Sacai H, Sakoori K, Konno K, Nagahama K, Suzuki H, Watanabe T, Watanabe M, Uesaka N, Kano M. Autism spectrum disorder-like behavior caused by reduced excitatory synaptic transmission in pyramidal neurons of mouse prefrontal cortex. Nature communications. 2020.10; 11 (1): 5140. ( PubMed, DOI )

Nagumo Yasuyuki, Ueta Yoshifumi, Nakayama Hisako, Osaki Hironobu, Takeuchi Yuichi, Uesaka Naofumi, Kano Masanobu, Miyata Mariko. Tonic GABAergic Inhibition Is Essential for Nerve Injury-Induced Afferent Remodeling in the Somatosensory Thalamus and Ectopic Sensations CELL REPORTS. 2020.06; 31 (12): 107797. ( PubMed, DOI )

Rai Y, Watanabe T, Matsuyama K, Sakimura K, Uesaka N, Kano M. Phospholipase C β3 is Required for Climbing Fiber Synapse Elimination in Aldolase C-positive Compartments of the Developing Mouse Cerebellum. Neuroscience. 2020.04; ( PubMed, DOI )

Watanabe Takaki, Suzuki Honoka, Sakoori Kazuto, Inoue Shutaro, Akamatsu Tsubasa, Abe Manabu, Sakimura Kenji, Uesaka Naofumi, Kano Masanobu. Protocadherin 10 delays developmental climbing fiber synapse elimination in a subset of aldolase C-positive Purkinje cells in the cerebellum(和訳中) The Journal of Physiological Sciences. 2020.03; 70 (Suppl.1): S97. ( 医中誌 )

Saito R, Koebis M, Nagai T, Shimizu K, Liao J, Wulaer B, Sugaya Y, Nagahama K, Uesaka N, Kushima I, Mori D, Maruyama K, Nakao K, Kurihara H, Yamada K, Kano M, Fukada Y, Ozaki N, Aiba A. Comprehensive analysis of a novel mouse model of the 22q11.2 deletion syndrome: a model with the most common 3.0-Mb deletion at the human 22q11.2 locus. Translational psychiatry. 2020.02; 10 (1): 35. ( PubMed, DOI )

Kushibe Kyoko, Mercier Celine, Watanabe Takaki, Miyazaki Taisuke, Yamasaki Miwako, Watanabe Masahiko, Uesaka Naofumi, Kano Masanobu. Fndc3bは小脳のSTAT3を阻害することにより登上線維のシナプス刈り込みを部分的に促進する(Fndc3b promotes climbing fiber synapse elimination partly by inhibiting STAT3 in the cerebellum) The Journal of Physiological Sciences. 2019.06; 69 (Suppl.1): S127. ( 医中誌 )

Nagahama Kenichiro, Sakoori Kazuto, Watanabe Takaki, Uesaka Naofumi, Kano Masanobu. 精神障害関連エピジェネティック因子の欠如による前頭前野でのシナプス入力の減少(Reduced synaptic inputs in prefrontal cortex by lack of a mental disorder-related epigenetic factor) The Journal of Physiological Sciences. 2019.06; 69 (Suppl.1): S143. ( 医中誌 )

Uesaka Naofumi, Kao Tzu-Huei, Kano Masanobu. 健康および疾患におけるシナプスのリモデリングとその先　小脳発生における活動依存性シナプス刈り込み(Synaptic remodeling and beyond in health and disease　Activity-dependent synapse elimination in the developing cerebellum) The Journal of Physiological Sciences. 2019.06; 69 (Suppl.1): S35. ( 医中誌 )

Watanabe Takaki, Inoue Shutaro, Akamatsu Tsubasa, Suzuki Honoka, Abe Manabu, Sakimura Kenji, Uesaka Naofumi, Kano Masanobu. Protocadherin 10を欠く小脳プルキンエ細胞における登上線維のシナプス刈り込みの促進(Accelerated climbing fiber synapse elimination in cerebellar Purkinje cells lacking protocadherin 10) The Journal of Physiological Sciences. 2019.06; 69 (Suppl.1): S221. ( 医中誌 )

Kano M, Watanabe T, Uesaka N, Watanabe M. Multiple Phases of Climbing Fiber Synapse Elimination in the Developing Cerebellum. Cerebellum (London, England). 2018.12; 17 (6): 722-734. ( PubMed, DOI )

Nagahama Kenichiro, Sakoori Kazuto, Watanabe Takaki, Uesaka Naofumi, Kano Masanobu. 生後発達期のマウス内側前頭前野のニューロンにおいて統合失調症関連分子Setd1aをノックダウンした場合のシナプス伝達の減弱(Reduced synaptic transmission in neurons of mouse medial prefrontal cortex by knockdown of a schizophrenia-related molecule, Setd1a, during postnatal development) The Journal of Physiological Sciences. 2018.03; 68 (Suppl.1): S131. ( 医中誌 )

Uesaka N, Kano M. Presynaptic Mechanisms Mediating Retrograde Semaphorin Signals for Climbing Fiber Synapse Elimination During Postnatal Cerebellar Development. Cerebellum (London, England). 2018.02; 17 (1): 17-22. ( PubMed, DOI )

Uesaka N, Abe M, Konno K, Yamazaki M, Sakoori K, Watanabe T, Kao TH, Mikuni T, Watanabe M, Sakimura K, Kano M. Retrograde Signaling from Progranulin to Sort1 Counteracts Synapse Elimination in the Developing Cerebellum. Neuron. 2018.02; 97 (4): 796-805.e5. ( PubMed, DOI )

Choo M, Miyazaki T, Yamazaki M, Kawamura M, Nakazawa T, Zhang J, Tanimura A, Uesaka N, Watanabe M, Sakimura K, Kano M. Retrograde BDNF to TrkB signaling promotes synapse elimination in the developing cerebellum. Nature communications. 2017.08; 8 (1): 195. ( PubMed, DOI )

Leto Ketty, Arancillo Marife, Becker Esther B. E., Buffo Annalisa, Chiang Chin, Ding Baojin, Dobyns William B., Dusart Isabelle, Haldipur Parthiv, Hatten Mary E., Hoshino Mikio, Joyner Alexandra L., Kano Masanobu, Kilpatrick Daniel L., Koibuchi Noriyuki, Marino Silvia, Martinez Salvador, Millen Kathleen J., Millner Thomas O., Miyata Takaki, Parmigiani Elena, Schilling Karl, Sekerkova Gabriella, Sillitoe Roy V., Sotelo Constantino, Uesaka Naofumi, Wefers Annika, Wingate Richard J. T., Hawkes Richard. Consensus Paper: Cerebellar Development CEREBELLUM. 2016.12; 15 (6): 789-828. ( DOI )

Narushima Madoka, Uchigashima Motokazu, Yagasaki Yuki, Harada Takeshi, Nagumo Yasuyuki, Uesaka Naofumi, Hashimoto Kouichi, Aiba Atsu, Watanabe Masahiko, Miyata Mariko, Kano Masanobu. The Metabotropic Glutamate Receptor Subtype 1 Mediates Experience-Dependent Maintenance of Mature Synaptic Connectivity in the Visual Thalamus NEURON. 2016.09; 91 (5): 1097-1109. ( DOI )

Uesaka Naofumi, Uchigashima Motokazu, Mikuni Takayasu, Hirai Hirokazu, Watanabe Masahiko, Kano Masanobu. Retrograde Signaling for Climbing Fiber Synapse Elimination CEREBELLUM. 2015.02; 14 (1): 4-7. ( DOI )

Uesaka Naofumi, Uchigashima Motokazu, Mikuni Takayasu, Nakazawa Takanobu, Nakao Harumi, Hirai Hirokazu, Aiba Atsu, Watanabe Masahiko, Kano Masanobu. Retrograde semaphorin signaling regulates synapse elimination in the developing mouse brain SCIENCE. 2014.05; 344 (6187): 1020-1023. ( DOI )

Mikuni Takayasu, Uesaka Naofumi, Okuno Hiroyuki, Hirai Hirokazu, Deisseroth Karl, Bito Haruhiko, Kano Masanobu. Arc/Arg3.1 Is a Postsynaptic Mediator of Activity-Dependent Synapse Elimination in the Developing Cerebellum NEURON. 2013.06; 78 (6): 1024-1035. ( DOI )

Uesaka Naofumi, Mikuni Takayasu, Hirai Hirokazu, Kano Masanobu. Cell-type specific gene transfer in olivo-cerebellar coculture preparation for the study of developmental synapse elimination JOURNAL OF PHYSIOLOGICAL SCIENCES. 2013; 63 (1): S40.

Uesaka Naofumi, Mikuni Takayasu, Hashimoto Kouichi, Hirai Hirokazu, Sakimura Kenji, Kano Masanobu. Organotypic Coculture Preparation for the Study of Developmental Synapse Elimination in Mammalian Brain JOURNAL OF NEUROSCIENCE. 2012.08; 32 (34): 11657-11670. ( DOI )

Tanimura Asami, Uchigashima Motokazu, Yamazaki Maya, Uesaka Naofumi, Mikuni Takayasu, Abe Manabu, Hashimoto Kouichi, Watanabe Masahiko, Sakimura Kenji, Kano Masanobu. Synapse type-independent degradation of the endocannabinoid 2-arachidonoylglycerol after retrograde synaptic suppression PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2012.07; 109 (30): 12195-12200. ( DOI )

Mikuni Takayasu, Uesaka Naofumi, Kano Masanobu. Roles of Purkinje cell activity in climbing fiber synapse elimination in an organotypic coculture preparation of the cerebellum and medulla oblongata NEUROSCIENCE RESEARCH. 2011; 71 (S): E93. ( DOI )

Tanimura Asami, Yamazaki Maya, Uchigashima Motokazu, Uesaka Naofumi, Mikuni Takayasu, Hashimoto Kouichi, Watanabe Masahiko, Sakimura Kenji, Kano Masanobu. Synapse "non-specific" degradation of the endocannabinoid 2-arachidonoylglycerol mediating depolarization-induced retrograde synaptic suppression in cerebellar Purkinje cells NEUROSCIENCE RESEARCH. 2011; 71 (S): E56. ( DOI )

Sugo Noriyuki, Oshiro Hiroaki, Takemura Mitsuhiro, Kobayashi Toshiaki, Kohno Yusuke, Uesaka Naofumi, Song Wen-Jie, Yamamoto Nobuhiko. Nucleocytoplasmic translocation of HDAC9 regulates gene expression and dendritic growth in developing cortical neurons EUROPEAN JOURNAL OF NEUROSCIENCE. 2010.05; 31 (9): 1521-1532. ( DOI )

Yamada Akito, Uesaka Naofumi, Hayano Yasufumi, Tabata Toshihide, Kano Masanobu, Yamamoto Nobuhiko. Role of pre- and postsynaptic activity in thalamocortical axon branching PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010.04; 107 (16): 7562-7567. ( DOI )

Mikuni Takayasu, Uesaka Naofumi, Kano Masanobu. Applications of gene transfer techniques to CNS organotypic cultures JOURNAL OF PHYSIOLOGICAL SCIENCES. 2010; 60 (1): S135.

Uesaka Naofumi, Mikuni Takayasu, Kano Masanobu. An in vitro coculture preparation suitable for investigating the mechanisms of synapse development in rodent cerebellum NEUROSCIENCE RESEARCH. 2010; 68 (1): E61. ( DOI )

Mikuni Takayasu, Uesaka Naofumi, Kano Masanobu. Effective modification of neural activity in CNS organotypic cultures NEUROSCIENCE RESEARCH. 2010; 68 (1): E135. ( DOI )

Uesaka Naofumi, Mikuni Takayasu, Kano Masanobu. Gene transfer techniques for CNS organotypic cultures NEUROSCIENCE RESEARCH. 2009; 65 (1): S132-S133. ( DOI )

Ohnami Soichiro, Endo Mitsuharu, Hirai Satoshi, Uesaka Naofumi, Hatanaka Yumiko, Yamashita Toshihide, Yamamoto Nobuhiko. Role of RhoA in activity-dependent cortical axon branching JOURNAL OF NEUROSCIENCE. 2008.09; 28 (37): 9117-9121. ( DOI )

Uesaka Naofumi, Nishiwaki Maki, Yamamoto Nobuhiko. Single cell electroporation method for axon tracing in cultured slices DEVELOPMENT GROWTH & DIFFERENTIATION. 2008.08; 50 (6): 475-477. ( DOI )

Ohnami Soichiro, Endo Mitsuharu, Hirai Satoshi, Uesaka Naofumi, Hatanaka Yumiko, Yamashita Toshihide, Yamamoto Nobuhiko. RhoA is involved in activity-dependent cortical axon branching NEUROSCIENCE RESEARCH. 2008; 61 S233.

Uesaka Naofumi, Kano Masanobu. Formation of functional synapses in organotypic cocultures of the medulla and cerebellum NEUROSCIENCE RESEARCH. 2008; 61 S88.

Uesaka Naofumi, Hayano Yasufumi, Yamada Akito, Yamamoto Nobuhiko. Interplay between laminar specificity and activity-dependent mechanisms of thalamocortical axon branching JOURNAL OF NEUROSCIENCE. 2007.05; 27 (19): 5215-5223. ( DOI )

Yamada Akito, Uesaka Naofumi, Hayano Yasufumi, Tabata Toshihide, Kano Masanobu, Yamamoto Nobuhiko. The role of neural activities of thalamic and cortical neurons in thalamocortical axon branching NEUROSCIENCE RESEARCH. 2007; 58 (1): S89. ( DOI )

Uesaka N, Ruthazer ES, Yamamoto N. The role of neural activity in cortical axon branching NEUROSCIENTIST. 2006.04; 12 (2): 102-106. ( DOI )

Sugo Noriyuki, Takemura Mitsuhiro, Kobayashi Toshiald, Uesaka Naofumi, Yamamoto Nobuhiko. Activity-dependent nucleocytoplasmic translocation of HDAC9 in cortical neurons NEUROSCIENCE RESEARCH. 2006; 55 (1): S53.

Uesaka Naofumi, Hayano Yasufumi, Yamada Akito, Yamamoto Nobuhiko. The role of neuronal activity in lamina-specific thalamocortical axon branching NEUROSCIENCE RESEARCH. 2006; 55 (1): S63.

Uesaka N, Hirai S, Maruyama T, Ruthazer ES, Yamamoto N. Activity dependence of cortical axon branch formation: A morphological and electrophysiological study using organotypic slice cultures JOURNAL OF NEUROSCIENCE. 2005.01; 25 (1): 1-9. ( DOI )

上阪 直史. シナプス刈り込みの破綻による疾患発症の機構解明 上原記念生命科学財団研究報告集. 2021.12; 35 1-5. ( 医中誌 )

上阪直史. 脳の機能発達を担うシナプス刈り込みのメカニズム 口腔病学会雑誌. 2021.03; 88 (1): 9-14.

上阪 直史. 【小脳研究の未来】発生発達　発達期小脳のシナプス刈り込み 生体の科学. 2021.02; 72 (1): 13-17. ( 医中誌 )

上阪 直史. 口腔と全身のネットワーク〜咀嚼・嚥下と脳・神経系の連関〜　運動機能を司る小脳の発達　咀嚼嚥下の機能発達の理解を目指して Journal of Oral Biosciences Supplement. 2020.09; 2020 90. ( 医中誌 )

上阪 直史. シナプス刈り込みにおけるグリア細胞の役割 ブレインサイエンス・レビュー. 2017.02; 2017 99-114. ( 医中誌 )

上阪直史. 運動機能を司る小脳の発達：咀嚼嚥下の機能発達の理解を目指して. 第62回 歯科基礎医学会学術大会 2020.09.22 日本（Webシンポジウム）

渡邉 貴樹1,2, 佐郡 和人1, 鈴木 穂香1, 赤松 翼1, 松山 恭子1, 井上 秀太郎1, 阿部 学3, 﨑村 建司3, 上阪 直史1,2, 狩野 方伸1,2. Protocadherin 10は一部のアルドラーゼＣ陽性の小脳プルキンエ細胞において発達期の登上線維シナプスの刈り込みを遅延させる. 2020.07.29

神経回路形成機構の解明に基づく咀嚼嚥下機能の理解. 口腔病学会講演会 2020.10.28