Kazuki Takahashi, Miho Kobayashi, Hisae Katsumata, Shiori Tokizaki, Tatsuhiko Anzai, Yukinori Ikeda, Daniel M Alcaide, Kentaro Maeda, Makoto Ishihara, Katsutoshi Tahara, Yoshiaki Kubota, Fumiko Itoh, Jihwan Park, Kunihiko Takahashi, Yukiko T Matsunaga, Yasuhiro Yoshimatsu, Katarzyna A Podyma-Inoue, Tetsuro Watabe. CD40 is expressed in the subsets of endothelial cells undergoing partial endothelial-mesenchymal transition in tumor microenvironment. Cancer Sci. 2024.02; 115 (2): 490-506. ( PubMed, DOI )

Kayo Hirooka, Hiroki Fukahori, Ayako Ninomiya, Sakiko Fukui, Kunihiko Takahashi, Tatsuhiko Anzai, Tomoaki Ishibashi. Impact of family involvement and an advance directive to not hospitalize on hospital transfers of residents in long-term care facilities. Arch Gerontol Geriatr. 2024.02; 117 105183. ( PubMed, DOI )

Yuki Iijima, Masaru Ejima, Takashi Yamana, Shiro Sonoda, Sho Shibata, Tsuyoshi Shirai, Tsukasa Okamoto, Haruhiko Furusawa, Tomoya Tateishi, Takuya Adachi, Mio Mori, Susumu Kirimura, Tatsuhiko Anzai, Kunihiko Takahashi, Yasunari Miyazaki. Assessment of clinical relevance of antigen improves diagnostic accuracy of hypersensitivity pneumonitis. BMC Pulm Med. 2024.02; 24 (1): 84. ( PubMed, DOI )

Yuta Matsubara, Hiroki Kiyohara, Yohei Mikami, Kosaku Nanki, Ho Namkoong, Shotaro Chubachi, Hiromu Tanaka, Shuhei Azekawa, Shinya Sugimoto, Yusuke Yoshimatsu, Tomohisa Sujino, Kaoru Takabayashi, Naoki Hosoe, Toshiro Sato, Makoto Ishii, Naoki Hasegawa, Yukinori Okada, Ryuji Koike, Yuko Kitagawa, Akinori Kimura, Seiya Imoto, Satoru Miyano, Seishi Ogawa, Koichi Fukunaga, Takanori Kanai, . Gastrointestinal symptoms in COVID-19 and disease severity: a Japanese registry-based retrospective cohort study. J Gastroenterol. 2024.01; ( PubMed, DOI )

Mitsuaki Nishikimi, Shinichiro Ohshimo, Wataru Fukumoto, Jun Hamaguchi, Kazuki Matsumura, Kenji Fujizuka, Yoshihiro Hagiwara, Ryuichi Nakayama, Naofumi Bunya, Junichi Maruyama, Toshikazu Abe, Tatsuhiko Anzai, Yoshitaka Ogata, Hiromichi Naito, Yu Amemiya, Tokuji Ikeda, Masayuki Yagi, Yutaro Furukawa, Hayato Taniguchi, Tsukasa Yagi, Ken Katsuta, Daisuke Konno, Ginga Suzuki, Yuki Kawasaki, Noriyuki Hattori, Tomoyuki Nakamura, Natsuki Kondo, Hitoshi Kikuchi, Shinichi Kai, Saaya Ichiyama, Kazuo Awai, Kunihiko Takahashi, Nobuaki Shime; J-CARVE registry group.. Chest CT findings in severe acute respiratory distress syndrome requiring V-V ECMO: J-CARVE registry. J Intensive Care. 2024.01; 12 (1): 5. ( PubMed, DOI )

Shun Endo, Tsukasa Okamoto, Tatsuo Kawahara, Tatsuhiko Anzai, Kunihiko Takahashi, Yasunari Miyazaki. Effect of warm and humid days on the positivity rate of anti-Trichosporon asahii antibody test for the diagnosis of summer-type hypersensitivity pneumonitis. Respir Investig. 2024.01; 62 (1): 150-156. ( PubMed, DOI )

Maiko Noguchi-Watanabe, Takako Ishikawa, Kasumi Ikuta, Miya Aishima, Sayuri Nonaka, Kunihiko Takahashi, Tatsuhiko Anzai, Sakiko Fukui. Physical function decline predictors in nursing home residents using new national quality indicators. Geriatr Gerontol Int. 2024.01; 24 (1): 123-132. ( PubMed, DOI )

Hikaru Aoki, Yasunari Miyazaki, Tatsuhiko Anzai, Kota Yokoyama, Junichi Tsuchiya, Tsuyoshi Shirai, Sho Shibata, Rie Sakakibara, Takahiro Mitsumura, Takayuki Honda, Haruhiko Furusawa, Tsukasa Okamoto, Tomoya Tateishi, Meiyo Tamaoka, Masahide Yamamoto, Kunihiko Takahashi, Ukihide Tateishi, Tetsuo Yamaguchi. Deep convolutional neural network for differentiating between sarcoidosis and lymphoma based on 18F-FDG maximum-intensity projection images. Eur Radiol. 2024.01; 34 (1): 374-383. ( PubMed, DOI )

Tomomi Sakano, Tatsuhiko Anzai, Kunihiko Takahashi, Sakiko Fukui. Impact of home-visit nursing service use on costs in the last 3 months of life among older adults: A retrospective cohort study. J Nurs Scholarsh. 2024.01; 56 (1): 191-201. ( PubMed, DOI )

Atsuko Murashima, Kayoko Kaneko, Hiroshi Oguro, Yukiko Mori, Mikako Goto, Shuko Mishima, Tatsuhiko Anzai, Kunihiko Takahashi. Pregnancy-related issues from the perspective of patients with inflammatory rheumatic diseases - Results from a survey of the members of the National Association for Inflammatory Rheumatic Diseases. Mod Rheumatol. 2024; ( PubMed, DOI )

Mikako Goto, Tatsuhiko Anzai, Ritsuko Yamane, Naho Yakuwa, Kunihiko Takahashi, Atsuko Murashima. Pregnancy outcomes after first-trimester exposure to fluoroquinolones: Findings based on an integrated database from two Japanese institutions. Congenit Anom (Kyoto). 2024; ( PubMed, DOI )

Nobuhisa Morimoto, Shingo Shioji, Yuichiro Akagi, Tamami Fujiki, Shintaro Mandai, Fumiaki Ando, Takayasu Mori, Koichiro Susa, Shotaro Naito, Eisei Sohara, Tatsuhiko Anzai, Kunihiko Takahashi, Wataru Akita, Akihito Ohta, Shinichi Uchida, Soichiro Iimori. Associations Between Dietary Potassium Intake From Different Food Sources and Hyperkalemia in Patients With Chronic Kidney Disease. J Ren Nutr. 2024; ( PubMed, DOI )

Takahiro Ando, Sho Shimada, Jun Sugihara, Koji Takayama, Masayoshi Kobayashi, Yoshihiro Miyashita, Tatsuya Ito, Kaori Okayasu, Shun Tsuyuki, Takehiko Ohba, Masafumi Doi, Hiroaki Saito, Toshihide Fujie, Tomoshige Chiaki, Atsushi Nakagawa, Tatsuhiko Anzai, Kunihiko Takahashi, Sho Shibata, Tomoya Tateishi, Yasunari Miyazaki. Impairment of Social-Related Quality of Life in COVID-19 Pneumonia Survivors: A Prospective Longitudinal Study. J Clin Med. 2023.12; 12 (24): ( PubMed, DOI )

Miya Aishima, Takako Ishikawa, Kasumi Ikuta, Maiko Noguchi-Watanabe, Sayuri Nonaka, Kunihiko Takahashi, Tatsuhiko Anzai, Sakiko Fukui. Unplanned Hospital Visits and Poor Oral Health With Undernutrition in Nursing Home Residents. J Am Med Dir Assoc. 2023.12; 24 (12): 1855-1860.e1. ( PubMed, DOI )

Mitsuaki Nishikimi, Shinichiro Ohshimo, Jun Hamaguchi, Kenji Fujizuka, Yoshihiro Hagiwara, Tatsuhiko Anzai, Junki Ishii, Yoshitaka Ogata, Toshiyuki Aokage, Tokuji Ikeda, Tsukasa Yagi, Ginga Suzuki, Ken Ishikura, Ken Katsuta, Daisuke Konno, Noriyuki Hattori, Tomoyuki Nakamura, Yosuke Matsumura, Daisuke Kasugai, Hitoshi Kikuchi, Tatsuhiko Iino, Shinichi Kai, Haruka Hashimoto, Takeshi Yoshida, Yumi Igarashi, Takayuki Ogura, Kazuki Matsumura, Keiki Shimizu, Mitsunobu Nakamura, Shingo Ichiba, Kunihiko Takahashi, Nobuaki Shime. High versus low positive end-expiratory pressure setting in patients receiving veno-venous extracorporeal membrane oxygenation support for severe acute respiratory distress syndrome: study protocol for the multicentre, randomised ExPress SAVER Trial. BMJ Open. 2023.10; 13 (10): e072680. ( PubMed, DOI )

Yuki Nishida, Tatsuhiko Anzai, Kunihiko Takahashi, Takahide Kozuma, Eiichiro Kanda, Keita Yamauchi, Fuminori Katsukawa. Multimorbidity patterns in the working age population with the top 10% medical cost from exhaustive insurance claims data of Japan Health Insurance Association. PLoS One. 2023.09; 18 (9): e0291554. ( PubMed, DOI )

Hiroyuki Inose, Takuya Takahashi, Yu Matsukura, Jun Hashimoto, Kurando Utagawa, Satoru Egawa, Kentaro Yamada, Takashi Hirai, Kunihiko Takahashi, Toshitaka Yoshii. Effect of vitamin D deficiency on surgical outcomes of degenerative cervical myelopathy. N Am Spine Soc J. 2023.09; 15 100239. ( PubMed, DOI )

COVID-19 Host Genetics Initiative. A second update on mapping the human genetic architecture of COVID-19. Nature. 2023.09; 621 (7977): E7-E26. ( PubMed, DOI )

Tsubasa Ito, Takahiro Otani, Tatsuhiko Anzai, Takashi Okumura, Kunihiko Takahashi. Potential Biases of the Transmission Risks of COVID-19 estimated by Contact Tracing Surveys in Japan. Epidemiology, Biostatistics, and Public Health. 2023.08; ( DOI )

Hiroyuki Inose, Tsuyoshi Kato, Yu Matsukura, Takashi Hirai, Toshitaka Yoshii, Shigenori Kawabata, Kunihiko Takahashi, Atsushi Okawa. Factors influencing the long-term outcomes of instrumentation surgery for degenerative lumbar spondylolisthesis: a post-hoc analysis of a prospective randomized study. Spine J. 2023.06; 23 (6): 799-804. ( PubMed, DOI )

Saeka Takabayashi, Emiko Okada, Takumi Hirata, Hidemi Takimoto, Mieko Nakamura, Satoshi Sasaki, Kunihiko Takahashi, Koshi Nakamura, Shigekazu Ukawa, Akiko Tamakoshi. Nutritional Adequacy Assessment of the Japanese Diet Using the Number of Dishes Compared to Existing Dietary Diversity Indices: A Cross-Sectional Analysis from the 2012 National Health and Nutrition Survey, Japan. J Nutr Sci Vitaminol (Tokyo). 2023.06; 69 (3): 197-205. ( PubMed, DOI )

Asuka Hirose, Masakazu Terauchi, Tamami Odai, Ayako Fudono, Kotoi Tsurane, Masaki Sekiguchi, Misako Iwata, Tatsuhiko Anzai, Kunihiko Takahashi, Naoyuki Miyasaka. Investigation of exacerbating factors for postpartum hair loss: a questionnaire-based cross-sectional study. Int J Womens Dermatol. 2023.06; 9 (2): e084. ( PubMed, DOI )

Mitsuaki Nishikimi, Shinichiro Ohshimo, Wataru Fukumoto, Tatsuhiko Anzai, Kazuo Awai, Takayuki Ogura, Toshikazu Abe, Mamoru Masuda, Kenji Fujizuka, Mitsunobu Nakamura, Michihito Kyo, Kunihiko Takahashi, Nobuaki Shime. Characteristics of the pulmonary opacities on chest CT associated with difficulty in short-term liberation from veno-venous ECMO in patients with severe ARDS. Respir Res. 2023.05; 24 (1): 128. ( PubMed, DOI )

Ryuya Edahiro, Yuya Shirai, Yusuke Takeshima, Shuhei Sakakibara, Yuta Yamaguchi, Teruaki Murakami, Takayoshi Morita, Yasuhiro Kato, Yu-Chen Liu, Daisuke Motooka, Yoko Naito, Ayako Takuwa, Fuminori Sugihara, Kentaro Tanaka, James B Wing, Kyuto Sonehara, Yoshihiko Tomofuji; Japan COVID-19 Task Force; Ho Namkoong, Hiromu Tanaka, Ho Lee, Koichi Fukunaga, Haruhiko Hirata, Yoshito Takeda, Daisuke Okuzaki, Atsushi Kumanogoh, Yukinori Okada. Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity. Nat Genet. 2023.05; 55 (5): 753-767. ( PubMed, DOI )

Shintaro Shimizu, Gen Tanabe, Kairi Hayashi, Hiroshi Churei, Tatsuhiko Anzai, Kunihiko Takahashi, Toshiaki Ueno, Kenji Fueki. Quantitative text analysis of the mechanisms of tooth injury: Analysis of accidents in five sports that occurred in 15years under school control. Dent Traumatol. 2023.04; 39 (2): 132-139. ( PubMed, DOI )

Hiroyuki Inose, Tsuyoshi Kato, Shoichi Ichimura, Hiroaki Nakamura, Masatoshi Hoshino, Shinji Takahashi, Daisuke Togawa, Toru Hirano, Yasuaki Tokuhashi, Tetsuro Ohba, Hirotaka Haro, Takashi Tsuji, Kimiaki Sato, Yutaka Sasao, Masahiko Takahata, Koji Otani, Suketaka Momoshima, Takashi Hirai, Toshitaka Yoshii, Kunihiko Takahashi, Atsushi Okawa. Factors affecting the quality of life in the chronic phase of thoracolumbar osteoporotic vertebral fracture managed conservatively with a brace. Spine J. 2023.03; 23 (3): 425-432. ( PubMed, DOI )

Nobuyuki Nosaka, Tatsuhiko Anzai, Ryo Uchimido, Yuka Mishima, Kunihiko Takahashi, Kenji Wakabayashi. An anthropometric evidence against the use of age-based estimation of bodyweight in pediatric patients admitted to intensive care units. Sci Rep. 2023.03; 13 (1): 3574. ( PubMed, DOI )

Masaki Ozawa, Tatsuhiko Anzai, Takashi Yamauchi, Kunihiko Takahashi. Do changes in working hours increase stress in Japanese white-collar workers? Front Public Health. 2023.02; 11 1076024. ( PubMed, DOI )

Kohtaro Kikuchi, Tatsuhiko Anzai, Kunihiko Takahashi. The Unusual Increase in Suicides Among Women in Japan During the COVID-19 Pandemic: A Time-series Analysis Until October 2021. J Epidemiol. 2023.01; 33 (1): 45-51. ( PubMed, DOI )

Shohei Yamashita, Tsukasa Okamoto, Tatsuo Kawahara, Tomoya Tateishi, Tatsuhiko Anzai, Kunihiko Takahashi, Kiyohide Fushimi, Yasunari Miyazaki. Database analysis of hypersensitivity pneumonitis in Japan. Respir Investig. 2023.01; 61 (2): 172-180. ( PubMed, DOI )

Tomoki Nakaya, Kunihiko Takahashi, Hideto Takahashi, Seiji Yasumura, Tetsuya Ohira, Hiroki Shimura, Satoru Suzuki, Satoshi Suzuki, Manabu Iwadate, Susumu Yokoya, Hitoshi Ohto, Kenji Kamiya. Revisiting the Geographical Distribution of Thyroid Cancer Incidence in Fukushima Prefecture: Analysis of Data From the Second- and Third-round Thyroid Ultrasound Examination. J Epidemiol. 2022.12; 32 (Suppl_XII): S76-S83. ( PubMed, DOI )

Hiroyuki Inose, Tsuyoshi Kato, Shoji Tomizawa, Akane Ariga, Takayuki Motoyoshi, Kazuyuki Fukushima, Kunihiko Takahashi, Toshitaka Yoshii, Atsushi Okawa. Impact of romosozumab on serum calcium concentration and factors predicting the fluctuations in calcium concentration upon romosozumab administration: A multicenter retrospective study. Bone Rep. 2022.12; 17 101635. ( PubMed, DOI )

Ho Lee, Shotaro Chubachi, Ho Namkoong, Takanori Asakura, Hiromu Tanaka, Shiro Otake, Kensuke Nakagawara, Atsuho Morita, Takahiro Fukushima, Mayuko Watase, Tatsuya Kusumoto, Katsunori Masaki, Hirofumi Kamata, Makoto Ishii, Naoki Hasegawa, Norihiro Harada, Tetsuya Ueda, Soichiro Ueda, Takashi Ishiguro, Ken Arimura, Fukuki Saito, Takashi Yoshiyama, Yasushi Nakano, Yoshikazu Mutoh, Yusuke Suzuki, Koji Murakami, Yukinori Okada, Ryuji Koike, Yuko Kitagawa, Akinori Kimura, Seiya Imoto, Satoru Miyano, Seishi Ogawa, Takanori Kanai, Koichi Fukunaga, . Characteristics of hospitalized patients with COVID-19 during the first to fifth waves of infection: a report from the Japan COVID-19 Task Force. BMC Infect Dis. 2022.12; 22 (1): 935. ( PubMed, DOI )

Noriyuki Takahashi, Takaharu Matsuhisa, Kunihiko Takahashi, Muneyoshi Aomatsu, Stewart W Mercer, Nobutaro Ban. A 2-item version of the Japanese Consultation and Relational Empathy measure: a pilot study using secondary analysis of a cross-sectional survey in primary care. Fam Pract. 2022.11; 39 (6): 1169-1175. ( PubMed, DOI )

Miki Amemiya, Masateru Takigawa, Masahiko Goya, Claire A Martin, Tatsuhiko Anzai, Kunihiko Takahashi, Yuki Shimizu, Takashi Ikenouchi, Tatsuaki Kamata, Tasuku Yamamoto, Takuro Nishimura, Yasuhiro Shirai, Susumu Tao, Shinsuke Miyazaki, Tetsuo Sasano. Comparison of two catheters measuring local impedance: local impedance variation vs lesion characteristics and steam pops. J Interv Card Electrophysiol. 2022.11; 65 (2): 419-428. ( PubMed, DOI )

Tatsuhiko Anzai, Kohtaro Kikuchi, Keisuke Fukui, Yuri Ito, Kunihiko Takahashi. Have restrictions on human mobility impacted suicide rates during the COVID-19 pandemic in Japan? Psychiatry Res. 2022.11; 317 114898. ( PubMed, DOI )

Keibun Liu, Kensuke Nakamura, Sapna R Kudchadkar, Hajime Katsukawa, Peter Nydahl, Eugene Wesley Ely, Kunihiko Takahashi, Shigeaki Inoue, Osamu Nishida. Mobilization and Rehabilitation Practice in ICUs During the COVID-19 Pandemic. J Intensive Care Med. 2022.09; 37 (9): 1256-1264. ( PubMed, DOI )

Takahiro Mitsumura, Tsukasa Okamoto, Mizuho Tosaka, Takashi Yamana, Sho Shimada, Yuki Iijima, Rie Sakakibara, Sho Shibata, Takayuki Honda, Tsuyoshi Shirai, Masahiro Ishizuka, Junichi Aiboshi, Haruhiko Furusawa, Tomoya Tateishi, Meiyo Tamaoka, Hidenobu Shigemitsu, Hirokuni Arai, Yasuhiro Otomo, Shuji Tohda, Tatsuhiko Anzai, Kunihiko Takahashi, Shinsuke Yasuda, Yasunari Miyazaki. Association of SARS-CoV-2 RNA Copy Number with the COVID-19 Mortality Rate and Its Effect on the Predictive Performance of Mortality in Severe Cases. Jpn J Infect Dis. 2022.09; 75 (5): 504-510. ( PubMed, DOI )

Akira Endo, Kazuma Yamakawa, Takashi Tagami, Yutaka Umemura, Kyosuke Takahashi, Hiroki Nagasawa, Yuichi Araki, Mitsuaki Kojima, Toshiki Sera, Masayuki Yagi, Ryo Yamamoto, Jiro Takahashi, Masaki Nakane, Chikashi Takeda, Chihiro Narita, Satoshi Kazuma, Hiroko Okura, Hiroyuki Takahashi, Takeshi Wada, Shu Tahara, Ayaka Matsuoka, Todani Masaki, Atsushi Shiraishi, Keiichiro Shimoyama, Yuta Yokokawa, Rintaro Nakamura, Hisako Sageshima, Yuichiro Yanagida, Kunihiko Takahashi, Yasuhiro Otomo. Optimal target blood pressure in elderly with septic shock (OPTPRESS) trial: study protocol for a randomized controlled trial. Trials. 2022.09; 23 (1): 799. ( PubMed, DOI )

Ayako Morita, Yoshimitsu Takahashi, Kunihiko Takahashi, Takeo Fujiwara. Depressive symptoms homophily among community-dwelling older adults in japan: A social networks analysis. Front Public Health. 2022.09; 10 965026. ( PubMed, DOI )

Naho Yakuwa, Kunihiko Takahashi, Tatsuhiko Anzai, Naoki Ito, Mikako Goto, Sachi Koinuma, Chiaki Uno, Tomo Suzuki, Omi Watanabe, Akimasa Yamatani, Atsuko Murashima. Pregnancy Outcomes With Exposure to Second-Generation Antipsychotics During the First Trimester. J Clin Psychiatry. 2022.08; 83 (4): 21m14081. ( PubMed, DOI )

Ho Namkoong, Ryuya Edahiro, Tomomi Takano, Hiroshi Nishihara, Yuya Shirai, Kyuto Sonehara, Hiromu Tanaka, Shuhei Azekawa, Yohei Mikami, Ho Lee, Takanori Hasegawa, Koji Okudela, Daisuke Okuzaki, Daisuke Motooka, Masahiro Kanai, Tatsuhiko Naito, Kenichi Yamamoto, Qingbo S Wang, Ryunosuke Saiki, Rino Ishihara, Yuta Matsubara, Junko Hamamoto, Hiroyuki Hayashi, Yukihiro Yoshimura, Natsuo Tachikawa, Emmy Yanagita, Takayoshi Hyugaji, Eigo Shimizu, Kotoe Katayama, Yasuhiro Kato, Takayoshi Morita, Kazuhisa Takahashi, Norihiro Harada, Toshio Naito, Makoto Hiki, Yasushi Matsushita, Haruhi Takagi, Ryousuke Aoki, Ai Nakamura, Sonoko Harada, Hitoshi Sasano, Hiroki Kabata, Katsunori Masaki, Hirofumi Kamata, Shinnosuke Ikemura, Shotaro Chubachi, Satoshi Okamori, Hideki Terai, Atsuho Morita, Takanori Asakura, Junichi Sasaki, Hiroshi Morisaki, Yoshifumi Uwamino, Kosaku Nanki, Sho Uchida, Shunsuke Uno, Tomoyasu Nishimura, Takashi Ishiguro, Taisuke Isono, Shun Shibata, Yuma Matsui, Chiaki Hosoda, Kenji Takano, Takashi Nishida, Yoichi Kobayashi, Yotaro Takaku, Noboru Takayanagi, Soichiro Ueda, Ai Tada, Masayoshi Miyawaki, Masaomi Yamamoto, Eriko Yoshida, Reina Hayashi, Tomoki Nagasaka, Sawako Arai, Yutaro Kaneko, Kana Sasaki, Etsuko Tagaya, Masatoshi Kawana, Ken Arimura, Kunihiko Takahashi, Tatsuhiko Anzai, Satoshi Ito, Akifumi Endo, Yuji Uchimura, Yasunari Miyazaki, Takayuki Honda, Tomoya Tateishi, Shuji Tohda, Naoya Ichimura, Kazunari Sonobe, Chihiro Tani Sassa, Jun Nakajima, Yasushi Nakano, Yukiko Nakajima, Ryusuke Anan, Ryosuke Arai, Yuko Kurihara, Yuko Harada, Kazumi Nishio, Tetsuya Ueda, Masanori Azuma, Ryuichi Saito, Toshikatsu Sado, Yoshimune Miyazaki, Ryuichi Sato, Yuki Haruta, Tadao Nagasaki, Yoshinori Yasui, Yoshinori Hasegawa, Yoshikazu Mutoh, Tomoki Kimura, Tomonori Sato, Reoto Takei, Satoshi Hagimoto, Yoichiro Noguchi, Yasuhiko Yamano, Hajime Sasano, Sho Ota, Yasushi Nakamori, Kazuhisa Yoshiya, Fukuki Saito, Tomoyuki Yoshihara, Daiki Wada, Hiromu Iwamura, Syuji Kanayama, Shuhei Maruyama, Takashi Yoshiyama, Ken Ohta, Hiroyuki Kokuto, Hideo Ogata, Yoshiaki Tanaka, Kenichi Arakawa, Masafumi Shimoda, Takeshi Osawa, Hiroki Tateno, Isano Hase, Shuichi Yoshida, Shoji Suzuki, Miki Kawada, Hirohisa Horinouchi, Fumitake Saito, Keiko Mitamura, Masao Hagihara, Junichi Ochi, Tomoyuki Uchida, Rie Baba, Daisuke Arai, Takayuki Ogura, Hidenori Takahashi, Shigehiro Hagiwara, Genta Nagao, Shunichiro Konishi, Ichiro Nakachi, Koji Murakami, Mitsuhiro Yamada, Hisatoshi Sugiura, Hirohito Sano, Shuichiro Matsumoto, Nozomu Kimura, Yoshinao Ono, Hiroaki Baba, Yusuke Suzuki, Sohei Nakayama, Keita Masuzawa, Shinichi Namba, Ken Suzuki, Yoko Naito, Yu-Chen Liu, Ayako Takuwa, Fuminori Sugihara, James B Wing, Shuhei Sakakibara, Nobuyuki Hizawa, Takayuki Shiroyama, Satoru Miyawaki, Yusuke Kawamura, Akiyoshi Nakayama, Hirotaka Matsuo, Yuichi Maeda, Takuro Nii, Yoshimi Noda, Takayuki Niitsu, Yuichi Adachi, Takatoshi Enomoto, Saori Amiya, Reina Hara, Yuta Yamaguchi, et al. DOCK2 is involved in the host genetics and biology of severe COVID-19. Nature. 2022.08; 609 754-760. ( PubMed, DOI )

Yasushi Murakami, Yuichiro Shindo, Masahiro Sano, Junya Okumura, Hironori Kobayashi, Toshihiro Sakakibara, Mitsutaka Iguchi, Kunihiko Takahashi, Tetsuya Yagi, Shigeyuki Matsui, Yoshinori Hasegawa. Effects of lymphocyte and neutrophil counts and their time courses on mortality in patients with postoperative pneumonia. Sci Rep. 2022.08; 12 (1): 14564. ( PubMed, DOI )

Qingbo S Wang, Ryuya Edahiro, Ho Namkoong, Takanori Hasegawa, Yuya Shirai, Kyuto Sonehara, Hiromu Tanaka, Ho Lee, Ryunosuke Saiki, Takayoshi Hyugaji, Eigo Shimizu, Kotoe Katayama, Masahiro Kanai, Tatsuhiko Naito, Noah Sasa, Kenichi Yamamoto, Yasuhiro Kato, Takayoshi Morita, Kazuhisa Takahashi, Norihiro Harada, Toshio Naito, Makoto Hiki, Yasushi Matsushita, Haruhi Takagi, Masako Ichikawa, Ai Nakamura, Sonoko Harada, Yuuki Sandhu, Hiroki Kabata, Katsunori Masaki, Hirofumi Kamata, Shinnosuke Ikemura, Shotaro Chubachi, Satoshi Okamori, Hideki Terai, Atsuho Morita, Takanori Asakura, Junichi Sasaki, Hiroshi Morisaki, Yoshifumi Uwamino, Kosaku Nanki, Sho Uchida, Shunsuke Uno, Tomoyasu Nishimura, Takashri Ishiguro, Taisuke Isono, Shun Shibata, Yuma Matsui, Chiaki Hosoda, Kenji Takano, Takashi Nishida, Yoichi Kobayashi, Yotaro Takaku, Noboru Takayanagi, Soichiro Ueda, Ai Tada, Masayoshi Miyawaki, Masaomi Yamamoto, Eriko Yoshida, Reina Hayashi, Tomoki Nagasaka, Sawako Arai, Yutaro Kaneko, Kana Sasaki, Etsuko Tagaya, Masatoshi Kawana, Ken Arimura, Kunihiko Takahashi, Tatsuhiko Anzai, Satoshi Ito, Akifumi Endo, Yuji Uchimura, Yasunari Miyazaki, Takayuki Honda, Tomoya Tateishi, Shuji Tohda, Naoya Ichimura, Kazunari Sonobe, Chihiro Tani Sassa, Jun Nakajima, Yasushi Nakano, Yukiko Nakajima, Ryusuke Anan, Ryosuke Arai, Yuko Kurihara, Yuko Harada, Kazumi Nishio, Tetsuya Ueda, Masanori Azuma, Ryuichi Saito, Toshikatsu Sado, Yoshimune Miyazaki, Ryuichi Sato, Yuki Haruta, Tadao Nagasaki, Yoshinori Yasui, Yoshinori Hasegawa, Yoshikazu Mutoh, Tomoki Kimura, Tomonori Sato, Reoto Takei, Satoshi Hagimoto, Yoichiro Noguchi, Yasuhiko Yamano, Hajime Sasano, Sho Ota, Yasushi Nakamori, Kazuhisa Yoshiya, Fukuki Saito, Tomoyuki Yoshihara, Daiki Wada, Hiromu Iwamura, Syuji Kanayama, Shuhei Maruyama, Takashi Yoshiyama, Ken Ohta, Hiroyuki Kokuto, Hideo Ogata, Yoshiaki Tanaka, Kenichi Arakawa, Masafumi Shimoda, Takeshi Osawa, Hiroki Tateno, Isano Hase, Shuichi Yoshida, Shoji Suzuki, Miki Kawada, Hirohisa Horinouchi, Fumitake Saito, Keiko Mitamura, Masao Hagihara, Junichi Ochi, Tomoyuki Uchida, Rie Baba, Daisuke Arai, Takayuki Ogura, Hidenori Takahashi, Shigehiro Hagiwara, Genta Nagao, Shunichiro Konishi, Ichiro Nakachi, Koji Murakami, Mitsuhiro Yamada, Hisatoshi Sugiura, Hirohito Sano, Shuichiro Matsumoto, Nozomu Kimura, Yoshinao Ono, Hiroaki Baba, Yusuke Suzuki, Sohei Nakayama, Keita Masuzawa, Shinichi Namba, Takayuki Shiroyama, Yoshimi Noda, Takayuki Niitsu, Yuichi Adachi, Takatoshi Enomoto, Saori Amiya, Reina Hara, Yuta Yamaguchi, Teruaki Murakami, Tomoki Kuge, Kinnosuke Matsumoto, Yuji Yamamoto, Makoto Yamamoto, Midori Yoneda, Kazunori Tomono, Kazuto Kato, Haruhiko Hirata, Yoshito Takeda, Hidefumi Koh, Tadashi Manabe, Yohei Funatsu, Fumimaro Ito, Takahiro Fukui, Keisuke Shinozuka, Sumiko Kohashi, Masatoshi Miyazaki, Tomohisa Shoko, Mitsuaki Kojima, Tomohiro Adachi, Motonao Ishikawa, Kenichiro Takahashi, Takashi Inoue, Toshiyuki Hirano, Keigo Kobayashi, Hatsuyo Takaoka, et al. The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force. Nat Commun. 2022.08; 13 (1): 4830. ( PubMed, DOI )

Kazuki Nishida, Takuya Usami, Nana Matsumoto, Mitsuaki Nishikimi, Kunihiko Takahashi, Shigeyuki Matsui. The finger-to-nose test improved diagnosis of cerebrovascular events in patients presenting with isolated dizziness in the emergency department. Nagoya J Med Sci. 2022.08; 84 (3): 621-629. ( PubMed, DOI )

Shiro Hatakeyama, Mikako Goto, Ayaka Yamamoto, Jiro Ogura, Norikazu Watanabe, Seiji Tsutsumi, Naho Yakuwa, Ritsuko Yamane, Satoru Nagase, Kunihiko Takahashi, Rika Kosaki, Atsuko Murashima, Hiroaki Yamaguchi. The safety of pranlukast and montelukast during the first trimester of pregnancy: A prospective, two-centered cohort study in Japan. Congenit Anom (Kyoto). 2022.07; 62 (4): 161-168. ( PubMed, DOI )

Hiroyuki Inose, Akane Ariga, Takayuki Motoyoshi, Kazuyuki Fukushima, Shoji Tomizawa, Tsuyoshi Kato, Kunihiko Takahashi, Toshitaka Yoshii, Atsushi Okawa. The Real-World Effect of 12 Months of Romosozumab Treatment on Patients With Osteoporosis With a High Risk of Fracture and Factors Predicting the Rate of Bone Mass Increase: A Multicenter Retrospective Study. JBMR Plus. 2022.07; 6 (7): e10637. ( PubMed, DOI )

Masahiro Sano, Yuichiro Shindo, Kunihiko Takahashi, Junya Okumura, Toshihiro Sakakibara, Yasushi Murakami, Mitsutaka Iguchi, Tetsuya Yagi, Shigeyuki Matsui, Yoshinori Hasegawa. Risk factors for antibiotic resistance in hospital-acquired and ventilator-associated pneumonia. J Infect Chemother. 2022.06; 28 (6): 745-752. ( PubMed, DOI )

Keibun Liu, Junichiro Shibata, Kiyoyasu Fukuchi, Kunihiko Takahashi, Tomohiro Sonoo, Takayuki Ogura, Tadahiro Goto. Optimal timing of introducing mobilization therapy for ICU patients with sepsis. J Intensive Care. 2022.04; 10 (1): 22. ( PubMed, DOI )

Takako Ishikawa, Sakiko Fukui, Junko Fujita, Aya Fujikawa, Yuka Iwahara, Kunihiko Takahashi. Factors Related to End-of-Life Care Discussions Among Community-Dwelling People in Japan. J Pain Symptom Manage. 2022.04; 63 (4): 539-547. ( PubMed, DOI )

Hiroyuki Inose, Takashi Hirai, Toshitaka Yoshii, Atsushi Kimura, Katsushi Takeshita, Hirokazu Inoue, Asato Maekawa, Kenji Endo, Takuya Miyamoto, Takeo Furuya, Akira Nakamura, Kanji Mori, Shunsuke Kanbara, Shiro Imagama, Shoji Seki, Shunji Matsunaga, Kunihiko Takahashi, Atsushi Okawa. Factors contributing to neck pain in patients with degenerative cervical myelopathy: A prospective multicenter study. J Orthop Surg (Hong Kong). 2022.04; 30 (1): 10225536221091848. ( PubMed, DOI )

Masateru Takigawa, Masahiko Goya, Hidehiro Iwakawa, Claire A Martin, Tatsuhiko Anzai, Kunihiko Takahashi, Tatsuaki Kamata, Yu Matsumura, Miki Amemiya, Tasuku Yamamoto, Tatsuhiko Hirao, Masahiro Sekigawa, Yasuhiro Shirai, Susumu Tao, Yoshihide Takahashi, Tetsuo Sasano. Impact of a formula combining local impedance and conventional parameters on lesion size prediction. J Interv Card Electrophysiol. 2022.03; 63 (2): 389-398. ( PubMed, DOI )

Noriyuki Takahashi, Takaharu Matsuhisa, Kunihiko Takahashi, Nobutaro Ban. Diversity of academic general medicine: A cross-sectional bibliometric study of original English-language research articles in general medicine and cardiology in Japan. Medicine (Baltimore). 2022.03; 101 (11): ( PubMed, DOI )

Keibun Liu, Toru Kotani, Kensuke Nakamura, Takai Chihiro, Yasunari Morita, Kenzo Ishii, Kenji Fujizuka, Daisetsu Yasumura, Daisuke Taniguchi, Tomohiro Hamagami, Nobutake Shimojo, Masakazu Nitta, Takashi Hongo, Kazuki Akieda, Maeda Atsuo, Tadashi Kaneko, Yutaka Sakuda, Kohkichi Andoh, Akiyoshi Nagatomi, Yukiko Tanaka, Yuhei Irie, Hiroshi Kamijo, Manabu Hanazawa, Daisuke Kasugai, Matsuoka Ayaka, Kenji Oike, Alan Kawarai Lefor, Kunihiko Takahashi, Hajime Katsukawa, Takayuki Ogura. Effects of evidence-based ICU care on long-term outcomes of patients with sepsis or septic shock (ILOSS): protocol for a multicentre prospective observational cohort study in Japan. BMJ Open. 2022.03; 12 (3): e054478. ( PubMed, DOI )

Hidehiro Iwakawa, Masateru Takigawa, Masahiko Goya, Toyoto Iwata, Claire A Martin, Tatsuhiko Anzai, Kunihiko Takahashi, Miki Amemiya, Tasuku Yamamoto, Masahiro Sekigawa, Yasuhiro Shirai, Susumu Tao, Tatsuya Hayashi, Yoshihide Takahashi, Hiroyuki Watanabe, Tetsuo Sasano. Clinical implications of local impedance measurement using the IntellaNav MiFi OI ablation catheter: an ex vivo study. J Interv Card Electrophysiol. 2022.01; 63 (1): 185-195. ( PubMed, DOI )

Toshihiro Sakakibara, Yuichiro Shindo, Daisuke Kobayashi, Masahiro Sano, Junya Okumura, Yasushi Murakami, Kunihiko Takahashi, Shigeyuki Matsui, Tetsuya Yagi, Hideo Saka, Yoshinori Hasegawa. A prediction rule for severe adverse events in all inpatients with community-acquired pneumonia: a multicenter observational study. BMC Pulm Med. 2022.01; 22 (1): 34. ( PubMed, DOI )

Ryota Sato, Daisuke Hasegawa, Narut Prasitlumkum, Miki Ueoka, Kazuki Nishida, Kunihiko Takahashi, Michitaka Nasu, Siddharth Dugar. Effect of IV High-Dose Vitamin C on Mortality in Patients With Sepsis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Crit Care Med. 2021.12; 49 (12): 2121-2130. ( PubMed, DOI )

COVID-19 Host Genetics Initiative. Mapping the human genetic architecture of COVID-19. Nature. 2021.12; 600 (7889): 472-477. ( PubMed, DOI )

Sakiko Fukui, Takako Ishikawa, Yuka Iwahara, Aya Fujikawa, Junko Fujita, Kunihiko Takahashi. Measuring well-being in older adults: Identifying an appropriate single-item questionnaire. Geriatr Gerontol Int. 2021.12; 21 (12): 1131-1137. ( PubMed, DOI )

Ryota Sato, Daisuke Hasegawa, Kazuki Nishida, Kunihiko Takahashi, Mary Schleicher, Neal Chaisson. Prevalence of pulmonary embolism in patients with acute exacerbations of COPD: A systematic review and meta-analysis. Am J Emerg Med. 2021.12; 50 606-617. ( PubMed, DOI )

Hiromu Tanaka, Ho Lee, Atsuho Morita, Ho Namkoong, Shotaro Chubachi, Hiroki Kabata, Hirofumi Kamata, Makoto Ishii, Naoki Hasegawa, Norihiro Harada, Tetsuya Ueda, Soichiro Ueda, Takashi Ishiguro, Ken Arimura, Fukuki Saito, Takashi Yoshiyama, Yasushi Nakano, Yoshikazu Mutoh, Yusuke Suzuki, Koji Murakami, Yukinori Okada, Ryuji Koike, Yuko Kitagawa, Katsushi Tokunaga, Akinori Kimura, Seiya Imoto, Satoru Miyano, Seishi Ogawa, Takanori Kanai, Koichi Fukunaga, The Japan COVID-19 Task Force. Clinical Characteristics of Patients with Coronavirus Disease (COVID-19): Preliminary Baseline Report of Japan COVID-19 Task Force, a Nationwide Consortium to Investigate Host Genetics of COVID-19. Int J Infect Dis. 2021.12; 113 74-81. ( PubMed, DOI )

Takahiro Otani, Kunihiko Takahashi. Flexible scan statistics for detecting spatial disease clusters: The rflexscan R package. J Stat Softw. 2021.10; 99 (13): 1-29. ( DOI )

Keibun Liu, Kensuke Nakamura, Hajime Katsukawa, Peter Nydahl, Eugene Wesley Ely, Sapna R Kudchadkar, Kunihiko Takahashi, Muhammed Elhadi, Mohan Gurjar, Be Kim Leong, Chi Ryang Chung, Jayachandran Balachandran, Shigeaki Inoue, Alan Kawarai Lefor, Osamu Nishida. Implementation of the ABCDEF Bundle for Critically Ill ICU Patients During the COVID-19 Pandemic: A Multi-National 1-Day Point Prevalence Study. Front Med (Lausanne). 2021.10; 8 735860. ( PubMed, DOI )

Hiroyuki Inose, Tsuyoshi Kato, Shoichi Ichimura, Hiroaki Nakamura, Masatoshi Hoshino, Daisuke Togawa, Toru Hirano, Yasuaki Tokuhashi, Tetsuro Ohba, Hirotaka Haro, Takashi Tsuji, Kimiaki Sato, Yutaka Sasao, Masahiko Takahata, Koji Otani, Suketaka Momoshima, Kunihiko Takahashi, Masato Yuasa, Takashi Hirai, Toshitaka Yoshii, Atsushi Okawa. Risk factors for subsequent vertebral fracture after acute osteoporotic vertebral fractures. Eur Spine J. 2021.09; 30 (9): 2698-2707. ( PubMed, DOI )

Chie Kohno, Kayoko Kaneko, Kunihiko Takahashi, Yukihiro Ohya, Hiroshi Nakajima, Atsuko Murashima. Intrauterine exposure to immunosuppressants influences the development of postnatal allergic diseases. Allergy. 2021.09; 76 (9): 2890-2893. ( PubMed, DOI )

Hiroyuki Inose, Toshitaka Yoshii, Atsushi Kimura, Katsushi Takeshita, Hirokazu Inoue, Asato Maekawa, Kenji Endo, Takuya Miyamoto, Takeo Furuya, Akira Nakamura, Kanji Mori, Shunsuke Kanbara, Shiro Imagama, Shoji Seki, Shunji Matsunaga, Kunihiko Takahashi, Atsushi Okawa. Predictors of Falls in Patients with Degenerative Cervical Myelopathy: A Prospective Multi-institutional Study. Spine (Phila Pa 1976). 2021.08; 46 (15): 1007-1013. ( PubMed, DOI )

Toshiki Fukasawa, Hayato Takahashi, Kunihiko Takahashi, Nanae Tanemura, Masayuki Amagai, Hisashi Urushihara. Risk of Stevens-Johnson syndrome and toxic epidermal necrolysis associated with anticonvulsants in a Japanese population: Matched case-control and cohort studies. Allergol Int. 2021.07; 70 (3): 335-342. ( PubMed, DOI )

Tatsuhiko Anzai, Takashi Yamauchi, Masaki Ozawa, Kunihiko Takahashi. A Generalized Structural Equation Model Approach to Long Working Hours and Near-Misses among Healthcare Professionals in Japan. Int J Environ Res Public Health. 2021.07; 18 (13): 7154. ( PubMed, DOI )

Daisuke Kasugai, Masayuki Ozaki, Kazuki Nishida, Yukari Goto, Kunihiko Takahashi, Shigeyuki Matsui, Naoyuki Matsuda. Relative platelet reductions provide better pathophysiologic signatures of coagulopathies in sepsis. Sci Rep. 2021.07; 11 (1): 14033. ( PubMed, DOI )

Masaru Ejima, Tsukasa Okamoto, Takafumi Suzuki, Tatsuhiko Anzai, Kunihiko Takahashi, Yasunari Miyazaki. Efficacy of treatment with corticosteroids for fibrotic hypersensitivity pneumonitis: a propensity score-matched cohort analysis. BMC Pulm Med. 2021.07; 21 (1): 243. ( PubMed, DOI )

Takahiro Mitsumura, Tsukasa Okamoto, Tsuyoshi Shirai, Yuki Iijima, Rie Sakakibara, Takayuki Honda, Masahiro Ishizuka, Junichi Aiboshi, Tomoya Tateishi, Meiyo Tamaoka, Hidenobu Shigemitsu, Hirokuni Arai, Yasuhiro Otomo, Shuji Tohda, Tatsuhiko Anzai, Kunihiko Takahashi, Shinsuke Yasuda, Yasunari Miyazaki. Predictors associated with clinical improvement of SARS-CoV-2 pneumonia. J Infect Chemother. 2021.06; 27 (6): 857-863. ( PubMed, DOI )

Ryota Sato, Daisuke Hasegawa, Natsumi T Hamahata, Swetha Narala, Kazuki Nishida, Kunihiko Takahashi, Tomoki Sempokuya, Ehab G Daoud. The predictive value of airway occlusion pressure at 100 msec (P0.1) on successful weaning from mechanical ventilation: A systematic review and meta-analysis. J Crit Care. 2021.06; 63 124-132. ( PubMed, DOI )

Daisuke Hasegawa, Ryota Sato, Narut Prasitlumkum, Kazuki Nishida, Kunihiko Takahashi, Tomoaki Yatabe, Osamu Nishida. Effect of Ultrashort-Acting β-Blockers on Mortality in Patients With Sepsis With Persistent Tachycardia Despite Initial Resuscitation: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Chest. 2021.06; 159 (6): 2289-2300. ( PubMed, DOI )

Junji Morisawa, Takahiro Otani, Jo Nishino, Ryo Emoto, Kunihiko Takahashi, Shigeyuki Matsui. Semi-parametric empirical Bayes factor for genome-wide association studies. Eur J Hum Genet. 2021.05; 29 800-807. ( PubMed, DOI )

Kayoko Hishinuma, Ritsuko Yamane, Ikuko Yokoo, Takahide Arimoto, Kunihiko Takahashi, Mikako Goto, Yoshiyuki Saito, Ken Nakajima, Atsuko Murashima, Masahiro Hayashi. Pregnancy outcome after first trimester exposure to domperidone-An observational cohort study. J Obstet Gynaecol Res. 2021.05; 47 (5): 1704-1710. ( PubMed, DOI )

Hiroyuki Inose, Takashi Hirai, Toshitaka Yoshii, Atsushi Kimura, Katsushi Takeshita, Hirokazu Inoue, Asato Maekawa, Kenji Endo, Takeo Furuya, Akira Nakamura, Kanji Mori, Shunsuke Kanbara, Shiro Imagama, Shoji Seki, Shunji Matsunaga, Kunihiko Takahashi, Atsushi Okawa. Predictors associated with neurological recovery after anterior decompression with fusion for degenerative cervical myelopathy. BMC Surg. 2021.03; 21 (1): 144. ( PubMed, DOI )

Keibun Liu, Kensuke Nakamura, Hajime Katsukawa, Muhammed Elhadi, Peter Nydahl, Eugene Wesley Ely, Sapna R Kudchadkar, Kunihiko Takahashi, Shigeaki Inoue, Alan Kawarai Lefor, Jozef Kesecioglu, Osamu Nishida. ABCDEF Bundle and Supportive ICU Practices for Patients With Coronavirus Disease 2019 Infection: An International Point Prevalence Study. Crit Care Explor. 2021.03; 3 (3): e0353. ( PubMed, DOI )

Aya Isumi, Kunihiko Takahashi, Takeo Fujiwara. Prenatal Sociodemographic Factors Predicting Maltreatment of Children up to 3 Years Old: A Prospective Cohort Study Using Administrative Data in Japan. Int J Environ Res Public Health. 2021.03; 18 (5): 2505. ( PubMed, DOI )

Takaharu Matsuhisa, Noriyuki Takahashi, Kunihiko Takahashi, Yuki Yoshikawa, Muneyoshi Aomatsu, Juichi Sato, Stewart W Mercer, Nobutaro Ban. Effect of physician attire on patient perceptions of empathy in Japan: a quasi-randomized controlled trial in primary care. BMC Fam Pract. 2021.03; 22 (1): 59. ( PubMed, DOI )

Yuki Iijima, Tsukasa Okamoto, Tsuyoshi Shirai, Takahiro Mitsumura, Rie Sakakibara, Takayuki Honda, Masahiro Ishizuka, Tomoya Tateishi, Meiyo Tamaoka, Junichi Aiboshi, Yasuhiro Otomo, Tatsuhiko Anzai, Kunihiko Takahashi, Yasunari Miyazaki. MuLBSTA score is a useful tool for predicting COVID-19 disease behavior. J Infect Chemother. 2021.02; 27 (2): 284-290. ( PubMed, DOI )

Tatsuhiko Anzai, Keisuke Fukui, Tsubasa Ito, Yuri Ito, Kunihiko Takahashi. Excess Mortality From Suicide During the Early COVID-19 Pandemic Period in Japan: A Time-Series Modeling Before the Pandemic. J Epidemiol. 2021.02; 31 (2): 152-156. ( PubMed, DOI )

Hiroyuki Inose, Tsuyoshi Kato, Hiroaki Nakamura, Masatoshi Hoshino, Daisuke Togawa, Toru Hirano, Yasuaki Tokuhashi, Tetsuro Ohba, Hirotaka Haro, Takashi Tsuji, Kimiaki Sato, Yutaka Sasao, Masahiko Takahata, Koji Otani, Suketaka Momoshima, Kunihiko Takahashi, Masato Yuasa, Takashi Hirai, Toshitaka Yoshii, Atsushi Okawa. Predictors for quality of life improvement after acute osteoporotic vertebral fracture: results of post hoc analysis of a prospective randomized study. Qual Life Res. 2021.01; 30 (1): 129-135. ( PubMed, DOI )

Aya Isumi, Satomi Doi, Yui Yamaoka, Kunihiko Takahashi, Takeo Fujiwara. Do suicide rates in children and adolescents change during school closure in Japan? The acute effect of the first wave of COVID-19 pandemic on child and adolescent mental health. Child Abuse Negl. 2020.12; 110 (Pt 2): 104680. ( PubMed, DOI )

Takashi Yamauchi, Kunihiko Takahashi, Machi Suka, Takeshi Sasaki, Masaya Takahashi, Toru Yoshikawa, Hiroto Okoshi, Shigeo Umezaki, Hiroyuki Yanagisawa. Longitudinal association between near-misses/minor injuries and moderate/severe injuries in industrial settings by presence/absence of depressive symptoms in a nationally representative sample of workers in Japan. Occup Environ Med. 2020.12; 77 (12): 832-838. ( PubMed, DOI )

Ryo Emoto, Atsushi Kawaguchi, Kunihiko Takahashi, Shigeyuki Matsui. Effect-Size Estimation Using Semiparametric Hierarchical Mixture Models in Disease-Association Studies with Neuroimaging Data. Comput Math Methods Med. 2020.12; 2020 7482403. ( PubMed, DOI )

Daisuke Kasugai, Akihiko Hirakawa, Masuyuki Ozaki, Kazuki Nishida, Takao Ikeda, Kunihiko Takahashi, Shigeyuki Matsui, Norimichi Uenishi. Maximum Norepinephrine Dosage Within 24 Hours as an Indicator of Refractory Septic Shock: A Retrospective Study. J Intensive Care Med. 2020.11; 35 (11): 1285-1289. ( PubMed, DOI )

Kunihiko Takahashi, Hideyasu Shimadzu. Detecting multiple spatial disease clusters: information criterion and scan statistic approach. Int J Health Geogr. 2020.09; 19 (1): 33. ( PubMed, DOI )

Masato Yoshihara, Hiroaki Kajiyama, Satoshi Tamauchi, Shohei Iyoshi, Akira Yokoi, Shiro Suzuki, Michiyasu Kawai, Tetsuro Nagasaka, Kunihiko Takahashi, Shigeyuki Matsui, Fumitaka Kikkawa. Impact of uterus-preserving surgery on Stage I primary mucinous epithelial ovarian carcinoma: A multi-institutional study with propensity score-weighted analysis. Int J Gynaecol Obstet. 2020.08; 150 (2): 177-183. ( PubMed, DOI )

Kunihiko Takahashi, Hideto Takahashi, Tomoki Nakaya, Seiji Yasumura, Tetsuya Ohira, Hitoshi Ohto, Akira Ohtsuru, Sanae Midorikawa, Shinichi Suzuki, Hiroki Shimura, Shunichi Yamashita, Koichi Tanigawa, Kenji Kamiya. Factors Influencing the Proportion of Non-examinees in the Fukushima Health Management Survey for Childhood and Adolescent Thyroid Cancer: Results From the Baseline Survey. J Epidemiol. 2020.07; 30 (7): 301-308. ( PubMed, DOI )

Hideto Takahashi, Seiji Yasumura, Kunihiko Takahashi, Tetsuya Ohira, Akira Ohtsuru, Sanae Midorikawa, Satoru Suzuki, Hiroki Shimura, Tetsuo Ishikawa, Akira Sakai, Shinichi Suzuki, Susumu Yokoya, Koichi Tanigawa, Hitoshi Ohto, Kenji Kamiya. Nested matched case control study for the Japan Fukushima Health Management Survey's first full-scale (second-round) thyroid examination. Medicine (Baltimore). 2020.07; 99 (27): e20440. ( PubMed, DOI )

Maki Takagishi, Nobutoshi Esaki, Kunihiko Takahashi, Masahide Takahashi. Cytoplasmic Dynein Functions in Planar Polarization of Basal Bodies within Ciliated Cells. iScience. 2020.06; 23 (6): 101213. ( PubMed, DOI )

Tatsuhiko Anzai, Kunihiko Takahashi, Michiko Watanabe, Mayumi Mochizuki, Atsuko Murashima. Adverse event reports in patients taking psychiatric medication during pregnancy from spontaneous reports in Japan and the United States: an approach using latent class analysis. BMC Psychiatry. 2020.03; 20 (1): 118. ( PubMed, DOI )

Hiroshi Takagi, Daisuke Hagiwara, Tomoko Handa, Mariko Sugiyama, Takeshi Onoue, Taku Tsunekawa, Yoshihiro Ito, Shintaro Iwama, Motomitsu Goto, Hidetaka Suga, Ryoichi Banno, Kunihiko Takahashi, Shigeyuki Matsui, Hiroshi Arima. Diagnosis of central diabetes insipidus using a vasopressin radioimmunoassay during hypertonic saline infusion. Endocr J. 2020.03; 67 (3): 267-274. ( PubMed, DOI )

Yuma Yasuda, Mitsuaki Nishikimi, Kazuki Nishida, Kunihiko Takahashi, Atsushi Numaguchi, Michiko Higashi, Shigeyuki Matsui, Naoyuki Matsuda. Relationship Between Serum Norepinephrine Levels at ICU Admission and the Risk of ICU-Acquired Delirium: Secondary Analysis of the Melatonin Evaluation of Lowered Inflammation of ICU Trial. Crit Care Explor. 2020.02; 2 (2): e0082. ( PubMed, DOI )

Masato Yoshihara, Hiroaki Kajiyama, Satoshi Tamauchi, Shohei Iyoshi, Akira Yokoi, Shiro Suzuki, Michiyasu Kawai, Tetsuro Nagasaka, Kunihiko Takahashi, Shigeyuki Matsui, Fumitaka Kikkawa. Prognostic impact of pelvic and para-aortic lymphadenectomy on clinically-apparent stage I primary mucinous epithelial ovarian carcinoma: a multi-institutional study with propensity score-weighted analysis. Jpn J Clin Oncol. 2020.02; 50 (2): 145-151. ( PubMed, DOI )

Tasuku Fujii, Yasuyuki Shibata, Yasutaka Ban, Akira Shitaokoshi, Kunihiko Takahashi, Shigeyuki Matsui, Kimitoshi Nishiwaki. A single paravertebral injection via a needle vs. a catheter for the spreading to multiple intercostal levels: a randomized controlled trial. J Anesth. 2020.02; 34 (1): 72-78. ( PubMed, DOI )

T Fujii, Y Shibata, A Akane, W Aoki, A Sekiguchi, K Takahashi, S Matsui, K Nishiwaki. A randomised controlled trial of pectoral nerve-2 (PECS 2) block vs. serratus plane block for chronic pain after mastectomy. Anaesthesia. 2019; 74 (12): 1558-1562. ( PubMed, DOI )

Keibun Liu, Takayuki Ogura, Kunihiko Takahashi, Mitsunobu Nakamura, Hiroaki Ohtake, Kenji Fujiduka, Emi Abe, Hitoshi Oosaki, Dai Miyazaki, Hiroyuki Suzuki, Mitsuaki Nishikimi, Mamoru Komatsu, Alan Kawarai Lefor, Takashi Mato. A Progressive Early Mobilization Program Is Significantly Associated With Clinical and Economic Improvement: A Single-Center Quality Comparison Study. Crit. Care Med.. 2019; 47 (9): e744-e752. ( PubMed, DOI )

Shiori Komori, Shinji Ueno, Yasuki Ito, Akira Sayo, Monika Meinert, Taro Kominami, Daiki Inooka, Masahiro Kitagawa, Kazuki Nishida, Kunihiko Takahashi, Shigeyuki Matsui, Hiroko Terasaki. Steeper Macular Curvature in Eyes With Non-Highly Myopic Retinitis Pigmentosa. Invest. Ophthalmol. Vis. Sci.. 2019; 60 (8): 3135-3141. ( PubMed, DOI )

Takashi Yamauchi, Takeshi Sasaki, Kunihiko Takahashi, Shigeo Umezaki, Masaya Takahashi, Toru Yoshikawa, Machi Suka, Hiroyuki Yanagisawa. Long working hours, sleep-related problems, and near-misses/injuries in industrial settings using a nationally representative sample of workers in Japan. PLoS ONE. 2019; 14 (7): e0219657. ( PubMed, DOI )

Takanori Kawabata, Ryo Emoto, Jo Nishino, Kunihiko Takahashi, Shigeyuki Matsui. Two-stage analysis for selecting fixed numbers of features in omics association studies. Stat Med. 2019; 38 (16): 2956-2971. ( PubMed, DOI )

Mitsuaki Nishikimi, Takayuki Ogura, Kazuki Nishida, Kunihiko Takahashi, Mitsunobu Nakamura, Shigeyuki Matsui, Naoyuki Matsuda, Taku Iwami. External validation of a risk classification at the emergency department of post-cardiac arrest syndrome patients undergoing targeted temperature management. Resuscitation. 2019; 140 135-141. ( PubMed, DOI )

Daisuke Kasugai, Mitsuaki Nishikimi, Kazuki Nishida, Michiko Higashi, Takanori Yamamoto, Atsushi Numaguchi, Kunihiko Takahashi, Shigeyuki Matsui, Naoyuki Matsuda. Timing of administration of epinephrine predicts the responsiveness to epinephrine in norepinephrine-refractory septic shock: a retrospective study. J Intensive Care. 2019; 7 20. ( PubMed, DOI )

Tatsuhiko Anzai, Kunihiko Takahashi, Michiko Watanabe. Adverse reaction reports of neuroleptic malignant syndrome induced by atypical antipsychotic agents in the Japanese Adverse Drug Event Report (JADER) database. Psychiatry Clin. Neurosci.. 2019; 73 (1): 27-33. ( PubMed, DOI )

Kengo Nomura, Takeshi Y Hiyama, Hiraki Sakuta, Takashi Matsuda, Chia-Hao Lin, Kenta Kobayashi, Kazuto Kobayashi, Tomoyuki Kuwaki, Kunihiko Takahashi, Shigeyuki Matsui, Masaharu Noda. [Na+] increases in body fluids sensed by central Nax induce sympathetically mediated blood pressure elevations via H+-dependent activation of ASIC1a. Neuron. 2019; 101 (1): 60-75.e6. ( PubMed, DOI )

Emiko Okada, Kunihiko Takahashi, Koshi Nakamura, Shigekazu Ukawa, Saeka Takabayashi, Mieko Nakamura, Satoshi Sasaki, Akiko Tamakoshi, Hidemi Takimoto. Dietary patterns and abnormal glucose tolerance among Japanese: findings from the National Health and Nutrition Survey, 2012. Public Health Nutr. 2019; 22 (13): 2460-2468. ( PubMed, DOI )

Hiroki Nakajima, Mitsuaki Nishikimi, Miho Shimizu, Kazuhiro Hayashi, Takayuki Inoue, Kazuki Nishida, Kunihiko Takahashi, Shigeyuki Matsui, Yoshihiro Nishida, Naoyuki Matsuda. Clinical Frailty Scale Score Before ICU Admission Is Associated With Mobility Disability in Septic Patients Receiving Early Rehabilitation. Crit Care Explor. 2019; 1 (12): e0066. ( PubMed, DOI )

Masato Yoshihara, Hiroaki Kajiyama, Satoshi Tamauchi, Shiro Suzuki, Kunihiko Takahashi, Shigeyuki Matsui, Fumitaka Kikkawa. Prognostic factors and effects of fertility-sparing surgery in women of reproductive age with ovarian clear-cell carcinoma: a propensity score analysis. J Gynecol Oncol. 2019; 30 (6): e102. ( PubMed, DOI )

Takahiro Otani, Kunihiko Takahashi, Ayano Takeuchi, Mari Asami. Comparison of Spatial Interpolation Methods based on Exposure Assessments of Air Pollutants: A Case Study on Nuclear Substances in Fukushima. Proceedings of the 12th International Joint Conference on Biomedical Engineering Systems and Technologies. 2019; 5 415-421. ( DOI )

Yoshihiro Nishida, Akira Kawai, Junya Toguchida, Akira Ogose, Keisuke Ae, Toshiyuki Kunisada, Yoshihiro Matsumoto, Tomoya Matsunobu, Kunihiko Takahashi, Kazuki Nishida, Toshifumi Ozaki. Clinical features and treatment outcome of desmoid-type fibromatosis: based on a bone and soft tissue tumor registry in Japan. Int J Clin Oncol. 2019; 24 (11): 1498-1505. ( PubMed, DOI )

Masataka Igeta, Kunihiko Takahashi, Shigeyuki Matsui. Power and sample size calculation incorporating misspecifications of the variance function in comparative clinical trials with over-dispersed count data. Biometrics. 2018; 74 (4): 1459-1467. ( PubMed, DOI )

Keibun Liu, Takayuki Ogura, Kunihiko Takahashi, Mitsunobu Nakamura, Hiroaki Ohtake, Kenji Fujiduka, Emi Abe, Hitoshi Oosaki, Dai Miyazaki, Hiroyuki Suzuki, Mitsuaki Nishikimi, Alan Kawarai Lefor, Takashi Mato. The safety of a novel early mobilization protocol conducted by ICU physicians: a prospective observational study. J Intensive Care. 2018; 6 10. ( PubMed, DOI )

Mitsuaki Nishikimi, Takayuki Ogura, Kota Matsui, Kunihiko Takahashi, Kenji Fukaya, Keibun Liu, Hideo Morita, Mitsunobu Nakamura, Shigeyuki Matsui, Naoyuki Matsuda. Accuracy of the first interpretation of early brain CT images for predicting the prognosis of post-cardiac arrest syndrome patients at the emergency department. J Intensive Care. 2018; 6 26. ( PubMed, DOI )

Junya Okumura, Yuichiro Shindo, Kunihiko Takahashi, Masahiro Sano, Yasuteru Sugino, Tetsuya Yagi, Hiroyuki Taniguchi, Hideo Saka, Shigeyuki Matsui, Yoshinori Hasegawa. Mortality in patients with community-onset pneumonia at low risk of drug-resistant pathogens: Impact of β-lactam plus macrolide combination therapy. Respirology. 2018; 23 (5): 526-534. ( PubMed, DOI )

Mitsuaki Nishikimi, Takayuki Ogura, Kazuki Nishida, Kunihiko Takahashi, Kenji Fukaya, Keibun Liu, Mitsunobu Nakamura, Shigeyuki Matsui, Naoyuki Matsuda. Differential effect of mild therapeutic hypothermia depending on the findings of hypoxic encephalopathy on early CT images in patients with post-cardiac arrest syndrome. Resuscitation. 2018; 128 11-15. ( PubMed, DOI )

Mitsuaki Nishikimi, Atsushi Numaguchi, Kunihiko Takahashi, Yasuhiro Miyagawa, Kota Matsui, Michiko Higashi, Go Makishi, Shigeyuki Matsui, Naoyuki Matsuda. Effect of Administration of Ramelteon, a Melatonin Receptor Agonist, on the Duration of Stay in the ICU: A Single-Center Randomized Placebo-Controlled Trial. Crit. Care Med.. 2018; 46 (7): 1099-1105. ( PubMed, DOI )

Saeko Fukamachi, Masayuki Hashiguchi, Kunihiko Takahashi, Mayumi Mochizuki. Exploratory evaluation of a commercially available Japanese medical record database as an external control for comparative clinical trials in new drug development: Amyotrophic lateral sclerosis. Neurology and Clinical Neuroscience. 2018; 6 (4): 94-99. ( DOI )

Yoshiko Tominaga, Tohru Aomori, Tomohisa Hayakawa, Nobuhiko Kijima, Donald E Morisky, Kunihiko Takahashi, Mayumi Mochizuki. Possible associations of personality traits representing harm avoidance and self-directedness with medication adherence in Japanese patients with type 2 diabetes. J Pharm Health Care Sci. 2018; 4 16. ( PubMed, DOI )

Takaharu Matsuhisa, Noriyuki Takahashi, Muneyoshi Aomatsu, Kunihiko Takahashi, Jo Nishino, Nobutaro Ban, Stewart W Mercer. How many patients are required to provide a high level of reliability in the Japanese version of the CARE Measure? A secondary analysis. BMC Fam Pract. 2018; 19 (1): 138. ( PubMed, DOI )

Takayuki Ogura, Yoshihiko Nakamura, Kunihiko Takahashi, Kazuki Nishida, Daisuke Kobashi, Shigeyuki Matsui. Treatment of patients with sepsis in a closed intensive care unit is associated with improved survival: a nationwide observational study in Japan. J Intensive Care. 2018; 6 57. ( PubMed, DOI )

Satoshi Kuriki, Kunihiko Takahashi, Hisayuki Hara. Multiplicity adjustment for temporal and spatial scan statistics using Markov property Japanese Journal of Statistics and Data Science. 2018; 1 (1): 191-231. ( DOI )

Y Tominaga, T Aomori, T Hayakawa, D E Morisky, K Takahashi, M Mochizuki. Relationship between medication adherence and glycemic control in Japanese patients with type 2 diabetes. Pharmazie. 2018; 73 (10): 609-612. ( PubMed, DOI )

Emiko Okada, Kunihiko Takahashi, Hidemi Takimoto, Saeka Takabayashi, Tomoko Kishi, Tohru Kobayashi, Koshi Nakamura, Shigekazu Ukawa, Mieko Nakamura, Satoshi Sasaki, Akiko Tamakoshi. Dietary patterns among Japanese adults: findings from the National Health and Nutrition Survey, 2012. Asia Pac J Clin Nutr. 2018; 27 (5): 1120-1130. ( PubMed, DOI )

Kunihiko Takahashi, Hideyasu Shimadzu. Multiple-cluster detection test for purely temporal disease clustering: Integration of scan statistics and generalized linear models. PLoS ONE. 2018; 13 (11): e0207821. ( PubMed, DOI )

Tomoki Nakaya, Kunihiko Takahashi, Hideto Takahashi, Seiji Yasumura, Tetsuya Ohira, Hitoshi Ohto, Akira Ohtsuru, Sanae Midorikawa, Shinichi Suzuki, Hiroki Shimura, Shunichi Yamashita, Koichi Tanigawa, Kenji Kamiya. Spatial analysis of the geographical distribution of thyroid cancer cases from the first-round thyroid ultrasound examination in Fukushima Prefecture. Sci Rep. 2018; 8 (1): 17661. ( PubMed, DOI )

Ken Horisaki, Kunihiko Takahashi, Hidemi Ito, Shigeyuki Matsui. A Dose-Response Meta-analysis of Coffee Consumption and Colorectal Cancer Risk in the Japanese Population: Application of a Cubic-Spline Model. J Epidemiol. 2018; 28 (12): 503-509. ( PubMed, DOI )

Mitsuaki Nishikimi, Atsushi Numaguchi, Kunihiko Takahashi, Shigeyuki Matsui, Naoyuki Matsuda. The authors reply. Crit Care Med. 2018; 46 (10): e1010-e1011. ( PubMed, DOI )

Mitsuaki Nishikimi, Atsushi Numaguchi, Kunihiko Takahashi, Shigeyuki Matsui, Naoyuki Matsuda. The authors reply. Crit Care Med. 2018; 46 (12): e1225-e1226. ( PubMed, DOI )

Akira Sayo, Shinji Ueno, Taro Kominami, Kazuki Nishida, Daiki Inooka, Ayami Nakanishi, Shunsuke Yasuda, Satoshi Okado, Kunihiko Takahashi, Shigeyuki Matsui, Hiroko Terasaki. Longitudinal study of visual field changes determined by Humphrey Field Analyzer 10-2 in patients with Retinitis Pigmentosa. Sci Rep. 2017; 7 (1): 16383. ( PubMed, DOI )

Kunihiko Takahashi, Hisateru Tachimori, Chiemi Kan, Daisuke Nishi, Yasuyuki Okumura, Naohiro Kato, Tadashi Takeshima. Spatial analysis for regional behavior of patients with mental disorders in Japan. Psychiatry Clin. Neurosci.. 2017; 71 (4): 254-261. ( PubMed, DOI )

Mitsuaki Nishikimi, Naoyuki Matsuda, Kota Matsui, Kunihiko Takahashi, Tadashi Ejima, Keibun Liu, Takayuki Ogura, Michiko Higashi, Hitoshi Umino, Go Makishi, Atsushi Numaguchi, Satoru Matsushima, Hideki Tokuyama, Mitsunobu Nakamura, Shigeyuki Matsui. A novel scoring system for predicting the neurologic prognosis prior to the initiation of induced hypothermia in cases of post-cardiac arrest syndrome: the CAST score. Scand J Trauma Resusc Emerg Med. 2017; 25 (1): 49. ( PubMed, DOI )

Maki Takagishi, Masato Sawada, Shinya Ohata, Naoya Asai, Atsushi Enomoto, Kunihiko Takahashi, Liang Weng, Kaori Ushida, Hosne Ara, Shigeyuki Matsui, Kozo Kaibuchi, Kazunobu Sawamoto, Masahide Takahashi. Daple Coordinates Planar Polarized Microtubule Dynamics in Ependymal Cells and Contributes to Hydrocephalus. Cell Rep. 2017; 20 (4): 960-972. ( PubMed, DOI )

Yasuyuki Okumura, Nobuo Sakata, Kunihiko Takahashi, Daisuke Nishi, Hisateru Tachimori. Epidemiology of overdose episodes from the period prior to hospitalization for drug poisoning until discharge in Japan: An exploratory descriptive study using a nationwide claims database. J Epidemiol. 2017; 27 (8): 373-380. ( PubMed, DOI )

Hideto Takahashi, Kunihiko Takahashi, Hiroki Shimura, Seiji Yasumura, Satoru Suzuki, Akira Ohtsuru, Sanae Midorikawa, Tetsuya Ohira, Hitoshi Ohto, Shunichi Yamashita, Kenji Kamiya. Simulation of expected childhood and adolescent thyroid cancer cases in Japan using a cancer-progression model based on the National Cancer Registry: Application to the first-round thyroid examination of the Fukushima Health Management Survey. Medicine (Baltimore). 2017; 96 (48): e8631. ( PubMed, DOI )

Eiji Sadashima, Satoshi Hattori, Kunihiko Takahashi. Meta-analysis of prognostic studies for a biomarker with a study-specific cutoff value. Res Synth Methods. 2016; 7 (4): 402-419. ( PubMed, DOI )

Mitsuaki Nishikimi, Naoyuki Matsuda, Kota Matsui, Kunihiko Takahashi, Tadashi Ejima, Keibun Liu, Takayuki Ogura, Michiko Higashi, Hitoshi Umino, Go Makishi, Atsushi Numaguchi, Satoru Matsushima, Hideki Tokuyama, Mitsunobu Nakamura, Shigeyuki Matsui. CAST: a new score for early prediction of neurological outcomes after cardiac arrest before therapeutic hypothermia with high accuracy. Intensive Care Med. 2016; 42 (12): 2106-2107. ( PubMed, DOI )

Kunihiko Takahashi, Hideyasu Shimadzu. The daily incidence of out-of-hospital cardiac arrest unexpectedly increases around New Year's Day in Japan. Resuscitation. 2015; 96 156-162. ( PubMed, DOI )

Kaori Nomura, Kunihiko Takahashi, Yasushi Hinomura, Genta Kawaguchi, Yasuyuki Matsushita, Hiroko Marui, Tatsuhiko Anzai, Masayuki Hashiguchi, Mayumi Mochizuki. Effect of database profile variation on drug safety assessment: an analysis of spontaneous adverse event reports of Japanese cases. Drug Des Devel Ther. 2015; 9 3031-3041. ( PubMed, DOI )

Daisuke Ogino, Kunihiko Takahashi, Hajime Sato. Characteristics of clinical trial websites: information distribution between ClinicalTrials.gov and 13 primary registries in the WHO registry network. Trials. 2014; 15 428. ( PubMed, DOI )

Tatsuya Kubokawa, Mana Hasukawa, Kunihiko Takahashi. On measuring uncertainty of benchmarked predictors with application to disease risk estimate. Scandinavian Journal of Statistics. 2014; 41 394-413. ( DOI )

Tsutomu Nakashima, Hiroaki Sato, Kiyofumi Gyo, Naohito Hato, Tadao Yoshida, Mariko Shimono, Masaaki Teranishi, Michihiko Sone, Yukari Fukunaga, Gen Kobashi, Kunihiko Takahashi, Shigeyuki Matsui, Kaoru Ogawa. Idiopathic sudden sensorineural hearing loss in Japan. Acta Otolaryngol.. 2014; 134 (11): 1158-1163. ( PubMed, DOI )

Kunihiko Takahashi, Hiroyuki Nakao, Satoshi Hattori. Cubic spline regression of J-shaped dose-response curves with likelihood-based assignments of grouped exposure levels Journal of Biometrics & Biostatistics. 2013; 4 181. ( DOI )

Hiroshi Yokomichi, Tetsuji Yokoyama, Kunihiko Takahashi, Nobuo Yoshiike, Zentaro Yamagata, Toshiro Tango. An improved statistical method to estimate usual intake distribution of nutrients by age group Journal of Nutrition & Food Sciences. 2013; 3 196. ( DOI )

Toshiro Tango, Kunihiko Takahashi. A flexible spatial scan statistic with a restricted likelihood ratio for detecting disease clusters. Stat Med. 2012; 31 (30): 4207-4218. ( PubMed, DOI )

Toshiro Tango, Kunihiko Takahashi, Kazuaki Kohriyama. A space-time scan statistic for detecting emerging outbreaks. Biometrics. 2011; 67 (1): 106-115. ( PubMed, DOI )

Takeshi Nishiyama, Kunihiko Takahashi, Toshiro Tango, Dalila Pinto, Stephen W Scherer, Satoshi Takami, Hirohisa Kishino. A scan statistic to extract causal gene clusters from case-control genome-wide rare CNV data. BMC Bioinformatics. 2011; 12 205. ( PubMed, DOI )

Kunihiko Takahashi, Toshiro Tango. Assignment of grouped exposure levels for trend estimation in a regression analysis of summarized data. Stat Med. 2010; 29 (25): 2605-2616. ( PubMed, DOI )

Yuriko Doi, Testuji Yokoyama, Toshiro Tango, Kunihiko Takahashi, Kenichi Fujimoto, Imaharu Nakano. Temporal trends and geographic clusters of mortality from amyotrophic lateral sclerosis in Japan, 1995-2004. J. Neurol. Sci.. 2010; 298 (1-2): 78-84. ( PubMed, DOI )

Takeo Fujiwara, Makiko Okuyama, Kunihiko Takahashi. Paternal involvement in childcare and unintentional injury of young children: a population-based cohort study in Japan. Int J Epidemiol. 2010; 39 (2): 588-597. ( PubMed, DOI )

Tomoko Tachibana, Kunihiko Takahashi, Toyoo Sakurayama. Factors causing the rapid turnover among novice nursing staff: analyses of the survey conducted in 2006 on the employment situation of nursing staff in the Tokyo metropolitan area. Journal of the National Institute of Public Health. 2010; 59 (2): 178-187. ( ichushi )

Kunihiko Takahashi, Martin Kulldorff, Toshiro Tango, Katherine Yih. A flexibly shaped space-time scan statistic for disease outbreak detection and monitoring. Int J Health Geogr. 2008; 7 14. ( PubMed, DOI )

Y Doi, T Yokoyama, M Sakai, Y Nakamura, T Tango, K Takahashi. Spatial clusters of Creutzfeldt-Jakob disease mortality in Japan between 1995 and 2004. Neuroepidemiology. 2008; 30 (4): 222-228. ( PubMed, DOI )

Kunihiko Takahashi, Toshiro Tango. An extended power of cluster detection tests. Stat Med. 2006; 25 (5): 841-852. ( PubMed, DOI )

Toshiro Tango, Kunihiko Takahashi. A flexibly shaped spatial scan statistic for detecting clusters. Int J Health Geogr. 2005; 4 11. ( PubMed, DOI )

Masafumi Akahira, Kunihiko Takahashi. A higher order large-deviation approximation for the discrete distributions. Journal of the Japan Statistical Society. 2001; 31 (2): 257-267. ( DOI )

Masafumi Akahira, Kunihiko Takahashi, Kei Takeuchi. The higher order large-deviation approximation for the distribution of the sum of independent discrete random variables. Communications in Statistics - Theory and Methods. 1999; 28 705-726. ( DOI )

Kunihiko Takahashi. Randomized confidence intervals of a parameter for the negative binomial and logarithmic series distributions. Journal of the Japan Statistical Society. 1999; 29 (2): 201-212. ( DOI )

Masafumi Akahira, Hiroyuki Kashima, Kunihiko Takahashi. A generalized binomial distribution determined by a two-state Markov chain and a distribution by the Bayesian approach. Statistical Papers. 1997; 38 (1): 27-42. ( DOI )

Masafumi Akahira, Kunihiko Takahashi, Kei Takeuchi. Randomized confidence intervals of a parameter for a family of discrete exponential type distributions. Communications in Statistics - Simulation and Computation. 1997; 26 (3): 1103-1128. ( DOI )

Takahashi K, Shimadzu H. Detecting multiple spatial-clusters by scan statistics. XXIXth International Biometric Conference 2018.07

Takahashi K. Spatial epidemiology: risk assessment of spatio-temporal events. 13th DIA JAPAN Anuual Meeting 2016: Invited 2016.11.15

Takahashi K, Shimadzu H. A multiple cluster detection test for disease clustering based on scan statistics. XXVIIIth International Biometric Conference 2016.07

Takahashi K, Tachimori H. Applied spatial statistics for epidemiological studies on mental health. World Psychiatric Association (WPA) Regional Congress Osaka Japan 2015: Symposium 2015.06.04

Takahashi K, Nakao H, Hattori S. Meta-analysis of J-shaped dose-response curves with likelihood-based assignments of grouped exposure levels. XXVIIth International Biometric Conference 2014.07