Personnel Information

写真a

HIRA Riichiro


Job title

Associate Professor

Birth date

1984
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Graduating School 【 display / non-display 】

  • Tohoku University, Faculty of Medicine, 2009.03, Graduated

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Graduate School 【 display / non-display 】

  • The University of Tokyo, Graduate School, Division of Medical Sciences, Doctor's Course, 2013.03, Completed

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Campus Career 【 display / non-display 】

  • 2020.04
    -
    2024.09
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Systemic Organ Regulation， Physiology and Cell Biology， Associate Professor
  • 2024.10
    -
    Now
    Institute of Science Tokyo， -， Graduate Schools， Systemic Organ Regulation， Department of Physiology and Cell Biology， Associate Professor
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External Career 【 display / non-display 】

  • 2013.04
    -
    2016.03
    , Assistant Professor
  • 2016.04
    -
    2018.10
    UNC Chapel Hill, Neuroscience center, Postdoc
  • 2018.11
    -
    2020.03
    UC Santa Barbara, Bioengineering, Postdoc
  • 2020.04
    -
    Now
    Tokyo Medical and Dental University, Depeartment of Cell biology and Physiology, Associate Professor
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Research Areas 【 display / non-display 】

  • Physiology

  • Neuroscience-general

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Qualification Acquired 【 display / non-display 】

  • Doctor

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Research Theme 【 display / non-display 】

  • Large-scale neural activity recordings and a holistic understanding of the brain, 2021.08 - 2024.03

  • Holism in neuroscience: Large-scale recording and simulation, 2021.08 - 2024.03

  • Holism in neuroscience: Large-scale recording and simulation, 2021.08 - 2024.03

  • Intentional control of learning by BMI, 2020.09 - 2022.03

  • Updating the concept of morality based on science, 2016.04 - 2019.03

  • Development of a Nonlinear Timeseries Analysis for Functional Neural Connectivity Estimation, 2015.07 - 2019.03

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Published Papers & Misc 【 display / non-display 】

  1. Hikaru Sugino, Sho Tanno, Tatsumi Yoshida, Yoshikazu Isomura, Riichiro Hira. Functional segregation and dynamic integration of the corticotectal descending signal in rat. Neuroscience research. 2024.09; 210 38-50. ( PubMed, DOI )

  2. Riichiro Hira. Closed-loop experiments and brain machine interfaces with multiphoton microscopy Neurophotonics. 2024.02;

  3. Rios A, Nonomura S, Kato S, Yoshida J, Matsushita N, Nambu A, Takada M, Hira R, Kobayashi K, Sakai Y, Kimura M, Isomura Y. Reward expectation enhances action-related activity of nigral dopaminergic and two striatal output pathways Commun Biol. 2023.09; 6 (1): 914. ( PubMed, DOI )

  4. Riichiro Hira, Leah B. Townsend, Ikuko T. Smith, Che-Hang Yu, Jeffrey N. Stirman, Yiyi Yu, Spencer LaVere Smith. Mesoscale functional architecture in medial posterior parietal cortex bioRxiv (preprint). 2023.08; ( PubMed, DOI )

  5. Tomohiko Yoshizawa , Yuuto Miyamura , Yuta Ochi , Riichiro Hira , Makoto Funahashi , Yutaka Sakai , Yilong Cui , Yoshikazu Isomura. Working memory-based and -free reward prediction in a dual dopamine system in the basal ganglia bioRxiv (preprint). 2023.03; ( DOI )

  6. CH Yu, JN Stirman, Y Yu, R Hira, SL Smith. Diesel2p mesoscope with dual independent scan engines for flexible capture of dynamics in distributed neural circuitry Nature Communications. 2021.11; 12 (1): 6639. ( PubMed, DOI )

  7. Kato Daisuke, Wake Hiroaki, Lee Philip, Tachibana Yoshihisa, Ono Riho, Sugio Shouta, Tsuji Yukio, Tanaka Yasuyo, Tanaka Yasuhiro, Masamizu Yoshito, Hira Riichiro, Moorhouse Andrew, Tamamaki Nobuaki, Ikenaka Kazuhiro, Matsukawa Noriyuki, Fields Douglas, Nabekura Junichi, Matsuzaki Masanori. 学習障害を引き起こす髄鞘機能障害の神経回路基盤(Illumination of abnormal neural activities caused by myelin impairment suggests possible contribution to learning deficits) The Journal of Physiological Sciences. 2020.03; 70 (Suppl.1): S172. ( ichushi )

  8. Daisuke Kato, Hiroaki Wake, Philip R Lee, Yoshihisa Tachibana, Riho Ono, Shouta Sugio, Yukio Tsuji, Yasuyo H Tanaka, Yasuhiro R Tanaka, Yoshito Masamizu, Riichiro Hira, Andrew J Moorhouse, Nobuaki Tamamaki, Kazuhiro Ikenaka, Noriyuki Matsukawa, R Douglas Fields, Junichi Nabekura, Masanori Matsuzaki. Motor learning requires myelination to reduce asynchrony and spontaneity in neural activity. Glia. 2020.01; 68 (1): 193-210. ( PubMed, DOI )

  9. Teppei Ebina, Yoshito Masamizu, Yasuhiro R Tanaka, Akiya Watakabe, Reiko Hirakawa, Yuka Hirayama, Riichiro Hira, Shin-Ichiro Terada, Daisuke Koketsu, Kazuo Hikosaka, Hiroaki Mizukami, Atsushi Nambu, Erika Sasaki, Tetsuo Yamamori, Masanori Matsuzaki. Two-photon imaging of neuronal activity in motor cortex of marmosets during upper-limb movement tasks. Nat Commun. 2018.12; 9 (1): 1879. ( PubMed, DOI )

  10. Yiyi Yu, Riichiro Hira, Jeffrey N Stirman, Waylin Yu, Ikuko T Smith, Spencer L Smith. Mice use robust and common strategies to discriminate natural scenes. Sci Rep. 2018.01; 8 (1): 1379. ( PubMed, DOI )

  11. Riichiro Hira, Shin-Ichiro Terada, Masashi Kondo, Masanori Matsuzaki. Distinct Functional Modules for Discrete and Rhythmic Forelimb Movements in the Mouse Motor Cortex. J. Neurosci.. 2015.09; 35 (39): 13311-13322. ( PubMed, DOI )

  12. Riichiro Hira, Fuki Ohkubo, Yoshito Masamizu, Masamichi Ohkura, Junichi Nakai, Takashi Okada, Masanori Matsuzaki. Reward-timing-dependent bidirectional modulation of cortical microcircuits during optical single-neuron operant conditioning. Nat Commun. 2014.11; 5 5551. ( PubMed, DOI )

  13. Yoshito Masamizu, Yasuhiro R Tanaka, Yasuyo H Tanaka, Riichiro Hira, Fuki Ohkubo, Kazuo Kitamura, Yoshikazu Isomura, Takashi Okada, Masanori Matsuzaki. Two distinct layer-specific dynamics of cortical ensembles during learning of a motor task. Nat. Neurosci.. 2014.07; 17 (7): 987-994. ( PubMed, DOI )

  14. Brent Asrican, George J Augustine, Ken Berglund, Susu Chen, Nick Chow, Karl Deisseroth, Guoping Feng, Bernd Gloss, Riichiro Hira, Carolin Hoffmann, Haruo Kasai, Malvika Katarya, Jinsook Kim, John Kudolo, Li Ming Lee, Shun Qiang Lo, James Mancuso, Masanori Matsuzaki, Ryuichi Nakajima, Li Qiu, Gregory Tan, Yanxia Tang, Jonathan T Ting, Sachiko Tsuda, Lei Wen, Xuying Zhang, Shengli Zhao. Next-generation transgenic mice for optogenetic analysis of neural circuits. Front Neural Circuits. 2013.11; 7 160. ( PubMed, DOI )

  15. Riichiro Hira, Fuki Ohkubo, Yasuhiro R Tanaka, Yoshito Masamizu, George J Augustine, Haruo Kasai, Masanori Matsuzaki. In vivo optogenetic tracing of functional corticocortical connections between motor forelimb areas. Front Neural Circuits. 2013.04; 7 55. ( PubMed, DOI )

  16. Riichiro Hira, Fuki Ohkubo, Katsuya Ozawa, Yoshikazu Isomura, Kazuo Kitamura, Masanobu Kano, Haruo Kasai, Masanori Matsuzaki. Spatiotemporal dynamics of functional clusters of neurons in the mouse motor cortex during a voluntary movement. J. Neurosci.. 2013.01; 33 (4): 1377-1390. ( PubMed, DOI )

  17. Rie Ako, Mayu Wakimoto, Haruka Ebisu, Kaori Tanno, Riichiro Hira, Haruo Kasai, Masanori Matsuzaki, Hiroshi Kawasaki. Simultaneous visualization of multiple neuronal properties with single-cell resolution in the living rodent brain. Mol. Cell. Neurosci.. 2011.11; 48 (3): 246-257. ( PubMed, DOI )

  18. Riichiro Hira, Naoki Honkura, Jun Noguchi, Yoshio Maruyama, George J Augustine, Haruo Kasai, Masanori Matsuzaki. Transcranial optogenetic stimulation for functional mapping of the motor cortex. J. Neurosci. Methods. 2009.05; 179 (2): 258-263. ( PubMed, DOI )

  19. Atsushi Ohsaga, Yoshimichi Murata, Yoshiaki Kondo, Riichiro Hira, Yoshio Maruyama. Asymmetry of Rb+ conduction emerged under bi-ionic conditions in epithelial maxi-K+ channels. J Physiol Sci. 2008.12; 58 (6): 363-369. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display 】

  1. 報酬履歴は黒質ドーパミン作動性線条体出力経路の行動関連活動を強化する. 第 101 回日本生理学会大会 2024.03.28 北九州国際会議場

  2. Hikaru Sugino, Tatsumi Yoshida, Yoshikazu Isomura, Riichiro Hira. Layer specific temporal activity patterns in superior colliculus in response to cortical input. 第253回生理学東京談話会 2023.12.09 帝京大学（板橋）

  3. Riichiro Hira. Holism in neuroscience: Large-scale recording and simulation.. 6TH JP-EU WORKSHOP ON NEUROROBOTICS 2023.09.15 Univ. of Tokyo, Tokyo

  4. 宮村裕人, 吉澤知彦, 平理一郎, 礒村宜和. A hierarchical structure of reservoir model enables flexible behavior based on the presence of regularity without synaptic plasticity. 第33回日本神経回路学会 2023.09.05 東京大学（文京区）

  5. YoshizawaT, Miyamura Y, Ochi Y, Hira R, Funahashi M, Sakai Y, Cui Y, Isomura Y. Parallel processing of working memory-based and -free reward prediction in dual dopamine system of the basal ganglia . 第46回日本神経科学大会（仙台国際センター, 宮城県） 2023.08.03

  6. Alain RIos. Integration of Reward Expectation and Action Selection in the Nigrostriatal System. The 46th annual meeting, Sendai International Center, August 1 - 4, 2023 2023.08.01

  7. Imamura Fumiya, Imamura Hiroto, Ikeda Hiroo, Isomura Yoshikazu, Hira Riichiro. Diesel2pメソスコープの構築と条件付けタスク中の広視野2光子カルシウムイメージング(In-house manufacture of Diese12p mesoscope and demonstration of large field-of-view two-photon calcium imaging during a conditioning task). The Journal of Physiological Sciences 2023.05.01

  8. Sugino Hikaru, Yoshida Tatsumi, Isomura Yoshikazu, Hira Riichiro. 大脳皮質から黒質網様部へのマルチシナプス経路の広範囲機能的マッピング(High-throughput mapping of multi-synaptic functional pathways from the cerebrum to the SNr). The Journal of Physiological Sciences 2023.05.01

  9. Yoshizawa Tomohiko, Miyamura Yuuto, Ochi Yuta, Hira Riichiro, Funahashi Makoto, Sakai Yutaka, Cui Yilong, Isomura Yoshikazu. 大脳基底核の二重ドーパミン系による作業記憶依存性・非依存性の報酬予測(Working memory-based and -free reward prediction in dual dopamine system of the basal ganglia). The Journal of Physiological Sciences 2023.05.01

  10. Miyamura Yuuto, Yoshizawa Tomohiko, Hira Riichiro, Isomura Yoshikazu. 回路再編成なしで柔軟な行動変容を実現するマルチリザーバーモデル(A multi-reservoir model enabling flexible behavior based on the presence of rule without reorganization of neural circuits). The Journal of Physiological Sciences 2023.05.01

  11. Yamamoto Hinako, Igarashi Jun, Isomura Yoshikazu, Hira Riichiro. げっ歯類の大脳皮質-大脳基底核-小脳回路を用いた中規模スパイキングニューラルネットワークモデルの構築(A medium-scale spiking neural network model of rodent cerebral cortex-basal ganglia-cerebellar circuit that can be run in a lab desktop environment). The Journal of Physiological Sciences 2023.05.01

  12. Hira Riichiro, Yamauchi Yuji, Isomura Yoshikazu. 安価な広視野2光子顕微鏡の製作(In-house manufacture of an inexpensive large field-of-view two-photon microscope). The Journal of Physiological Sciences 2022.12.01

  13. Riichiro Hira, Shinichiro Tsutsumi. Holism in neuroscience: Large-scale recording and simulation. the 44th Annual Meeting of the Japan Neuroscience Society/the 1st CJK International Meeting 2021.07.30 Kobe

  14. Riichiro Hira, Spencer L Smith. Large-scale imaging reveals concordance between mesoscale functional and anatomical input correlations. the 44th Annual Meeting of the Japan Neuroscience Society/the 1st CJK International Meeting 2021.07.30 Kobe

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Campus class subject 【 display / non-display 】

  • Introduction to Medical Neurosciences，2024

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