaiyawong Nattawat, Hakimi Hassan, Asada Masahito, Tachibana Mayumi, Ishino Tomoko, Yahata Kazuhide, Kaneko Osamu. A novel Plasmodium yoelii pseudokinase, PypPK1, is involved in erythrocyte invasion and exflagellation center formation PARASITOLOGY INTERNATIONAL. 2020.06; 76 102056. ( PubMed, DOI )

  6. Iriko Hideyuki, Ishino Tomoko, Tachibana Mayumi, Omoda Ayaka, Torii Motomi, Tsuboi Takafumi. Skeleton binding protein 1 (SBP1) of Plasmodium falciparum accumulates in electron-dense material before passing through the parasitophorous vacuole membrane PARASITOLOGY INTERNATIONAL. 2020.04; 75 102003. ( PubMed, DOI )

  7. Ishino Tomoko, Tachibana Mayumi, Baba Minami, Iriko Hideyuki, Tsuboi Takafumi, Torii Motomi. Observation of morphological changes of female osmiophilic bodies prior to Plasmodium gametocyte egress from erythrocytes MOLECULAR AND BIOCHEMICAL PARASITOLOGY. 2020.03; 236 111261. ( PubMed, DOI )

  8. Tachibana Mayumi, Baba Minami, Takashima Eizo, Tsuboi Takafumi, Torii Motomi, Ishino Tomoko. The C-terminal region of the Plasmodium yoelii microgamete surface antigen PyMiGS induces potent anti-malarial transmission-blocking immunity in mice VACCINE. 2020.03; 38 (15): 3129-3136. ( PubMed, DOI )

  9. Nozaki Mamoru, Baba Minami, Tachibana Mayumi, Tokunaga Naohito, Torii Motomi, Ishino Tomoko. Detection of the Rhoptry Neck Protein Complex in Plasmodium Sporozoites and Its Contribution to Sporozoite Invasion of Salivary Glands MSPHERE. 2020; 5 (4): ( PubMed, DOI )

  10. Miura Kazutoyo, Tachibana Mayumi, Takashima Eizo, Morita Masayuki, Kanoi Bernard N., Nagaoka Hikaru, Baba Minami, Torii Motomi, Ishino Tomoko, Tsuboi Takafumi. Malaria transmission-blocking vaccines: wheat germ cell-free technology can accelerate vaccine development EXPERT REVIEW OF VACCINES. 2019.10; 18 (10): 1017-1027. ( PubMed, DOI )

  11. Tokunaga Naohito, Nozaki Mamoru, Tachibana Mayumi, Baba Minami, Matsuoka Kazuhiro, Tsuboi Takafumi, Torii Motomi, Ishino Tomoko. Expression and Localization Profiles of Rhoptry Proteins in Plasmodium berghei Sporozoites FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY. 2019.09; 9 316. ( PubMed, DOI )

  12. Bantuchai Sirasate, Nozaki Mamoru, Thongkukiatkul Amporn, Lorsuwannarat Natcha, Tachibana Mayumi, Baba Minami, Matsuoka Kazuhiro, Tsuboi Takafumi, Torii Motomi, Ishino Tomoko. Rhoptry neck protein 11 has crucial roles during malaria parasite sporozoite invasion of salivary glands and hepatocytes INTERNATIONAL JOURNAL FOR PARASITOLOGY. 2019.08; 49 (9): 725-735. ( PubMed, DOI )

  13. Gupta Devendra Kumar, Dembele Laurent, Voorberg-van der Wel Annemarie, Roma Guglielmo, Yip Andy, Chuenchob Vorada, Kangwanrangsan Niwat, Ishino Tomoko, Vaughan Ashley M., Kappe Stefan H., Flannery Erika L., Sattabongkot Jetsumon, Mikolajczak Sebastian, Bifani Pablo, Kocken Clemens H. M., Diagana Thierry Tidiane. The Plasmodium liver-specific protein 2 (LISP2) is an early marker of liver stage development ELIFE. 2019.05; 8 ( PubMed, DOI )

  14. Tohmoto Tatsuhiro, Takashima Eizo, Takeo Satoru, Morita Masayuki, Nagaoka Hikaru, Udomsangpetch Rachanee, Sattabongkot Jetsumon, Ishino Tomoko, Torii Motomi, Tsuboi Takafumi. Anti-MSP11 IgG inhibits Plasmodium falciparum merozoite invasion into erythrocytes in vitro PARASITOLOGY INTERNATIONAL. 2019.04; 69 25-29. ( PubMed, DOI )

  15. Nagaoka Hikaru, Sasaoka Chisa, Yuguchi Takaaki, Kanoi Bernard N., Ito Daisuke, Morita Masayuki, Udomsangpetch Rachanee, Sattabongkot Jetsumon, Ishino Tomoko, Tsuboi Takafumi, Takashima Eizo. PfMSA180 is a novel Plasmodium falciparum vaccine antigen that interacts with human erythrocyte integrin associated protein (CD47) SCIENTIFIC REPORTS. 2019.04; 9 (1): 5923. ( PubMed, DOI )

  16. Tachibana Mayumi, Miura Kazutoyo, Takashima Eizo, Morita Masayuki, Nagaoka Hikaru, Zhou Luwen, Long Carole A., King C. Richter, Torii Motomi, Tsuboi Takafumi, Ishino Tomoko. Identification of domains within Pfs230 that elicit transmission blocking antibody responses VACCINE. 2019.03; 37 (13): 1799-1806. ( PubMed, DOI )

  17. Ito Daisuke, Takashima Eizo, Yamasaki Tsutomu, Hatano Shinya, Hasegawa Tomoyuki, Miura Kazutoyo, Morita Masayuki, Thongkukiatkul Amporn, Diakite Mahamadou, Long Carole A., Sattabongkot Jetsumon, Udomsangpetch Rachanee, Iriko Hideyuki, Ishino Tomoko, Tsuboi Takafumi. Antibodies against a Plasmodium falciparum RON12 inhibit merozoite invasion into erythrocytes PARASITOLOGY INTERNATIONAL. 2019.02; 68 (1): 87-91. ( PubMed, DOI )

  18. Oda-Yokouchi Yuki, Tachibana Mayumi, Iriko Hideyuki, Torii Motomi, Ishino Tomoko, Tsuboi Takafumi. Plasmodium RON12 localizes to the rhoptry body in sporozoites PARASITOLOGY INTERNATIONAL. 2019.02; 68 (1): 17-23. ( PubMed, DOI )

  19. Ishino Tomoko, Murata Eri, Tokunaga Naohito, Baba Minami, Tachibana Mayumi, Thongkukiatkul Amporn, Tsuboi Takafumi, Torii Motomi. Rhoptry neck protein 2 expressed in Plasmodium sporozoites plays a crucial role during invasion of mosquito salivary glands CELLULAR MICROBIOLOGY. 2019.01; 21 (1): e12964. ( PubMed, DOI )

  20. Miura Kazutoyo, Tachibana Mayumi, Takashima Eizo, Morita Masayuki, Nagaoka Hikaru, Phama Thao P., Long Carole A., King C. Richter, Torii Motomi, Ishino Tomoko, Tsuboi Takafumi. CYSTEINE MOTIF 1 DOMAIN IN PFS230 MOLECULE IS CRUCIAL TO MAINTAIN THE CORRECT CONFORMATION OF PFS230-BASED TRANSMISSION-BLOCKING VACCINES AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE. 2019; 101 133.

  21. Ishino Tomoko, Tokunaga Naohito, Nozaki Mamoru, Tsuboi Takafumi, Torii Motomi. EXPRESSION AND LOCALIZATION PROFILES OF RHOPTRY PROTEINS IN PLASMODIUM BERGHEI SPOROZOITES AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE. 2019; 101 269.

  22. Thongpoon Sataporn, Roobsoong Wanlapa, Chotirat Sadudee, Tsuboi Takafumi, Takashima Eizo, Cui Liwang, Ishino Tomoko, Tachibana Mayumi, Sattabongkot Jetsumon. NATURALLY ACQUIRED TRANSMISSION-BLOCKING ANTIBODIES AGAINST PLASMODIUM VIVAX AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE. 2019; 101 132.

  23. Baba Minami, Nozaki Mamoru, Tachibana Mayumi, Torii Motomi, Tsuboi Takafumi, Ishino Tomoko. THE ROLE OF RON4 IN PLASMODIUM SPOROZOITE INFECTION OF THE LIVER AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE. 2019; 101 469.

  24. Tachibana Mayumi, Miura Kazutoyo, Takahima Eizo, Morita Masayuki, Nagaoka Hikaru, Zhou Luwen, Long Carole A., King C. Richter, Torii Motomi, Tsuboi Takafumi, Ishino Tomoko. SCREENING FOR CANDIDATE DOMAINS WITHIN PFS230 THAT ELICIT TRANSMISSION-BLOCKING ANTIBODY RESPONSE AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE. 2019; 101 527.

  25. Jenwithisuk Rachaneeporn, Kangwanrangsan Niwat, Tachibana Mayumi, Thongkukiatkul Amporn, Otsuki Hitoshi, Sattabongkot Jetsumon, Tsuboi Takafumi, Torii Motomi, Ishino Tomoko. Identification of a PH domain-containing protein which is localized to crystalloid bodies of Plasmodium ookinetes MALARIA JOURNAL. 2018.12; 17 (1): 466. ( PubMed, DOI )

  26. Aliprandini Eduardo, Tavares Joana, Panatieri Raquel Hoffmann, Thiberge Sabine, Yamamoto Marcio Massao, Silvie Olivier, Ishino Tomoko, Yuda Masao, Dartevelle Sylvie, Traincard Francois, Boscardin Silvia Beatriz, Amino Rogerio. Cytotoxic anti-circumsporozoite antibodies target malaria sporozoites in the host skin NATURE MICROBIOLOGY. 2018.11; 3 (11): 1224-1233. ( PubMed, DOI )

  27. Arredondo Silvia A., Swearingen Kristian E., Martinson Thomas, Steel Ryan, Dankwa Dorender A., Harupa Anke, Camargo Nelly, Betz William, Vigdorovich Vladimir, Oliver Brian G., Kangwanrangsan Niwat, Ishino Tomoko, Sather Noah, Mikolajczak Sebastian, Vaughan Ashley M., Torii Motomi, Moritz Robert L., Kappe Stefan H. I.. The Micronemal Plasmodium Proteins P36 and P52 Act in Concert to Establish the Replication-Permissive Compartment Within Infected Hepatocytes FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY. 2018.11; 8 413. ( PubMed, DOI )

  28. Tachibana Mayumi, Ishino Tomoko, Tsuboi Takafumi, Torii Motomi. The Plasmodium yoelii microgamete surface antigen (PyMiGS) induces anti-malarial transmission blocking immunity that reduces microgamete motility/release from activated male gametocytes VACCINE. 2018.11; 36 (49): 7463-7471. ( PubMed, DOI )

  29. Iriko Hideyuki, Ishino Tomoko, Otsuki Hitoshi, Ito Daisuke, Tachibana Mayumi, Torii Motomi, Tsuboi Takafumi. Plasmodium falciparum Exported Protein 1 is localized to dense granules in merozoites PARASITOLOGY INTERNATIONAL. 2018.10; 67 (5): 637-639. ( PubMed, DOI )

  30. Ishino Tomoko, Tsuboi Takafumi. Progress toward a transmission-blocking vaccine against malaria LANCET INFECTIOUS DISEASES. 2018.09; 18 (9): 927-928. ( PubMed, DOI )

  31. Miura Toyokazu, Takeo Satoru, Ntege Edward H., Otsuki Hitoshi, Sawasaki Tatsuya, Ishino Tomoko, Takashima Eizo, Tsuboi Takafumi. The malaria parasite RhopH protein complex interacts with erythrocyte calmyrin identified from a comprehensive erythrocyte protein library BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2018.06; 500 (2): 261-267. ( PubMed, DOI )

  32. Tachibana Mayumi, Ishino Tomoko, Takashima Eizo, Tsuboi Takafumi, Torii Motomi. A male gametocyte osmiophilic body and microgamete surface protein of the rodent malaria parasite Plasmodium yoelii (PyMiGS) plays a critical role in male osmiophilic body formation and exflagellation CELLULAR MICROBIOLOGY. 2018.05; 20 (5): e12821. ( PubMed, DOI )

  33. Sakamoto Hirokazu, Takeo Satoru, Takashima Eizo, Miura Kazutoyo, Kanoi Bernard N., Kaneko Takamasa, Han Eun-Taek, Tachibana Mayumi, Matsuoka Kazuhiro, Sattabongkot Jetsumon, Udomsangpetch Rachanee, Ishino Tomoko, Tsuboi Takafumi. Identification of target proteins of clinical immunity to Plasmodium falciparum in a region of low malaria transmission PARASITOLOGY INTERNATIONAL. 2018.04; 67 (2): 203-208. ( PubMed, DOI )

  34. Tachibana Mayumi, Torii Motomi, Tsuboi Takafumi, Ishino Tomoko. ANTIBODIES AGAINST PYMIGS, A NOVEL TRANSMISSION-BLOCKING VACCINE CANDIDATE, REDUCE THE MOTILITY OF MICROGAMETES AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE. 2018; 99 (4): 582.

  35. Arredondo Silvia, Swearingen Kristian, Martinson Thomas, Steel Ryan, Dankwa Dorender, Harupa Anke, Camargo Nelly, Vigdorovich Vladimir, Oliver Brian, Ishino Tomoko, Sather Noah, Mikolajczak Sebastian, Vaughan Ashley, Torii Motomi, Moritz Robert, Kappe Stefan. IT TAKES TWO TO TANGO: THE P52/P36 HEPATOCYTE INVASION COMPLEX AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE. 2018; 99 (4): 217.

  36. Matsuoka Kazuhiro, Thongkukiatkul Amporn, Tsuboi Takafumi, Torii Motomi, Ishino Tomoko. ROLE OF APICAL SUSHI PROTEIN IN SPOROZOITE INVASION OF SALIVARY GLANDS AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE. 2018; 99 (4): 217.

  37. Miura Kazutoyo, Deng Binging, Zhou Luwen, Ishino Tomoko, Tsuboi Takafumi, Long Carole A.. DEVELOPMENT OF PLASMODIUM FALCIPARUM EXFLAGELLATION ASSAY AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE. 2017.11; 95 (5): 123.

  38. Ntege Edward H., Takashima Eizo, Morita Masayuki, Nagaoka Hikaru, Ishino Tomoko, Tsuboi Takafumi. Blood-stage malaria vaccines: post-genome strategies for the identification of novel vaccine candidates EXPERT REVIEW OF VACCINES. 2017; 16 (8): 769-779. ( PubMed, DOI )

  39. Bantuchai Sirasate, Nozaki Mamoru, Thongkukiatkul Amporn, Lorsuwannarat Natcha, Tachibana Mayumi, Matsuoka Kazuhiro, Tsuboi Takafumi, Torii Motomi, Ishino Tomoko. FUNCTIONAL ANALYSIS OF A SPOROZOITE RHOPTRY PROTEIN DURING HEPATOCYTE INFECTION AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE. 2017; 97 (5): 20.

  40. Tachibana Mayumi, Torii Motomi, Tsuboi Takafumi, Ishino Tomoko. PYGM75, A PROTEIN IN OSMIOPHILIC BODIES, IS DISPENSABLE FOR EGRESS OF MALE GAMETOCYTES BUT IMPORTANT FOR EXFLAGELLATION OF MICROGAMETES AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE. 2017; 97 (5): 289.

  41. Ishino Tomoko, Sugino Yuka, Nozaki Mamoru, Tachibana Mayumi, Tsuboi Takafumi, Torii Motomi. A PLASMODIUM RHOPTRY PROTEIN IS INVOLVED IN SPOROZOITE INVASION OF HEPATOCYTES AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE. 2015.10; 93 (4): 397.

  42. Bantuchai Sirasate, Nozaki Mamoru, Tsuboi Takafumi, Torii Motomi, Ishino Tomoko. ONE OF THE PLASMODIUM RHOPTRY PROTEINS IS ESSENTIAL FOR MALARIA SPOROZOITE GLIDING MOTILITY, WHICH IS REQUIRED FOR MOSQUITO SALIVARY GLAND INVASION MACHINERY AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE. 2015.10; 93 (4): 59.

  43. Lorsuwannarat Natcha, Shinzawa Naoaki, Tachibana Mayumi, Katsube Riko, Tsuboi Takafumi, Torii Motomi, Ishino Tomoko. THE FUNCTIONAL ANALYSES OF A PLASMODIUM ALVEOLIN PROTEIN DURING MOSQUITO STAGE PARASITE DEVELOPMENT AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE. 2015.10; 93 (4): 60.

  44. Tachibana Mayumi, Torii Motomi, Sudo Moe, Tsuboi Takafumi, Ishino Tomoko. SCREENING FOR HIGHLY IMMUNOGENIC REGION OF PYGM75, A NOVEL TRANSMISSION-BLOCKING VACCINE CANDIDATE AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE. 2015.10; 93 (4): 301-302.

  45. Itani Satoko, Torii Motomi, Ishino Tomoko. D-Glucose concentration is the key factor facilitating liver stage maturation of Plasmodium PARASITOLOGY INTERNATIONAL. 2014.08; 63 (4): 584-590. ( PubMed, DOI )

  46. Zhao H, Aoshi T, Kawai S, Mori Y, Konishi A, Ozkan M, Fujita Y, Haseda Y, Shimizu M, Kohyama M, Kobiyama K, Eto K, Nabekura J, Horii T, Ishino T, Yuda M, Hemmi H, Kaisho T, Akira S, Kinoshita M, Tohyama K, Yoshioka Y, Ishii KJ, Coban C. Olfactory plays a key role in spatiotemporal pathogenesis of cerebral malaria. Cell host & microbe. 2014.05; 15 (5): 551-63. ( PubMed, DOI )

  47. Arumugam Thangavelu U., Ito Daisuke, Takashima Eizo, Tachibana Mayumi, Ishino Tomoko, Torii Motomi, Tsuboi Takafumi. Application of wheat germ cell-free protein expression system for novel malaria vaccine candidate discovery EXPERT REVIEW OF VACCINES. 2014.01; 13 (1): 75-85. ( PubMed, DOI )

  48. Shinzawa Naoaki, Ishino Tomoko, Tachibana Mayumi, Tsuboi Takafumi, Torii Motomi. Phenotypic Dissection of a Plasmodium-Refractory Strain of Malaria Vector Anopheles stephensi: The Reduced Susceptibility to P. berghei and P. yoelii PLOS ONE. 2013.05; 8 (5): e63753. ( PubMed, DOI )

  49. Kangwanrangsan Niwat, Tachibana Mayumi, Jenwithisuk Rachaneeporn, Tsuboi Takafumi, Riengrojpitak Suda, Torii Motomi, Ishino Tomoko. A member of the CPW-WPC protein family is expressed in and localized to the surface of developing ookinetes MALARIA JOURNAL. 2013.04; 12 129. ( PubMed, DOI )

  50. Orito Y, Ishino T, Iwanaga S, Kaneko I, Kato T, Menard R, Chinzei Y, Yuda M. Liver-specific protein 2: a Plasmodium protein exported to the hepatocyte cytoplasm and required for merozoite formation. Molecular microbiology. 2013.01; 87 (1): 66-79. ( PubMed, DOI )

  51. Gueirard P, Tavares J, Thiberge S, Bernex F, Ishino T, Milon G, Franke-Fayard B, Janse CJ, Ménard R, Amino R. Development of the malaria parasite in the skin of the mammalian host. Proceedings of the National Academy of Sciences of the United States of America. 2010.10; 107 (43): 18640-5. ( PubMed, DOI )

  52. Ishino Tomoko, Boisson Bertrand, Orito Yuki, Lacroix Celine, Bischoff Emmanuel, Loussert Celine, Janse Chris, Menard Robert, Yuda Masao, Baldacci Patricia. LISP1 IS IMPORTANT FOR THE EGRESS OF PLASMODIUM PARASITES FROM LIVER CELLS AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE. 2009.11; 81 (5): 267.

  53. Ishino T, Boisson B, Orito Y, Lacroix C, Bischoff E, Loussert C, Janse C, Ménard R, Yuda M, Baldacci P. LISP1 is important for the egress of Plasmodium berghei parasites from liver cells. Cellular microbiology. 2009.09; 11 (9): 1329-39. ( PubMed, DOI )

  54. Amino R, Giovannini D, Thiberge S, Gueirard P, Boisson B, Dubremetz JF, Prévost MC, Ishino T, Yuda M, Ménard R. Host cell traversal is important for progression of the malaria parasite through the dermis to the liver. Cell host & microbe. 2008.02; 3 (2): 88-96. ( PubMed, DOI )

  55. Ishino T, Kunieda T, Natori S, Sekimizu K, Kubo T. Identification of novel members of the Xenopus Ca2+ -dependent lectin family and analysis of their gene expression during tail regeneration and development. Journal of biochemistry. 2007.04; 141 (4): 479-88. ( PubMed, DOI )

  56. Kariu T, Ishino T, Yano K, Chinzei Y, Yuda M. CelTOS, a novel malarial protein that mediates transmission to mosquito and vertebrate hosts. Molecular microbiology. 2006.03; 59 (5): 1369-79. ( PubMed, DOI )

  57. Ishino T, Orito Y, Chinzei Y, Yuda M. A calcium-dependent protein kinase regulates Plasmodium ookinete access to the midgut epithelial cell. Molecular microbiology. 2006.02; 59 (4): 1175-84. ( PubMed, DOI )

  58. Ishino T, Chinzei Y, Yuda M. Two proteins with 6-cys motifs are required for malarial parasites to commit to infection of the hepatocyte. Molecular microbiology. 2005.12; 58 (5): 1264-75. ( PubMed, DOI )

  59. Ishino T, Chinzei Y, Yuda M. A Plasmodium sporozoite protein with a membrane attack complex domain is required for breaching the liver sinusoidal cell layer prior to hepatocyte infection. Cellular microbiology. 2005.02; 7 (2): 199-208. ( PubMed, DOI )

  60. Yuda M, Ishino T. Liver invasion by malarial parasites--how do malarial parasites break through the host barrier? Cellular microbiology. 2004.12; 6 (12): 1119-25. ( PubMed, DOI )

  61. Kadota K, Ishino T, Matsuyama T, Chinzei Y, Yuda M. Essential role of membrane-attack protein in malarial transmission to mosquito host. Proceedings of the National Academy of Sciences of the United States of America. 2004.11; 101 (46): 16310-5. ( PubMed, DOI )

  62. Ishino T, Yano K, Chinzei Y, Yuda M. Cell-passage activity is required for the malarial parasite to cross the liver sinusoidal cell layer. PLoS biology. 2004.01; 2 (1): E4. ( PubMed, DOI )

  63. Ishino T, Shirai M, Kunieda T, Sekimizu K, Natori S, Kubo T. Identification of genes induced in regenerating Xenopus tadpole tails by using the differential display method. Developmental dynamics : an official publication of the American Association of Anatomists. 2003.02; 226 (2): 317-25. ( PubMed, DOI )

  64. T Ishino, S Ohtsuki, K Homma, S Natori. cDNA cloning of mouse prolyl endopeptidase and its involvement in DNA synthesis by Swiss 3T3 cells JOURNAL OF BIOCHEMISTRY. 1998.03; 123 (3): 540-545. ( PubMed, DOI )

  65. 馬場 みなみ, 野崎 守, 橘 真由美, 鳥居 本美, 石野 智子. マラリア原虫スポロゾイトの肝臓感染におけるRON4作用機序の解析 日本獣医学会学術集会講演要旨集. 2020.10; 163回 205. ( 医中誌 )

  66. Bantuchai Sirasate, 野崎 守, Thongkukiatkul Amporn, Lorsuwannarat Natcha, 橘 真由美, 松岡 和弘, 坪井 敬文, 鳥居 本美, 石野 智子. マラリア原虫スポロゾイトの唾液腺および肝細胞侵入に関与する膜タンパク質RON11の同定 日本生化学会大会プログラム・講演要旨集. 2019.09; 92回 [1T16a-05]. ( 医中誌 )

  67. 馬場 みなみ, 野崎 守, 鳥居 本美, 石野 智子. マラリア原虫スポロゾイトの肝臓感染におけるRON4の役割の解析 日本獣医学会学術集会講演要旨集. 2019.08; 162回 361. ( 医中誌 )

  68. 石野 智子, 橘 真由美, 高島 英造, 坪井 敬文, 鳥居 本美. マラリア原虫の媒介蚊体内における受精・発育の分子基盤 衛生動物. 2018.09; 69 (3): 153-154. ( 医中誌 )

  69. 石野 智子, 橘 真由美, 鳥居 本美. 蚊とマダニ 病原体とベクターの生物学 マラリア原虫の媒介蚊体内における受精・発育の分子基盤 衛生動物. 2018.03; 69 (Suppl.): 37. ( 医中誌 )

  70. 石野 智子, 鳥居 本美. マラリア原虫スポロゾイトの感染性の違いは、肝臓感染のどのステップで生じるのか 生命科学系学会合同年次大会. 2017.12; 2017年度 [2P-0971]. ( 医中誌 )

  71. 入子 英幸, 見村 琴美, 大槻 均, 橘 真由美, 石野 智子, 鳥居 本美, 坪井 敬文. 熱帯熱マラリア原虫・生殖母体期のヘモグロビン輸送における寄生胞膜動態の形態学的アプローチ 生命科学系学会合同年次大会. 2017.12; 2017年度 [4AT05-08(3P. ( 医中誌 )

▼全件表示

講演・口頭発表等 【 表示 / 非表示

  1. Tomoko Ishino. Molecular mechanisms of sporozoite transmission to mammals, the target of the first malara vaccine. 難病のプロテオ医学研究2021 The Genetics, Biology and Epidemiology of Diseases of Poverty 2021.12.11 東温市、愛媛県

  2. Tachibana M, Torii M, Baba M, Tsuboi T, Ishino T. Functional analysis of PyMiGS during the sexual stage based on the structure. Molecular Approaches to Malaria 2020 2020.02.23 Lorne Australia

  3. Baba M, Nozaki M, Torii M, Ishino T. RON4 is involved in sporozoite motility and liver invasion. Molecular Approaches to Malaria 2020 2020.02.23 Lorne Australia

  4. Ishino T, Nozaki M, Baba M, Tachibana M, Tsuboi T, Torii M. Detection of rhoptry neck protein complex in Plasmodium sporozoites and its contribution on sporozoite invasion of salivary glands.. Molecular Approaches to Malaria 2020 2020.02.23 Lorne Australia

  5. 石野智子. Role of Apical Sushi Protein in malaria sporozoite invasion of salivary glands. ASTMH 2018.10.28

  6. 石野智子. Involvement of Plasmodium rhoptry proteins in sporozoite invasion of mammalian hepatocytes. PIM 2018 2018.09.12

  7. 石野智子. Involvement of Plasmodium rhoptry proteins in sporozoite invasion of mammalian hepatocytes. ICOPA 2018 2018.08.19

  8. 石野智子. Identification of a male specific protein involved in exflagellation. Johns Hopkins Malaria Research Institute, malaria Friday seminar 2017.11.10

  9. Sirasate Bantuchai, Mamoru Nozaki, Amporn Thongkukiatkul, Natcha Lorsuwannarat, Mayumi Tachibana, Kazuhiro Matsuoka, Takafumi Tsuboi, Motomi Torii, Tomoko Ishino. Functional analysis of a sporozoite rhoptry protein hepatocyte infection. 66th Annual meeting of American Society of Tropical Medicine & Hygene 2017 Baltimore,Maryland USA

  10. Mayumi Tachibana, Motomi Torii, Takafumi Tsuboi, Tomoko Ishino. PyGM75, a protein in osmiophilic bodies, is dispensable for egress of male gametocytes but important for exflagellation of microgametes. 66th Annual meeting of American Society of Tropical Medicine & Hygene 2017 Baltimore,Maryland USA

  11. Mayumi Tachibana, Motomi Torii, Moe Sudo, Takafumi Tsuboi, Tomoko Ishino. C-terminus region of male gamete surface protein, PyGM75 induce malaria transmission-blocking antibody. Molecular approaches to Malaria 2016 2016 Lorne,Victoria,Australia

  12. Tomoko Ishino, Yuka Sugino, Mamoru Nozaki, Eri Murata, Naohito Tokunaga, Mayumi Tachibana, Takafumi Tsuboi, Motomi Torii. Rhoptry proteins have important roles during sporozoite invasion of mosquito salivary glands or mammalian hepatocytes. Molecular approaches to Malaria 2016 2016 Lorne,Victoria,Australia

  13. Tomoko Ishino. Functional analyses of sporozoite rhoptry proteins of Plasmodium berghei during target cell invasion. 2nd International Symposium "matryoshika-type Evolution" 2015 Tsukuba、Japan

  14. Natcha Lorsuwannarat, Naoaki Shinzawa, Mayumi Tachibana, Riko Katsube, Takafumi Tsuboi, Motomi Torii, Tomoko Ishino. The functional analysis of a Plasmodium alveolin protein during mosquito stage parasite development. 64th Annual Meeting of American Society of Tropical Medicine and Hygiene 2015 Philadelphia,USA

  15. Sirasate Bantuchai, Mamoru Nozaki, Takafumi Tsuboi, Motomi Torii, Tomoko Ishino. One of the Plasmodium rhoptry protein is essential for malaria sporozoite gliding motility, which is required for mosquito salivary gland invasion machinery. 64th Annual Meeting of American Society of Tropical Medicine and Hygiene 2015 Philadelphia,USA

  16. Mayumi Tachibana, Motomi Torii, Moe Sudo, Takafumi Tsuboi, Tomoko Ishino. Screening for highly immunogenic region of PyGM75, a novel transmission-blocking vaccine candidate. 64th Annual Meeting of American Society of Tropical Medicine and Hygiene 2015 Philadelphia,USA

  17. Tomoko Ishino, Yuka Sugino, Mamoru Nozaki, Mayumi Tachibana, Takafumi Tsuboi, Motomi Torii. A Plasmodium rhoptry protein is involved in sporozoite invasion of hepatocyte. 64th Annual Meeting of American Society of Tropical Medicine and Hygiene 2015 Philadelphia,USA

  18. Tachibana M, Torii M, Sudo M, Tsuboi T, Ishino T. Identification of the novel transmission-blocking vaccine target expressing on the surface of male gametes. 63rd Annual Meeting of American Society of Tropical Medicine and Hygiene 2014 New Orleans, USA

  19. Nozaki M, Ishino T, Tokunaga N, Tsuboi T, Torii M. Rhoptry proteins are involved in sporozoite invasion of the salivary gland. 63rd Annual Meeting of American Society of Tropical Medicine and Hygiene 2014 New Orleans, USA

  20. 石野智子. 蚊を介したマラリア原虫伝搬の分子機構の解明に向けて. 女性研究者の視点による感染症予防への取組 2021.11.16 オンライン

  21. 石野智子. スポロゾイトにおけるロプトリータンパク質群の網羅的機能解析. 第26回分子寄生虫学ワークショップ/ 第16回分子寄生虫・マラリア研究フォーラム合同大会 2018.09.19

  22. 石野智子. マラリア原虫の媒介蚊体内における受精・発育の分子基盤. 衛生動物学会 2018.05.11

  23. 石野智子. スポロゾイトの肝細胞侵入におけるP36/P36p蛋白質の機能解析. 第87回 日本寄生虫学会 2018.03.17

  24. 入子英幸, 橘真由美, 石野智子, 鳥居本美, 大槻均, 坪井敬文. ETRAMP4は熱帯熱マラリア原虫の生殖母体期に発現する寄生胞膜分子である. 第87回日本寄生虫学会大会 2018 東京

  25. 石野智子, 原岡優子, 鳥居本美. スポロゾイトの肝細胞侵入における P36/P36p蛋白質の機能解析. 第87回日本寄生虫学会大会 2018 東京

  26. 橘真由美, 鳥居本美, 坪井敬文, 石野智子. 新規伝搬阻止ワクチン候補PyGiMGS抗体は、ミクロガメートの動きを止める. 第87回日本寄生虫学会大会 2018 東京

  27. 橘真由美, 鳥居本美, 須藤萌, 坪井敬文, 石野智子. 雄特異的osmiophilic bodyタンパク質PyGM75の生殖体・接合体形成過程における役割の解析. 第86回日本寄生虫学会大会 2017 札幌市

  28. Sirasate Bantuchai, 野崎守、Amporn Thongkukiatkul, Natcha Lorsuwannarat, 橘真由美, 松岡和弘, 坪井敬文, 鳥居本美, 石野智子. マラリア原虫スポロゾイトの唾液腺および肝細胞侵入に関与する新規膜タンパク質の同定. 第86回日本寄生虫学会大会 2017 札幌市

  29. 三浦憲豊, Deng Bingbing, Zhou Luwen, 石野智子, 坪井敬文, Long Carole. Development of Plasmodium falciparum exflagellation assay. 第85回日本寄生虫学会大会 2016 宮崎市

  30. 入子英幸, 大槻均, 橘真由美, 石野智子, 鳥居本美, 坪井敬文, 福本宗嗣. ETRAMPファミリーは赤血球期マラリア原虫における膜輸送の指標となる. 第85回日本寄生虫学会大会 2016 宮崎市

  31. 松岡和弘, 野崎守, 徳永順士, 橘真由美, 坪井敬文, 鳥居本美, 石野智子. マラリア原虫スポロゾイトの唾液腺侵入におけるApical susi protein (ASP)の機能解析. 第85回日本寄生虫学会大会 2016 宮崎市

  32. 大槻均, 菅井千明, 近藤陽子, 入子英幸, 石野智子, 金子修, 坪井敬文, 鳥居本美. ネズミマラリア原虫赤血球侵入リガンドEBL領域4の機能解析. 第85回日本寄生虫学会大会 2016 宮崎市

  33. 大槻均, 菅井千明, 入子英幸, 石野智子, 金子修, 福本宗嗣, 坪井敬文, 鳥居本美. ネズミマラリア原虫赤血球侵入リガンドEBL 領域3-5の機能解析. 第84回日本寄生虫学会大会 2015 東京都三鷹市

  34. 石野智子, 杉野友香, 鳥居本美. ほ乳類への感染におけるRhoptry neck protein 2の役割の解析. 第84回日本寄生虫学会大会 2015 東京都三鷹市

  35. 野崎守, 徳永順士, 坪井敬文, 石野智子, 鳥居本美. ネズミマラリア原虫のRhoptry-associated membrane antigen(RAMA)はスポロゾイトのロプトリーにおいてRON 複合体の蓄積に必要である. 第84回日本寄生虫学会大会 2015 東京都三鷹市

  36. 橘真由美, 鳥居本美, 須藤萌, 坪井敬文, 石野智子. 雄性生殖体表面に局在するPyGM75は受精に重要である. 第84回日本寄生虫学会大会 2015 東京都三鷹市

  37. 入子英幸, 石野智子, 橘真由美, 鳥居本美, 坪井敬文, 大槻均, 福本宗嗣. 生殖母体期マラリア原虫のヘモグロビン輸送機構の解析. 第84回日本寄生虫学会大会 2015 東京都三鷹市

  38. 勝部璃子, 新澤直明, 橘真由美, 坪井敬文, 石野智子, 鳥居本美. マラリア原虫の侵入ステージに共通してみられるALVEOLIN2のオーキネート形成における役割の解析. 第83回日本寄生虫学会大会 2014 松山市

  39. 杉野友香, 徳永順士, 坪井敬文, 石野智子, 鳥居本美. マラリア原虫ロプトリータンパク質RON3はスポロゾイトの肝細胞寄生において重要である. 第83回日本寄生虫学会大会 2014 松山市

  40. 野崎守, 徳永順士, 坪井敬文, 石野智子, 鳥居本美. スポロゾイトによる蚊の唾液腺侵入においてRON複合体が機能する. 第83回日本寄生虫学会大会 2014 松山市

  41. 大槻均, 入子英幸, 石野智子, 金子修, 福本宗嗣, 坪井敬文, 鳥居本美. ネズミマラリア原虫赤血球侵入リガンドEBL領域3-5の機能解析. 第83回日本寄生虫学会大会 2014 松山市

  42. 入子英幸, 大槻均, 橘真由美, 石野智子, 鳥居本美, 坪井敬文, 福本宗嗣. マラリア原虫のヘモグロビン輸送における寄生胞膜の動態. 第83回日本寄生虫学会大会 2014 松山市

▼全件表示

受賞学術賞 【 表示 / 非表示

  • 奨励賞,日本寄生虫学会,2007年03月

 

担当授業科目(学内) 【 表示 / 非表示

  • 環境社会医歯学,2022年 - 現在

  • 病原体検査学実習,2021年 - 現在

  • 医動物学実習,2021年 - 現在

  • 疾患予防パブリックヘルス医学概論,2021年 - 現在

  • 医動物学講義,2021年 - 現在

担当授業科目(学外) 【 表示 / 非表示

  • 生命環境科学特別講義,東京大学