Published Papers & Misc - UESAKA Naofumi

1. Mercier, C; Watanabe, T; Okuno, Y; Matsuyama, K; Kushibe, K; Denny, H; Miyazaki, T; Yamasaki, M; Kawamura, M; Abe, M; Sakimura, K; Watanabe, M; Uesaka, N; Kano, M. The ER/Golgi Protein FNDC3B Facilitates Climbing Fibre to Purkinje Cell Synapse Elimination in the Developing Mouse Cerebellum EUROPEAN JOURNAL OF NEUROSCIENCE. 2026.01; 63 (2): e70411. ( PubMed, DOI )

2. Convergent Recruitment of Cerebellar Purkinje Cells by Mechanistically Diverse General Anesthetics. 2025.12; 169 (12): e70331. ( PubMed, DOI )

3. Kao TH, Okuno Y, Matsuyama K, Watanabe T, Uesaka N, Kano M. Synaptic transmission is dispensable for selecting the winner input but is crucial for the subsequent events of synapse elimination. Proceedings of the National Academy of Sciences of the United States of America. 2025.08; 122 (34): e2416797122. ( PubMed, DOI )

4. Zhang, JL; Watanabe, T; Miyazaki, T; Yamasaki, M; Konno, K; Okuno, Y; Matsuyama, K; Noro, T; Watanabe, M; Uesaka, N; Kano, M. The transcription factor ZFP64 promotes activity-dependent synapse elimination during postnatal cerebellar development ISCIENCE. 2025.06; 28 (6): 112746. ( PubMed, DOI )

5. Shizuki Inaba, Naofumi Uesaka, Daisuke H Tanaka. Automatic quantification of disgust reactions in mice using machine learning. Sci Rep. 2025.05; 15 (1): 17573. ( PubMed, DOI )

6. Wanchen Wang, Kohei Kumegawa, Owen S Chapman, Ryo Shiraishi, Zhize Xiao, Konstantin Okonechnikov, Yang Sun, Stefan M Pfister, Weijun Feng, Naofumi Uesaka, Mikio Hoshino, Satoru Takahashi, Andrey Korshunov, Lukas Chavez, Reo Maruyama, Daisuke Kawauchi. Chromatin modification abnormalities by CHD7 and KMT2C loss promote medulloblastoma progression. Cell Rep. 2025.05; 44 (5): 115673. ( PubMed, DOI )

7. Lai, ESK; Uesaka, N; Miyazaki, T; Hashimoto, K; Watanabe, M; Kano, M. Reduced GABAergic inhibition and impaired synapse elimination by neuroligin-2 deletion from Purkinje cells of the developing cerebellum FRONTIERS IN NEURAL CIRCUITS. 2025.03; 19 1530141. ( PubMed, DOI )

8. Yibin Han, Daisuke H Tanaka, Naofumi Uesaka. Innate liking and disgust reactions elicited by intraoral capsaicin in male mice. Chem Senses. 2025.02; ( PubMed, DOI )

9. Kanatani, S; Kreutzmann, JC; Li, Y; West, Z; Larsen, LL; Nikou, DV; Eidhof, I; Walton, A; Zhang, SB; Rodríguez-Kirby, LR; Skytte, JL; Salinas, CG; Takamatsu, K; Li, XF; Tanaka, DH; Kaczynska, D; Fukumoto, K; Karamzadeh, R; Xiang, YJ; Uesaka, N; Tanabe, T; Adner, M; Hartman, J; Miyakawa, A; Sundström, E; Castelo-Branco, G; Roostalu, U; Hecksher-Sorensen, J; Uhlén, P. Whole-brain spatial transcriptional analysis at cellular resolution SCIENCE. 2024.11; 386 (6724): 907-915. ( PubMed, DOI )

10. Aritoshi Uchida,Kazuharu Nakagawa ,Kanako Yoshimi,Yuki Nagasawa ,Kohei Yamaguchi,Naofumi Uesaka,Haruka Tohara. Intermittent breaking of isolation may ameliorate decrease in physical activity caused by isolation PLoS ONE. 2024.11; ( PubMed, DOI )

11. Tanigawa, M; Liu, MK; Sekiguchi, M; Goda, K; Kato, C; Ono, T; Uesaka, N. Nasal obstruction during development leads to defective synapse elimination, hypersynchrony, and impaired cerebellar function COMMUNICATIONS BIOLOGY. 2024.10; 7 (1): ( PubMed, DOI )

12. Nakayama, H; Miyazaki, T; Abe, M; Yamazaki, M; Kawamura, Y; Choo, M; Konno, K; Kawata, S; Uesaka, N; Hashimoto, K; Miyata, M; Sakimura, K; Watanabe, M; Kano, M. Direct and indirect pathways for heterosynaptic interaction underlying developmental synapse elimination in the mouse cerebellum COMMUNICATIONS BIOLOGY. 2024.07; 7 (1): 806. ( PubMed, DOI )

13. Shizuki Inaba, Naofumi Uesaka, Daisuke H. Tanaka. Automatic quantification of disgust taste reactivity in mice using machine learning bioRxiv. 2023.04;

14. Yuki Nagasawa, Sayaka Katagiri, Kazuharu Nakagawa, Tomomitsu Hirota, Kanako Yoshimi, Aritoshi Uchida, Masahiro Hatasa, Keiji Komatsu, Takahiko Shiba, Yujin Ohsugi, Naofumi Uesaka, Takanori Iwata, Haruka Tohara. Xanthan gum-based fluid thickener decreases postprandial blood glucose associated with increase of Glp1 and Glp1r expression in ileum and alteration of gut microbiome 2022.11;

15. Itami C, Uesaka N, Huang JY, Lu HC, Sakimura K, Kano M, Kimura F. Endocannabinoid-dependent formation of columnar axonal projection in the mouse cerebral cortex. Proceedings of the National Academy of Sciences of the United States of America. 2022.09; 119 (37): e2122700119. ( PubMed, DOI )

16. Uesaka Naofumi, Akamatsu Tsubasa, Suzuki Honoka, Kato Masanobu. アストロサイト2型イノシトール3リン酸受容体を介して発達期小脳のシナプス刈り込みを制御する(Astrocytes regulate synapse elimination in the developing cerebellum through type 2 inositol 1,4,5-trisphosphate receptor) The Journal of Physiological Sciences. 2021.08; 71 (Suppl.1): 94. ( ichushi )

17. Suzuki Honoka, Choo Myeongjeong, Watanabe Takaki, Sakimura Kenji, Uesaka Naofumi, Kato Masanobu. MEF2Dは発達期の小脳において後期のシナプス刈り込みに関与する(Myocyte Enhancer Factor 2D(MEF2D) mediates late phase synapse elimination in the developing cerebellum) The Journal of Physiological Sciences. 2021.08; 71 (Suppl.1): 110. ( ichushi )

18. Nagahama K, Fujino S, Watanabe T, Uesaka N, Kano M. Combining electrophysiology and optogenetics for functional screening of pyramidal neurons in the mouse prefrontal cortex. STAR protocols. 2021.06; 2 (2): 100469. ( PubMed, DOI )

19. Fleck D, Kenzler L, Mundt N, Strauch M, Uesaka N, Moosmann R, Bruentgens F, Missel A, Mayerhofer A, Merhof D, Spehr J, Spehr M. ATP activation of peritubular cells drives testicular sperm transport. eLife. 2021.01; 10 ( PubMed, DOI )

20. Kano, M; Watanabe, T; Uesaka, N. mGluR1 Is a Molecular "Hub" for Synapse Elimination in the Developing Cerebellum CEREBELLUM AS A CNS HUB. 2021; 77-89. ( DOI )

21. Yamashiro K, Hori K, Lai ESK, Aoki R, Shimaoka K, Arimura N, Egusa SF, Sakamoto A, Abe M, Sakimura K, Watanabe T, Uesaka N, Kano M, Hoshino M. AUTS2 Governs Cerebellar Development, Purkinje Cell Maturation, Motor Function and Social Communication. iScience. 2020.12; 23 (12): 101820. ( PubMed, DOI )

22. Sacai H, Sakoori K, Konno K, Nagahama K, Suzuki H, Watanabe T, Watanabe M, Uesaka N, Kano M. Autism spectrum disorder-like behavior caused by reduced excitatory synaptic transmission in pyramidal neurons of mouse prefrontal cortex. Nature communications. 2020.10; 11 (1): 5140. ( PubMed, DOI )

23. Nagumo Yasuyuki, Ueta Yoshifumi, Nakayama Hisako, Osaki Hironobu, Takeuchi Yuichi, Uesaka Naofumi, Kano Masanobu, Miyata Mariko. Tonic GABAergic Inhibition Is Essential for Nerve Injury-Induced Afferent Remodeling in the Somatosensory Thalamus and Ectopic Sensations CELL REPORTS. 2020.06; 31 (12): 107797. ( PubMed, DOI )

24. Rai Y, Watanabe T, Matsuyama K, Sakimura K, Uesaka N, Kano M. Phospholipase C β3 is Required for Climbing Fiber Synapse Elimination in Aldolase C-positive Compartments of the Developing Mouse Cerebellum. Neuroscience. 2020.04; ( PubMed, DOI )

25. Watanabe Takaki, Suzuki Honoka, Sakoori Kazuto, Inoue Shutaro, Akamatsu Tsubasa, Abe Manabu, Sakimura Kenji, Uesaka Naofumi, Kano Masanobu. Protocadherin 10 delays developmental climbing fiber synapse elimination in a subset of aldolase C-positive Purkinje cells in the cerebellum(和訳中) The Journal of Physiological Sciences. 2020.03; 70 (Suppl.1): S97. ( ichushi )

26. Saito R, Koebis M, Nagai T, Shimizu K, Liao J, Wulaer B, Sugaya Y, Nagahama K, Uesaka N, Kushima I, Mori D, Maruyama K, Nakao K, Kurihara H, Yamada K, Kano M, Fukada Y, Ozaki N, Aiba A. Comprehensive analysis of a novel mouse model of the 22q11.2 deletion syndrome: a model with the most common 3.0-Mb deletion at the human 22q11.2 locus. Translational psychiatry. 2020.02; 10 (1): 35. ( PubMed, DOI )

27. Kushibe Kyoko, Mercier Celine, Watanabe Takaki, Miyazaki Taisuke, Yamasaki Miwako, Watanabe Masahiko, Uesaka Naofumi, Kano Masanobu. Fndc3bは小脳のSTAT3を阻害することにより登上線維のシナプス刈り込みを部分的に促進する(Fndc3b promotes climbing fiber synapse elimination partly by inhibiting STAT3 in the cerebellum) The Journal of Physiological Sciences. 2019.06; 69 (Suppl.1): S127. ( ichushi )

28. Watanabe Takaki, Inoue Shutaro, Akamatsu Tsubasa, Suzuki Honoka, Abe Manabu, Sakimura Kenji, Uesaka Naofumi, Kano Masanobu. Protocadherin 10を欠く小脳プルキンエ細胞における登上線維のシナプス刈り込みの促進(Accelerated climbing fiber synapse elimination in cerebellar Purkinje cells lacking protocadherin 10) The Journal of Physiological Sciences. 2019.06; 69 (Suppl.1): S221. ( ichushi )

29. Nagahama Kenichiro, Sakoori Kazuto, Watanabe Takaki, Uesaka Naofumi, Kano Masanobu. 精神障害関連エピジェネティック因子の欠如による前頭前野でのシナプス入力の減少(Reduced synaptic inputs in prefrontal cortex by lack of a mental disorder-related epigenetic factor) The Journal of Physiological Sciences. 2019.06; 69 (Suppl.1): S143. ( ichushi )

30. Uesaka Naofumi, Kao Tzu-Huei, Kano Masanobu. 健康および疾患におけるシナプスのリモデリングとその先　小脳発生における活動依存性シナプス刈り込み(Synaptic remodeling and beyond in health and disease　Activity-dependent synapse elimination in the developing cerebellum) The Journal of Physiological Sciences. 2019.06; 69 (Suppl.1): S35. ( ichushi )

31. Kano M, Watanabe T, Uesaka N, Watanabe M. Multiple Phases of Climbing Fiber Synapse Elimination in the Developing Cerebellum. Cerebellum (London, England). 2018.12; 17 (6): 722-734. ( PubMed, DOI )

32. Nagahama Kenichiro, Sakoori Kazuto, Watanabe Takaki, Uesaka Naofumi, Kano Masanobu. 生後発達期のマウス内側前頭前野のニューロンにおいて統合失調症関連分子Setd1aをノックダウンした場合のシナプス伝達の減弱(Reduced synaptic transmission in neurons of mouse medial prefrontal cortex by knockdown of a schizophrenia-related molecule, Setd1a, during postnatal development) The Journal of Physiological Sciences. 2018.03; 68 (Suppl.1): S131. ( ichushi )

33. Uesaka N, Kano M. Presynaptic Mechanisms Mediating Retrograde Semaphorin Signals for Climbing Fiber Synapse Elimination During Postnatal Cerebellar Development. Cerebellum (London, England). 2018.02; 17 (1): 17-22. ( PubMed, DOI )

34. Uesaka N, Abe M, Konno K, Yamazaki M, Sakoori K, Watanabe T, Kao TH, Mikuni T, Watanabe M, Sakimura K, Kano M. Retrograde Signaling from Progranulin to Sort1 Counteracts Synapse Elimination in the Developing Cerebellum. Neuron. 2018.02; 97 (4): 796-805.e5. ( PubMed, DOI )

35. Choo M, Miyazaki T, Yamazaki M, Kawamura M, Nakazawa T, Zhang J, Tanimura A, Uesaka N, Watanabe M, Sakimura K, Kano M. Retrograde BDNF to TrkB signaling promotes synapse elimination in the developing cerebellum. Nature communications. 2017.08; 8 (1): 195. ( PubMed, DOI )

36. Leto Ketty, Arancillo Marife, Becker Esther B. E., Buffo Annalisa, Chiang Chin, Ding Baojin, Dobyns William B., Dusart Isabelle, Haldipur Parthiv, Hatten Mary E., Hoshino Mikio, Joyner Alexandra L., Kano Masanobu, Kilpatrick Daniel L., Koibuchi Noriyuki, Marino Silvia, Martinez Salvador, Millen Kathleen J., Millner Thomas O., Miyata Takaki, Parmigiani Elena, Schilling Karl, Sekerkova Gabriella, Sillitoe Roy V., Sotelo Constantino, Uesaka Naofumi, Wefers Annika, Wingate Richard J. T., Hawkes Richard. Consensus Paper: Cerebellar Development CEREBELLUM. 2016.12; 15 (6): 789-828. ( DOI )

37. Narushima Madoka, Uchigashima Motokazu, Yagasaki Yuki, Harada Takeshi, Nagumo Yasuyuki, Uesaka Naofumi, Hashimoto Kouichi, Aiba Atsu, Watanabe Masahiko, Miyata Mariko, Kano Masanobu. The Metabotropic Glutamate Receptor Subtype 1 Mediates Experience-Dependent Maintenance of Mature Synaptic Connectivity in the Visual Thalamus NEURON. 2016.09; 91 (5): 1097-1109. ( DOI )

38. Uesaka Naofumi, Uchigashima Motokazu, Mikuni Takayasu, Hirai Hirokazu, Watanabe Masahiko, Kano Masanobu. Retrograde Signaling for Climbing Fiber Synapse Elimination CEREBELLUM. 2015.02; 14 (1): 4-7. ( DOI )

39. Uesaka Naofumi, Uchigashima Motokazu, Mikuni Takayasu, Nakazawa Takanobu, Nakao Harumi, Hirai Hirokazu, Aiba Atsu, Watanabe Masahiko, Kano Masanobu. Retrograde semaphorin signaling regulates synapse elimination in the developing mouse brain SCIENCE. 2014.05; 344 (6187): 1020-1023. ( DOI )

40. Mikuni Takayasu, Uesaka Naofumi, Okuno Hiroyuki, Hirai Hirokazu, Deisseroth Karl, Bito Haruhiko, Kano Masanobu. Arc/Arg3.1 Is a Postsynaptic Mediator of Activity-Dependent Synapse Elimination in the Developing Cerebellum NEURON. 2013.06; 78 (6): 1024-1035. ( DOI )

41. Uesaka Naofumi, Mikuni Takayasu, Hirai Hirokazu, Kano Masanobu. Cell-type specific gene transfer in olivo-cerebellar coculture preparation for the study of developmental synapse elimination JOURNAL OF PHYSIOLOGICAL SCIENCES. 2013; 63 (1): S40.

42. Uesaka Naofumi, Mikuni Takayasu, Hashimoto Kouichi, Hirai Hirokazu, Sakimura Kenji, Kano Masanobu. Organotypic Coculture Preparation for the Study of Developmental Synapse Elimination in Mammalian Brain JOURNAL OF NEUROSCIENCE. 2012.08; 32 (34): 11657-11670. ( DOI )

43. Tanimura Asami, Uchigashima Motokazu, Yamazaki Maya, Uesaka Naofumi, Mikuni Takayasu, Abe Manabu, Hashimoto Kouichi, Watanabe Masahiko, Sakimura Kenji, Kano Masanobu. Synapse type-independent degradation of the endocannabinoid 2-arachidonoylglycerol after retrograde synaptic suppression PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2012.07; 109 (30): 12195-12200. ( DOI )

44. Mikuni Takayasu, Uesaka Naofumi, Kano Masanobu. Roles of Purkinje cell activity in climbing fiber synapse elimination in an organotypic coculture preparation of the cerebellum and medulla oblongata NEUROSCIENCE RESEARCH. 2011; 71 (S): E93. ( DOI )

45. Tanimura Asami, Yamazaki Maya, Uchigashima Motokazu, Uesaka Naofumi, Mikuni Takayasu, Hashimoto Kouichi, Watanabe Masahiko, Sakimura Kenji, Kano Masanobu. Synapse "non-specific" degradation of the endocannabinoid 2-arachidonoylglycerol mediating depolarization-induced retrograde synaptic suppression in cerebellar Purkinje cells NEUROSCIENCE RESEARCH. 2011; 71 (S): E56. ( DOI )

46. Sugo Noriyuki, Oshiro Hiroaki, Takemura Mitsuhiro, Kobayashi Toshiaki, Kohno Yusuke, Uesaka Naofumi, Song Wen-Jie, Yamamoto Nobuhiko. Nucleocytoplasmic translocation of HDAC9 regulates gene expression and dendritic growth in developing cortical neurons EUROPEAN JOURNAL OF NEUROSCIENCE. 2010.05; 31 (9): 1521-1532. ( DOI )

47. Yamada Akito, Uesaka Naofumi, Hayano Yasufumi, Tabata Toshihide, Kano Masanobu, Yamamoto Nobuhiko. Role of pre- and postsynaptic activity in thalamocortical axon branching PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010.04; 107 (16): 7562-7567. ( DOI )

48. Mikuni Takayasu, Uesaka Naofumi, Kano Masanobu. Applications of gene transfer techniques to CNS organotypic cultures JOURNAL OF PHYSIOLOGICAL SCIENCES. 2010; 60 (1): S135.

49. Uesaka Naofumi, Mikuni Takayasu, Kano Masanobu. An in vitro coculture preparation suitable for investigating the mechanisms of synapse development in rodent cerebellum NEUROSCIENCE RESEARCH. 2010; 68 (1): E61. ( DOI )

50. Mikuni Takayasu, Uesaka Naofumi, Kano Masanobu. Effective modification of neural activity in CNS organotypic cultures NEUROSCIENCE RESEARCH. 2010; 68 (1): E135. ( DOI )

51. Uesaka Naofumi, Mikuni Takayasu, Kano Masanobu. Gene transfer techniques for CNS organotypic cultures NEUROSCIENCE RESEARCH. 2009; 65 (1): S132-S133. ( DOI )

52. Ohnami Soichiro, Endo Mitsuharu, Hirai Satoshi, Uesaka Naofumi, Hatanaka Yumiko, Yamashita Toshihide, Yamamoto Nobuhiko. Role of RhoA in activity-dependent cortical axon branching JOURNAL OF NEUROSCIENCE. 2008.09; 28 (37): 9117-9121. ( DOI )

53. Uesaka Naofumi, Nishiwaki Maki, Yamamoto Nobuhiko. Single cell electroporation method for axon tracing in cultured slices DEVELOPMENT GROWTH & DIFFERENTIATION. 2008.08; 50 (6): 475-477. ( DOI )

54. Ohnami Soichiro, Endo Mitsuharu, Hirai Satoshi, Uesaka Naofumi, Hatanaka Yumiko, Yamashita Toshihide, Yamamoto Nobuhiko. RhoA is involved in activity-dependent cortical axon branching NEUROSCIENCE RESEARCH. 2008; 61 S233.

55. Uesaka Naofumi, Kano Masanobu. Formation of functional synapses in organotypic cocultures of the medulla and cerebellum NEUROSCIENCE RESEARCH. 2008; 61 S88.

56. Uesaka Naofumi, Hayano Yasufumi, Yamada Akito, Yamamoto Nobuhiko. Interplay between laminar specificity and activity-dependent mechanisms of thalamocortical axon branching JOURNAL OF NEUROSCIENCE. 2007.05; 27 (19): 5215-5223. ( DOI )

57. Yamada Akito, Uesaka Naofumi, Hayano Yasufumi, Tabata Toshihide, Kano Masanobu, Yamamoto Nobuhiko. The role of neural activities of thalamic and cortical neurons in thalamocortical axon branching NEUROSCIENCE RESEARCH. 2007; 58 (1): S89. ( DOI )

58. Uesaka N, Ruthazer ES, Yamamoto N. The role of neural activity in cortical axon branching NEUROSCIENTIST. 2006.04; 12 (2): 102-106. ( DOI )

59. Sugo Noriyuki, Takemura Mitsuhiro, Kobayashi Toshiald, Uesaka Naofumi, Yamamoto Nobuhiko. Activity-dependent nucleocytoplasmic translocation of HDAC9 in cortical neurons NEUROSCIENCE RESEARCH. 2006; 55 (1): S53.

60. Uesaka Naofumi, Hayano Yasufumi, Yamada Akito, Yamamoto Nobuhiko. The role of neuronal activity in lamina-specific thalamocortical axon branching NEUROSCIENCE RESEARCH. 2006; 55 (1): S63.

61. Uesaka N, Hirai S, Maruyama T, Ruthazer ES, Yamamoto N. Activity dependence of cortical axon branch formation: A morphological and electrophysiological study using organotypic slice cultures JOURNAL OF NEUROSCIENCE. 2005.01; 25 (1): 1-9. ( DOI )