Personnel Information

写真a

ISHINO Tomoko


Job title

Professor

Research Areas, Keywords

Parasitology, Malaria, Infection mechanism, Sporozoite, Fertilization

Field Introduction URL

https://sites.google.com/view/tmdu-parasitology/

Graduating School 【 display / non-display

  • The University of Tokyo, Faculty of Pharmaceutical Science, 1996.03, Graduated

Graduate School 【 display / non-display

  • The University of Tokyo, Graduate School, Division of Pharmaceutical Sciences, Master's Course, 1998.03, Completed

  • The University of Tokyo, Graduate School, Division of Pharmaceutical Sciences, Doctor's Course, 2001.03, Completed

Campus Career 【 display / non-display

  • 2021.08
    -
    2021.11
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Public Health, Environmental Parasitology, Professor
  • 2021.12
    -
    Now
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Division of Public Health, Department of Parasitology & Tropical Medicine, Professor

External Career 【 display / non-display

  • 2001.04
    -
    2005.03
    Mie University, Project Researcher
  • 2005.04
    -
    2006.06
    Mie University, Assistant Professor
  • 2006.07
    -
    2009.02
    Institut Pasteur, Project Researcher
  • 2009.03
    -
    2021.07
    Ehime Univerisity, Associate Professor
  • 2013.04
    -
    2021.07
    Ehime Univerisity, Associate Professor
  • 2022
    -
    Now
    , Visiting Lecturer
  • 2022.04
    -
    Now
    , Visiting Lecturer
  • 2022.04
    -
    Now
    , Visiting Lecturer
  • 2023
    -
    Now
    , Visiting Lecturer

▼display all

Research Areas 【 display / non-display

  • Parasitology

Qualification Acquired 【 display / non-display

  • High School Teacher Specialization License (first and second kind,specialization)

  • Pharmacist

 

Research Theme 【 display / non-display

  • Elucidation of molecular mechanisms of fertilization of malaria parasites

  • Investigation of infection mechanisms of Plasmodium sporozoites

Published Papers & Misc 【 display / non-display

  1. Omoda A, Matsumoto K, Yoshino KI, Tachibana M, Tsuboi T, Torii M, Ishino T, Iriko H. Skeleton binding protein 1 localizes to the Maurer's cleft and interacts with PfHSP70-1 and PfHSP70-x in Plasmodium falciparum gametocyte-infected erythrocytes. Parasitology international. 2024.02; 100 102864. ( PubMed, DOI )

  2. Kunkeaw, N; Nguitragool, W; Takashima, E; Kangwanrangsan, N; Muramatsu, H; Tachibana, M; Ishino, T; Lin, PJC; Tam, YK; Pichyangkul, S; Tsuboi, T; Pardi, N; Sattabongkot, J. A Pvs25 mRNA vaccine induces complete and durable transmission-blocking immunity to <i>Plasmodium vivax</i> NPJ VACCINES. 2023.12; 8 (1): 187. ( PubMed, DOI )

  3. Thongpoon, S; Roobsoong, W; Nguitragool, W; Chotirat, S; Tsuboi, T; Takashima, E; Cui, LW; Ishino, T; Tachibana, M; Miura, K; Sattabongkot, J. Naturally Acquired Transmission-Blocking Immunity Against Different Strains of Plasmodium vivax in a Malaria-Endemic Area in Thailand JOURNAL OF INFECTIOUS DISEASES. 2023.11; 229 (2): 567-575. ( PubMed, DOI )

  4. Ladzekpo Danielle, Kwofie Kofi Dadzie, Kawada Hayato, Mikami Fusako, Tsuji Naotoshi, Iwanaga Shiroh, Dadzie Samuel Kweku, Hatta Takeshi, Ishino Tomoko. A possible circulation of a dominant Dibothriocephalus nihonkaiensis haplotype in Japan revealed by molecular analysis of clinical tapeworm samples Parasitology International. 2023.10; 96 1-9. ( ichushi )

  5. Baba M, Nozaki M, Tachibana M, Tsuboi T, Torii M, Ishino T. Rhoptry neck protein 4 plays important roles during Plasmodium sporozoite infection of the mammalian liver. mSphere. 2023.06; 8 (4): e0058722. ( PubMed, DOI )

  6. Otsuki H, Kaneko O, Ito D, Kondo Y, Iriko H, Ishino T, Tachibana M, Tsuboi T, Torii M. Cysteine Residues in Region 6 of the Plasmodium yoelii Erythrocyte-Binding-like Ligand That Are Related to Its Localization and the Course of Infection. Biomolecules. 2023.03; 13 (3): ( PubMed, DOI )

  7. Azerigyik FA, Faizah AN, Kobayashi D, Amoa-Bosompem M, Matsumura R, Kai I, Sasaki T, Higa Y, Isawa H, Iwanaga S, Ishino T. Evaluating the mosquito host range of Getah virus and the vector competence of selected medically important mosquitoes in Getah virus transmission. Parasites & vectors. 2023.03; 16 (1): 99. ( PubMed, DOI )

  8. Mahazu S, Prah I, Ota Y, Hayashi T, Nukui Y, Suzuki M, Hoshino Y, Akeda Y, Suzuki T, Ishino T, Ablordey A, Saito R. Klebsiella Species and Enterobacter cloacae Isolates Harboring bla(OXA-181) and bla(OXA-48): Resistome, Fitness Cost, and Plasmid Stability. Microbiology spectrum. 2022.12; 10 (6): e0332022. ( PubMed, DOI )

  9. Huang Wei-Chiao, Mabrouk Moustafa T., Zhou Luwen, Baba Minami, Tachibana Mayumi, Torii Motomi, Takashima Eizo, Locke Emily, Plieskatt Jordan, King C. Richter, Coelho Camila H., Duffy Patrick E., Long Carole, Tsuboi Takafumi, Miura Kazutoyo, Wu Yimin, Ishino Tomoko, Lovell Jonathan F.. Vaccine co-display of CSP and Pfs230 on liposomes targeting two Plasmodium falciparum differentiation stages COMMUNICATIONS BIOLOGY. 2022.08; 5 (1): 773. ( PubMed, DOI )

  10. Tachibana Mayumi, Takashima Eizo, Morita Masayuki, Sattabongkot Jetsumon, Ishino Tomoko, Culleton Richard, Torii Motomi, Tsuboi Takafumi. Plasmodium vivax transmission-blocking vaccines: Progress, challenges and innovation(和訳中) Parasitology International. 2022.04; 87 1-9. ( ichushi )

  11. Miura K, Takashima E, Pham TP, Deng B, Zhou L, Huang WC, Diouf A, Gebremicale YT, Tachibana M, Ishino T, Richter King C, Lovell JF, Long CA, Tsuboi T. Elucidating functional epitopes within the N-terminal region of malaria transmission blocking vaccine antigen Pfs230. NPJ vaccines. 2022.01; 7 (1): 4. ( PubMed, DOI )

  12. Cha SJ, Yu X, Gregory BD, Lee YS, Ishino T, Opoka RO, John CC, Jacobs-Lorena M. Identification of Key Determinants of Cerebral Malaria Development and Inhibition Pathways. mBio. 2022.01; 13 (1): e0370821. ( PubMed, DOI )

  13. Kubota R, Ishino T, Iwanaga S, Shinzawa N. Evaluation of the Effect of Gene Duplication by Genome Editing on Drug Resistance in <i>Plasmodium falciparum</i>. Frontiers in cellular and infection microbiology. 2022; 12 915656. ( PubMed, DOI )

  14. Tachibana M, Takashima E, Morita M, Sattabongkot J, Ishino T, Culleton R, Torii M, Tsuboi T. Plasmodium vivax transmission-blocking vaccines: Progress, challenges and innovation. Parasitology international. 2021.12; 87 102525. ( PubMed, DOI )

  15. Tachibana Mayumi, Iriko Hideyuki, Baba Minami, Torii Motomi, Ishino Tomoko. PSOP1(Putative Secreted Ookinete Protein 1)はネズミマラリア原虫Plasmodium yoeliiとP.bergheiオーキネートのマイクロネームに局在化する(PSOP1, putative secreted ookinete protein 1, is localized to the micronemes of Plasmodium yoelii and P. berghei ookinetes) Parasitology International. 2021.10; 84 1-4. ( ichushi )

  16. Tachibana M, Iriko H, Baba M, Torii M, Ishino T. PSOP1, putative secreted ookinete protein 1, is localized to the micronemes of Plasmodium yoelii and P. berghei ookinetes. Parasitology international. 2021.06; 84 102407. ( PubMed, DOI )

  17. Ishizaki Takahiro, Chaiyawong Nattawat, Hakimi Hassan, Asada Masahito, Tachibana Mayumi, Ishino Tomoko, Yahata Kazuhide, Kaneko Osamu. A novel Plasmodium yoelii pseudokinase, PypPK1, is involved in erythrocyte invasion and exflagellation center formation PARASITOLOGY INTERNATIONAL. 2020.06; 76 102056. ( PubMed, DOI )

  18. Iriko Hideyuki, Ishino Tomoko, Tachibana Mayumi, Omoda Ayaka, Torii Motomi, Tsuboi Takafumi. Skeleton binding protein 1 (SBP1) of Plasmodium falciparum accumulates in electron-dense material before passing through the parasitophorous vacuole membrane PARASITOLOGY INTERNATIONAL. 2020.04; 75 102003. ( PubMed, DOI )

  19. Ishino Tomoko, Tachibana Mayumi, Baba Minami, Iriko Hideyuki, Tsuboi Takafumi, Torii Motomi. Observation of morphological changes of female osmiophilic bodies prior to Plasmodium gametocyte egress from erythrocytes MOLECULAR AND BIOCHEMICAL PARASITOLOGY. 2020.03; 236 111261. ( PubMed, DOI )

  20. Tachibana Mayumi, Baba Minami, Takashima Eizo, Tsuboi Takafumi, Torii Motomi, Ishino Tomoko. The C-terminal region of the Plasmodium yoelii microgamete surface antigen PyMiGS induces potent anti-malarial transmission-blocking immunity in mice VACCINE. 2020.03; 38 (15): 3129-3136. ( PubMed, DOI )

  21. Nozaki Mamoru, Baba Minami, Tachibana Mayumi, Tokunaga Naohito, Torii Motomi, Ishino Tomoko. Detection of the Rhoptry Neck Protein Complex in Plasmodium Sporozoites and Its Contribution to Sporozoite Invasion of Salivary Glands MSPHERE. 2020; 5 (4): ( PubMed, DOI )

  22. Miura Kazutoyo, Tachibana Mayumi, Takashima Eizo, Morita Masayuki, Kanoi Bernard N., Nagaoka Hikaru, Baba Minami, Torii Motomi, Ishino Tomoko, Tsuboi Takafumi. Malaria transmission-blocking vaccines: wheat germ cell-free technology can accelerate vaccine development EXPERT REVIEW OF VACCINES. 2019.10; 18 (10): 1017-1027. ( PubMed, DOI )

  23. Tokunaga Naohito, Nozaki Mamoru, Tachibana Mayumi, Baba Minami, Matsuoka Kazuhiro, Tsuboi Takafumi, Torii Motomi, Ishino Tomoko. Expression and Localization Profiles of Rhoptry Proteins in Plasmodium berghei Sporozoites FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY. 2019.09; 9 316. ( PubMed, DOI )

  24. Bantuchai Sirasate, Nozaki Mamoru, Thongkukiatkul Amporn, Lorsuwannarat Natcha, Tachibana Mayumi, Baba Minami, Matsuoka Kazuhiro, Tsuboi Takafumi, Torii Motomi, Ishino Tomoko. Rhoptry neck protein 11 has crucial roles during malaria parasite sporozoite invasion of salivary glands and hepatocytes INTERNATIONAL JOURNAL FOR PARASITOLOGY. 2019.08; 49 (9): 725-735. ( PubMed, DOI )

  25. Gupta Devendra Kumar, Dembele Laurent, Voorberg-van der Wel Annemarie, Roma Guglielmo, Yip Andy, Chuenchob Vorada, Kangwanrangsan Niwat, Ishino Tomoko, Vaughan Ashley M., Kappe Stefan H., Flannery Erika L., Sattabongkot Jetsumon, Mikolajczak Sebastian, Bifani Pablo, Kocken Clemens H. M., Diagana Thierry Tidiane. The Plasmodium liver-specific protein 2 (LISP2) is an early marker of liver stage development ELIFE. 2019.05; 8 ( PubMed, DOI )

  26. Tohmoto Tatsuhiro, Takashima Eizo, Takeo Satoru, Morita Masayuki, Nagaoka Hikaru, Udomsangpetch Rachanee, Sattabongkot Jetsumon, Ishino Tomoko, Torii Motomi, Tsuboi Takafumi. Anti-MSP11 IgG inhibits Plasmodium falciparum merozoite invasion into erythrocytes in vitro PARASITOLOGY INTERNATIONAL. 2019.04; 69 25-29. ( PubMed, DOI )

  27. Nagaoka Hikaru, Sasaoka Chisa, Yuguchi Takaaki, Kanoi Bernard N., Ito Daisuke, Morita Masayuki, Udomsangpetch Rachanee, Sattabongkot Jetsumon, Ishino Tomoko, Tsuboi Takafumi, Takashima Eizo. PfMSA180 is a novel Plasmodium falciparum vaccine antigen that interacts with human erythrocyte integrin associated protein (CD47) SCIENTIFIC REPORTS. 2019.04; 9 (1): 5923. ( PubMed, DOI )

  28. Tachibana Mayumi, Miura Kazutoyo, Takashima Eizo, Morita Masayuki, Nagaoka Hikaru, Zhou Luwen, Long Carole A., King C. Richter, Torii Motomi, Tsuboi Takafumi, Ishino Tomoko. Identification of domains within Pfs230 that elicit transmission blocking antibody responses VACCINE. 2019.03; 37 (13): 1799-1806. ( PubMed, DOI )

  29. Ito Daisuke, Takashima Eizo, Yamasaki Tsutomu, Hatano Shinya, Hasegawa Tomoyuki, Miura Kazutoyo, Morita Masayuki, Thongkukiatkul Amporn, Diakite Mahamadou, Long Carole A., Sattabongkot Jetsumon, Udomsangpetch Rachanee, Iriko Hideyuki, Ishino Tomoko, Tsuboi Takafumi. Antibodies against a Plasmodium falciparum RON12 inhibit merozoite invasion into erythrocytes PARASITOLOGY INTERNATIONAL. 2019.02; 68 (1): 87-91. ( PubMed, DOI )

  30. Oda-Yokouchi Yuki, Tachibana Mayumi, Iriko Hideyuki, Torii Motomi, Ishino Tomoko, Tsuboi Takafumi. Plasmodium RON12 localizes to the rhoptry body in sporozoites PARASITOLOGY INTERNATIONAL. 2019.02; 68 (1): 17-23. ( PubMed, DOI )

  31. Ishino Tomoko, Murata Eri, Tokunaga Naohito, Baba Minami, Tachibana Mayumi, Thongkukiatkul Amporn, Tsuboi Takafumi, Torii Motomi. Rhoptry neck protein 2 expressed in Plasmodium sporozoites plays a crucial role during invasion of mosquito salivary glands CELLULAR MICROBIOLOGY. 2019.01; 21 (1): e12964. ( PubMed, DOI )

  32. Miura Kazutoyo, Tachibana Mayumi, Takashima Eizo, Morita Masayuki, Nagaoka Hikaru, Phama Thao P., Long Carole A., King C. Richter, Torii Motomi, Ishino Tomoko, Tsuboi Takafumi. CYSTEINE MOTIF 1 DOMAIN IN PFS230 MOLECULE IS CRUCIAL TO MAINTAIN THE CORRECT CONFORMATION OF PFS230-BASED TRANSMISSION-BLOCKING VACCINES AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE. 2019; 101 133.

  33. Ishino Tomoko, Tokunaga Naohito, Nozaki Mamoru, Tsuboi Takafumi, Torii Motomi. EXPRESSION AND LOCALIZATION PROFILES OF RHOPTRY PROTEINS IN PLASMODIUM BERGHEI SPOROZOITES AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE. 2019; 101 269.

  34. Baba Minami, Nozaki Mamoru, Tachibana Mayumi, Torii Motomi, Tsuboi Takafumi, Ishino Tomoko. THE ROLE OF RON4 IN PLASMODIUM SPOROZOITE INFECTION OF THE LIVER AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE. 2019; 101 469.

  35. Tachibana Mayumi, Miura Kazutoyo, Takahima Eizo, Morita Masayuki, Nagaoka Hikaru, Zhou Luwen, Long Carole A., King C. Richter, Torii Motomi, Tsuboi Takafumi, Ishino Tomoko. SCREENING FOR CANDIDATE DOMAINS WITHIN PFS230 THAT ELICIT TRANSMISSION-BLOCKING ANTIBODY RESPONSE AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE. 2019; 101 527.

  36. Thongpoon Sataporn, Roobsoong Wanlapa, Chotirat Sadudee, Tsuboi Takafumi, Takashima Eizo, Cui Liwang, Ishino Tomoko, Tachibana Mayumi, Sattabongkot Jetsumon. NATURALLY ACQUIRED TRANSMISSION-BLOCKING ANTIBODIES AGAINST PLASMODIUM VIVAX AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE. 2019; 101 132.

  37. Jenwithisuk Rachaneeporn, Kangwanrangsan Niwat, Tachibana Mayumi, Thongkukiatkul Amporn, Otsuki Hitoshi, Sattabongkot Jetsumon, Tsuboi Takafumi, Torii Motomi, Ishino Tomoko. Identification of a PH domain-containing protein which is localized to crystalloid bodies of Plasmodium ookinetes MALARIA JOURNAL. 2018.12; 17 (1): 466. ( PubMed, DOI )

  38. Aliprandini Eduardo, Tavares Joana, Panatieri Raquel Hoffmann, Thiberge Sabine, Yamamoto Marcio Massao, Silvie Olivier, Ishino Tomoko, Yuda Masao, Dartevelle Sylvie, Traincard Francois, Boscardin Silvia Beatriz, Amino Rogerio. Cytotoxic anti-circumsporozoite antibodies target malaria sporozoites in the host skin NATURE MICROBIOLOGY. 2018.11; 3 (11): 1224-1233. ( PubMed, DOI )

  39. Arredondo Silvia A., Swearingen Kristian E., Martinson Thomas, Steel Ryan, Dankwa Dorender A., Harupa Anke, Camargo Nelly, Betz William, Vigdorovich Vladimir, Oliver Brian G., Kangwanrangsan Niwat, Ishino Tomoko, Sather Noah, Mikolajczak Sebastian, Vaughan Ashley M., Torii Motomi, Moritz Robert L., Kappe Stefan H. I.. The Micronemal Plasmodium Proteins P36 and P52 Act in Concert to Establish the Replication-Permissive Compartment Within Infected Hepatocytes FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY. 2018.11; 8 413. ( PubMed, DOI )

  40. Tachibana Mayumi, Ishino Tomoko, Tsuboi Takafumi, Torii Motomi. The Plasmodium yoelii microgamete surface antigen (PyMiGS) induces anti-malarial transmission blocking immunity that reduces microgamete motility/release from activated male gametocytes VACCINE. 2018.11; 36 (49): 7463-7471. ( PubMed, DOI )

  41. Iriko Hideyuki, Ishino Tomoko, Otsuki Hitoshi, Ito Daisuke, Tachibana Mayumi, Torii Motomi, Tsuboi Takafumi. Plasmodium falciparum Exported Protein 1 is localized to dense granules in merozoites PARASITOLOGY INTERNATIONAL. 2018.10; 67 (5): 637-639. ( PubMed, DOI )

  42. Ishino Tomoko, Tsuboi Takafumi. Progress toward a transmission-blocking vaccine against malaria LANCET INFECTIOUS DISEASES. 2018.09; 18 (9): 927-928. ( PubMed, DOI )

  43. Miura Toyokazu, Takeo Satoru, Ntege Edward H., Otsuki Hitoshi, Sawasaki Tatsuya, Ishino Tomoko, Takashima Eizo, Tsuboi Takafumi. The malaria parasite RhopH protein complex interacts with erythrocyte calmyrin identified from a comprehensive erythrocyte protein library BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2018.06; 500 (2): 261-267. ( PubMed, DOI )

  44. Tachibana Mayumi, Ishino Tomoko, Takashima Eizo, Tsuboi Takafumi, Torii Motomi. A male gametocyte osmiophilic body and microgamete surface protein of the rodent malaria parasite Plasmodium yoelii (PyMiGS) plays a critical role in male osmiophilic body formation and exflagellation CELLULAR MICROBIOLOGY. 2018.05; 20 (5): e12821. ( PubMed, DOI )

  45. Sakamoto Hirokazu, Takeo Satoru, Takashima Eizo, Miura Kazutoyo, Kanoi Bernard N., Kaneko Takamasa, Han Eun-Taek, Tachibana Mayumi, Matsuoka Kazuhiro, Sattabongkot Jetsumon, Udomsangpetch Rachanee, Ishino Tomoko, Tsuboi Takafumi. Identification of target proteins of clinical immunity to Plasmodium falciparum in a region of low malaria transmission PARASITOLOGY INTERNATIONAL. 2018.04; 67 (2): 203-208. ( PubMed, DOI )

  46. Tachibana Mayumi, Torii Motomi, Tsuboi Takafumi, Ishino Tomoko. ANTIBODIES AGAINST PYMIGS, A NOVEL TRANSMISSION-BLOCKING VACCINE CANDIDATE, REDUCE THE MOTILITY OF MICROGAMETES AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE. 2018; 99 (4): 582.

  47. Arredondo Silvia, Swearingen Kristian, Martinson Thomas, Steel Ryan, Dankwa Dorender, Harupa Anke, Camargo Nelly, Vigdorovich Vladimir, Oliver Brian, Ishino Tomoko, Sather Noah, Mikolajczak Sebastian, Vaughan Ashley, Torii Motomi, Moritz Robert, Kappe Stefan. IT TAKES TWO TO TANGO: THE P52/P36 HEPATOCYTE INVASION COMPLEX AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE. 2018; 99 (4): 217.

  48. Matsuoka Kazuhiro, Thongkukiatkul Amporn, Tsuboi Takafumi, Torii Motomi, Ishino Tomoko. ROLE OF APICAL SUSHI PROTEIN IN SPOROZOITE INVASION OF SALIVARY GLANDS AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE. 2018; 99 (4): 217.

  49. Miura Kazutoyo, Deng Binging, Zhou Luwen, Ishino Tomoko, Tsuboi Takafumi, Long Carole A.. DEVELOPMENT OF PLASMODIUM FALCIPARUM EXFLAGELLATION ASSAY AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE. 2017.11; 95 (5): 123.

  50. Ntege Edward H., Takashima Eizo, Morita Masayuki, Nagaoka Hikaru, Ishino Tomoko, Tsuboi Takafumi. Blood-stage malaria vaccines: post-genome strategies for the identification of novel vaccine candidates EXPERT REVIEW OF VACCINES. 2017; 16 (8): 769-779. ( PubMed, DOI )

  51. Bantuchai Sirasate, Nozaki Mamoru, Thongkukiatkul Amporn, Lorsuwannarat Natcha, Tachibana Mayumi, Matsuoka Kazuhiro, Tsuboi Takafumi, Torii Motomi, Ishino Tomoko. FUNCTIONAL ANALYSIS OF A SPOROZOITE RHOPTRY PROTEIN DURING HEPATOCYTE INFECTION AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE. 2017; 97 (5): 20.

  52. Tachibana Mayumi, Torii Motomi, Tsuboi Takafumi, Ishino Tomoko. PYGM75, A PROTEIN IN OSMIOPHILIC BODIES, IS DISPENSABLE FOR EGRESS OF MALE GAMETOCYTES BUT IMPORTANT FOR EXFLAGELLATION OF MICROGAMETES AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE. 2017; 97 (5): 289.

  53. Ishino Tomoko, Sugino Yuka, Nozaki Mamoru, Tachibana Mayumi, Tsuboi Takafumi, Torii Motomi. A PLASMODIUM RHOPTRY PROTEIN IS INVOLVED IN SPOROZOITE INVASION OF HEPATOCYTES AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE. 2015.10; 93 (4): 397.

  54. Bantuchai Sirasate, Nozaki Mamoru, Tsuboi Takafumi, Torii Motomi, Ishino Tomoko. ONE OF THE PLASMODIUM RHOPTRY PROTEINS IS ESSENTIAL FOR MALARIA SPOROZOITE GLIDING MOTILITY, WHICH IS REQUIRED FOR MOSQUITO SALIVARY GLAND INVASION MACHINERY AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE. 2015.10; 93 (4): 59.

  55. Lorsuwannarat Natcha, Shinzawa Naoaki, Tachibana Mayumi, Katsube Riko, Tsuboi Takafumi, Torii Motomi, Ishino Tomoko. THE FUNCTIONAL ANALYSES OF A PLASMODIUM ALVEOLIN PROTEIN DURING MOSQUITO STAGE PARASITE DEVELOPMENT AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE. 2015.10; 93 (4): 60.

  56. Tachibana Mayumi, Torii Motomi, Sudo Moe, Tsuboi Takafumi, Ishino Tomoko. SCREENING FOR HIGHLY IMMUNOGENIC REGION OF PYGM75, A NOVEL TRANSMISSION-BLOCKING VACCINE CANDIDATE AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE. 2015.10; 93 (4): 301-302.

  57. Itani Satoko, Torii Motomi, Ishino Tomoko. D-Glucose concentration is the key factor facilitating liver stage maturation of Plasmodium PARASITOLOGY INTERNATIONAL. 2014.08; 63 (4): 584-590. ( PubMed, DOI )

  58. Zhao H, Aoshi T, Kawai S, Mori Y, Konishi A, Ozkan M, Fujita Y, Haseda Y, Shimizu M, Kohyama M, Kobiyama K, Eto K, Nabekura J, Horii T, Ishino T, Yuda M, Hemmi H, Kaisho T, Akira S, Kinoshita M, Tohyama K, Yoshioka Y, Ishii KJ, Coban C. Olfactory plays a key role in spatiotemporal pathogenesis of cerebral malaria. Cell host & microbe. 2014.05; 15 (5): 551-63. ( PubMed, DOI )

  59. Arumugam Thangavelu U., Ito Daisuke, Takashima Eizo, Tachibana Mayumi, Ishino Tomoko, Torii Motomi, Tsuboi Takafumi. Application of wheat germ cell-free protein expression system for novel malaria vaccine candidate discovery EXPERT REVIEW OF VACCINES. 2014.01; 13 (1): 75-85. ( PubMed, DOI )

  60. Shinzawa Naoaki, Ishino Tomoko, Tachibana Mayumi, Tsuboi Takafumi, Torii Motomi. Phenotypic Dissection of a Plasmodium-Refractory Strain of Malaria Vector Anopheles stephensi: The Reduced Susceptibility to P. berghei and P. yoelii PLOS ONE. 2013.05; 8 (5): e63753. ( PubMed, DOI )

  61. Kangwanrangsan Niwat, Tachibana Mayumi, Jenwithisuk Rachaneeporn, Tsuboi Takafumi, Riengrojpitak Suda, Torii Motomi, Ishino Tomoko. A member of the CPW-WPC protein family is expressed in and localized to the surface of developing ookinetes MALARIA JOURNAL. 2013.04; 12 129. ( PubMed, DOI )

  62. Orito Y, Ishino T, Iwanaga S, Kaneko I, Kato T, Menard R, Chinzei Y, Yuda M. Liver-specific protein 2: a Plasmodium protein exported to the hepatocyte cytoplasm and required for merozoite formation. Molecular microbiology. 2013.01; 87 (1): 66-79. ( PubMed, DOI )

  63. Gueirard P, Tavares J, Thiberge S, Bernex F, Ishino T, Milon G, Franke-Fayard B, Janse CJ, Ménard R, Amino R. Development of the malaria parasite in the skin of the mammalian host. Proceedings of the National Academy of Sciences of the United States of America. 2010.10; 107 (43): 18640-5. ( PubMed, DOI )

  64. Ishino Tomoko, Boisson Bertrand, Orito Yuki, Lacroix Celine, Bischoff Emmanuel, Loussert Celine, Janse Chris, Menard Robert, Yuda Masao, Baldacci Patricia. LISP1 IS IMPORTANT FOR THE EGRESS OF PLASMODIUM PARASITES FROM LIVER CELLS AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE. 2009.11; 81 (5): 267.

  65. Ishino T, Boisson B, Orito Y, Lacroix C, Bischoff E, Loussert C, Janse C, Ménard R, Yuda M, Baldacci P. LISP1 is important for the egress of Plasmodium berghei parasites from liver cells. Cellular microbiology. 2009.09; 11 (9): 1329-39. ( PubMed, DOI )

  66. Amino R, Giovannini D, Thiberge S, Gueirard P, Boisson B, Dubremetz JF, Prévost MC, Ishino T, Yuda M, Ménard R. Host cell traversal is important for progression of the malaria parasite through the dermis to the liver. Cell host & microbe. 2008.02; 3 (2): 88-96. ( PubMed, DOI )

  67. Ishino T, Kunieda T, Natori S, Sekimizu K, Kubo T. Identification of novel members of the Xenopus Ca2+ -dependent lectin family and analysis of their gene expression during tail regeneration and development. Journal of biochemistry. 2007.04; 141 (4): 479-88. ( PubMed, DOI )

  68. Kariu T, Ishino T, Yano K, Chinzei Y, Yuda M. CelTOS, a novel malarial protein that mediates transmission to mosquito and vertebrate hosts. Molecular microbiology. 2006.03; 59 (5): 1369-79. ( PubMed, DOI )

  69. Ishino T, Orito Y, Chinzei Y, Yuda M. A calcium-dependent protein kinase regulates Plasmodium ookinete access to the midgut epithelial cell. Molecular microbiology. 2006.02; 59 (4): 1175-84. ( PubMed, DOI )

  70. Ishino T, Chinzei Y, Yuda M. Two proteins with 6-cys motifs are required for malarial parasites to commit to infection of the hepatocyte. Molecular microbiology. 2005.12; 58 (5): 1264-75. ( PubMed, DOI )

  71. Ishino T, Chinzei Y, Yuda M. A Plasmodium sporozoite protein with a membrane attack complex domain is required for breaching the liver sinusoidal cell layer prior to hepatocyte infection. Cellular microbiology. 2005.02; 7 (2): 199-208. ( PubMed, DOI )

  72. Yuda M, Ishino T. Liver invasion by malarial parasites--how do malarial parasites break through the host barrier? Cellular microbiology. 2004.12; 6 (12): 1119-25. ( PubMed, DOI )

  73. Kadota K, Ishino T, Matsuyama T, Chinzei Y, Yuda M. Essential role of membrane-attack protein in malarial transmission to mosquito host. Proceedings of the National Academy of Sciences of the United States of America. 2004.11; 101 (46): 16310-5. ( PubMed, DOI )

  74. Ishino T, Yano K, Chinzei Y, Yuda M. Cell-passage activity is required for the malarial parasite to cross the liver sinusoidal cell layer. PLoS biology. 2004.01; 2 (1): E4. ( PubMed, DOI )

  75. Ishino T, Shirai M, Kunieda T, Sekimizu K, Natori S, Kubo T. Identification of genes induced in regenerating Xenopus tadpole tails by using the differential display method. Developmental dynamics : an official publication of the American Association of Anatomists. 2003.02; 226 (2): 317-25. ( PubMed, DOI )

  76. T Ishino, S Ohtsuki, K Homma, S Natori. cDNA cloning of mouse prolyl endopeptidase and its involvement in DNA synthesis by Swiss 3T3 cells JOURNAL OF BIOCHEMISTRY. 1998.03; 123 (3): 540-545. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display

  1. Mahazu Samiratu, Prah Isaac, Ota Yusuke, Hayashi Takaya, Nukui Yoko, Suzuki Masato, Hoshino Yoshihiko, Akeda Yukihiro, Suzuki Toshihiko, Ishino Tomoko, Ablordey Anthony, Saito Ryoichi. Genetic analysis of carbapenemase-producing Enterobacter cloacae and Klebsiella species(タイトル和訳中). 日本臨床微生物学会雑誌 2022.12.01

  2. Mahazu Samiratu, Prah Isaac, Ota Yusuke, Hayashi Takaya, Nukui Yoko, Suzuki Masato, Hoshino Yoshihiko, Akeda Yukihiro, Suzuki Toshihiko, Ishino Tomoko, Ablordey Anthony, Saito Ryoichi. カルバペネマーゼ産生Enterobacter cloacaeおよびKlebsiella属菌の遺伝子解析(Genetic analysis of carbapenemase-producing Enterobacter cloacae and Klebsiella species). 日本臨床微生物学会雑誌 2022.12.01

  3. Tomoko Ishino. Molecular mechanisms of malaria transmission to mammals via mosquito vectors. 第20回あわじ感染と免疫国際フォーラム 2022.09.08 大阪

  4. Tomoko Ishino. Molecular mechanisms of malaria parasite transmission from mosquitoes to mammals.. 第91回日本寄生虫学会 2022.05.29 帯広、北海道

  5. Tomoko Ishino. Molecular mechanisms of sporozoite transmission to mammals, the target of the first malara vaccine. 難病のプロテオ医学研究2021 The Genetics, Biology and Epidemiology of Diseases of Poverty 2021.12.11 東温市、愛媛県

  6. Tachibana M, Torii M, Baba M, Tsuboi T, Ishino T. Functional analysis of PyMiGS during the sexual stage based on the structure. Molecular Approaches to Malaria 2020 2020.02.23 Lorne Australia

  7. Baba M, Nozaki M, Torii M, Ishino T. RON4 is involved in sporozoite motility and liver invasion. Molecular Approaches to Malaria 2020 2020.02.23 Lorne Australia

  8. Ishino T, Nozaki M, Baba M, Tachibana M, Tsuboi T, Torii M. Detection of rhoptry neck protein complex in Plasmodium sporozoites and its contribution on sporozoite invasion of salivary glands.. Molecular Approaches to Malaria 2020 2020.02.23 Lorne Australia

  9. 石野智子. Role of Apical Sushi Protein in malaria sporozoite invasion of salivary glands. ASTMH 2018.10.28

  10. 石野智子. Involvement of Plasmodium rhoptry proteins in sporozoite invasion of mammalian hepatocytes. PIM 2018 2018.09.12

  11. 石野智子. Involvement of Plasmodium rhoptry proteins in sporozoite invasion of mammalian hepatocytes. ICOPA 2018 2018.08.19

  12. 石野智子. Identification of a male specific protein involved in exflagellation. Johns Hopkins Malaria Research Institute, malaria Friday seminar 2017.11.10

  13. Sirasate Bantuchai, Mamoru Nozaki, Amporn Thongkukiatkul, Natcha Lorsuwannarat, Mayumi Tachibana, Kazuhiro Matsuoka, Takafumi Tsuboi, Motomi Torii, Tomoko Ishino. Functional analysis of a sporozoite rhoptry protein hepatocyte infection. 66th Annual meeting of American Society of Tropical Medicine & Hygene 2017 Baltimore,Maryland USA

  14. Mayumi Tachibana, Motomi Torii, Takafumi Tsuboi, Tomoko Ishino. PyGM75, a protein in osmiophilic bodies, is dispensable for egress of male gametocytes but important for exflagellation of microgametes. 66th Annual meeting of American Society of Tropical Medicine & Hygene 2017 Baltimore,Maryland USA

  15. Mayumi Tachibana, Motomi Torii, Moe Sudo, Takafumi Tsuboi, Tomoko Ishino. C-terminus region of male gamete surface protein, PyGM75 induce malaria transmission-blocking antibody. Molecular approaches to Malaria 2016 2016 Lorne,Victoria,Australia

  16. Tomoko Ishino, Yuka Sugino, Mamoru Nozaki, Eri Murata, Naohito Tokunaga, Mayumi Tachibana, Takafumi Tsuboi, Motomi Torii. Rhoptry proteins have important roles during sporozoite invasion of mosquito salivary glands or mammalian hepatocytes. Molecular approaches to Malaria 2016 2016 Lorne,Victoria,Australia

  17. Tomoko Ishino. Functional analyses of sporozoite rhoptry proteins of Plasmodium berghei during target cell invasion. 2nd International Symposium "matryoshika-type Evolution" 2015 Tsukuba、Japan

  18. Natcha Lorsuwannarat, Naoaki Shinzawa, Mayumi Tachibana, Riko Katsube, Takafumi Tsuboi, Motomi Torii, Tomoko Ishino. The functional analysis of a Plasmodium alveolin protein during mosquito stage parasite development. 64th Annual Meeting of American Society of Tropical Medicine and Hygiene 2015 Philadelphia,USA

  19. Sirasate Bantuchai, Mamoru Nozaki, Takafumi Tsuboi, Motomi Torii, Tomoko Ishino. One of the Plasmodium rhoptry protein is essential for malaria sporozoite gliding motility, which is required for mosquito salivary gland invasion machinery. 64th Annual Meeting of American Society of Tropical Medicine and Hygiene 2015 Philadelphia,USA

  20. Mayumi Tachibana, Motomi Torii, Moe Sudo, Takafumi Tsuboi, Tomoko Ishino. Screening for highly immunogenic region of PyGM75, a novel transmission-blocking vaccine candidate. 64th Annual Meeting of American Society of Tropical Medicine and Hygiene 2015 Philadelphia,USA

  21. Tomoko Ishino, Yuka Sugino, Mamoru Nozaki, Mayumi Tachibana, Takafumi Tsuboi, Motomi Torii. A Plasmodium rhoptry protein is involved in sporozoite invasion of hepatocyte. 64th Annual Meeting of American Society of Tropical Medicine and Hygiene 2015 Philadelphia,USA

  22. Tachibana M, Torii M, Sudo M, Tsuboi T, Ishino T. Identification of the novel transmission-blocking vaccine target expressing on the surface of male gametes. 63rd Annual Meeting of American Society of Tropical Medicine and Hygiene 2014 New Orleans, USA

  23. Nozaki M, Ishino T, Tokunaga N, Tsuboi T, Torii M. Rhoptry proteins are involved in sporozoite invasion of the salivary gland. 63rd Annual Meeting of American Society of Tropical Medicine and Hygiene 2014 New Orleans, USA

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