Personnel Information

写真a

SEGAWA Katsumori


Job title

Professor

Field Introduction URL

https://www.tmd.ac.jp/mri/mche/index.html

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Graduating School 【 display / non-display 】

  • Osaka Prefecture University, Faculty of Engineering, 2004.03, Graduated

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Campus Career 【 display / non-display 】

  • 2021.04
    -
    2022.04
    Tokyo Medical and Dental University， Medical Research Institute， Advanced Molecular Medicine， Department of Medical Chemistry， Professor
  • 2022.05
    -
    2024.09
    Tokyo Medical and Dental University， Medical Research Institute， Division of Visionary Life Science， Department of Medical Chemistry， Professor
  • 2024.10
    -
    Now
    Institute of Science Tokyo， -， Institute of Integrated Research， -， Department of Medical Chemistry， Professor
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External Career 【 display / non-display 】

  • 2015.07
    -
    2017.01
    Osaka university, immunology frontier research center, Assistant Professor
  • 2017.02
    -
    2021.03
    Osaka university, Immunology frontier research center, Associate Professor
  • 2021.04
    -
    Now
    Tokyo Medical and Dental University, Medical Research Institute, Professor
  • 2024.10
    -
    Now
    Institute of Science Tokyo, Medical Research Laboratory, Professor
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Academic Society Affiliations 【 display / non-display 】

  • THE JAPANESE BIOCHEMICAL SOCIETY

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Research Areas 【 display / non-display 】

  • Medical biochemistry

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Research Theme 【 display / non-display 】

  • Self-referential immune perception, 2022.06 - 2027.03

  • Self-referential immune perception, 2022.06 - 2027.03

  • Establishment of a method to control distribution of phospholipids in biological membranes, 2019.06 - 2021.03

  • Molecular basis for membrane dynamics of phospholipids and its physiology & pathology, 2018.04 - 2021.03

  • Mecanisms for the plasma membrane phospholipid asymmetry and its physiological and pathological roles, 2015.04 - 2018.03

  • Mecanisms for the plasma membrane phospholipid asymmetry and its physiological and pathological roles, 2015.04 - 2018.03

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Published Papers & Misc 【 display / non-display 】

  1. Miyata Y, Nishimura M, Nagata A, Jing X, Sultan C.S, Kuribayashi R, Takahashi K, Lee Y, Nishizawa T, Segawa K. Membrane structure-responsive lipid scramblase activity of the TMEM63/OSCA family FEBS Letters. 2024.12; doi: 10.1002/1873-3468.15084. ( DOI )

  2. Segawa K, Nishizawa T. TMEM63B scrambles phospholipids in response to changes in membrane structure Nat. Struct. Mol. Biol. 2024.10; 32 (1): 10-11.

  3. Miyata Y, Takahashi K, Lee Y, Sultan CS, Kuribayashi R, Takahashi M, Hata K, Bamba T, Izumi Y, Liu K, Uemura T, Nomura N, Iwata S, Nagata S, Nishizawa T, Segawa K. Membrane structure-responsive lipid scrambling by TMEM63B to control plasma membrane lipid distribution Nat Struct Mol Biol. 2024.10; 32 (1): 185-198. ( PubMed, DOI )

  4. Miyata Y, Segawa K. Protocol to analyze lipid asymmetry in the plasma membrane. STAR protocols. 2022.12; 3 (4): 101870. ( PubMed, DOI )

  5. 免疫系による自己認識とその意義 Phosphatidylserineを介した死細胞の感知とクリアランス(Phosphatidylserine-mediated sensing and clearance of dying cells) 2022.11; 95回 2S08m-01. ( ichushi )

  6. Ochiai Y, Suzuki C, Segawa K, Uchiyama Y, Nagata S. Inefficient development of syncytiotrophoblasts in the <i>Atp11a</i>-deficient mouse placenta. Proceedings of the National Academy of Sciences of the United States of America. 2022.05; 119 (18): e2200582119. ( PubMed, DOI )

  7. Katsumori Segawa, Sachiko Kurata, Shigekazu Nagata. Human Type IV P-type ATPases That Work as Plasma Membrane Phospholipid Flippases and Their Regulation by Caspase and Calcium. J Biol Chem. 2016.01; 291 (2): 762-772. ( PubMed, DOI )

  8. Katsumori Segawa, Shigekazu Nagata. An Apoptotic 'Eat Me' Signal: Phosphatidylserine Exposure. Trends Cell Biol. 2015.11; 25 (11): 639-650. ( PubMed, DOI )

  9. Satoshi Toda, Chihiro Nishi, Yuichi Yanagihashi, Katsumori Segawa, Shigekazu Nagata. Clearance of Apoptotic Cells and Pyrenocytes. Curr Top Dev Biol. 2015; 114 267-295. ( PubMed, DOI )

  10. Hiroyuki Takatsu, Gaku Tanaka, Katsumori Segawa, Jun Suzuki, Shigekazu Nagata, Kazuhisa Nakayama, Hye-Won Shin. Phospholipid flippase activities and substrate specificities of human type IV P-type ATPases localized to the plasma membrane. J Biol Chem. 2014.11; 289 (48): 33543-33556. ( PubMed, DOI )

  11. Satoshi Toda, Katsumori Segawa, Shigekazu Nagata. MerTK-mediated engulfment of pyrenocytes by central macrophages in erythroblastic islands. Blood. 2014.06; 123 (25): 3963-3971. ( PubMed, DOI )

  12. Katsumori Segawa, Sachiko Kurata, Yuichi Yanagihashi, Thijn R Brummelkamp, Fumihiko Matsuda, Shigekazu Nagata. Caspase-mediated cleavage of phospholipid flippase for apoptotic phosphatidylserine exposure. Science. 2014.06; 344 (6188): 1164-1168. ( PubMed, DOI )

  13. Chihiro Nishi, Satoshi Toda, Katsumori Segawa, Shigekazu Nagata. Tim4- and MerTK-mediated engulfment of apoptotic cells by mouse resident peritoneal macrophages. Mol Cell Biol. 2014.04; 34 (8): 1512-1520. ( PubMed, DOI )

  14. Katsumori Segawa, Jun Suzuki, Shigekazu Nagata. Flippases and scramblases in the plasma membrane. Cell Cycle. 2014; 13 (19): 2990-2991. ( PubMed, DOI )

  15. Masanori Miyanishi, Katsumori Segawa, Shigekazu Nagata. Synergistic effect of Tim4 and MFG-E8 null mutations on the development of autoimmunity. Int Immunol. 2012.09; 24 (9): 551-559. ( PubMed, DOI )

  16. Katsumori Segawa, Jun Suzuki, Shigekazu Nagata. Constitutive exposure of phosphatidylserine on viable cells. Proc Natl Acad Sci U S A. 2011.11; 108 (48): 19246-19251. ( PubMed, DOI )

  17. Katsumori Segawa, Morihiro Matsuda, Atsunori Fukuhara, Kentaro Morita, Yosuke Okuno, Ryutaro Komuro, Iichiro Shimomura. Identification of a novel distal enhancer in human adiponectin gene. J Endocrinol. 2009.01; 200 (1): 107-116. ( PubMed, DOI )

  18. Maiko Nozaki, Atsunori Fukuhara, Katsumori Segawa, Yosuke Okuno, Manabu Abe, Naomi Hosogai, Morihiro Matsuda, Ryutaro Komuro, Iichiro Shimomura. Nitric oxide dysregulates adipocytokine expression in 3T3-L1 adipocytes. Biochem Biophys Res Commun. 2007.12; 364 (1): 33-39. ( PubMed, DOI )

  19. Masaki Tanaka, Maiko Nozaki, Atsunori Fukuhara, Katsumori Segawa, Naohito Aoki, Morihiro Matsuda, Ryutaro Komuro, Iichiro Shimomura. Visfatin is released from 3T3-L1 adipocytes via a non-classical pathway. Biochem Biophys Res Commun. 2007.07; 359 (2): 194-201. ( PubMed, DOI )

  20. Naomi Hosogai, Atsunori Fukuhara, Kazuya Oshima, Yugo Miyata, Sachiyo Tanaka, Katsumori Segawa, Shigetada Furukawa, Yoshihiro Tochino, Ryutaro Komuro, Morihiro Matsuda, Iichiro Shimomura. Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation. Diabetes. 2007.04; 56 (4): 901-911. ( PubMed, DOI )

  21. Katsumori Segawa, Atsunori Fukuhara, Naomi Hosogai, Kentaro Morita, Yosuke Okuno, Masaki Tanaka, Yasuhiko Nakagawa, Shinji Kihara, Tohru Funahashi, Ryutaro Komuro, Morihiro Matsuda, Iichiro Shimomura. Visfatin in adipocytes is upregulated by hypoxia through HIF1alpha-dependent mechanism. Biochem Biophys Res Commun. 2006.10; 349 (3): 875-882. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display 】

  1. Katsumori Segawa. Phospholipid asymmetry in the plasma membrane and human diseases. The International Symposium on Microbiology and Immunology The 14th International Symposium of IFReC 2024.11.12 OSAKA

  2. ホスファチジルセリンを介した死細胞の感知と貪食. 第95回 日本生化学会大会 2022.11.10

  3. 瀬川 勝盛. 免疫系による自己認識とその意義　Phosphatidylserineを介した死細胞の感知とクリアランス(Phosphatidylserine-mediated sensing and clearance of dying cells). 日本生化学会大会プログラム・講演要旨集 2022.11.01

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