Published Papers & Misc - UESAKA Naofumi

1. Mercier, C; Watanabe, T; Okuno, Y; Matsuyama, K; Kushibe, K; Denny, H; Miyazaki, T; Yamasaki, M; Kawamura, M; Abe, M; Sakimura, K; Watanabe, M; Uesaka, N; Kano, M. The ER/Golgi Protein FNDC3B Facilitates Climbing Fibre to Purkinje Cell Synapse Elimination in the Developing Mouse Cerebellum EUROPEAN JOURNAL OF NEUROSCIENCE. 2026.01; 63 (2): e70411. ( PubMed, DOI )

2. Convergent Recruitment of Cerebellar Purkinje Cells by Mechanistically Diverse General Anesthetics. 2025.12; 169 (12): e70331. ( PubMed, DOI )

3. Kao TH, Okuno Y, Matsuyama K, Watanabe T, Uesaka N, Kano M. Synaptic transmission is dispensable for selecting the winner input but is crucial for the subsequent events of synapse elimination. Proceedings of the National Academy of Sciences of the United States of America. 2025.08; 122 (34): e2416797122. ( PubMed, DOI )

4. Zhang, JL; Watanabe, T; Miyazaki, T; Yamasaki, M; Konno, K; Okuno, Y; Matsuyama, K; Noro, T; Watanabe, M; Uesaka, N; Kano, M. The transcription factor ZFP64 promotes activity-dependent synapse elimination during postnatal cerebellar development ISCIENCE. 2025.06; 28 (6): 112746. ( PubMed, DOI )

5. Shizuki Inaba, Naofumi Uesaka, Daisuke H Tanaka. Automatic quantification of disgust reactions in mice using machine learning. Sci Rep. 2025.05; 15 (1): 17573. ( PubMed, DOI )

6. Wanchen Wang, Kohei Kumegawa, Owen S Chapman, Ryo Shiraishi, Zhize Xiao, Konstantin Okonechnikov, Yang Sun, Stefan M Pfister, Weijun Feng, Naofumi Uesaka, Mikio Hoshino, Satoru Takahashi, Andrey Korshunov, Lukas Chavez, Reo Maruyama, Daisuke Kawauchi. Chromatin modification abnormalities by CHD7 and KMT2C loss promote medulloblastoma progression. Cell Rep. 2025.05; 44 (5): 115673. ( PubMed, DOI )

7. Lai, ESK; Uesaka, N; Miyazaki, T; Hashimoto, K; Watanabe, M; Kano, M. Reduced GABAergic inhibition and impaired synapse elimination by neuroligin-2 deletion from Purkinje cells of the developing cerebellum FRONTIERS IN NEURAL CIRCUITS. 2025.03; 19 1530141. ( PubMed, DOI )

8. Yibin Han, Daisuke H Tanaka, Naofumi Uesaka. Innate liking and disgust reactions elicited by intraoral capsaicin in male mice. Chem Senses. 2025.02; ( PubMed, DOI )

9. Kanatani, S; Kreutzmann, JC; Li, Y; West, Z; Larsen, LL; Nikou, DV; Eidhof, I; Walton, A; Zhang, SB; Rodríguez-Kirby, LR; Skytte, JL; Salinas, CG; Takamatsu, K; Li, XF; Tanaka, DH; Kaczynska, D; Fukumoto, K; Karamzadeh, R; Xiang, YJ; Uesaka, N; Tanabe, T; Adner, M; Hartman, J; Miyakawa, A; Sundström, E; Castelo-Branco, G; Roostalu, U; Hecksher-Sorensen, J; Uhlén, P. Whole-brain spatial transcriptional analysis at cellular resolution SCIENCE. 2024.11; 386 (6724): 907-915. ( PubMed, DOI )

10. Aritoshi Uchida,Kazuharu Nakagawa ,Kanako Yoshimi,Yuki Nagasawa ,Kohei Yamaguchi,Naofumi Uesaka,Haruka Tohara. Intermittent breaking of isolation may ameliorate decrease in physical activity caused by isolation PLoS ONE. 2024.11; ( PubMed, DOI )

11. Tanigawa, M; Liu, MK; Sekiguchi, M; Goda, K; Kato, C; Ono, T; Uesaka, N. Nasal obstruction during development leads to defective synapse elimination, hypersynchrony, and impaired cerebellar function COMMUNICATIONS BIOLOGY. 2024.10; 7 (1): ( PubMed, DOI )

12. Nakayama, H; Miyazaki, T; Abe, M; Yamazaki, M; Kawamura, Y; Choo, M; Konno, K; Kawata, S; Uesaka, N; Hashimoto, K; Miyata, M; Sakimura, K; Watanabe, M; Kano, M. Direct and indirect pathways for heterosynaptic interaction underlying developmental synapse elimination in the mouse cerebellum COMMUNICATIONS BIOLOGY. 2024.07; 7 (1): 806. ( PubMed, DOI )

13. Shizuki Inaba, Naofumi Uesaka, Daisuke H. Tanaka. Automatic quantification of disgust taste reactivity in mice using machine learning bioRxiv. 2023.04;

14. Yuki Nagasawa, Sayaka Katagiri, Kazuharu Nakagawa, Tomomitsu Hirota, Kanako Yoshimi, Aritoshi Uchida, Masahiro Hatasa, Keiji Komatsu, Takahiko Shiba, Yujin Ohsugi, Naofumi Uesaka, Takanori Iwata, Haruka Tohara. Xanthan gum-based fluid thickener decreases postprandial blood glucose associated with increase of Glp1 and Glp1r expression in ileum and alteration of gut microbiome 2022.11;

15. Itami C, Uesaka N, Huang JY, Lu HC, Sakimura K, Kano M, Kimura F. Endocannabinoid-dependent formation of columnar axonal projection in the mouse cerebral cortex. Proceedings of the National Academy of Sciences of the United States of America. 2022.09; 119 (37): e2122700119. ( PubMed, DOI )

16. Uesaka Naofumi, Akamatsu Tsubasa, Suzuki Honoka, Kato Masanobu. アストロサイト2型イノシトール3リン酸受容体を介して発達期小脳のシナプス刈り込みを制御する(Astrocytes regulate synapse elimination in the developing cerebellum through type 2 inositol 1,4,5-trisphosphate receptor) The Journal of Physiological Sciences. 2021.08; 71 (Suppl.1): 94. ( ichushi )

17. Suzuki Honoka, Choo Myeongjeong, Watanabe Takaki, Sakimura Kenji, Uesaka Naofumi, Kato Masanobu. MEF2Dは発達期の小脳において後期のシナプス刈り込みに関与する(Myocyte Enhancer Factor 2D(MEF2D) mediates late phase synapse elimination in the developing cerebellum) The Journal of Physiological Sciences. 2021.08; 71 (Suppl.1): 110. ( ichushi )

18. Nagahama K, Fujino S, Watanabe T, Uesaka N, Kano M. Combining electrophysiology and optogenetics for functional screening of pyramidal neurons in the mouse prefrontal cortex. STAR protocols. 2021.06; 2 (2): 100469. ( PubMed, DOI )

19. Fleck D, Kenzler L, Mundt N, Strauch M, Uesaka N, Moosmann R, Bruentgens F, Missel A, Mayerhofer A, Merhof D, Spehr J, Spehr M. ATP activation of peritubular cells drives testicular sperm transport. eLife. 2021.01; 10 ( PubMed, DOI )

20. Kano, M; Watanabe, T; Uesaka, N. mGluR1 Is a Molecular "Hub" for Synapse Elimination in the Developing Cerebellum CEREBELLUM AS A CNS HUB. 2021; 77-89. ( DOI )